ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 37/418 191/7206 4.31469722475e-11 ko04621 NOD-like receptor signaling pathway 32/418 157/7206 2.41951712978e-10 ko05164 Influenza A 32/418 167/7206 1.26359727336e-09 ko04380 Osteoclast differentiation 26/418 134/7206 3.61239670366e-08 ko04064 NF-kappa B signaling pathway 21/418 96/7206 8.96069052325e-08 ko04217 Necroptosis 30/418 178/7206 9.11766579858e-08 ko04630 Jak-STAT signaling pathway 24/418 132/7206 4.36643120125e-07 ko05140 Leishmaniasis 17/418 75/7206 9.03266538728e-07 ko05162 Measles 22/418 120/7206 1.14859445876e-06 ko00350 Tyrosine metabolism 11/418 33/7206 1.32900710243e-06 ko05168 Herpes simplex infection 28/418 182/7206 1.68452958656e-06 ko04658 Th1 and Th2 cell differentiation 19/418 96/7206 1.88630127873e-06 ko04620 Toll-like receptor signaling pathway 19/418 100/7206 3.58215057621e-06 ko05340 Primary immunodeficiency 10/418 30/7206 4.07478636367e-06 ko00120 Primary bile acid biosynthesis 8/418 20/7206 8.13998503444e-06 ko05145 Toxoplasmosis 21/418 126/7206 9.69806691759e-06 ko05321 Inflammatory bowel disease (IBD) 13/418 56/7206 1.33566076891e-05 ko00360 Phenylalanine metabolism 7/418 17/7206 2.45911525338e-05 ko05150 Staphylococcus aureus infection 10/418 36/7206 2.51630819567e-05 ko04659 Th17 cell differentiation 18/418 106/7206 3.23772543644e-05 ko04622 RIG-I-like receptor signaling pathway 13/418 62/7206 4.26746497848e-05 ko00140 Steroid hormone biosynthesis 10/418 41/7206 8.54275220377e-05 ko05133 Pertussis 15/418 87/7206 0.000122618820385 ko04650 Natural killer cell mediated cytotoxicity 16/418 97/7206 0.000126491872069 ko00950 Isoquinoline alkaloid biosynthesis 5/418 10/7206 0.000126744836193 ko04672 Intestinal immune network for IgA production 9/418 37/7206 0.000197855615131 ko04080 Neuroactive ligand-receptor interaction 9/418 423/7206 0.000346741052001 ko05161 Hepatitis B 22/418 173/7206 0.000423039685683 ko04623 Cytosolic DNA-sensing pathway 9/418 41/7206 0.00045306953022 ko04723 Retrograde endocannabinoid signaling 1/418 175/7206 0.000482299668119 ko00592 alpha-Linolenic acid metabolism 6/418 19/7206 0.000521706481419 ko04062 Chemokine signaling pathway 24/418 201/7206 0.000628454883953 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 3/418 4/7206 0.000741958836932 ko00643 Styrene degradation 3/418 4/7206 0.000741958836932 ko04360 Axon guidance 3/418 233/7206 0.000883509590095 ko04657 IL-17 signaling pathway 13/418 87/7206 0.00139914322137 ko04612 Antigen processing and presentation 12/418 77/7206 0.00145971469835 ko04146 Peroxisome 13/418 89/7206 0.00173016785939 ko05323 Rheumatoid arthritis 13/418 89/7206 0.00173016785939 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 3/418 5/7206 0.0017749773904 ko05330 Allograft rejection 6/418 24/7206 0.00202072191389 ko04390 Hippo signaling pathway 2/418 188/7206 0.00217303795719 ko04660 T cell receptor signaling pathway 16/418 124/7206 0.00261858352762 ko00590 Arachidonic acid metabolism 9/418 52/7206 0.00270083204907 ko05034 Alcoholism 4/418 238/7206 0.0027562311065 ko05332 Graft-versus-host disease 5/418 18/7206 0.00292616369096 ko04310 Wnt signaling pathway 2/418 181/7206 0.00310609268898 ko04110 Cell cycle 1/418 145/7206 0.00332193717368 ko00254 Aflatoxin biosynthesis 2/418 2/7206 0.00335725317964 ko05152 Tuberculosis 21/418 187/7206 0.00362076741102 ko05132 Salmonella infection 13/418 98/7206 0.00411956231272 ko05167 Kaposi's sarcoma-associated herpesvirus infection 21/418 191/7206 0.00419988609755 ko05224 Breast cancer 2/418 174/7206 0.00443071805963 ko04668 TNF signaling pathway 15/418 120/7206 0.0045352043413 ko04713 Circadian entrainment 1/418 136/7206 0.00473581729341 ko04114 Oocyte meiosis 1/418 139/7206 0.00490762972717 ko04210 Apoptosis 20/418 180/7206 0.00514259324286 ko05320 Autoimmune thyroid disease 6/418 29/7206 0.00557649216303 ko00100 Steroid biosynthesis 5/418 21/7206 0.00601799996207 ko03013 RNA transport 2/418 166/7206 0.00621464648562 ko04540 Gap junction 1/418 128/7206 0.00686147319424 ko05131 Shigellosis 11/418 82/7206 0.00738086908422 ko00380 Tryptophan metabolism 8/418 50/7206 0.00749895850543 ko05160 Hepatitis C 17/418 153/7206 0.00823610160549 ko04611 Platelet activation 18/418 163/7206 0.00950277646602 ko04728 Dopaminergic synapse 3/418 185/7206 0.00974216988072 ko05142 Chagas disease (American trypanosomiasis) 15/418 130/7206 0.011637229146 ko04724 Glutamatergic synapse 2/418 152/7206 0.0125104923007 ko04015 Rap1 signaling pathway 7/418 278/7206 0.01256487975 ko05310 Asthma 4/418 17/7206 0.0145225394438 ko00920 Sulfur metabolism 3/418 10/7206 0.0171243360277 ko04916 Melanogenesis 2/418 142/7206 0.0172457242612 ko04662 B cell receptor signaling pathway 11/418 88/7206 0.0174059634151 ko04610 Complement and coagulation cascades 10/418 79/7206 0.0240410832929 ko04726 Serotonergic synapse 2/418 137/7206 0.0246483347138 ko04550 Signaling pathways regulating pluripotency of stem cells 3/418 165/7206 0.0263061329424 ko04666 Fc gamma R-mediated phagocytosis 13/418 122/7206 0.0295867737084 ko00281 Geraniol degradation 2/418 5/7206 0.0298601693123 ko04350 TGF-beta signaling pathway 1/418 103/7206 0.0307440802882 ko04914 Progesterone-mediated oocyte maturation 1/418 104/7206 0.0311256150375 ko00983 Drug metabolism - other enzymes 6/418 42/7206 0.0327334439221 ko04940 Type I diabetes mellitus 5/418 32/7206 0.0353507105028 ko05134 Legionellosis 9/418 74/7206 0.0382313799603 ko00362 Benzoate degradation 2/418 6/7206 0.0430915279565 ko05144 Malaria 6/418 45/7206 0.0440007323846 ko05211 Renal cell carcinoma 1/418 96/7206 0.0442788716333