ko pathway ratio_in_study ratio_in_pop p_value ko04721 Synaptic vesicle cycle 40/700 80/7206 2.77557496429e-20 ko05033 Nicotine addiction 32/700 56/7206 9.25916033754e-19 ko04728 Dopaminergic synapse 59/700 185/7206 1.89739704184e-17 ko04080 Neuroactive ligand-receptor interaction 98/700 423/7206 2.87908039478e-17 ko04724 Glutamatergic synapse 51/700 152/7206 2.94608939013e-16 ko04713 Circadian entrainment 41/700 136/7206 1.39394088548e-11 ko05032 Morphine addiction 36/700 110/7206 1.80724319898e-11 ko04723 Retrograde endocannabinoid signaling 47/700 175/7206 4.06478622772e-11 ko04727 GABAergic synapse 34/700 110/7206 3.81715572562e-10 ko05031 Amphetamine addiction 28/700 91/7206 1.54933353287e-08 ko04360 Axon guidance 51/700 233/7206 1.56506808291e-08 ko04911 Insulin secretion 32/700 117/7206 3.51512504636e-08 ko05014 Amyotrophic lateral sclerosis (ALS) 24/700 74/7206 5.38215289682e-08 ko04060 Cytokine-cytokine receptor interaction 1/700 191/7206 8.6630032845e-08 ko04514 Cell adhesion molecules (CAMs) 33/700 130/7206 1.51932604846e-07 ko04725 Cholinergic synapse 38/700 160/7206 1.81989273252e-07 ko05030 Cocaine addiction 23/700 73/7206 1.85945276266e-07 ko04726 Serotonergic synapse 33/700 137/7206 5.66712330892e-07 ko04261 Adrenergic signaling in cardiomyocytes 43/700 205/7206 8.8544462763e-07 ko04024 cAMP signaling pathway 53/700 279/7206 1.36278908683e-06 ko04966 Collecting duct acid secretion 12/700 26/7206 1.72355036492e-06 ko04720 Long-term potentiation 23/700 99/7206 5.42436149901e-05 ko01200 Carbon metabolism 1/700 128/7206 5.61810904026e-05 ko03013 RNA transport 3/700 166/7206 8.67256633761e-05 ko03040 Spliceosome 2/700 145/7206 9.07059971077e-05 ko04961 Endocrine and other factor-regulated calcium reabsorption 16/700 59/7206 0.000107031359412 ko04120 Ubiquitin mediated proteolysis 2/700 138/7206 0.000201406409651 ko05110 Vibrio cholerae infection 16/700 63/7206 0.000246926533498 ko05322 Systemic lupus erythematosus 3/700 151/7206 0.000251966586524 ko04970 Salivary secretion 21/700 95/7206 0.000296187593258 ko05120 Epithelial cell signaling in Helicobacter pylori infection 20/700 92/7206 0.000499736583347 ko04742 Taste transduction 15/700 61/7206 0.000556850170602 ko04010 MAPK signaling pathway 50/700 321/7206 0.000675034170531 ko05162 Measles 2/700 120/7206 0.000863635562968 ko04145 Phagosome 29/700 162/7206 0.00108849716641 ko05203 Viral carcinogenesis 12/700 277/7206 0.00121653001207 ko04950 Maturity onset diabetes of the young 9/700 29/7206 0.00122806384135 ko00604 Glycosphingolipid biosynthesis - ganglio series 6/700 14/7206 0.00124722077232 ko04540 Gap junction 24/700 128/7206 0.00136432218956 ko05168 Herpes simplex infection 6/700 182/7206 0.00138164257589 ko04141 Protein processing in endoplasmic reticulum 6/700 184/7206 0.00141080283759 ko04744 Phototransduction 10/700 36/7206 0.00171520692026 ko04146 Peroxisome 1/700 89/7206 0.00187281661937 ko04962 Vasopressin-regulated water reabsorption 13/700 58/7206 0.00313342241955 ko04391 Hippo signaling pathway - fly 18/700 90/7206 0.00324168306034 ko03018 RNA degradation 1/700 84/7206 0.00434401491953 ko04924 Renin secretion 17/700 86/7206 0.00479180709726 ko05164 Influenza A 6/700 167/7206 0.00497254834138 ko05146 Amoebiasis 2/700 99/7206 0.00538616964946 ko03008 Ribosome biogenesis in eukaryotes 1/700 79/7206 0.00619342683419 ko04611 Platelet activation 6/700 163/7206 0.00679475983914 ko04971 Gastric acid secretion 18/700 98/7206 0.00858645416505 ko00310 Lysine degradation 1/700 73/7206 0.00877427029878 ko00010 Glycolysis / Gluconeogenesis 1/700 74/7206 0.0088977560174 ko04621 NOD-like receptor signaling pathway 6/700 157/7206 0.00897295381212 ko04730 Long-term depression 15/700 78/7206 0.0104197915775 ko04932 Non-alcoholic fatty liver disease (NAFLD) 8/700 182/7206 0.0108178400931 ko00533 Glycosaminoglycan biosynthesis - keratan sulfate 5/700 15/7206 0.011196668506 ko04022 cGMP-PKG signaling pathway 32/700 216/7206 0.0139375879936 ko04972 Pancreatic secretion 19/700 111/7206 0.0140296690025 ko01230 Biosynthesis of amino acids 2/700 85/7206 0.0154498269018 ko04630 Jak-STAT signaling pathway 5/700 132/7206 0.0167753236791 ko04921 Oxytocin signaling pathway 31/700 209/7206 0.0169803186316 ko04964 Proximal tubule bicarbonate reclamation 7/700 29/7206 0.0184741130824 ko05130 Pathogenic Escherichia coli infection 14/700 77/7206 0.0186164047555 ko04064 NF-kappa B signaling pathway 3/700 96/7206 0.0231713047823 ko04626 Plant-pathogen interaction 5/700 18/7206 0.0250288685916 ko00330 Arginine and proline metabolism 1/700 61/7206 0.0275811634978 ko05205 Proteoglycans in cancer 16/700 271/7206 0.0280136155387 ko05323 Rheumatoid arthritis 15/700 89/7206 0.0295613142383 ko04066 HIF-1 signaling pathway 5/700 123/7206 0.0305196858256 ko01524 Platinum drug resistance 2/700 76/7206 0.0310433978206 ko04140 Autophagy - animal 8/700 164/7206 0.032221385788 ko00240 Pyrimidine metabolism 4/700 110/7206 0.0327617222015 ko00603 Glycosphingolipid biosynthesis - globo and isoglobo series 3/700 8/7206 0.0352272458901 ko04260 Cardiac muscle contraction 16/700 98/7206 0.0370372455034 ko00480 Glutathione metabolism 1/700 55/7206 0.03982382703 ko04350 TGF-beta signaling pathway 4/700 103/7206 0.0431569927919 ko04214 Apoptosis - fly 2/700 72/7206 0.0439111890837 ko04550 Signaling pathways regulating pluripotency of stem cells 24/700 165/7206 0.0446156730539