ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	179/1092	423/7206	2.48676060811e-44
ko04724	Glutamatergic synapse	91/1092	152/7206	1.97981583731e-37
ko05032	Morphine addiction	72/1092	110/7206	1.97066611547e-33
ko05033	Nicotine addiction	49/1092	56/7206	2.18215597256e-33
ko04713	Circadian entrainment	79/1092	136/7206	2.75301393562e-31
ko04727	GABAergic synapse	67/1092	110/7206	2.15910891546e-28
ko04728	Dopaminergic synapse	88/1092	185/7206	3.56027939259e-26
ko04725	Cholinergic synapse	77/1092	160/7206	2.06697543821e-23
ko04723	Retrograde endocannabinoid signaling	81/1092	175/7206	3.54251746071e-23
ko04024	cAMP signaling pathway	102/1092	279/7206	2.10039712315e-19
ko04911	Insulin secretion	58/1092	117/7206	1.11219656289e-18
ko04726	Serotonergic synapse	61/1092	137/7206	1.06801861908e-16
ko04721	Synaptic vesicle cycle	44/1092	80/7206	1.15467991079e-16
ko04921	Oxytocin signaling pathway	78/1092	209/7206	1.91364813739e-15
ko04742	Taste transduction	36/1092	61/7206	3.5375120635e-15
ko04261	Adrenergic signaling in cardiomyocytes	74/1092	205/7206	5.29079513298e-14
ko05031	Amphetamine addiction	44/1092	91/7206	5.7234264629e-14
ko04720	Long-term potentiation	45/1092	99/7206	4.8823806268e-13
ko04020	Calcium signaling pathway	86/1092	265/7206	6.14192137998e-13
ko04744	Phototransduction	24/1092	36/7206	3.42141076151e-12
ko04925	Aldosterone synthesis and secretion	43/1092	105/7206	1.10843256721e-10
ko05030	Cocaine addiction	34/1092	73/7206	1.57862145566e-10
ko04971	Gastric acid secretion	40/1092	98/7206	5.62174881264e-10
ko04970	Salivary secretion	39/1092	95/7206	7.55408887348e-10
ko03040	Spliceosome	1/1092	145/7206	1.377908095e-09
ko04010	MAPK signaling pathway	87/1092	321/7206	1.59308017721e-08
ko04360	Axon guidance	68/1092	233/7206	2.54410117965e-08
ko04022	cGMP-PKG signaling pathway	63/1092	216/7206	1.11011192116e-07
ko04972	Pancreatic secretion	38/1092	111/7206	6.11246208485e-07
ko04740	Olfactory transduction	30/1092	80/7206	7.33894229086e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1092	74/7206	1.38967885832e-06
ko04060	Cytokine-cytokine receptor interaction	8/1092	191/7206	1.73318437176e-06
ko05322	Systemic lupus erythematosus	5/1092	151/7206	3.05646681768e-06
ko04072	Phospholipase D signaling pathway	55/1092	197/7206	4.05063927223e-06
ko04961	Endocrine and other factor-regulated calcium reabsorption	23/1092	59/7206	6.73972462769e-06
ko03013	RNA transport	7/1092	166/7206	8.95893090615e-06
ko04070	Phosphatidylinositol signaling system	35/1092	112/7206	1.36958913451e-05
ko04711	Circadian rhythm - fly	9/1092	13/7206	1.63938235205e-05
ko04730	Long-term depression	27/1092	78/7206	1.74299289962e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1092	79/7206	2.15735399643e-05
ko05203	Viral carcinogenesis	19/1092	277/7206	2.47847119992e-05
ko04915	Estrogen signaling pathway	38/1092	131/7206	3.90234969148e-05
ko03008	Ribosome biogenesis in eukaryotes	1/1092	79/7206	5.20197892361e-05
ko04745	Phototransduction - fly	16/1092	38/7206	5.65952265077e-05
ko04612	Antigen processing and presentation	1/1092	77/7206	7.94437373092e-05
ko04260	Cardiac muscle contraction	30/1092	98/7206	9.05874775982e-05
ko05414	Dilated cardiomyopathy	33/1092	112/7206	9.12863263256e-05
ko04924	Renin secretion	27/1092	86/7206	0.000116076566996
ko04141	Protein processing in endoplasmic reticulum	11/1092	184/7206	0.000153805074874
ko04014	Ras signaling pathway	66/1092	279/7206	0.000159374964896
ko04371	Apelin signaling pathway	46/1092	177/7206	0.000169215110018
ko04514	Cell adhesion molecules (CAMs)	36/1092	130/7206	0.000183634429149
ko04912	GnRH signaling pathway	34/1092	122/7206	0.00028841900159
ko04750	Inflammatory mediator regulation of TRP channels	34/1092	122/7206	0.00028841900159
ko04640	Hematopoietic cell lineage	1/1092	64/7206	0.000629369363262
ko04540	Gap junction	34/1092	128/7206	0.000694226644089
ko04621	NOD-like receptor signaling pathway	10/1092	157/7206	0.000999997701891
ko04710	Circadian rhythm	15/1092	43/7206	0.0010707170886
ko04110	Cell cycle	9/1092	145/7206	0.00141847265116
