ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	185/1089	423/7206	1.1746281556e-48
ko04724	Glutamatergic synapse	83/1089	152/7206	2.90634593083e-30
ko05033	Nicotine addiction	44/1089	56/7206	3.23518376345e-26
ko05032	Morphine addiction	63/1089	110/7206	9.86158664837e-25
ko04728	Dopaminergic synapse	81/1089	185/7206	2.48364596015e-21
ko04713	Circadian entrainment	67/1089	136/7206	2.78073026534e-21
ko04721	Synaptic vesicle cycle	49/1089	80/7206	2.93364035516e-21
ko04727	GABAergic synapse	58/1089	110/7206	1.95861536907e-20
ko04725	Cholinergic synapse	72/1089	160/7206	6.65747125068e-20
ko04024	cAMP signaling pathway	99/1089	279/7206	6.90422985609e-18
ko04723	Retrograde endocannabinoid signaling	71/1089	175/7206	1.23364888633e-16
ko04020	Calcium signaling pathway	91/1089	265/7206	2.86731836494e-15
ko04742	Taste transduction	36/1089	61/7206	3.23690030045e-15
ko04911	Insulin secretion	52/1089	117/7206	2.00948909512e-14
ko04726	Serotonergic synapse	56/1089	137/7206	1.55911766752e-13
ko04360	Axon guidance	78/1089	233/7206	1.07790670825e-12
ko04921	Oxytocin signaling pathway	71/1089	209/7206	5.05754617322e-12
ko04261	Adrenergic signaling in cardiomyocytes	69/1089	205/7206	1.58232361481e-11
ko05031	Amphetamine addiction	39/1089	91/7206	1.48659713944e-10
ko04970	Salivary secretion	39/1089	95/7206	6.95486409581e-10
ko04720	Long-term potentiation	40/1089	99/7206	7.42998610934e-10
ko03040	Spliceosome	1/1089	145/7206	2.27698848817e-09
ko04744	Phototransduction	20/1089	36/7206	2.12043516453e-08
ko05168	Herpes simplex infection	6/1089	182/7206	2.83852833096e-07
ko03013	RNA transport	5/1089	166/7206	4.67207760936e-07
ko05203	Viral carcinogenesis	15/1089	277/7206	4.97655707812e-07
ko04740	Olfactory transduction	30/1089	80/7206	6.90974615124e-07
ko05030	Cocaine addiction	28/1089	73/7206	9.51364206943e-07
ko04022	cGMP-PKG signaling pathway	60/1089	216/7206	1.05155341419e-06
ko04060	Cytokine-cytokine receptor interaction	8/1089	191/7206	1.73269359783e-06
ko05164	Influenza A	6/1089	167/7206	1.81669458532e-06
ko04925	Aldosterone synthesis and secretion	35/1089	105/7206	2.73362217141e-06
ko05322	Systemic lupus erythematosus	5/1089	151/7206	4.7295377928e-06
ko04010	MAPK signaling pathway	79/1089	321/7206	4.72953941044e-06
ko04971	Gastric acid secretion	33/1089	98/7206	5.01147591131e-06
ko04924	Renin secretion	29/1089	86/7206	1.29812423793e-05
ko04514	Cell adhesion molecules (CAMs)	39/1089	130/7206	1.71918516465e-05
ko04120	Ubiquitin mediated proteolysis	5/1089	138/7206	1.95506359561e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	26/1089	74/7206	2.01061103216e-05
ko04014	Ras signaling pathway	68/1089	279/7206	3.66441662105e-05
ko04621	NOD-like receptor signaling pathway	7/1089	157/7206	3.75490206807e-05
ko03008	Ribosome biogenesis in eukaryotes	1/1089	79/7206	5.22450109396e-05
ko04745	Phototransduction - fly	16/1089	38/7206	5.46804353825e-05
ko04141	Protein processing in endoplasmic reticulum	10/1089	184/7206	6.01988908796e-05
ko04070	Phosphatidylinositol signaling system	33/1089	112/7206	8.77796189927e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1089	79/7206	8.88995004114e-05
ko04730	Long-term depression	25/1089	78/7206	0.000163264447481
ko04966	Collecting duct acid secretion	12/1089	26/7206	0.000164416851014
ko04972	Pancreatic secretion	32/1089	111/7206	0.000234204782443
ko04260	Cardiac muscle contraction	29/1089	98/7206	0.000282568376836
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1089	14/7206	0.000339800057469
ko04540	Gap junction	35/1089	128/7206	0.000397262983316
ko04610	Complement and coagulation cascades	2/1089	79/7206	0.000411158457265
ko05414	Dilated cardiomyopathy	31/1089	112/7206	0.000488452634186
ko04750	Inflammatory mediator regulation of TRP channels	33/1089	122/7206	0.000520891270398
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1089	59/7206	0.000795546222133
ko05140	Leishmaniasis	2/1089	75/7206	0.000918756605843
