ko pathway ratio_in_study ratio_in_pop p_value ko03040 Spliceosome 91/648 145/7206 4.82474481233e-60 ko04110 Cell cycle 62/648 145/7206 5.10809957697e-28 ko03013 RNA transport 64/648 166/7206 7.93939176282e-26 ko04111 Cell cycle - yeast 44/648 90/7206 4.60356308476e-23 ko03030 DNA replication 28/648 38/7206 5.90010383344e-22 ko03460 Fanconi anemia pathway 29/648 51/7206 5.91798586996e-18 ko03440 Homologous recombination 26/648 41/7206 6.8330531909e-18 ko04113 Meiosis - yeast 32/648 70/7206 5.24703303284e-16 ko03420 Nucleotide excision repair 24/648 46/7206 6.133091562e-14 ko00240 Pyrimidine metabolism 38/648 110/7206 6.18353932249e-14 ko03022 Basal transcription factors 22/648 44/7206 2.16144631273e-12 ko03008 Ribosome biogenesis in eukaryotes 29/648 79/7206 1.10008987507e-11 ko03430 Mismatch repair 15/648 22/7206 1.63615529465e-11 ko04144 Endocytosis 4/648 342/7206 6.96504670934e-10 ko03410 Base excision repair 18/648 38/7206 7.07510283303e-10 ko03015 mRNA surveillance pathway 29/648 93/7206 1.00687382895e-09 ko03018 RNA degradation 26/648 84/7206 8.90817634808e-09 ko03020 RNA polymerase 14/648 29/7206 4.26474171634e-08 ko04060 Cytokine-cytokine receptor interaction 1/648 191/7206 4.88787108569e-07 ko04024 cAMP signaling pathway 6/648 279/7206 3.28988033534e-06 ko05010 Alzheimer's disease 3/648 202/7206 1.44347919209e-05 ko00230 Purine metabolism 36/648 194/7206 2.0133215875e-05 ko05152 Tuberculosis 3/648 187/7206 4.27463250173e-05 ko04151 PI3K-Akt signaling pathway 15/648 390/7206 8.07226304784e-05 ko04022 cGMP-PKG signaling pathway 5/648 216/7206 9.22124752693e-05 ko05203 Viral carcinogenesis 45/648 277/7206 9.23802104568e-05 ko04270 Vascular smooth muscle contraction 2/648 154/7206 9.30987831819e-05 ko04621 NOD-like receptor signaling pathway 2/648 157/7206 9.64180510805e-05 ko04114 Oocyte meiosis 27/648 139/7206 0.000117283164629 ko04010 MAPK signaling pathway 11/648 321/7206 0.000125770355687 ko03010 Ribosome 1/648 129/7206 0.000129368128184 ko04723 Retrograde endocannabinoid signaling 3/648 175/7206 0.000132009033616 ko04142 Lysosome 2/648 151/7206 0.000136601036783 ko04724 Glutamatergic synapse 2/648 152/7206 0.000138871843864 ko04810 Regulation of actin cytoskeleton 8/648 264/7206 0.000164247503258 ko04921 Oxytocin signaling pathway 5/648 209/7206 0.000186001570098 ko04120 Ubiquitin mediated proteolysis 26/648 138/7206 0.000233320283147 ko04261 Adrenergic signaling in cardiomyocytes 5/648 205/7206 0.000264079305504 ko04668 TNF signaling pathway 1/648 120/7206 0.000282657160027 ko04932 Non-alcoholic fatty liver disease (NAFLD) 4/648 182/7206 0.000320839324735 ko05166 HTLV-I infection 45/648 292/7206 0.000329696839029 ko04713 Circadian entrainment 2/648 136/7206 0.000417896080132 ko04911 Insulin secretion 1/648 117/7206 0.000435149238252 ko05322 Systemic lupus erythematosus 27/648 151/7206 0.000450297895025 ko05169 Epstein-Barr virus infection 34/648 206/7206 0.000452685292602 ko05168 Herpes simplex infection 31/648 182/7206 0.000515583577671 ko05012 Parkinson's disease 3/648 155/7206 0.000541323304633 ko04014 Ras signaling pathway 10/648 279/7206 0.000566862174465 ko04510 Focal adhesion 8/648 240/7206 0.000784515820462 ko04914 Progesterone-mediated oocyte maturation 20/648 104/7206 0.000873214797567 ko01200 Carbon metabolism 2/648 128/7206 0.000878783706501 ko04218 Cellular senescence 29/648 177/7206 0.00126463041968 ko03450 Non-homologous end-joining 6/648 15/7206 0.00127322070606 ko04360 Axon guidance 8/648 233/7206 0.00148191793478 ko04015 Rap1 signaling pathway 11/648 278/7206 0.00175813815328 ko04725 