ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04724	Glutamatergic synapse	76/883	152/7206	1.19123482293e-30
ko05033	Nicotine addiction	43/883	56/7206	9.71596096981e-29
ko04080	Neuroactive ligand-receptor interaction	132/883	423/7206	9.6844911245e-27
ko04727	GABAergic synapse	59/883	110/7206	4.42990657699e-26
ko05032	Morphine addiction	57/883	110/7206	3.20581626525e-24
ko04723	Retrograde endocannabinoid signaling	68/883	175/7206	9.47754197272e-20
ko04713	Circadian entrainment	57/883	136/7206	1.50621771166e-18
ko04728	Dopaminergic synapse	67/883	185/7206	1.41482292891e-17
ko04744	Phototransduction	26/883	36/7206	1.06694161121e-16
ko04725	Cholinergic synapse	58/883	160/7206	2.21606788272e-15
ko04721	Synaptic vesicle cycle	37/883	80/7206	4.24134150544e-14
ko04024	cAMP signaling pathway	77/883	279/7206	2.04239743593e-12
ko04726	Serotonergic synapse	47/883	137/7206	1.06227953873e-11
ko04742	Taste transduction	27/883	61/7206	4.23003442273e-10
ko04911	Insulin secretion	40/883	117/7206	4.26154636111e-10
ko04921	Oxytocin signaling pathway	57/883	209/7206	2.37660074857e-09
ko04020	Calcium signaling pathway	63/883	265/7206	1.49197742189e-07
ko05031	Amphetamine addiction	30/883	91/7206	1.678779576e-07
ko03040	Spliceosome	1/883	145/7206	2.32840636214e-07
ko04261	Adrenergic signaling in cardiomyocytes	51/883	205/7206	4.05782539438e-07
ko05203	Viral carcinogenesis	10/883	277/7206	5.17820693298e-07
ko05030	Cocaine addiction	25/883	73/7206	8.00504581744e-07
ko05164	Influenza A	3/883	167/7206	1.05372590814e-06
ko04740	Olfactory transduction	26/883	80/7206	1.51992476961e-06
ko04970	Salivary secretion	29/883	95/7206	1.64657340078e-06
ko05162	Measles	1/883	120/7206	3.87711741545e-06
ko04141	Protein processing in endoplasmic reticulum	6/883	184/7206	3.04463477806e-05
ko04514	Cell adhesion molecules (CAMs)	33/883	130/7206	3.34254054319e-05
ko03013	RNA transport	5/883	166/7206	3.6250094251e-05
ko04720	Long-term potentiation	27/883	99/7206	3.91294270358e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	22/883	74/7206	4.63335008565e-05
ko04060	Cytokine-cytokine receptor interaction	7/883	191/7206	4.65178602101e-05
ko04022	cGMP-PKG signaling pathway	47/883	216/7206	7.76454538392e-05
ko04110	Cell cycle	4/883	145/7206	9.13347778383e-05
ko05205	Proteoglycans in cancer	14/883	271/7206	9.48368455398e-05
ko04925	Aldosterone synthesis and secretion	27/883	105/7206	0.000127589805658
ko05169	Epstein-Barr virus infection	9/883	206/7206	0.000138067204011
ko04972	Pancreatic secretion	28/883	111/7206	0.000182625924349
ko04120	Ubiquitin mediated proteolysis	4/883	138/7206	0.000186211996875
ko05322	Systemic lupus erythematosus	5/883	151/7206	0.000217017147071
ko04010	MAPK signaling pathway	62/883	321/7206	0.000227986196882
ko04260	Cardiac muscle contraction	25/883	98/7206	0.000264647032937
ko04971	Gastric acid secretion	25/883	98/7206	0.000264647032937
ko05168	Herpes simplex infection	8/883	182/7206	0.000503913364216
ko05215	Prostate cancer	3/883	111/7206	0.000644885493523
ko04612	Antigen processing and presentation	1/883	77/7206	0.0007422493134
ko03008	Ribosome biogenesis in eukaryotes	1/883	79/7206	0.000763804851785
ko05161	Hepatitis B	8/883	173/7206	0.000909314354733
ko04621	NOD-like receptor signaling pathway	7/883	157/7206	0.00124102141362
ko04974	Protein digestion and absorption	23/883	96/7206	0.00137673056672
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	20/883	79/7206	0.00141492471105
ko04976	Bile secretion	20/883	80/7206	0.00156306802006
ko04964	Proximal tubule bicarbonate reclamation	10/883	29/7206	0.00162164801404
ko04218	Cellular senescence	9/883	177/7206	0.0016367934012
