ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 33/444 152/7206 1.05682263671e-10 ko04020 Calcium signaling pathway 44/444 265/7206 8.90144567016e-10 ko04713 Circadian entrainment 28/444 136/7206 1.01160701659e-08 ko05031 Amphetamine addiction 20/444 91/7206 4.46578411478e-07 ko04514 Cell adhesion molecules (CAMs) 24/444 130/7206 9.78056111755e-07 ko04721 Synaptic vesicle cycle 18/444 80/7206 1.17289574101e-06 ko04720 Long-term potentiation 20/444 99/7206 1.84739977358e-06 ko04728 Dopaminergic synapse 29/444 185/7206 2.52204278672e-06 ko04022 cGMP-PKG signaling pathway 32/444 216/7206 3.55376585408e-06 ko04080 Neuroactive ligand-receptor interaction 50/444 423/7206 5.56741445461e-06 ko04921 Oxytocin signaling pathway 30/444 209/7206 1.19486031454e-05 ko04970 Salivary secretion 18/444 95/7206 1.5493583333e-05 ko04911 Insulin secretion 20/444 117/7206 2.59106331837e-05 ko04745 Phototransduction - fly 10/444 38/7206 7.04604305991e-05 ko04922 Glucagon signaling pathway 20/444 128/7206 9.707448419e-05 ko04727 GABAergic synapse 18/444 110/7206 0.000117611106168 ko04360 Axon guidance 30/444 233/7206 0.000127308794646 ko05014 Amyotrophic lateral sclerosis (ALS) 14/444 74/7206 0.000138640089379 ko04261 Adrenergic signaling in cardiomyocytes 27/444 205/7206 0.000160177834265 ko04925 Aldosterone synthesis and secretion 17/444 105/7206 0.000206779075344 ko04924 Renin secretion 15/444 86/7206 0.000209162201283 ko04014 Ras signaling pathway 33/444 279/7206 0.000296057238936 ko05110 Vibrio cholerae infection 12/444 63/7206 0.000386453713024 ko05033 Nicotine addiction 11/444 56/7206 0.000510450363963 ko04015 Rap1 signaling pathway 32/444 278/7206 0.00051328834703 ko00680 Methane metabolism 8/444 34/7206 0.000852934312032 ko04971 Gastric acid secretion 15/444 98/7206 0.000887826316684 ko04710 Circadian rhythm 9/444 43/7206 0.00101503228494 ko04725 Cholinergic synapse 21/444 160/7206 0.00116629118509 ko05322 Systemic lupus erythematosus 1/444 151/7206 0.00158473087323 ko00010 Glycolysis / Gluconeogenesis 12/444 74/7206 0.00171634575405 ko04010 MAPK signaling pathway 34/444 321/7206 0.00180328550289 ko03040 Spliceosome 1/444 145/7206 0.00234085516898 ko04730 Long-term depression 12/444 78/7206 0.00271722239511 ko04740 Olfactory transduction 12/444 80/7206 0.00337169156408 ko04114 Oocyte meiosis 18/444 139/7206 0.0034548951034 ko05032 Morphine addiction 15/444 110/7206 0.00376529165714 ko04626 Plant-pathogen interaction 5/444 18/7206 0.00380554870336 ko05010 Alzheimer's disease 23/444 202/7206 0.00418123593071 ko03010 Ribosome 1/444 129/7206 0.00471896465869 ko04024 cAMP signaling pathway 29/444 279/7206 0.00489990672511 ko04726 Serotonergic synapse 17/444 137/7206 0.00583691890036 ko04668 TNF signaling pathway 1/444 120/7206 0.00678461096656 ko05168 Herpes simplex infection 3/444 182/7206 0.00701591355521 ko04070 Phosphatidylinositol signaling system 14/444 112/7206 0.00934185194095 ko05323 Rheumatoid arthritis 12/444 89/7206 0.0114154628082 ko00051 Fructose and mannose metabolism 7/444 42/7206 0.0132603592938 ko03013 RNA transport 3/444 166/7206 0.01328342573 ko04540 Gap junction 15/444 128/7206 0.0144245984828 ko04630 Jak-STAT signaling pathway 2/444 132/7206 0.0170498971444 ko04931 Insulin resistance 2/444 137/7206 0.0176516799441 ko04120 Ubiquitin mediated proteolysis 2/444 138/7206 0.0179373885812 ko04141 Protein processing in endoplasmic reticulum 4/444 184/7206 0.0187149580139 ko04966 Collecting duct acid secretion 5/444 26/7206 0.0194644603767 ko05203 Viral carcinogenesis 8/444 277/7206 0.0207255634184 ko00471 D-Glutamine and D-glutamate metabolism 2/444 4/7206 0.0209137265733 ko04066 HIF-1 signaling pathway 14/444 123/7206 0.0221018246261 ko04210 Apoptosis 4/444 180/7206 0.0260725242653 ko05152 Tuberculosis 19/444 187/7206 0.0295017046111 ko04964 Proximal tubule bicarbonate reclamation 5/444 29/7206 0.0302220524424 ko05162 Measles 2/444 120/7206 0.0338370278608 ko05164 Influenza A 4/444 167/7206 0.0343063434515 ko04110 Cell cycle 3/444 145/7206 0.0349275888253 ko05161 Hepatitis B 4/444 173/7206 0.0352440064784 ko04723 Retrograde endocannabinoid signaling 18/444 175/7206 0.0361229084604 ko04371 Apelin signaling pathway 18/444 177/7206 0.0372855067492 ko04711 Circadian rhythm - fly 3/444 13/7206 0.0418340744774 ko04917 Prolactin signaling pathway 1/444 87/7206 0.0432056714134 ko05222 Small cell lung cancer 1/444 89/7206 0.0434393008338