ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	177/894	423/7206	1.74423789704e-56
ko05033	Nicotine addiction	46/894	56/7206	7.49604657198e-33
ko04724	Glutamatergic synapse	77/894	152/7206	3.60121241399e-31
ko05032	Morphine addiction	57/894	110/7206	6.0694562463e-24
ko04713	Circadian entrainment	63/894	136/7206	6.17415512705e-23
ko04727	GABAergic synapse	55/894	110/7206	3.67331605961e-22
ko04728	Dopaminergic synapse	73/894	185/7206	2.82199364069e-21
ko04723	Retrograde endocannabinoid signaling	66/894	175/7206	4.17192993819e-18
ko04725	Cholinergic synapse	61/894	160/7206	4.42387338874e-17
ko04024	cAMP signaling pathway	84/894	279/7206	9.3522339126e-16
ko04721	Synaptic vesicle cycle	39/894	80/7206	1.40720216883e-15
ko04020	Calcium signaling pathway	81/894	265/7206	1.44271130993e-15
ko04911	Insulin secretion	47/894	117/7206	1.93557578732e-14
ko04726	Serotonergic synapse	51/894	137/7206	5.54130207366e-14
ko04742	Taste transduction	30/894	61/7206	2.09520719303e-12
ko04921	Oxytocin signaling pathway	62/894	209/7206	1.3700839348e-11
ko05031	Amphetamine addiction	35/894	91/7206	1.87296307725e-10
ko04261	Adrenergic signaling in cardiomyocytes	59/894	205/7206	1.94178448434e-10
ko04720	Long-term potentiation	35/894	99/7206	2.68926454268e-09
ko04970	Salivary secretion	33/894	95/7206	1.27249902141e-08
ko05030	Cocaine addiction	28/894	73/7206	1.34842679086e-08
ko05203	Viral carcinogenesis	8/894	277/7206	2.26961190965e-08
ko03040	Spliceosome	1/894	145/7206	1.42387165391e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	26/894	74/7206	3.46658907426e-07
ko04971	Gastric acid secretion	30/894	98/7206	1.33038716988e-06
ko04010	MAPK signaling pathway	70/894	321/7206	1.4118656842e-06
ko04925	Aldosterone synthesis and secretion	31/894	105/7206	2.92815841672e-06
ko04972	Pancreatic secretion	32/894	111/7206	2.93430561152e-06
ko05168	Herpes simplex infection	5/894	182/7206	5.9812652246e-06
ko04360	Axon guidance	53/894	233/7206	7.00438037861e-06
ko05164	Influenza A	4/894	167/7206	7.02038082413e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	24/894	79/7206	1.74375711529e-05
ko04514	Cell adhesion molecules (CAMs)	34/894	130/7206	1.87816005176e-05
ko04120	Ubiquitin mediated proteolysis	3/894	138/7206	2.23750121033e-05
ko05322	Systemic lupus erythematosus	4/894	151/7206	2.93596847113e-05
ko04540	Gap junction	33/894	128/7206	3.14626035375e-05
ko04260	Cardiac muscle contraction	27/894	98/7206	3.99795418085e-05
ko04730	Long-term depression	23/894	78/7206	4.41214532072e-05
ko04060	Cytokine-cytokine receptor interaction	7/894	191/7206	4.74911197196e-05
ko04744	Phototransduction	14/894	36/7206	5.00453481783e-05
ko04072	Phospholipase D signaling pathway	44/894	197/7206	0.000100118878451
ko05414	Dilated cardiomyopathy	28/894	112/7206	0.000223023289736
ko04141	Protein processing in endoplasmic reticulum	8/894	184/7206	0.000253432958965
ko04022	cGMP-PKG signaling pathway	45/894	216/7206	0.000338466686861
ko05169	Epstein-Barr virus infection	10/894	206/7206	0.000351473369934
ko04750	Inflammatory mediator regulation of TRP channels	29/894	122/7206	0.000432780469381
ko03013	RNA transport	7/894	166/7206	0.000473507411612
ko04612	Antigen processing and presentation	1/894	77/7206	0.000737268943636
