ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	188/989	423/7206	8.63648973147e-58
ko05033	Nicotine addiction	49/989	56/7206	1.69795889018e-35
ko04724	Glutamatergic synapse	83/989	152/7206	2.12463715728e-33
ko04713	Circadian entrainment	70/989	136/7206	3.36896434429e-26
ko04727	GABAergic synapse	62/989	110/7206	3.51016397554e-26
ko05032	Morphine addiction	62/989	110/7206	3.51016397554e-26
ko04725	Cholinergic synapse	72/989	160/7206	2.06699996077e-22
ko04728	Dopaminergic synapse	78/989	185/7206	5.20566211005e-22
ko04723	Retrograde endocannabinoid signaling	73/989	175/7206	2.48591118635e-20
ko04024	cAMP signaling pathway	97/989	279/7206	7.45503626543e-20
ko04721	Synaptic vesicle cycle	45/989	80/7206	2.93543105017e-19
ko04742	Taste transduction	35/989	61/7206	1.27516748415e-15
ko04911	Insulin secretion	50/989	117/7206	8.68179122531e-15
ko04726	Serotonergic synapse	55/989	137/7206	1.00174356537e-14
ko04020	Calcium signaling pathway	83/989	265/7206	4.57875974075e-14
ko04921	Oxytocin signaling pathway	70/989	209/7206	1.40998852256e-13
ko04744	Phototransduction	24/989	36/7206	3.73927674186e-13
ko05031	Amphetamine addiction	40/989	91/7206	1.45072390745e-12
ko04720	Long-term potentiation	41/989	99/7206	8.10384215629e-12
ko04261	Adrenergic signaling in cardiomyocytes	64/989	205/7206	7.23256133928e-11
ko04740	Olfactory transduction	32/989	80/7206	4.61881618889e-09
ko05030	Cocaine addiction	30/989	73/7206	6.60849946736e-09
ko04970	Salivary secretion	35/989	95/7206	1.13458716494e-08
ko03040	Spliceosome	1/989	145/7206	1.45931246185e-08
ko05203	Viral carcinogenesis	10/989	277/7206	1.88865106521e-08
ko04971	Gastric acid secretion	34/989	98/7206	1.02800872738e-07
ko04060	Cytokine-cytokine receptor interaction	5/989	191/7206	1.78095075412e-07
ko04925	Aldosterone synthesis and secretion	35/989	105/7206	2.06889567301e-07
ko05168	Herpes simplex infection	5/989	182/7206	5.53734310393e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	27/989	74/7206	6.76299248349e-07
ko04010	MAPK signaling pathway	76/989	321/7206	7.77553572655e-07
ko04022	cGMP-PKG signaling pathway	55/989	216/7206	2.8111213971e-06
ko05164	Influenza A	5/989	167/7206	3.57830286909e-06
ko05322	Systemic lupus erythematosus	4/989	151/7206	6.09290851982e-06
ko04360	Axon guidance	57/989	233/7206	6.91340032269e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/989	79/7206	9.83518421859e-06
ko04966	Collecting duct acid secretion	13/989	26/7206	1.0418161012e-05
ko04972	Pancreatic secretion	32/989	111/7206	3.38135554809e-05
ko04260	Cardiac muscle contraction	29/989	98/7206	3.87157961979e-05
ko04621	NOD-like receptor signaling pathway	6/989	157/7206	5.26851715795e-05
ko04745	Phototransduction - fly	15/989	38/7206	7.3069881565e-05
ko03013	RNA transport	7/989	166/7206	8.27445309215e-05
ko04730	Long-term depression	24/989	78/7206	8.32229846035e-05
ko04072	Phospholipase D signaling pathway	47/989	197/7206	9.04430133487e-05
ko04141	Protein processing in endoplasmic reticulum	9/989	184/7206	0.000124284512357
ko05169	Epstein-Barr virus infection	11/989	206/7206	0.00012513844609
ko04120	Ubiquitin mediated proteolysis	5/989	138/7206	0.000137291020506
ko04924	Renin secretion	25/989	86/7206	0.000188794032287
ko04110	Cell cycle	6/989	145/7206	0.000210252909117
ko04540	Gap junction	33/989	128/7206	0.000230977650168
ko04070	Phosphatidylinositol signaling system	30/989	112/7206	0.000238238821721
ko04014	Ras signaling pathway	60/989	279/7206	0.000257663647123
ko04750	Inflammatory mediator regulation of TRP channels	32/989	122/7206	0.000258484774677
ko05110	Vibrio cholerae infection	20/989	63/7206	0.000267958702141
ko04612	Antigen processing and presentation	1/989	77/7206	0.000316430068038
ko04514	Cell adhesion molecules (CAMs)	33/989	130/7206	0.000411419980299
