ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 88/553 423/7206 4.13229187542e-19 ko04260 Cardiac muscle contraction 33/553 98/7206 7.41842543049e-14 ko04261 Adrenergic signaling in cardiomyocytes 49/553 205/7206 2.38761901403e-13 ko04921 Oxytocin signaling pathway 48/553 209/7206 2.07152636774e-12 ko05033 Nicotine addiction 23/553 56/7206 4.16233900113e-12 ko04724 Glutamatergic synapse 39/553 152/7206 7.08477314106e-12 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 26/553 79/7206 6.28304795451e-11 ko04911 Insulin secretion 32/553 117/7206 9.55799166348e-11 ko04020 Calcium signaling pathway 52/553 265/7206 1.3747458073e-10 ko05410 Hypertrophic cardiomyopathy (HCM) 29/553 100/7206 1.58369083721e-10 ko04713 Circadian entrainment 34/553 136/7206 3.51447581342e-10 ko04723 Retrograde endocannabinoid signaling 39/553 175/7206 6.88082271904e-10 ko04721 Synaptic vesicle cycle 23/553 80/7206 1.54686974967e-08 ko05414 Dilated cardiomyopathy 27/553 112/7206 5.47380086346e-08 ko04022 cGMP-PKG signaling pathway 40/553 216/7206 1.34158713732e-07 ko04024 cAMP signaling pathway 47/553 279/7206 2.10434418636e-07 ko04010 MAPK signaling pathway 50/553 321/7206 9.21584673123e-07 ko05014 Amyotrophic lateral sclerosis (ALS) 19/553 74/7206 1.89044438252e-06 ko04970 Salivary secretion 22/553 95/7206 1.96045830271e-06 ko04727 GABAergic synapse 24/553 110/7206 2.10838670845e-06 ko04728 Dopaminergic synapse 33/553 185/7206 3.76815817576e-06 ko04725 Cholinergic synapse 29/553 160/7206 1.22860536474e-05 ko05168 Herpes simplex infection 1/553 182/7206 1.33282929673e-05 ko04922 Glucagon signaling pathway 24/553 128/7206 3.23062569982e-05 ko04964 Proximal tubule bicarbonate reclamation 10/553 29/7206 3.43272537196e-05 ko05010 Alzheimer's disease 33/553 202/7206 3.66871920399e-05 ko04550 Signaling pathways regulating pluripotency of stem cells 1/553 165/7206 4.25794429024e-05 ko05164 Influenza A 1/553 167/7206 4.39818956948e-05 ko05031 Amphetamine addiction 19/553 91/7206 4.65729045634e-05 ko04726 Serotonergic synapse 25/553 137/7206 5.17347629818e-05 ko05032 Morphine addiction 21/553 110/7206 7.60343295173e-05 ko01200 Carbon metabolism 23/553 128/7206 0.000126718174182 ko04971 Gastric acid secretion 19/553 98/7206 0.000133805170479 ko03040 Spliceosome 1/553 145/7206 0.000205086052965 ko00020 Citrate cycle (TCA cycle) 10/553 35/7206 0.000206499566565 ko04360 Axon guidance 34/553 233/7206 0.000232599548899 ko04060 Cytokine-cytokine receptor interaction 3/553 191/7206 0.000282297108823 ko00010 Glycolysis / Gluconeogenesis 15/553 74/7206 0.000406129368439 ko04720 Long-term potentiation 18/553 99/7206 0.00045746505584 ko04742 Taste transduction 13/553 61/7206 0.000590229543298 ko04730 Long-term depression 15/553 78/7206 0.000730514633825 ko05322 Systemic lupus erythematosus 2/553 151/7206 0.000947723828363 ko05203 Viral carcinogenesis 8/553 277/7206 0.00112918461115 ko04514 Cell adhesion molecules (CAMs) 21/553 130/7206 0.00116714617193 ko05161 Hepatitis B 3/553 173/7206 0.00120422118296 