ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	205/1248	423/7206	7.1312801732e-53
ko04724	Glutamatergic synapse	92/1248	152/7206	1.67068227414e-33
ko05033	Nicotine addiction	48/1248	56/7206	4.45174725504e-29
ko04713	Circadian entrainment	81/1248	136/7206	6.77736162124e-29
ko05032	Morphine addiction	69/1248	110/7206	1.09604658591e-26
ko04727	GABAergic synapse	64/1248	110/7206	2.90135243853e-22
ko04721	Synaptic vesicle cycle	52/1248	80/7206	1.98883513138e-21
ko04728	Dopaminergic synapse	86/1248	185/7206	1.21381244091e-20
ko04725	Cholinergic synapse	78/1248	160/7206	2.16724204363e-20
ko04020	Calcium signaling pathway	105/1248	265/7206	1.66682361274e-18
ko04024	cAMP signaling pathway	106/1248	279/7206	6.01622974801e-17
ko04723	Retrograde endocannabinoid signaling	77/1248	175/7206	7.04642522378e-17
ko04742	Taste transduction	39/1248	61/7206	5.18427983254e-16
ko04921	Oxytocin signaling pathway	85/1248	209/7206	6.88511056885e-16
ko04911	Insulin secretion	58/1248	117/7206	7.00555833139e-16
ko04726	Serotonergic synapse	62/1248	137/7206	1.62930863894e-14
ko04720	Long-term potentiation	48/1248	99/7206	6.71383758523e-13
ko04744	Phototransduction	25/1248	36/7206	6.32687005725e-12
ko05031	Amphetamine addiction	44/1248	91/7206	6.99807377549e-12
ko04970	Salivary secretion	44/1248	95/7206	4.34449140821e-11
ko04740	Olfactory transduction	38/1248	80/7206	3.72298116093e-10
ko04261	Adrenergic signaling in cardiomyocytes	72/1248	205/7206	4.51818430609e-10
ko03040	Spliceosome	2/1248	145/7206	5.9923824636e-10
ko05168	Herpes simplex infection	6/1248	182/7206	6.62011681167e-09
ko04925	Aldosterone synthesis and secretion	43/1248	105/7206	9.93701088989e-09
ko05203	Viral carcinogenesis	17/1248	277/7206	3.77156454877e-08
ko04971	Gastric acid secretion	39/1248	98/7206	1.08675437827e-07
ko04540	Gap junction	46/1248	128/7206	3.54411388355e-07
ko03013	RNA transport	7/1248	166/7206	3.78314152902e-07
ko05030	Cocaine addiction	31/1248	73/7206	3.79595954895e-07
ko04022	cGMP-PKG signaling pathway	67/1248	216/7206	5.61856418632e-07
ko05322	Systemic lupus erythematosus	6/1248	151/7206	6.53754853651e-07
ko04060	Cytokine-cytokine receptor interaction	10/1248	191/7206	8.29016875389e-07
ko04924	Renin secretion	34/1248	86/7206	8.72692573425e-07
ko05164	Influenza A	8/1248	167/7206	1.32626903459e-06
ko04360	Axon guidance	70/1248	233/7206	1.45999417359e-06
ko04621	NOD-like receptor signaling pathway	7/1248	157/7206	1.70752762711e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1248	74/7206	2.6231813659e-06
ko04966	Collecting duct acid secretion	15/1248	26/7206	3.99302212292e-06
ko04120	Ubiquitin mediated proteolysis	6/1248	138/7206	6.26103708372e-06
ko04730	Long-term depression	30/1248	78/7206	7.1935654693e-06
ko04260	Cardiac muscle contraction	35/1248	98/7206	1.02120817562e-05
ko04514	Cell adhesion molecules (CAMs)	43/1248	130/7206	1.03990491634e-05
ko04110	Cell cycle	8/1248	145/7206	3.2195048061e-05
ko04972	Pancreatic secretion	37/1248	111/7206	3.6901769934e-05
ko04010	MAPK signaling pathway	84/1248	321/7206	4.27557476293e-05
ko04141	Protein processing in endoplasmic reticulum	13/1248	184/7206	6.64493415693e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1248	79/7206	7.02967654866e-05
ko04745	Phototransduction - fly	17/1248	38/7206	7.50556513618e-05
ko05169	Epstein-Barr virus infection	16/1248	206/7206	0.000109773878748
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1248	79/7206	0.000120854136626
ko04976	Bile secretion	28/1248	80/7206	0.000136803660362
ko04750	Inflammatory mediator regulation of TRP channels	38/1248	122/7206	0.000151354862534
ko04070	Phosphatidylinositol signaling system	35/1248	112/7206	0.000340523589616
ko04610	Complement and coagulation cascades	3/1248	79/7206	0.000458234431086
ko00520	Amino sugar and nucleotide sugar metabolism	1/1248	55/7206	0.000529582179826
ko04371	Apelin signaling pathway	49/1248	177/7206	0.000558372209211
ko05414	Dilated cardiomyopathy	34/1248	112/7206	0.000590783358014
ko04064	NF-kappa B signaling pathway	5/1248	96/7206	0.000597775240365
ko05110	Vibrio cholerae infection	22/1248	63/7206	0.000649868905569
