ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko03040	Spliceosome	110/1081	145/7206	5.17277497823e-62
ko03013	RNA transport	104/1081	166/7206	7.970897965e-46
ko03008	Ribosome biogenesis in eukaryotes	60/1081	79/7206	4.42510298979e-34
ko04080	Neuroactive ligand-receptor interaction	1/1081	423/7206	1.64210896373e-29
ko03030	DNA replication	32/1081	38/7206	3.21738553473e-21
ko04110	Cell cycle	69/1081	145/7206	5.48568368138e-21
ko03440	Homologous recombination	33/1081	41/7206	1.19908769544e-20
ko04111	Cell cycle - yeast	50/1081	90/7206	3.22736106222e-19
ko03050	Proteasome	34/1081	54/7206	9.40494636041e-16
ko03420	Nucleotide excision repair	31/1081	46/7206	1.03018935028e-15
ko03020	RNA polymerase	23/1081	29/7206	1.75509463103e-14
ko03460	Fanconi anemia pathway	31/1081	51/7206	7.27177190644e-14
ko05322	Systemic lupus erythematosus	58/1081	151/7206	9.82066044463e-13
ko00240	Pyrimidine metabolism	47/1081	110/7206	1.63847151664e-12
ko03022	Basal transcription factors	27/1081	44/7206	2.21267648582e-12
ko04113	Meiosis - yeast	35/1081	70/7206	4.83582916668e-12
ko04060	Cytokine-cytokine receptor interaction	2/1081	191/7206	2.11061200043e-11
ko04024	cAMP signaling pathway	9/1081	279/7206	1.0095104828e-10
ko03430	Mismatch repair	17/1081	22/7206	1.09988714316e-10
ko03015	mRNA surveillance pathway	38/1081	93/7206	1.09121861073e-09
ko05169	Epstein-Barr virus infection	63/1081	206/7206	7.92239276772e-09
ko03018	RNA degradation	34/1081	84/7206	1.10379461775e-08
ko04724	Glutamatergic synapse	2/1081	152/7206	1.18891824457e-08
ko04261	Adrenergic signaling in cardiomyocytes	6/1081	205/7206	1.38033985269e-08
ko04022	cGMP-PKG signaling pathway	7/1081	216/7206	1.81087902653e-08
ko05010	Alzheimer's disease	6/1081	202/7206	2.02553725913e-08
ko04723	Retrograde endocannabinoid signaling	4/1081	175/7206	2.20682427518e-08
ko04151	PI3K-Akt signaling pathway	24/1081	390/7206	4.89475538674e-08
ko04713	Circadian entrainment	2/1081	136/7206	1.43409901071e-07
ko04911	Insulin secretion	1/1081	117/7206	1.51553257757e-07
ko04921	Oxytocin signaling pathway	8/1081	209/7206	2.03662815397e-07
ko04725	Cholinergic synapse	4/1081	160/7206	2.38764102127e-07
ko04514	Cell adhesion molecules (CAMs)	2/1081	130/7206	3.15066582693e-07
ko05414	Dilated cardiomyopathy	1/1081	112/7206	3.51020651448e-07
ko03410	Base excision repair	19/1081	38/7206	3.90573194691e-07
ko00190	Oxidative phosphorylation	2/1081	127/7206	4.68823946499e-07
ko04015	Rap1 signaling pathway	15/1081	278/7206	4.96461048365e-07
ko04270	Vascular smooth muscle contraction	4/1081	154/7206	5.12453506262e-07
ko05203	Viral carcinogenesis	73/1081	277/7206	7.17147753527e-07
ko04728	Dopaminergic synapse	7/1081	185/7206	1.05994069346e-06
ko04010	MAPK signaling pathway	20/1081	321/7206	1.23684886746e-06
ko04510	Focal adhesion	12/1081	240/7206	1.24006414957e-06
ko05034	Alcoholism	64/1081	238/7206	1.780606129e-06
ko05012	Parkinson's disease	5/1081	155/7206	2.14498011102e-06
ko05146	Amoebiasis	1/1081	99/7206	2.87284311908e-06
ko05410	Hypertrophic cardiomyopathy (HCM)	1/1081	100/7206	2.97723065301e-06
ko05200	Pathways in cancer	40/1081	492/7206	3.0005231682e-06
ko04371	Apelin signaling pathway	7/1081	177/7206	3.14375705961e-06
ko04974	Protein digestion and absorption	1/1081	96/7206	4.35199844475e-06
ko04971	Gastric acid secretion	1/1081	98/7206	4.74345773848e-06
ko03060	Protein export	13/1081	23/7206	4.77989828328e-06