ko04961 Endocrine and other factor-regulated calcium reabsorption 12/553 59/7206 0.00146661601119 ko04140 Autophagy - animal 3/553 164/7206 0.00164928977303 ko03013 RNA transport 3/553 166/7206 0.00166524383125 ko04150 mTOR signaling pathway 4/553 184/7206 0.0018604854886 ko00250 Alanine, aspartate and glutamate metabolism 9/553 38/7206 0.00187438135019 ko04745 Phototransduction - fly 9/553 38/7206 0.00187438135019 ko04120 Ubiquitin mediated proteolysis 2/553 138/7206 0.00193890978191 ko04978 Mineral absorption 9/553 40/7206 0.00273968566247 ko04924 Renin secretion 15/553 86/7206 0.00305694250243 ko05166 HTLV-I infection 10/553 292/7206 0.00332463356168 ko04621 NOD-like receptor signaling pathway 3/553 157/7206 0.00340429149166 ko00710 Carbon fixation in photosynthetic organisms 7/553 27/7206 0.00345413878451 ko04914 Progesterone-mediated oocyte maturation 1/553 104/7206 0.00449013961839 ko04270 Vascular smooth muscle contraction 22/553 154/7206 0.00506046999393 ko01522 Endocrine resistance 2/553 124/7206 0.00573632125453 ko04972 Pancreatic secretion 17/553 111/7206 0.00582367841406 ko04371 Apelin signaling pathway 24/553 177/7206 0.00593801681131 ko05162 Measles 2/553 120/7206 0.00831593068308 ko04668 TNF signaling pathway 2/553 120/7206 0.00831593068308 ko00190 Oxidative phosphorylation 18/553 127/7206 0.010419966886 ko04960 Aldosterone-regulated sodium reabsorption 8/553 41/7206 0.0113873302918 ko05215 Prostate cancer 2/553 111/7206 0.0115608696667 ko04630 Jak-STAT signaling pathway 3/553 132/7206 0.0126872574171 ko00680 Methane metabolism 7/553 34/7206 0.0131149679404 ko04142 Lysosome 4/553 151/7206 0.0131169666724 ko04973 Carbohydrate digestion and absorption 8/553 42/7206 0.0131504856903 ko04917 Prolactin signaling pathway 1/553 87/7206 0.0137361323172 ko04657 IL-17 signaling pathway 1/553 87/7206 0.0137361323172 ko04146 Peroxisome 1/553 89/7206 0.014092409591 ko00500 Starch and sucrose metabolism 7/553 35/7206 0.0153414007454 ko04925 Aldosterone synthesis and secretion 15/553 105/7206 0.0157872324001 ko05142 Chagas disease (American trypanosomiasis) 3/553 130/7206 0.0181855311933 ko00604 Glycosphingolipid biosynthesis - ganglio series 4/553 14/7206 0.0184650726635 ko04976 Bile secretion 12/553 80/7206 0.019789443237 ko05220 Chronic myeloid leukemia 1/553 85/7206 0.0210508029217 ko00620 Pyruvate metabolism 8/553 46/7206 0.0222259825627 ko04210 Apoptosis 6/553 180/7206 0.0226604534315 ko04141 Protein processing in endoplasmic reticulum 6/553 184/7206 0.0233506576074 ko05030 Cocaine addiction 11/553 73/7206 0.0253140830399 ko01524 Platinum drug resistance 1/553 76/7206 0.028903435648 ko00030 Pentose phosphate pathway 6/553 32/7206 0.0324235446863 ko04620 Toll-like receptor signaling pathway 2/553 100/7206 0.0342088843221 ko05416 Viral myocarditis 9/553 55/7206 0.0350584239012 ko05200 Pathways in cancer 26/553 492/7206 0.0429812419568 ko05012 Parkinson's disease 19/553 155/7206 0.0450186516143 ko00240 Pyrimidine metabolism 3/553 110/7206 0.0463937469956