ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	181/992	423/7206	2.96417804606e-52
ko04724	Glutamatergic synapse	86/992	152/7206	4.36208945038e-36
ko05033	Nicotine addiction	46/992	56/7206	8.6669300408e-31
ko04727	GABAergic synapse	63/992	110/7206	4.76254821965e-27
ko05032	Morphine addiction	63/992	110/7206	4.76254821965e-27
ko04713	Circadian entrainment	71/992	136/7206	5.64179716337e-27
ko04728	Dopaminergic synapse	79/992	185/7206	1.27463499905e-22
ko04721	Synaptic vesicle cycle	47/992	80/7206	4.23067254427e-21
ko04723	Retrograde endocannabinoid signaling	74/992	175/7206	6.13440738883e-21
ko04725	Cholinergic synapse	70/992	160/7206	7.09248012997e-21
ko04024	cAMP signaling pathway	94/992	279/7206	4.5631295041e-18
ko04020	Calcium signaling pathway	90/992	265/7206	1.64955842236e-17
ko04726	Serotonergic synapse	58/992	137/7206	1.13771962501e-16
ko04911	Insulin secretion	51/992	117/7206	1.96073463016e-15
ko04921	Oxytocin signaling pathway	72/992	209/7206	1.15228094198e-14
ko05031	Amphetamine addiction	41/992	91/7206	3.04815061551e-13
ko04720	Long-term potentiation	43/992	99/7206	3.82367961575e-13
ko04742	Taste transduction	31/992	61/7206	4.81418671493e-12
ko04261	Adrenergic signaling in cardiomyocytes	64/992	205/7206	7.63880469546e-11
ko04744	Phototransduction	21/992	36/7206	4.81412030774e-10
ko04970	Salivary secretion	37/992	95/7206	7.6643906144e-10
ko04925	Aldosterone synthesis and secretion	38/992	105/7206	5.19083151068e-09
ko03040	Spliceosome	1/992	145/7206	1.44491984847e-08
ko04971	Gastric acid secretion	35/992	98/7206	3.10392811443e-08
ko04070	Phosphatidylinositol signaling system	38/992	112/7206	3.95135077791e-08
ko05014	Amyotrophic lateral sclerosis (ALS)	28/992	74/7206	1.85317607042e-07
ko04010	MAPK signaling pathway	77/992	321/7206	4.81703105305e-07
ko05030	Cocaine addiction	27/992	73/7206	5.24320119945e-07
ko05203	Viral carcinogenesis	13/992	277/7206	7.49714143103e-07
ko04514	Cell adhesion molecules (CAMs)	39/992	130/7206	1.09887727971e-06
ko04740	Olfactory transduction	28/992	80/7206	1.19378498385e-06
ko04966	Collecting duct acid secretion	14/992	26/7206	1.54440289845e-06
ko04120	Ubiquitin mediated proteolysis	3/992	138/7206	4.25708147784e-06
ko05322	Systemic lupus erythematosus	4/992	151/7206	6.19939396725e-06
ko04730	Long-term depression	26/992	78/7206	8.0047528611e-06
ko05168	Herpes simplex infection	7/992	182/7206	1.0316323455e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/992	79/7206	1.03971852452e-05
ko04072	Phospholipase D signaling pathway	50/992	197/7206	1.24407512198e-05
ko04745	Phototransduction - fly	16/992	38/7206	1.671174035e-05
ko04360	Axon guidance	56/992	233/7206	1.72261234453e-05
ko05110	Vibrio cholerae infection	22/992	63/7206	1.7229513032e-05
ko04022	cGMP-PKG signaling pathway	52/992	216/7206	3.28454255338e-05
ko04972	Pancreatic secretion	32/992	111/7206	3.46629331117e-05
ko04540	Gap junction	35/992	128/7206	4.23457431327e-05
ko04750	Inflammatory mediator regulation of TRP channels	34/992	122/7206	4.6467459482e-05
ko05164	Influenza A	7/992	167/7206	5.79103129751e-05
ko04924	Renin secretion	26/992	86/7206	5.79535285162e-05
ko04060	Cytokine-cytokine receptor interaction	9/992	191/7206	6.59368944385e-05
ko03013	RNA transport	7/992	166/7206	8.35173472698e-05
ko04141	Protein processing in endoplasmic reticulum	9/992	184/7206	0.000124455280363
ko04260	Cardiac muscle contraction	28/992	98/7206	0.000151888234373
ko04014	Ras signaling pathway	61/992	279/7206	0.000175465745961
ko04621	NOD-like receptor signaling pathway	7/992	157/7206	0.000230216293361
ko05414	Dilated cardiomyopathy	30/992	112/7206	0.000245060756594
ko04612	Antigen processing and presentation	1/992	77/7206	0.00031962590889
ko04110	Cell cycle	7/992	145/7206	0.000598873451036
ko05169	Epstein-Barr virus infection	13/992	206/7206	0.000933782298551
ko04915	Estrogen signaling pathway	32/992	131/7206	0.00117333497881