ko05110	Vibrio cholerae infection	20/1089	63/7206	0.00104769590005
ko04072	Phospholipase D signaling pathway	47/1089	197/7206	0.00113696258554
ko04371	Apelin signaling pathway	43/1089	177/7206	0.00129431358569
ko05205	Proteoglycans in cancer	23/1089	271/7206	0.00130619466325
ko04064	NF-kappa B signaling pathway	4/1089	96/7206	0.00132492066202
ko05169	Epstein-Barr virus infection	16/1089	206/7206	0.00206489006324
ko00480	Glutathione metabolism	1/1089	55/7206	0.00209113710029
ko04146	Peroxisome	4/1089	89/7206	0.00258013886006
ko04915	Estrogen signaling pathway	33/1089	131/7206	0.00280724295242
ko00240	Pyrimidine metabolism	6/1089	110/7206	0.00281469986659
ko04626	Plant-pathogen interaction	8/1089	18/7206	0.00281683058138
ko00590	Arachidonic acid metabolism	1/1089	52/7206	0.00313486852035
ko04110	Cell cycle	10/1089	145/7206	0.00327649508167
ko04612	Antigen processing and presentation	3/1089	77/7206	0.00340845888508
ko05161	Hepatitis B	13/1089	173/7206	0.00349432393217
ko00310	Lysine degradation	3/1089	73/7206	0.00477660431046
ko04923	Regulation of lipolysis in adipocytes	21/1089	77/7206	0.00573125454536
ko00330	Arginine and proline metabolism	2/1089	61/7206	0.00612574552041
ko04214	Apoptosis - fly	3/1089	72/7206	0.00711910536906
ko04015	Rap1 signaling pathway	58/1089	278/7206	0.00804213694485
ko03022	Basal transcription factors	1/1089	44/7206	0.0104536464015
ko00071	Fatty acid degradation	1/1089	45/7206	0.0106118556813
ko04976	Bile secretion	21/1089	80/7206	0.0108238193923
ko03420	Nucleotide excision repair	1/1089	46/7206	0.0110847164858
ko00280	Valine, leucine and isoleucine degradation	2/1089	54/7206	0.0127048124617
ko04640	Hematopoietic cell lineage	3/1089	64/7206	0.0138054090376
ko03018	RNA degradation	5/1089	84/7206	0.0139328586514
ko04115	p53 signaling pathway	4/1089	74/7206	0.0141240824299
ko04932	Non-alcoholic fatty liver disease (NAFLD)	16/1089	182/7206	0.0154125153034
ko00140	Steroid hormone biosynthesis	1/1089	41/7206	0.0155808329627
ko00983	Drug metabolism - other enzymes	1/1089	42/7206	0.0156949552885
ko00562	Inositol phosphate metabolism	22/1089	89/7206	0.0162754982569
ko05410	Hypertrophic cardiomyopathy (HCM)	24/1089	100/7206	0.0165439332348
ko04916	Melanogenesis	32/1089	142/7206	0.0173738795411
ko04391	Hippo signaling pathway - fly	22/1089	90/7206	0.0173866421215
ko01200	Carbon metabolism	10/1089	128/7206	0.01756865429
ko04722	Neurotrophin signaling pathway	35/1089	160/7206	0.0190044496852
ko05131	Shigellosis	5/1089	82/7206	0.0191587671102
ko04330	Notch signaling pathway	3/1089	62/7206	0.0195581486638
ko04622	RIG-I-like receptor signaling pathway	3/1089	62/7206	0.0195581486638
ko04668	TNF signaling pathway	9/1089	120/7206	0.0197202175128
ko05162	Measles	9/1089	120/7206	0.0197202175128
ko05145	Toxoplasmosis	10/1089	126/7206	0.0230890071972
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1089	40/7206	0.0238605355026
ko00380	Tryptophan metabolism	2/1089	50/7206	0.0269761428721
ko04658	Th1 and Th2 cell differentiation	7/1089	96/7206	0.0305313398308
ko04270	Vascular smooth muscle contraction	33/1089	154/7206	0.0307290770378
ko04964	Proximal tubule bicarbonate reclamation	9/1089	29/7206	0.0316764173656
ko05133	Pertussis	6/1089	87/7206	0.0335074859265
ko04217	Necroptosis	17/1089	178/7206	0.0340182055867
ko04930	Type II diabetes mellitus	14/1089	54/7206	0.0344832278613
ko00982	Drug metabolism - cytochrome P450	1/1089	37/7206	0.0350431557297
ko01524	Platinum drug resistance	5/1089	76/7206	0.0355081813696
ko00620	Pyruvate metabolism	2/1089	46/7206	0.0380146322282
ko05231	Choline metabolism in cancer	29/1089	134/7206	0.0382485046544
ko00270	Cysteine and methionine metabolism	2/1089	47/7206	0.0385265184933
ko05321	Inflammatory bowel disease (IBD)	3/1089	56/7206	0.0385861542742
ko05219	Bladder cancer	2/1089	48/7206	0.0397796012686
ko04620	Toll-like receptor signaling pathway	8/1089	100/7206	0.0480681428963
ko04630	Jak-STAT signaling pathway	12/1089	132/7206	0.0498944406252