ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 133/787 423/7206 1.26264222718e-32 ko04020 Calcium signaling pathway 79/787 265/7206 7.24483061353e-18 ko04724 Glutamatergic synapse 56/787 152/7206 1.58728751086e-17 ko05033 Nicotine addiction 27/787 56/7206 2.35225647534e-12 ko04713 Circadian entrainment 43/787 136/7206 3.757275805e-11 ko04024 cAMP signaling pathway 67/787 279/7206 2.10449569184e-10 ko04911 Insulin secretion 37/787 117/7206 8.89868950016e-10 ko04921 Oxytocin signaling pathway 52/787 209/7206 6.26285695354e-09 ko04725 Cholinergic synapse 43/787 160/7206 1.06359811537e-08 ko04728 Dopaminergic synapse 46/787 185/7206 5.41767733624e-08 ko04971 Gastric acid secretion 30/787 98/7206 8.09889442699e-08 ko04727 GABAergic synapse 32/787 110/7206 1.1390394234e-07 ko05032 Morphine addiction 31/787 110/7206 3.93731440828e-07 ko04726 Serotonergic synapse 36/787 137/7206 4.25182439642e-07 ko04970 Salivary secretion 28/787 95/7206 5.26202424989e-07 ko04261 Adrenergic signaling in cardiomyocytes 47/787 205/7206 5.53782553283e-07 ko03040 Spliceosome 1/787 145/7206 1.31266144338e-06 ko04720 Long-term potentiation 28/787 99/7206 1.32706833698e-06 ko04022 cGMP-PKG signaling pathway 47/787 216/7206 3.54894056938e-06 ko04742 Taste transduction 20/787 61/7206 3.66506716683e-06 ko04723 Retrograde endocannabinoid signaling 40/787 175/7206 3.80800978514e-06 ko05322 Systemic lupus erythematosus 2/787 151/7206 8.09281552077e-06 ko05031 Amphetamine addiction 25/787 91/7206 8.61079756655e-06 ko03010 Ribosome 1/787 129/7206 1.03748307381e-05 ko04710 Circadian rhythm 15/787 43/7206 2.62670207852e-05 ko05203 Viral carcinogenesis 11/787 277/7206 3.19939500597e-05 ko04360 Axon guidance 46/787 233/7206 6.13784943461e-05 ko04730 Long-term depression 21/787 78/7206 6.20478212278e-05 ko03013 RNA transport 4/787 166/7206 6.99366481689e-05 ko04072 Phospholipase D signaling pathway 40/787 197/7206 0.000102400682319 ko04750 Inflammatory mediator regulation of TRP channels 28/787 122/7206 0.000104105446491 ko04070 Phosphatidylinositol signaling system 26/787 112/7206 0.000166948519888 ko04744 Phototransduction 12/787 36/7206 0.000275744471464 ko04972 Pancreatic secretion 25/787 111/7206 0.00033415058432 ko04925 Aldosterone synthesis and secretion 24/787 105/7206 0.000378557296827 ko04260 Cardiac muscle contraction 23/787 98/7206 0.00041873290521 ko04745 Phototransduction - fly 12/787 38/7206 0.000485440789588 ko04540 Gap junction 27/787 128/7206 0.000794061972754 ko04120 Ubiquitin mediated proteolysis 4/787 138/7206 0.000810341230059 ko04721 Synaptic vesicle cycle 19/787 80/7206 0.000868470723614 ko05164 Influenza A 6/787 167/7206 0.000954001558633 ko04960 Aldosterone-regulated sodium reabsorption 12/787 41/7206 0.00104053161595 ko04145 Phagosome 6/787 162/7206 0.00130395192237 ko04110 Cell cycle 5/787 145/7206 0.00174393719311 ko05030 Cocaine addiction 17/787 73/7206 0.00202534459286 ko04514 Cell adhesion molecules (CAMs) 26/787 130/7206 0.00245325469083 ko04924 Renin secretion 19/787 86/7206 0.00247625105112 ko04964 Proximal tubule bicarbonate reclamation 9/787 29/7206 0.00280521149824 ko05169 Epstein-Barr virus infection 10/787 206/7206 0.00298919902109 ko04740 Olfactory transduction 18/787 80/7206 0.00303891110846 ko05161 Hepatitis B 8/787 173/7206 0.00437947114254 ko04961 Endocrine and other factor-regulated calcium reabsorption 14/787 59/7206 0.00478600637453 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 17/787 79/7206 0.00550522658029 ko04141 Protein processing in endoplasmic reticulum 9/787 184/7206 0.00556993881227 ko04270 Vascular smooth muscle contraction 28/787 154/7206 0.00581275981188 ko05014 Amyotrophic lateral sclerosis (ALS) 16/787 74/7206 0.00724091849174 ko05168 Herpes simplex infection 9/787 182/7206 0.00754752997978 ko00240 Pyrimidine metabolism 4/787 110/7206 0.00856043711768 ko04711 Circadian rhythm - fly 5/787 13/7206 0.00933093847706 ko04010 MAPK signaling pathway 50/787 321/7206 0.0100132276065 ko04014 Ras signaling pathway 44/787 279/7206 0.0107352735611 ko00604 Glycosphingolipid biosynthesis - ganglio series 5/787 14/7206 0.0132320528213 ko04930 Type II diabetes mellitus 12/787 54/7206 0.0138996239405 ko04919 Thyroid hormone signaling pathway 25/787 143/7206 0.0146920554164 ko05130 Pathogenic Escherichia coli infection 2/787 77/7206 0.0151765118405 ko04612 Antigen processing and presentation 2/787 77/7206 0.0151765118405 ko04973 Carbohydrate digestion and absorption 10/787 42/7206 0.0206752908738 ko04620 Toll-like receptor signaling pathway 4/787 100/7206 0.0225856824997 ko05133 Pertussis 3/787 87/7206 0.0227709456122 ko04142 Lysosome 8/787 151/7206 0.0240622102472 ko00520 Amino sugar and nucleotide sugar metabolism 1/787 55/7206 0.0270201410781 ko04976 Bile secretion 15/787 80/7206 0.0302728312627 ko05162 Measles 6/787 120/7206 0.0373496860668 ko04626 Plant-pathogen interaction 5/787 18/7206 0.0392388553088 ko00562 Inositol phosphate metabolism 16/787 89/7206 0.039271434539 ko03015 mRNA surveillance pathway 4/787 93/7206 0.0425182681634 ko00190 Oxidative phosphorylation 7/787 127/7206 0.0448312181135 ko05414 Dilated cardiomyopathy 19/787 112/7206 0.046296097254 ko05231 Choline metabolism in cancer 22/787 134/7206 0.0490040357266