ko04350	TGF-beta signaling pathway	3/989	103/7206	0.000413951447172
ko04214	Apoptosis - fly	1/989	72/7206	0.000451354910489
ko04915	Estrogen signaling pathway	32/989	131/7206	0.000787561166594
ko05162	Measles	5/989	120/7206	0.00111063977397
ko05205	Proteoglycans in cancer	20/989	271/7206	0.00115378779525
ko05414	Dilated cardiomyopathy	28/989	112/7206	0.00124469685402
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/989	14/7206	0.00127731844923
ko04932	Non-alcoholic fatty liver disease (NAFLD)	11/989	182/7206	0.0014096692086
ko03008	Ribosome biogenesis in eukaryotes	2/989	79/7206	0.00144596098505
ko05166	HTLV-I infection	23/989	292/7206	0.00226433225115
ko04140	Autophagy - animal	10/989	164/7206	0.00263390060309
ko00240	Pyrimidine metabolism	5/989	110/7206	0.00296950581808
ko05161	Hepatitis B	11/989	173/7206	0.00335673917725
ko04964	Proximal tubule bicarbonate reclamation	10/989	29/7206	0.00382569945891
ko05016	Huntington's disease	16/989	215/7206	0.00471564546262
ko00480	Glutathione metabolism	1/989	55/7206	0.00503407031568
ko04973	Carbohydrate digestion and absorption	13/989	42/7206	0.00506260917393
ko04626	Plant-pathogen interaction	7/989	18/7206	0.00719728592722
ko05215	Prostate cancer	6/989	111/7206	0.00769436421163
ko04146	Peroxisome	4/989	89/7206	0.00771188292039
ko04976	Bile secretion	20/989	80/7206	0.00781525407484
ko04640	Hematopoietic cell lineage	2/989	64/7206	0.00941945472811
ko05140	Leishmaniasis	3/989	75/7206	0.010381281114
ko04064	NF-kappa B signaling pathway	5/989	96/7206	0.0106825203428
ko04912	GnRH signaling pathway	27/989	122/7206	0.010931055732
ko04657	IL-17 signaling pathway	4/989	87/7206	0.0110136603062
ko00260	Glycine, serine and threonine metabolism	1/989	48/7206	0.0110671841018
ko05219	Bladder cancer	1/989	48/7206	0.0110671841018
ko05410	Hypertrophic cardiomyopathy (HCM)	23/989	100/7206	0.0118267451545
ko04015	Rap1 signaling pathway	53/989	278/7206	0.0124516678477
ko04961	Endocrine and other factor-regulated calcium reabsorption	15/989	59/7206	0.0132523214309
ko00330	Arginine and proline metabolism	2/989	61/7206	0.0136068818588
ko04330	Notch signaling pathway	2/989	62/7206	0.0140637999757
ko04371	Apelin signaling pathway	36/989	177/7206	0.0143793244976
ko00310	Lysine degradation	3/989	73/7206	0.0150793574055
ko03018	RNA degradation	4/989	84/7206	0.0153434723916
ko04930	Type II diabetes mellitus	14/989	54/7206	0.0153912975465
ko05144	Malaria	1/989	45/7206	0.0163956646332
ko00071	Fatty acid degradation	1/989	45/7206	0.0163956646332
ko03420	Nucleotide excision repair	1/989	46/7206	0.0164513826986
ko04217	Necroptosis	14/989	178/7206	0.0200787075674
ko04630	Jak-STAT signaling pathway	9/989	132/7206	0.0205817540279
ko04668	TNF signaling pathway	8/989	120/7206	0.0221296467132
ko00983	Drug metabolism - other enzymes	1/989	42/7206	0.0242408558747
ko03022	Basal transcription factors	1/989	44/7206	0.0249475671101
ko05321	Inflammatory bowel disease (IBD)	2/989	56/7206	0.0290639822699
ko05120	Epithelial cell signaling in Helicobacter pylori infection	20/989	92/7206	0.0318023089849
ko04658	Th1 and Th2 cell differentiation	6/989	96/7206	0.0349729579195
ko00980	Metabolism of xenobiotics by cytochrome P450	1/989	40/7206	0.0359113202834
ko04115	p53 signaling pathway	4/989	74/7206	0.0395527913469
ko04622	RIG-I-like receptor signaling pathway	3/989	62/7206	0.0401723832066
ko05231	Choline metabolism in cancer	27/989	134/7206	0.0412692070718
ko04923	Regulation of lipolysis in adipocytes	17/989	77/7206	0.0436882583983
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	5/989	15/7206	0.0442373627797
ko04218	Cellular senescence	15/989	177/7206	0.0455341082638
ko04071	Sphingolipid signaling pathway	31/989	162/7206	0.0491691550361