ko04727	GABAergic synapse	2/1081	110/7206	5.27430531711e-06
ko05032	Morphine addiction	2/1081	110/7206	5.27430531711e-06
ko04972	Pancreatic secretion	2/1081	111/7206	5.40751833203e-06
ko04144	Endocytosis	24/1081	342/7206	5.75885714871e-06
ko04810	Regulation of actin cytoskeleton	16/1081	264/7206	6.34613972286e-06
ko04932	Non-alcoholic fatty liver disease (NAFLD)	8/1081	182/7206	7.24488350038e-06
ko04621	NOD-like receptor signaling pathway	6/1081	157/7206	7.91693348325e-06
ko03450	Non-homologous end-joining	10/1081	15/7206	8.10200429521e-06
ko04062	Chemokine signaling pathway	10/1081	201/7206	8.28428162715e-06
ko04659	Th17 cell differentiation	2/1081	106/7206	1.23478286029e-05
ko04120	Ubiquitin mediated proteolysis	40/1081	138/7206	1.93234610612e-05
ko04070	Phosphatidylinositol signaling system	3/1081	112/7206	2.57471767987e-05
ko00970	Aminoacyl-tRNA biosynthesis	18/1081	44/7206	2.72191115766e-05
ko04726	Serotonergic synapse	5/1081	137/7206	2.88075033595e-05
ko04380	Osteoclast differentiation	5/1081	134/7206	4.124864532e-05
ko04668	TNF signaling pathway	4/1081	120/7206	4.88790663408e-05
ko04750	Inflammatory mediator regulation of TRP channels	4/1081	122/7206	5.13750330097e-05
ko04976	Bile secretion	1/1081	80/7206	5.28026492201e-05
ko04915	Estrogen signaling pathway	5/1081	131/7206	5.90233851509e-05
ko04630	Jak-STAT signaling pathway	5/1081	132/7206	6.05767319057e-05
ko04014	Ras signaling pathway	20/1081	279/7206	7.39258462733e-05
ko04925	Aldosterone synthesis and secretion	3/1081	105/7206	8.2356945457e-05
ko04922	Glucagon signaling pathway	5/1081	128/7206	8.43878162187e-05
ko00230	Purine metabolism	50/1081	194/7206	8.80004133992e-05
ko05145	Toxoplasmosis	5/1081	126/7206	0.000122541979436
ko04920	Adipocytokine signaling pathway	2/1081	89/7206	0.000130320722415
ko04141	Protein processing in endoplasmic reticulum	47/1081	184/7206	0.000145827598964
ko05030	Cocaine addiction	1/1081	73/7206	0.000188097967309
ko04924	Renin secretion	2/1081	86/7206	0.00019159727373
ko04611	Platelet activation	9/1081	163/7206	0.000215645951402
ko05142	Chagas disease (American trypanosomiasis)	6/1081	130/7206	0.00026983413398
ko04360	Axon guidance	17/1081	233/7206	0.000371260477129
ko04540	Gap junction	6/1081	128/7206	0.00038646154686
ko05031	Amphetamine addiction	3/1081	91/7206	0.000540350508161
ko04933	AGE-RAGE signaling pathway in diabetic complications	7/1081	135/7206	0.000559643914808
ko04923	Regulation of lipolysis in adipocytes	2/1081	77/7206	0.00061125528427
ko04640	Hematopoietic cell lineage	1/1081	64/7206	0.000624229462244
ko04620	Toll-like receptor signaling pathway	4/1081	100/7206	0.000631511834642
ko00562	Inositol phosphate metabolism	3/1081	89/7206	0.000802683990876
ko04742	Taste transduction	1/1081	61/7206	0.000934985884895
ko01200	Carbon metabolism	7/1081	128/7206	0.00105983399368
ko04658	Th1 and Th2 cell differentiation	4/1081	96/7206	0.00130360953388
ko04530	Tight junction	18/1081	228/7206	0.00131060144475
ko04931	Insulin resistance	8/1081	137/7206	0.00148718238192
ko04916	Melanogenesis	9/1081	142/7206	0.00191594528808
ko04912	GnRH signaling pathway	7/1081	122/7206	0.00201365410911
ko04072	Phospholipase D signaling pathway	15/1081	197/7206	0.00225437692938
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	3/1081	79/7206	0.00233275644056
ko04512	ECM-receptor interaction	3/1081	79/7206	0.00233275644056