ko04072	Phospholipase D signaling pathway	39/883	197/7206	0.00193937626322
ko05218	Melanoma	2/883	85/7206	0.00228275301286
ko04730	Long-term depression	19/883	78/7206	0.00265802906413
ko04966	Collecting duct acid secretion	9/883	26/7206	0.00267938560353
ko04932	Non-alcoholic fatty liver disease (NAFLD)	10/883	182/7206	0.00281050119921
ko04070	Phosphatidylinositol signaling system	25/883	112/7206	0.00315900446091
ko05166	HTLV-I infection	20/883	292/7206	0.00336741103978
ko04924	Renin secretion	20/883	86/7206	0.00417149491209
ko04745	Phototransduction - fly	11/883	38/7206	0.00460678494015
ko04217	Necroptosis	10/883	178/7206	0.00507572238748
ko04930	Type II diabetes mellitus	14/883	54/7206	0.00533455931054
ko04146	Peroxisome	3/883	89/7206	0.00544877360664
ko04350	TGF-beta signaling pathway	4/883	103/7206	0.0058691455548
ko05224	Breast cancer	10/883	174/7206	0.00665444142191
ko04978	Mineral absorption	11/883	40/7206	0.00704029255423
ko04630	Jak-STAT signaling pathway	7/883	132/7206	0.0105194725877
ko05212	Pancreatic cancer	3/883	83/7206	0.0108796248453
ko00480	Glutathione metabolism	1/883	55/7206	0.0117817494969
ko05416	Viral myocarditis	1/883	55/7206	0.0117817494969
ko04510	Focal adhesion	17/883	240/7206	0.0119128591839
ko05414	Dilated cardiomyopathy	23/883	112/7206	0.0124935484061
ko04961	Endocrine and other factor-regulated calcium reabsorption	14/883	59/7206	0.0143419254986
ko00830	Retinol metabolism	11/883	42/7206	0.0144345624927
ko04710	Circadian rhythm	11/883	43/7206	0.0160009139052
ko05131	Shigellosis	3/883	82/7206	0.0160139774053
ko04810	Regulation of actin cytoskeleton	20/883	264/7206	0.0165391486148
ko05200	Pathways in cancer	44/883	492/7206	0.0187139184015
ko05145	Toxoplasmosis	7/883	126/7206	0.0189183725747
ko04640	Hematopoietic cell lineage	2/883	64/7206	0.0202898139227
ko04210	Apoptosis	12/883	180/7206	0.0205680222719
ko04620	Toll-like receptor signaling pathway	5/883	100/7206	0.020977450962
ko00604	Glycosphingolipid biosynthesis - ganglio series	5/883	14/7206	0.0211583946455
ko05130	Pathogenic Escherichia coli infection	3/883	77/7206	0.021644557031
ko04664	Fc epsilon RI signaling pathway	3/883	77/7206	0.021644557031
ko04140	Autophagy - animal	11/883	164/7206	0.029236082495
ko04550	Signaling pathways regulating pluripotency of stem cells	11/883	165/7206	0.0295724441153
ko05220	Chronic myeloid leukemia	4/883	85/7206	0.0296334012663
ko05410	Hypertrophic cardiomyopathy (HCM)	20/883	100/7206	0.0296951304157
ko04150	mTOR signaling pathway	13/883	184/7206	0.0297815071834
ko00310	Lysine degradation	3/883	73/7206	0.0300474370398
ko04115	p53 signaling pathway	3/883	74/7206	0.0304512244187
ko04657	IL-17 signaling pathway	4/883	87/7206	0.0304565529019
ko05140	Leishmaniasis	3/883	75/7206	0.0311720581703
ko04014	Ras signaling pathway	46/883	279/7206	0.0320107585068
ko05418	Fluid shear stress and atherosclerosis	12/883	173/7206	0.0336370856164
ko04668	TNF signaling pathway	7/883	120/7206	0.0337069003226
ko05034	Alcoholism	40/883	238/7206	0.034426688232
ko04371	Apelin signaling pathway	31/883	177/7206	0.0362743182354
ko03022	Basal transcription factors	1/883	44/7206	0.0372260608042
ko00071	Fatty acid degradation	1/883	45/7206	0.0375373308465
ko03420	Nucleotide excision repair	1/883	46/7206	0.0384407736675
ko05211	Renal cell carcinoma	5/883	96/7206	0.0395517127443
ko04064	NF-kappa B signaling pathway	5/883	96/7206	0.0395517127443
ko05321	Inflammatory bowel disease (IBD)	2/883	56/7206	0.0411353911565
ko04380	Osteoclast differentiation	9/883	134/7206	0.0461592212106
ko04520	Adherens junction	6/883	103/7206	0.0477504703808
ko02010	ABC transporters	9/883	39/7206	0.0485327724917