ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 53/477 191/7206 2.87257134405e-20 ko04380 Osteoclast differentiation 40/477 134/7206 9.67102088205e-17 ko05321 Inflammatory bowel disease (IBD) 22/477 56/7206 1.84760407319e-12 ko04659 Th17 cell differentiation 30/477 106/7206 3.54594777841e-12 ko05340 Primary immunodeficiency 16/477 30/7206 6.52232322538e-12 ko04621 NOD-like receptor signaling pathway 36/477 157/7206 2.14114167639e-11 ko05140 Leishmaniasis 24/477 75/7206 3.07571945874e-11 ko05145 Toxoplasmosis 31/477 126/7206 8.25366414362e-11 ko05150 Staphylococcus aureus infection 16/477 36/7206 2.25766969792e-10 ko04658 Th1 and Th2 cell differentiation 26/477 96/7206 2.97095842825e-10 ko04064 NF-kappa B signaling pathway 26/477 96/7206 2.97095842825e-10 ko05164 Influenza A 34/477 167/7206 2.29746128265e-09 ko05162 Measles 28/477 120/7206 2.55247676947e-09 ko05152 Tuberculosis 36/477 187/7206 3.78184183061e-09 ko05168 Herpes simplex infection 35/477 182/7206 6.46955096524e-09 ko05330 Allograft rejection 12/477 24/7206 8.03867991439e-09 ko04640 Hematopoietic cell lineage 19/477 64/7206 1.47743808183e-08 ko04660 T cell receptor signaling pathway 27/477 124/7206 2.42123084028e-08 ko04630 Jak-STAT signaling pathway 28/477 132/7206 2.43324572379e-08 ko04672 Intestinal immune network for IgA production 14/477 37/7206 3.81463588121e-08 ko04650 Natural killer cell mediated cytotoxicity 23/477 97/7206 5.0442939151e-08 ko04620 Toll-like receptor signaling pathway 23/477 100/7206 9.24526531452e-08 ko05320 Autoimmune thyroid disease 12/477 29/7206 1.13559028833e-07 ko04610 Complement and coagulation cascades 20/477 79/7206 1.19305449197e-07 ko04217 Necroptosis 32/477 178/7206 1.53876944906e-07 ko05310 Asthma 9/477 17/7206 3.41398020401e-07 ko04612 Antigen processing and presentation 19/477 77/7206 3.82950615325e-07 ko05161 Hepatitis B 28/477 173/7206 7.91801253167e-06 ko05332 Graft-versus-host disease 8/477 18/7206 8.42172352813e-06 ko04622 RIG-I-like receptor signaling pathway 15/477 62/7206 8.46009096124e-06 ko04662 B cell receptor signaling pathway 18/477 88/7206 1.36366031728e-05 ko05144 Malaria 12/477 45/7206 2.36887884626e-05 ko05133 Pertussis 17/477 87/7206 4.39738236549e-05 ko04623 Cytosolic DNA-sensing pathway 11/477 41/7206 4.87886910188e-05 ko04611 Platelet activation 25/477 163/7206 7.37347887517e-05 ko05167 Kaposi's sarcoma-associated herpesvirus infection 28/477 191/7206 7.76259939407e-05 ko04062 Chemokine signaling pathway 28/477 201/7206 0.000142237628216 ko04723 Retrograde endocannabinoid signaling 1/477 175/7206 0.000149563422001 ko04145 Phagosome 24/477 162/7206 0.000162839252214 ko00120 Primary bile acid biosynthesis 7/477 20/7206 0.000193616519652 ko04668 TNF signaling pathway 19/477 120/7206 0.000305342580828 ko05142 Chagas disease (American trypanosomiasis) 20/477 130/7206 0.000441502356234 ko05323 Rheumatoid arthritis 15/477 89/7206 0.000661156229217 ko04940 Type I diabetes mellitus 8/477 32/7206 0.000887029594085 ko05160 Hepatitis C 21/477 153/7206 0.0013734133934 ko04664 Fc epsilon RI signaling pathway 13/477 77/7206 0.00146445836967 ko04713 Circadian entrainment 1/477 136/7206 0.00146952651046 ko04210 Apoptosis 23/477 180/7206 0.00206479246418 ko01200 Carbon metabolism 1/477 128/7206 0.00328248215226 ko03010 Ribosome 1/477 129/7206 0.00336112770261 ko04724 Glutamatergic synapse 2/477 152/7206 0.00428073787614 ko00590 Arachidonic acid metabolism 9/477 52/7206 0.0064666366469 ko00592 alpha-Linolenic acid metabolism 5/477 19/7206 0.00665666046393 ko04390 Hippo signaling pathway 4/477 188/7206 0.00713752951936 ko05034 Alcoholism 6/477 238/7206 0.00735543456933 ko05418 Fluid shear stress and atherosclerosis 21/477 173/7206 0.00745126831713 ko05166 HTLV-I infection 31/477 292/7206 0.00788073424459 ko04310 Wnt signaling pathway 4/477 181/7206 0.00983269344522 ko04728 Dopaminergic synapse 4/477 185/7206 0.00996682383066 ko04727 GABAergic synapse 1/477 110/7206 0.010163297662 ko05032 Morphine addiction 1/477 110/7206 0.010163297662 ko05131 Shigellosis 12/477 82/7206 0.0108266194518 ko05132 Salmonella infection 13/477 98/7206 0.013244110264 ko04657 IL-17 signaling pathway 12/477 87/7206 0.0140919270883 ko04666 Fc gamma R-mediated phagocytosis 15/477 122/7206 0.0164927976251 ko00140 Steroid hormone biosynthesis 7/477 41/7206 0.0167984435506 ko05143 African trypanosomiasis 6/477 32/7206 0.0169103140219 ko05224 Breast cancer 4/477 174/7206 0.0190170713808 ko00350 Tyrosine metabolism 6/477 33/7206 0.0195487587056 ko04137 Mitophagy - animal 11/477 82/7206 0.0221241697361 ko05169 Epstein-Barr virus infection 22/477 206/7206 0.0225424354831 ko00950 Isoquinoline alkaloid biosynthesis 3/477 10/7206 0.0243695319577 ko04916 Melanogenesis 3/477 142/7206 0.0252171459395 ko04110 Cell cycle 3/477 145/7206 0.0260190663 ko05416 Viral myocarditis 8/477 55/7206 0.0270900491508 ko00982 Drug metabolism - cytochrome P450 6/477 37/7206 0.0328701139736 ko05202 Transcriptional misregulation in cancer 20/477 188/7206 0.0355471897105 ko04114 Oocyte meiosis 3/477 139/7206 0.0359617712676 ko02010 ABC transporters 6/477 39/7206 0.0413111479489 ko04360 Axon guidance 8/477 233/7206 0.0442401859539