ko04152	AMPK signaling pathway	11/1081	161/7206	0.00236078521923
ko04721	Synaptic vesicle cycle	3/1081	80/7206	0.00236302860041
ko05152	Tuberculosis	14/1081	187/7206	0.00245622161837
ko04146	Peroxisome	4/1081	89/7206	0.00258876513341
ko00564	Glycerophospholipid metabolism	5/1081	99/7206	0.00273104243316
ko04930	Type II diabetes mellitus	1/1081	54/7206	0.00325667796558
ko05418	Fluid shear stress and atherosclerosis	13/1081	173/7206	0.00349025955643
ko04918	Thyroid hormone synthesis	4/1081	86/7206	0.00366286800685
ko04662	B cell receptor signaling pathway	4/1081	88/7206	0.00376357617555
ko05167	Kaposi's sarcoma-associated herpesvirus infection	15/1081	191/7206	0.00382361910755
ko00010	Glycolysis / Gluconeogenesis	3/1081	74/7206	0.00482437603123
ko04066	HIF-1 signaling pathway	8/1081	123/7206	0.004947656041
ko05140	Leishmaniasis	3/1081	75/7206	0.00494795357545
ko04660	T cell receptor signaling pathway	8/1081	124/7206	0.00494853717072
ko05204	Chemical carcinogenesis	1/1081	48/7206	0.00713419775186
ko04962	Vasopressin-regulated water reabsorption	2/1081	58/7206	0.00882718824989
ko05205	Proteoglycans in cancer	26/1081	271/7206	0.00919868442431
ko04720	Long-term potentiation	6/1081	99/7206	0.0100077116851
ko04730	Long-term depression	4/1081	78/7206	0.010162996691
ko04218	Cellular senescence	39/1081	177/7206	0.0104138824533
ko04216	Ferroptosis	1/1081	44/7206	0.0105152834872
ko00620	Pyruvate metabolism	1/1081	46/7206	0.0109402876168
ko04670	Leukocyte transendothelial migration	12/1081	151/7206	0.011146575043
ko04914	Progesterone-mediated oocyte maturation	25/1081	104/7206	0.0126312014278
ko04650	Natural killer cell mediated cytotoxicity	6/1081	97/7206	0.0138922389545
ko01230	Biosynthesis of amino acids	5/1081	85/7206	0.0139875111929
ko05133	Pertussis	5/1081	87/7206	0.01445013589
ko04666	Fc gamma R-mediated phagocytosis	9/1081	122/7206	0.0146920904391
ko05016	Huntington's disease	20/1081	215/7206	0.0152262816461
ko04068	FoxO signaling pathway	14/1081	167/7206	0.0152650767569
ko04623	Cytosolic DNA-sensing pathway	12/1081	41/7206	0.0156678657476
ko00565	Ether lipid metabolism	1/1081	42/7206	0.0156776185024
ko05161	Hepatitis B	15/1081	173/7206	0.0172647134364
ko00590	Arachidonic acid metabolism	2/1081	52/7206	0.018438369737
ko04913	Ovarian steroidogenesis	3/1081	63/7206	0.0197842899765
ko00561	Glycerolipid metabolism	3/1081	63/7206	0.0197842899765
ko04114	Oocyte meiosis	31/1081	139/7206	0.0218082867132
ko05323	Rheumatoid arthritis	6/1081	89/7206	0.0246620704596
ko05230	Central carbon metabolism in cancer	5/1081	81/7206	0.0268302359166
ko04138	Autophagy - yeast	5/1081	81/7206	0.0268302359166
ko05231	Choline metabolism in cancer	11/1081	134/7206	0.0270749831957
ko05164	Influenza A	15/1081	167/7206	0.0277224288797
ko04064	NF-kappa B signaling pathway	7/1081	96/7206	0.0305386038723
ko05224	Breast cancer	16/1081	174/7206	0.030967676609
ko04213	Longevity regulating pathway - multiple species	6/1081	86/7206	0.0331406567928
ko04672	Intestinal immune network for IgA production	1/1081	37/7206	0.0348832683656
ko00982	Drug metabolism - cytochrome P450	1/1081	37/7206	0.0348832683656
ko05130	Pathogenic Escherichia coli infection	5/1081	77/7206	0.035747774524
ko05162	Measles	10/1081	120/7206	0.0386580203547
ko04910	Insulin signaling pathway	16/1081	172/7206	0.0391414747949
ko00260	Glycine, serine and threonine metabolism	2/1081	48/7206	0.0393772662367