ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	136/820	423/7206	1.5011996526e-32
ko04724	Glutamatergic synapse	75/820	152/7206	5.83208676771e-32
ko05033	Nicotine addiction	44/820	56/7206	1.5112018622e-31
ko04727	GABAergic synapse	58/820	110/7206	7.48735229588e-27
ko05032	Morphine addiction	57/820	110/7206	6.83271693402e-26
ko04713	Circadian entrainment	60/820	136/7206	1.65566775978e-22
ko04728	Dopaminergic synapse	69/820	185/7206	1.07800021998e-20
ko04723	Retrograde endocannabinoid signaling	65/820	175/7206	1.95027298018e-19
ko04744	Phototransduction	26/820	36/7206	1.66344394478e-17
ko04024	cAMP signaling pathway	77/820	279/7206	2.4350935063e-14
ko04721	Synaptic vesicle cycle	36/820	80/7206	2.67871307278e-14
ko04725	Cholinergic synapse	53/820	160/7206	1.18056717377e-13
ko04726	Serotonergic synapse	47/820	137/7206	7.10114465295e-13
ko04742	Taste transduction	29/820	61/7206	1.61382190976e-12
ko04020	Calcium signaling pathway	70/820	265/7206	4.04380734156e-12
ko04921	Oxytocin signaling pathway	58/820	209/7206	4.18548463545e-11
ko05031	Amphetamine addiction	34/820	91/7206	8.03928756713e-11
ko04261	Adrenergic signaling in cardiomyocytes	55/820	205/7206	4.72033258206e-10
ko04911	Insulin secretion	38/820	117/7206	7.29234217407e-10
ko04720	Long-term potentiation	34/820	99/7206	1.10717399956e-09
ko05030	Cocaine addiction	28/820	73/7206	1.90518571223e-09
ko04740	Olfactory transduction	28/820	80/7206	2.05946201753e-08
ko05164	Influenza A	1/820	167/7206	4.69048023834e-08
ko05203	Viral carcinogenesis	7/820	277/7206	6.25884961051e-08
ko04970	Salivary secretion	30/820	95/7206	9.37797778613e-08
ko03040	Spliceosome	1/820	145/7206	8.69506389473e-07
ko04060	Cytokine-cytokine receptor interaction	4/820	191/7206	2.42407431664e-06
ko05169	Epstein-Barr virus infection	5/820	206/7206	3.22505958986e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	23/820	74/7206	4.02220453163e-06
ko04010	MAPK signaling pathway	64/820	321/7206	5.34326915993e-06
ko04260	Cardiac muscle contraction	27/820	98/7206	7.76763129565e-06
ko04730	Long-term depression	23/820	78/7206	1.07665003504e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	22/820	79/7206	4.45822550343e-05
ko04120	Ubiquitin mediated proteolysis	3/820	138/7206	0.000110349892546
ko04925	Aldosterone synthesis and secretion	26/820	105/7206	0.000126497200145
ko05322	Systemic lupus erythematosus	4/820	151/7206	0.0001358396549
ko05205	Proteoglycans in cancer	13/820	271/7206	0.000187615529772
ko05166	HTLV-I infection	15/820	292/7206	0.000227404188649
ko05161	Hepatitis B	6/820	173/7206	0.00024609575691
ko04972	Pancreatic secretion	26/820	111/7206	0.000246728743859
ko04110	Cell cycle	4/820	145/7206	0.00028311769783
ko04621	NOD-like receptor signaling pathway	5/820	157/7206	0.000314868845512
ko04070	Phosphatidylinositol signaling system	26/820	112/7206	0.000407799019592
ko04022	cGMP-PKG signaling pathway	42/820	216/7206	0.000435500305094
ko03013	RNA transport	6/820	166/7206	0.00047771519178
ko04924	Renin secretion	21/820	86/7206	0.000518596896292
ko04072	Phospholipase D signaling pathway	39/820	197/7206	0.000548302079939
ko04971	Gastric acid secretion	23/820	98/7206	0.000587305819496
ko04550	Signaling pathways regulating pluripotency of stem cells	6/820	165/7206	0.000684710493814
ko04745	Phototransduction - fly	12/820	38/7206	0.000707234377507
ko05414	Dilated cardiomyopathy	25/820	112/7206	0.000787994445087
ko04510	Focal adhesion	12/820	240/7206	0.000846777947283
