ko pathway ratio_in_study ratio_in_pop p_value ko04020 Calcium signaling pathway 52/649 265/7206 4.24470851274e-08 ko04713 Circadian entrainment 32/649 136/7206 2.68242701456e-07 ko04921 Oxytocin signaling pathway 42/649 209/7206 4.68596037702e-07 ko04922 Glucagon signaling pathway 29/649 128/7206 2.23583943662e-06 ko04724 Glutamatergic synapse 31/649 152/7206 1.08102245905e-05 ko04710 Circadian rhythm 14/649 43/7206 1.33008567659e-05 ko04745 Phototransduction - fly 13/649 38/7206 1.47600298311e-05 ko00120 Primary bile acid biosynthesis 9/649 20/7206 2.49613811147e-05 ko04726 Serotonergic synapse 27/649 137/7206 0.000103103410381 ko03010 Ribosome 1/649 129/7206 0.000129856726072 ko04730 Long-term depression 18/649 78/7206 0.000146126690032 ko04070 Phosphatidylinositol signaling system 23/649 112/7206 0.000150406842671 ko03040 Spliceosome 2/649 145/7206 0.000197546512823 ko00010 Glycolysis / Gluconeogenesis 17/649 74/7206 0.000235319781777 ko04022 cGMP-PKG signaling pathway 36/649 216/7206 0.000245939567565 ko04911 Insulin secretion 23/649 117/7206 0.000265970367529 ko04925 Aldosterone synthesis and secretion 21/649 105/7206 0.000407465501347 ko05031 Amphetamine addiction 19/649 91/7206 0.000561888818428 ko05322 Systemic lupus erythematosus 3/649 151/7206 0.000779353334813 ko04970 Salivary secretion 19/649 95/7206 0.000799780648688 ko04110 Cell cycle 3/649 145/7206 0.00109556645082 ko04725 Cholinergic synapse 27/649 160/7206 0.00117293751703 ko04720 Long-term potentiation 19/649 99/7206 0.00123082654107 ko04270 Vascular smooth muscle contraction 26/649 154/7206 0.00150885612701 ko01230 Biosynthesis of amino acids 17/649 85/7206 0.00159403727955 ko05032 Morphine addiction 20/649 110/7206 0.00206802610716 ko04728 Dopaminergic synapse 29/649 185/7206 0.00261772423538 ko03013 RNA transport 5/649 166/7206 0.00361592913551 ko05203 Viral carcinogenesis 12/649 277/7206 0.00367392944687 ko04626 Plant-pathogen interaction 6/649 18/7206 0.00376551833807 ko04924 Renin secretion 16/649 86/7206 0.0040874557953 ko04080 Neuroactive ligand-receptor interaction 55/649 423/7206 0.00489960305415 ko00592 alpha-Linolenic acid metabolism 6/649 19/7206 0.00509109012283 ko04727 GABAergic synapse 19/649 110/7206 0.0061219063186 ko04966 Collecting duct acid secretion 7/649 26/7206 0.00668572780681 ko04971 Gastric acid secretion 17/649 98/7206 0.00706843366178 ko00680 Methane metabolism 8/649 34/7206 0.00912564933054 ko00051 Fructose and mannose metabolism 9/649 42/7206 0.0109744823825 ko04919 Thyroid hormone signaling pathway 22/649 143/7206 0.01142759827 ko04744 Phototransduction 8/649 36/7206 0.0129657229589 ko00562 Inositol phosphate metabolism 15/649 89/7206 0.014640403001 ko02010 ABC transporters 8/649 39/7206 0.0207682139584 ko04350 TGF-beta signaling pathway 3/649 103/7206 0.0236048393371 ko04711 Circadian rhythm - fly 4/649 13/7206 0.0241079085437 ko04024 cAMP signaling pathway 36/649 279/7206 0.0248036892317 ko04261 Adrenergic signaling in cardiomyocytes 28/649 205/7206 0.0249935140069 ko05168 Herpes simplex infection 8/649 182/7206 0.0251221230182 ko04141 Protein processing in endoplasmic reticulum 8/649 184/7206 0.0254483857185 ko04930 Type II diabetes mellitus 10/649 54/7206 0.0266895637403 ko04550 Signaling pathways regulating pluripotency of stem cells 7/649 165/7206 0.0271860468021 ko01200 Carbon metabolism 19/649 128/7206 0.0278111684877 ko05217 Basal cell carcinoma 1/649 68/7206 0.0294918005485 ko04721 Synaptic vesicle cycle 13/649 80/7206 0.0300667623319 ko04740 Olfactory transduction 13/649 80/7206 0.0300667623319 ko03320 PPAR signaling pathway 12/649 69/7206 0.0304887846306 ko04068 FoxO signaling pathway 23/649 167/7206 0.0388503922058 ko00230 Purine metabolism 26/649 194/7206 0.0405782692389 ko04330 Notch signaling pathway 1/649 62/7206 0.0413317816239 ko04014 Ras signaling pathway 35/649 279/7206 0.0420625230614 ko05224 Breast cancer 8/649 174/7206 0.0429425981419 ko00290 Valine, leucine and isoleucine biosynthesis 2/649 4/7206 0.0429765999188 ko04371 Apelin signaling pathway 24/649 177/7206 0.0445103808935 ko05130 Pathogenic Escherichia coli infection 2/649 77/7206 0.0445371761999 ko03015 mRNA surveillance pathway 3/649 93/7206 0.0450907547835 ko05230 Central carbon metabolism in cancer 13/649 81/7206 0.0470345584669 ko05340 Primary immunodeficiency 6/649 30/7206 0.0478395237881