ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	130/831	423/7206	2.77774038003e-28
ko05033	Nicotine addiction	39/831	56/7206	1.64000590128e-24
ko04724	Glutamatergic synapse	66/831	152/7206	7.49938739501e-24
ko04721	Synaptic vesicle cycle	46/831	80/7206	2.11233496977e-23
ko04728	Dopaminergic synapse	67/831	185/7206	5.3397612531e-19
ko04727	GABAergic synapse	47/831	110/7206	6.00752996814e-17
ko05032	Morphine addiction	47/831	110/7206	6.00752996814e-17
ko04713	Circadian entrainment	50/831	136/7206	9.31845278763e-15
ko04723	Retrograde endocannabinoid signaling	57/831	175/7206	5.55658707285e-14
ko04725	Cholinergic synapse	52/831	160/7206	8.14492413004e-13
ko04024	cAMP signaling pathway	70/831	279/7206	1.59394620548e-10
ko04726	Serotonergic synapse	42/831	137/7206	1.05642084299e-09
ko04911	Insulin secretion	38/831	117/7206	1.07296884318e-09
ko05031	Amphetamine addiction	32/831	91/7206	2.44457442247e-09
ko04261	Adrenergic signaling in cardiomyocytes	51/831	205/7206	8.20084045659e-08
ko04744	Phototransduction	17/831	36/7206	9.83009683364e-08
ko04742	Taste transduction	23/831	61/7206	1.00361291898e-07
ko04360	Axon guidance	55/831	233/7206	1.71732219516e-07
ko05030	Cocaine addiction	25/831	73/7206	2.49382867319e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	25/831	74/7206	3.36151339211e-07
ko03040	Spliceosome	1/831	145/7206	5.43067703724e-07
ko04720	Long-term potentiation	29/831	99/7206	1.19895847081e-06
ko04514	Cell adhesion molecules (CAMs)	33/831	130/7206	9.31735037073e-06
ko04966	Collecting duct acid secretion	12/831	26/7206	1.05891845673e-05
ko04120	Ubiquitin mediated proteolysis	2/831	138/7206	1.11518328331e-05
ko04921	Oxytocin signaling pathway	45/831	209/7206	2.38549432694e-05
ko05168	Herpes simplex infection	5/831	182/7206	2.78311383558e-05
ko04060	Cytokine-cytokine receptor interaction	6/831	191/7206	4.48610286493e-05
ko04970	Salivary secretion	25/831	95/7206	5.7333811787e-05
ko05203	Viral carcinogenesis	13/831	277/7206	0.000105608411007
ko04010	MAPK signaling pathway	60/831	321/7206	0.000110323125818
ko03013	RNA transport	5/831	166/7206	0.000110633735961
ko04020	Calcium signaling pathway	50/831	265/7206	0.000373873362394
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/831	14/7206	0.000436582822741
ko05164	Influenza A	6/831	167/7206	0.000495520677205
ko05110	Vibrio cholerae infection	17/831	63/7206	0.00056528206542
ko04961	Endocrine and other factor-regulated calcium reabsorption	16/831	59/7206	0.000767907234666
ko05205	Proteoglycans in cancer	15/831	271/7206	0.000907201285403
ko03008	Ribosome biogenesis in eukaryotes	1/831	79/7206	0.00115194080019
ko04924	Renin secretion	20/831	86/7206	0.00181037843234
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	19/831	79/7206	0.00195569301204
ko04260	Cardiac muscle contraction	22/831	98/7206	0.00200736311765
ko04971	Gastric acid secretion	22/831	98/7206	0.00200736311765
ko04915	Estrogen signaling pathway	27/831	131/7206	0.00219230545613
ko05162	Measles	4/831	120/7206	0.00219947146664
ko04141	Protein processing in endoplasmic reticulum	9/831	184/7206	0.00228029001314
ko04214	Apoptosis - fly	1/831	72/7206	0.00253177163748
ko04621	NOD-like receptor signaling pathway	7/831	157/7206	0.00331794334587
ko04730	Long-term depression	18/831	78/7206	0.00353740653318
ko04964	Proximal tubule bicarbonate reclamation	9/831	29/7206	0.00407336838682
ko05322	Systemic lupus erythematosus	7/831	151/7206	0.00442013247106
ko05120	Epithelial cell signaling in Helicobacter pylori infection	20/831	92/7206	0.00453339299667
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/831	15/7206	0.00460965773088
ko04640	Hematopoietic cell lineage	1/831	64/7206	0.0055378371013
ko04064	NF-kappa B signaling pathway	3/831	96/7206	0.00563758810579
ko00240	Pyrimidine metabolism	4/831	110/7206	0.00610004193227
ko00330	Arginine and proline metabolism	1/831	61/7206	0.00815276207044
ko00561	Glycerolipid metabolism	1/831	63/7206	0.00842991319064
ko04972	Pancreatic secretion	22/831	111/7206	0.0100710084408
ko01200	Carbon metabolism	6/831	128/7206	0.0113230517972
ko04022	cGMP-PKG signaling pathway	37/831	216/7206	0.0124803570301
ko04014	Ras signaling pathway	46/831	279/7206	0.012502371848
ko04925	Aldosterone synthesis and secretion	21/831	105/7206	0.0125042028669
ko04626	Plant-pathogen interaction	6/831	18/7206	0.0126358396996
ko05169	Epstein-Barr virus infection	13/831	206/7206	0.014610645848
ko05166	HTLV-I infection	21/831	292/7206	0.0149794248925
ko04540	Gap junction	24/831	128/7206	0.0164806455365
ko00480	Glutathione metabolism	1/831	55/7206	0.0178326812038
ko04110	Cell cycle	8/831	145/7206	0.0178538587462
ko04391	Hippo signaling pathway - fly	18/831	90/7206	0.018519993126
ko04962	Vasopressin-regulated water reabsorption	13/831	58/7206	0.0199940977921
ko05034	Alcoholism	39/831	238/7206	0.0226225994451
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	7/831	26/7206	0.0243343446278
ko04140	Autophagy - animal	10/831	164/7206	0.0254705614689
ko00590	Arachidonic acid metabolism	1/831	52/7206	0.0264693387938
ko05161	Hepatitis B	11/831	173/7206	0.0295638106737
ko04612	Antigen processing and presentation	3/831	77/7206	0.0305802480464
ko04932	Non-alcoholic fatty liver disease (NAFLD)	12/831	182/7206	0.0338169773713
ko04745	Phototransduction - fly	9/831	38/7206	0.0351784729376
ko05219	Bladder cancer	1/831	48/7206	0.0383987986079
ko00564	Glycerophospholipid metabolism	5/831	99/7206	0.0390482118671
ko05146	Amoebiasis	5/831	99/7206	0.0390482118671
ko04072	Phospholipase D signaling pathway	32/831	197/7206	0.0413795720983
ko00310	Lysine degradation	3/831	73/7206	0.0424337547071
ko04146	Peroxisome	4/831	89/7206	0.0426049547323
ko05140	Leishmaniasis	3/831	75/7206	0.0431606164116
ko04145	Phagosome	27/831	162/7206	0.0457797465368