ko04964	Proximal tubule bicarbonate reclamation	10/820	29/7206	0.000909196514265
ko05168	Herpes simplex infection	8/820	182/7206	0.00129295758242
ko04932	Non-alcoholic fatty liver disease (NAFLD)	8/820	182/7206	0.00129295758242
ko04141	Protein processing in endoplasmic reticulum	8/820	184/7206	0.00132344467936
ko05215	Prostate cancer	3/820	111/7206	0.00138173346965
ko04966	Collecting duct acid secretion	9/820	26/7206	0.00158799831838
ko04612	Antigen processing and presentation	1/820	77/7206	0.00173314221981
ko04514	Cell adhesion molecules (CAMs)	27/820	130/7206	0.00184291513073
ko03008	Ribosome biogenesis in eukaryotes	1/820	79/7206	0.00185432005654
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/820	14/7206	0.00285734387175
ko04630	Jak-STAT signaling pathway	5/820	132/7206	0.00329193045794
ko05034	Alcoholism	42/820	238/7206	0.00345082540549
ko05222	Small cell lung cancer	2/820	89/7206	0.00356189416606
ko04350	TGF-beta signaling pathway	3/820	103/7206	0.00419579926304
ko04064	NF-kappa B signaling pathway	3/820	96/7206	0.00564914318229
ko04140	Autophagy - animal	8/820	164/7206	0.00580193105311
ko05145	Toxoplasmosis	5/820	126/7206	0.00644303070029
ko04540	Gap junction	25/820	128/7206	0.00688656182495
ko04710	Circadian rhythm	11/820	43/7206	0.00723996166596
ko05224	Breast cancer	9/820	174/7206	0.0073473515823
ko05200	Pathways in cancer	38/820	492/7206	0.00791950301145
ko05140	Leishmaniasis	2/820	75/7206	0.0101780509039
ko01524	Platinum drug resistance	2/820	76/7206	0.0101789441634
ko05130	Pathogenic Escherichia coli infection	2/820	77/7206	0.0103072375371
ko05410	Hypertrophic cardiomyopathy (HCM)	20/820	100/7206	0.010412934588
ko04146	Peroxisome	3/820	89/7206	0.0112265893007
ko04210	Apoptosis	10/820	180/7206	0.011883787178
ko05110	Vibrio cholerae infection	14/820	63/7206	0.0142839666426
ko00310	Lysine degradation	2/820	73/7206	0.0146799053472
ko04014	Ras signaling pathway	45/820	279/7206	0.015738755843
ko05218	Melanoma	3/820	85/7206	0.0157593926759
ko00562	Inositol phosphate metabolism	18/820	89/7206	0.0168830724208
ko04810	Regulation of actin cytoskeleton	18/820	264/7206	0.0172874951389
ko00480	Glutathione metabolism	1/820	55/7206	0.0177721458693
ko05217	Basal cell carcinoma	2/820	68/7206	0.0208017433754
ko03018	RNA degradation	3/820	84/7206	0.0226914142028
ko00590	Arachidonic acid metabolism	1/820	52/7206	0.0262349695283
ko04668	TNF signaling pathway	6/820	120/7206	0.0281410198035
ko04640	Hematopoietic cell lineage	2/820	64/7206	0.0296508934488
ko04218	Cellular senescence	11/820	177/7206	0.0300081050059
ko04150	mTOR signaling pathway	12/820	184/7206	0.0339047701298
ko04670	Leukocyte transendothelial migration	9/820	151/7206	0.0369886404223
ko05418	Fluid shear stress and atherosclerosis	11/820	173/7206	0.0382943026514
ko04620	Toll-like receptor signaling pathway	5/820	100/7206	0.0392044115242
ko04978	Mineral absorption	9/820	40/7206	0.040465703252
ko04931	Insulin resistance	8/820	137/7206	0.040514130874
ko04657	IL-17 signaling pathway	4/820	87/7206	0.0413736247768
ko04115	p53 signaling pathway	3/820	74/7206	0.0425963250834
ko04664	Fc epsilon RI signaling pathway	3/820	77/7206	0.0442188115584
ko04660	T cell receptor signaling pathway	7/820	124/7206	0.0445794684203
ko00240	Pyrimidine metabolism	6/820	110/7206	0.0484913967055
ko04976	Bile secretion	15/820	80/7206	0.0490454430667
ko04930	Type II diabetes mellitus	11/820	54/7206	0.049520607953