ko04610	Complement and coagulation cascades	2/992	79/7206	0.00145192798991
ko03008	Ribosome biogenesis in eukaryotes	2/992	79/7206	0.00145192798991
ko04626	Plant-pathogen interaction	8/992	18/7206	0.00152393080114
ko04146	Peroxisome	3/992	89/7206	0.00173733800695
ko05162	Measles	6/992	120/7206	0.00297847832109
ko00310	Lysine degradation	2/992	73/7206	0.00309081214712
ko04964	Proximal tubule bicarbonate reclamation	10/992	29/7206	0.0039124902104
ko00562	Inositol phosphate metabolism	22/992	89/7206	0.00485327042238
ko04912	GnRH signaling pathway	28/992	122/7206	0.00507543488077
ko04710	Circadian rhythm	13/992	43/7206	0.00564678607005
ko04961	Endocrine and other factor-regulated calcium reabsorption	16/992	59/7206	0.00654414003922
ko05161	Hepatitis B	12/992	173/7206	0.00695526192568
ko05166	HTLV-I infection	25/992	292/7206	0.00702987198571
ko05231	Choline metabolism in cancer	30/992	134/7206	0.00726679089352
ko00590	Arachidonic acid metabolism	1/992	52/7206	0.00748889106897
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/992	14/7206	0.0075072672569
ko04976	Bile secretion	20/992	80/7206	0.00789628141568
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/992	92/7206	0.00867072655431
ko04330	Notch signaling pathway	2/992	62/7206	0.00928141207195
ko04960	Aldosterone-regulated sodium reabsorption	12/992	41/7206	0.00964911543739
ko04064	NF-kappa B signaling pathway	5/992	96/7206	0.0106769266783
ko04973	Carbohydrate digestion and absorption	12/992	42/7206	0.0110271682314
ko05410	Hypertrophic cardiomyopathy (HCM)	23/992	100/7206	0.0119832386682
ko04350	TGF-beta signaling pathway	6/992	103/7206	0.0141003538592
ko05205	Proteoglycans in cancer	24/992	271/7206	0.0150632766048
ko04630	Jak-STAT signaling pathway	9/992	132/7206	0.0153442879564
ko04930	Type II diabetes mellitus	14/992	54/7206	0.0156321192645
ko04210	Apoptosis	14/992	180/7206	0.015693404215
ko05144	Malaria	1/992	45/7206	0.0163572829935
ko00071	Fatty acid degradation	1/992	45/7206	0.0163572829935
ko03420	Nucleotide excision repair	1/992	46/7206	0.0164638580747
ko04114	Oocyte meiosis	29/992	139/7206	0.0179932792528
ko04071	Sphingolipid signaling pathway	33/992	162/7206	0.0202722726037
ko04015	Rap1 signaling pathway	52/992	278/7206	0.0205336502145
ko04711	Circadian rhythm - fly	5/992	13/7206	0.0242314389147
ko00240	Pyrimidine metabolism	7/992	110/7206	0.0243895093965
ko04916	Melanogenesis	29/992	142/7206	0.0261163775363
ko05145	Toxoplasmosis	9/992	126/7206	0.0263514117417
ko04722	Neurotrophin signaling pathway	32/992	160/7206	0.0267994772314
ko00480	Glutathione metabolism	2/992	55/7206	0.0282313356154
ko05140	Leishmaniasis	4/992	75/7206	0.028326656001
ko04932	Non-alcoholic fatty liver disease (NAFLD)	15/992	182/7206	0.0286957028015
ko04550	Signaling pathways regulating pluripotency of stem cells	13/992	165/7206	0.0289652419222
ko05214	Glioma	18/992	79/7206	0.0307100781095
ko05202	Transcriptional misregulation in cancer	16/992	188/7206	0.031854578676
ko05016	Huntington's disease	19/992	215/7206	0.0342864215975
ko04012	ErbB signaling pathway	23/992	109/7206	0.0342966042671
ko00140	Steroid hormone biosynthesis	1/992	41/7206	0.0369162345973
ko04062	Chemokine signaling pathway	38/992	201/7206	0.0374473947916
ko04918	Thyroid hormone synthesis	19/992	86/7206	0.0385634741915
ko04115	p53 signaling pathway	4/992	74/7206	0.0396836335224
ko00330	Arginine and proline metabolism	3/992	61/7206	0.0400406190396
ko04622	RIG-I-like receptor signaling pathway	3/992	62/7206	0.0401954257127
ko00680	Methane metabolism	9/992	34/7206	0.0427012015225
ko05323	Rheumatoid arthritis	19/992	89/7206	0.0435886974317
ko04270	Vascular smooth muscle contraction	30/992	154/7206	0.0439149641211
ko04923	Regulation of lipolysis in adipocytes	17/992	77/7206	0.0441262454667
ko04371	Apelin signaling pathway	34/992	177/7206	0.0457698682314