Cholinergic synapse 4/648 160/7206 0.00180396032596 ko04971 Gastric acid secretion 1/648 98/7206 0.00198262523154 ko04530 Tight junction 8/648 228/7206 0.00199210690003 ko04915 Estrogen signaling pathway 3/648 131/7206 0.00312375385784 ko03060 Protein export 7/648 23/7206 0.00313273222106 ko04630 Jak-STAT signaling pathway 3/648 132/7206 0.00313565735603 ko04380 Osteoclast differentiation 3/648 134/7206 0.00322794348248 ko04728 Dopaminergic synapse 6/648 185/7206 0.00374963298996 ko04727 GABAergic synapse 2/648 110/7206 0.00379393307779 ko05032 Morphine addiction 2/648 110/7206 0.00379393307779 ko04972 Pancreatic secretion 2/648 111/7206 0.00383728443717 ko04070 Phosphatidylinositol signaling system 2/648 112/7206 0.00391271024876 ko04146 Peroxisome 1/648 89/7206 0.00427069425767 ko05145 Toxoplasmosis 3/648 126/7206 0.00440998576924 ko05142 Chagas disease (American trypanosomiasis) 3/648 130/7206 0.00461553072533 ko04152 AMPK signaling pathway 5/648 161/7206 0.00495454317663 ko04371 Apelin signaling pathway 6/648 177/7206 0.00496288052609 ko04072 Phospholipase D signaling pathway 7/648 197/7206 0.00499183754753 ko04611 Platelet activation 5/648 163/7206 0.00505122082116 ko04659 Th17 cell differentiation 2/648 106/7206 0.00546783006915 ko04750 Inflammatory mediator regulation of TRP channels 3/648 122/7206 0.00620578762618 ko04924 Renin secretion 1/648 86/7206 0.00650908068946 ko04620 Toll-like receptor signaling pathway 2/648 100/7206 0.00775573805982 ko04062 Chemokine signaling pathway 8/648 201/7206 0.00833457120331 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 1/648 79/7206 0.00902456049612 ko04512 ECM-receptor interaction 1/648 79/7206 0.00902456049612 ko04726 Serotonergic synapse 4/648 137/7206 0.00939624677322 ko04658 Th1 and Th2 cell differentiation 2/648 96/7206 0.0110821892484 ko04145 Phagosome 6/648 162/7206 0.0122515282137 ko05205 Proteoglycans in cancer 13/648 271/7206 0.0123017387212 ko05030 Cocaine addiction 1/648 73/7206 0.0131394562328 ko00010 Glycolysis / Gluconeogenesis 1/648 74/7206 0.0131421109425 ko05140 Leishmaniasis 1/648 75/7206 0.0132654961848 ko05031 Amphetamine addiction 2/648 91/7206 0.0157498321541 ko04922 Glucagon signaling pathway 4/648 128/7206 0.0178600977845 ko05034 Alcoholism 32/648 238/7206 0.0204678099634 ko05133 Pertussis 2/648 87/7206 0.0223992771809 ko05323 Rheumatoid arthritis 2/648 89/7206 0.0229695335377 ko00562 Inositol phosphate metabolism 2/648 89/7206 0.0229695335377 ko04931 Insulin resistance 5/648 137/7206 0.0230465472011 ko04925 Aldosterone synthesis and secretion 3/648 105/7206 0.0238721299602 ko04666 Fc gamma R-mediated phagocytosis 4/648 122/7206 0.0239742132414 ko04066 HIF-1 signaling pathway 4/648 123/7206 0.0242897542107 ko00670 One carbon pool by folate 5/648 20/7206 0.028748020009 ko05231 Choline metabolism in cancer 5/648 134/7206 0.031325629882 ko04138 Autophagy - yeast 2/648 81/7206 0.0316240966347 ko04933 AGE-RAGE signaling pathway in diabetic complications 5/648 135/7206 0.0316898489981 ko00564 Glycerophospholipid metabolism 3/648 99/7206 0.032734875404 ko01230 Biosynthesis of amino acids 2/648 85/7206 0.0328624771707 ko04115 p53 signaling pathway 12/648 74/7206 0.0388627497893 ko04622 RIG-I-like receptor signaling pathway 1/648 62/7206 0.0412769267746 ko05418 Fluid shear stress and atherosclerosis 8/648 173/7206 0.0426192224995 ko04923 Regulation of lipolysis in adipocytes 2/648 77/7206 0.0445436983795 ko04650 Natural killer cell mediated cytotoxicity 3/648 97/7206 0.0464051192108 ko05200 Pathways in cancer 32/648 492/7206 0.049583549489