ko04612	Antigen processing and presentation	3/1248	77/7206	0.000678911025391
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1248	59/7206	0.0007320370962
ko05205	Proteoglycans in cancer	27/1248	271/7206	0.000746557339704
ko05162	Measles	8/1248	120/7206	0.00091708708144
ko04915	Estrogen signaling pathway	38/1248	131/7206	0.000961189555686
ko05140	Leishmaniasis	3/1248	75/7206	0.00100949506675
ko04072	Phospholipase D signaling pathway	52/1248	197/7206	0.00111515313541
ko04330	Notch signaling pathway	2/1248	62/7206	0.00114554013474
ko00590	Arachidonic acid metabolism	1/1248	52/7206	0.00128454406564
ko04214	Apoptosis - fly	3/1248	72/7206	0.00143365326708
ko04626	Plant-pathogen interaction	9/1248	18/7206	0.00148048449046
ko05161	Hepatitis B	15/1248	173/7206	0.00151085770127
ko05166	HTLV-I infection	31/1248	292/7206	0.0015199891072
ko04146	Peroxisome	5/1248	89/7206	0.00170958801935
ko04964	Proximal tubule bicarbonate reclamation	12/1248	29/7206	0.00197738755519
ko04922	Glucagon signaling pathway	36/1248	128/7206	0.00203343815443
ko04014	Ras signaling pathway	68/1248	279/7206	0.00213054807369
ko04657	IL-17 signaling pathway	5/1248	87/7206	0.00242988996413
ko03420	Nucleotide excision repair	1/1248	46/7206	0.00278860786053
ko05410	Hypertrophic cardiomyopathy (HCM)	29/1248	100/7206	0.00323204894222
ko00240	Pyrimidine metabolism	8/1248	110/7206	0.00325350525551
ko04923	Regulation of lipolysis in adipocytes	24/1248	77/7206	0.00344330436026
ko00480	Glutathione metabolism	2/1248	55/7206	0.00369268272373
ko05321	Inflammatory bowel disease (IBD)	2/1248	56/7206	0.00379169395298
ko03022	Basal transcription factors	1/1248	44/7206	0.00424609713032
ko00071	Fatty acid degradation	1/1248	45/7206	0.00447102727069
ko00310	Lysine degradation	4/1248	73/7206	0.00463351588721
ko05131	Shigellosis	5/1248	82/7206	0.00478640256278
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1248	14/7206	0.0050895192999
ko04622	RIG-I-like receptor signaling pathway	3/1248	62/7206	0.0062255048113
ko04912	GnRH signaling pathway	33/1248	122/7206	0.00741700455553
ko05145	Toxoplasmosis	11/1248	126/7206	0.00856370122411
ko04217	Necroptosis	18/1248	178/7206	0.00883544942926
ko01524	Platinum drug resistance	5/1248	76/7206	0.00922679056443
ko04916	Melanogenesis	37/1248	142/7206	0.00948061269159
ko03410	Base excision repair	1/1248	38/7206	0.00957298099541
ko04630	Jak-STAT signaling pathway	12/1248	132/7206	0.0102219638264
ko04930	Type II diabetes mellitus	17/1248	54/7206	0.0102887217614
ko00562	Inositol phosphate metabolism	25/1248	89/7206	0.0105723155936
ko03018	RNA degradation	6/1248	84/7206	0.0126782704952
ko04115	p53 signaling pathway	5/1248	74/7206	0.0128143428541
ko04668	TNF signaling pathway	11/1248	120/7206	0.0147135361092
ko04270	Vascular smooth muscle contraction	38/1248	154/7206	0.0177894168205
ko00280	Valine, leucine and isoleucine degradation	3/1248	54/7206	0.0180514230064
ko04658	Th1 and Th2 cell differentiation	8/1248	96/7206	0.0199402496742
ko05133	Pertussis	7/1248	87/7206	0.0214971301815
ko00860	Porphyrin and chlorophyll metabolism	1/1248	34/7206	0.0215020450297
ko04620	Toll-like receptor signaling pathway	9/1248	100/7206	0.0235950085987
ko05217	Basal cell carcinoma	5/1248	68/7206	0.024341433275
ko05200	Pathways in cancer	67/1248	492/7206	0.0260983173612
ko04210	Apoptosis	20/1248	180/7206	0.0276155212938
ko05212	Pancreatic cancer	7/1248	83/7206	0.0284543714193
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1248	40/7206	0.0356197226462
ko00380	Tryptophan metabolism	3/1248	50/7206	0.0368404162558
ko04932	Non-alcoholic fatty liver disease (NAFLD)	21/1248	182/7206	0.0369395726676
ko04973	Carbohydrate digestion and absorption	13/1248	42/7206	0.0375060653082
ko04710	Circadian rhythm	13/1248	43/7206	0.0398952805833
ko05418	Fluid shear stress and atherosclerosis	20/1248	173/7206	0.0419431361812
ko05215	Prostate cancer	11/1248	111/7206	0.0420456839461
ko00600	Sphingolipid metabolism	5/1248	63/7206	0.0452991036238
ko05010	Alzheimer's disease	46/1248	202/7206	0.0469996090101
ko04350	TGF-beta signaling pathway	10/1248	103/7206	0.0477855905111
ko05320	Autoimmune thyroid disease	1/1248	29/7206	0.0479116231545