ko04976	Bile secretion	23/1092	80/7206	0.0015313973917
ko05168	Herpes simplex infection	13/1092	182/7206	0.00153719721445
ko04930	Type II diabetes mellitus	17/1092	54/7206	0.00201137917202
ko04015	Rap1 signaling pathway	61/1092	278/7206	0.00205450725808
ko04918	Thyroid hormone synthesis	24/1092	86/7206	0.00213475826389
ko04923	Regulation of lipolysis in adipocytes	22/1092	77/7206	0.00214422377993
ko05164	Influenza A	12/1092	167/7206	0.00215122918139
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1092	14/7206	0.00232025243771
ko04146	Peroxisome	4/1092	89/7206	0.00258244408119
ko05162	Measles	7/1092	120/7206	0.00281263933256
ko00240	Pyrimidine metabolism	6/1092	110/7206	0.00283104046667
ko04916	Melanogenesis	35/1092	142/7206	0.00285788932347
ko04722	Neurotrophin signaling pathway	38/1092	160/7206	0.00356641467161
ko04062	Chemokine signaling pathway	46/1092	201/7206	0.00358262279204
ko04064	NF-kappa B signaling pathway	5/1092	96/7206	0.00379281758272
ko00330	Arginine and proline metabolism	2/1092	61/7206	0.00614596055781
ko04960	Aldosterone-regulated sodium reabsorption	13/1092	41/7206	0.00698629341164
ko00260	Glycine, serine and threonine metabolism	1/1092	48/7206	0.00720601013653
ko05205	Proteoglycans in cancer	26/1092	271/7206	0.00738310849858
ko04120	Ubiquitin mediated proteolysis	10/1092	138/7206	0.00784348806607
ko04964	Proximal tubule bicarbonate reclamation	10/1092	29/7206	0.00785354885156
ko05034	Alcoholism	51/1092	238/7206	0.0097148029519
ko03320	PPAR signaling pathway	3/1092	69/7206	0.010107078914
ko03022	Basal transcription factors	1/1092	44/7206	0.0104385236941
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1092	100/7206	0.0105682282921
ko00071	Fatty acid degradation	1/1092	45/7206	0.0106345486107
ko04142	Lysosome	12/1092	151/7206	0.011147026382
ko03420	Nucleotide excision repair	1/1092	46/7206	0.0111479421968
ko04270	Vascular smooth muscle contraction	35/1092	154/7206	0.0119429669058
ko00480	Glutathione metabolism	2/1092	55/7206	0.0127968478872
ko05110	Vibrio cholerae infection	17/1092	63/7206	0.0129235818454
ko05321	Inflammatory bowel disease (IBD)	2/1092	56/7206	0.013211989816
ko05169	Epstein-Barr virus infection	19/1092	206/7206	0.0136110406278
ko03018	RNA degradation	5/1092	84/7206	0.0139059941504
ko04115	p53 signaling pathway	4/1092	74/7206	0.0140929784496
ko05140	Leishmaniasis	4/1092	75/7206	0.0141869888111
ko04071	Sphingolipid signaling pathway	36/1092	162/7206	0.0145054439116
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1092	15/7206	0.0175288469866
ko04350	TGF-beta signaling pathway	7/1092	103/7206	0.0175362401795
ko04213	Longevity regulating pathway - multiple species	21/1092	86/7206	0.0222689197863
ko04114	Oocyte meiosis	31/1092	139/7206	0.0227191321325
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1092	40/7206	0.0239358739989
ko04922	Glucagon signaling pathway	29/1092	128/7206	0.0242248771893
ko05016	Huntington's disease	21/1092	215/7206	0.0258768020149
ko04630	Jak-STAT signaling pathway	11/1092	132/7206	0.0267905056456
ko00513	Various types of N-glycan biosynthesis	12/1092	42/7206	0.027290638242
ko04973	Carbohydrate digestion and absorption	12/1092	42/7206	0.027290638242
ko05231	Choline metabolism in cancer	30/1092	134/7206	0.0275703825672
ko01212	Fatty acid metabolism	3/1092	60/7206	0.0280046860576
ko04012	ErbB signaling pathway	25/1092	109/7206	0.0302171084887
ko04217	Necroptosis	17/1092	178/7206	0.0339854243619
ko00982	Drug metabolism - cytochrome P450	1/1092	37/7206	0.0351195428893
ko00562	Inositol phosphate metabolism	21/1092	89/7206	0.0357199665203
ko05214	Glioma	19/1092	79/7206	0.0383456879499
ko00230	Purine metabolism	40/1092	194/7206	0.0415602409021
ko04626	Plant-pathogen interaction	6/1092	18/7206	0.0435686460585
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1092	182/7206	0.0462541775416
ko04966	Collecting duct acid secretion	8/1092	26/7206	0.0474433835777
ko04214	Apoptosis - fly	5/1092	72/7206	0.0479733829902
ko00310	Lysine degradation	5/1092	73/7206	0.0480104699946