ko04610	Complement and coagulation cascades	1/894	79/7206	0.000791174657892
ko05205	Proteoglycans in cancer	17/894	271/7206	0.000966261349213
ko04621	NOD-like receptor signaling pathway	7/894	157/7206	0.00127013668559
ko04550	Signaling pathways regulating pluripotency of stem cells	8/894	165/7206	0.00169410967587
ko04214	Apoptosis - fly	1/894	72/7206	0.0017076628844
ko04976	Bile secretion	20/894	80/7206	0.00172796619068
ko04740	Olfactory transduction	20/894	80/7206	0.00172796619068
ko04961	Endocrine and other factor-regulated calcium reabsorption	16/894	59/7206	0.00208264594046
ko04014	Ras signaling pathway	52/894	279/7206	0.00214626366114
ko05161	Hepatitis B	9/894	173/7206	0.00220134203646
ko04932	Non-alcoholic fatty liver disease (NAFLD)	10/894	182/7206	0.00282227879576
ko00240	Pyrimidine metabolism	4/894	110/7206	0.00306826867457
ko04915	Estrogen signaling pathway	28/894	131/7206	0.003090779195
ko05162	Measles	5/894	120/7206	0.00310742057835
ko04110	Cell cycle	7/894	145/7206	0.00314784975575
ko03008	Ribosome biogenesis in eukaryotes	2/894	79/7206	0.0032441742113
ko04070	Phosphatidylinositol signaling system	25/894	112/7206	0.0033392416581
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/894	14/7206	0.0044499329773
ko04745	Phototransduction - fly	11/894	38/7206	0.00506914178606
ko04146	Peroxisome	3/894	89/7206	0.00541495423898
ko05410	Hypertrophic cardiomyopathy (HCM)	22/894	100/7206	0.00575338955068
ko04964	Proximal tubule bicarbonate reclamation	9/894	29/7206	0.00664547605757
ko05215	Prostate cancer	5/894	111/7206	0.00828382985686
ko05166	HTLV-I infection	22/894	292/7206	0.00838405858781
ko04218	Cellular senescence	11/894	177/7206	0.0105120845445
ko04966	Collecting duct acid secretion	8/894	26/7206	0.0109164085335
ko04924	Renin secretion	19/894	86/7206	0.0121366551135
ko04142	Lysosome	9/894	151/7206	0.0121965154346
ko04350	TGF-beta signaling pathway	5/894	103/7206	0.0153541156742
ko04015	Rap1 signaling pathway	48/894	278/7206	0.0155831268675
ko00590	Arachidonic acid metabolism	1/894	52/7206	0.0176996983583
ko04930	Type II diabetes mellitus	13/894	54/7206	0.0195170838889
ko04330	Notch signaling pathway	2/894	62/7206	0.0201684147427
ko04217	Necroptosis	12/894	178/7206	0.0205269299471
ko04918	Thyroid hormone synthesis	18/894	86/7206	0.0209729596449
ko05140	Leishmaniasis	3/894	75/7206	0.0213472157653
ko05133	Pertussis	4/894	87/7206	0.021449235042
ko04140	Autophagy - animal	11/894	164/7206	0.0224578490156
ko04630	Jak-STAT signaling pathway	8/894	132/7206	0.022930895124
ko00260	Glycine, serine and threonine metabolism	1/894	48/7206	0.025561310424
ko05418	Fluid shear stress and atherosclerosis	12/894	173/7206	0.0259811746157
ko05016	Huntington's disease	16/894	215/7206	0.026677333862
ko04064	NF-kappa B signaling pathway	5/894	96/7206	0.028326805113
ko05220	Chronic myeloid leukemia	4/894	85/7206	0.02980423472
ko00310	Lysine degradation	3/894	73/7206	0.0302678082792
ko05110	Vibrio cholerae infection	14/894	63/7206	0.0315679768066
ko04973	Carbohydrate digestion and absorption	10/894	42/7206	0.033284906374
ko05231	Choline metabolism in cancer	25/894	134/7206	0.0335266466091
ko04923	Regulation of lipolysis in adipocytes	16/894	77/7206	0.0350354771259
ko04912	GnRH signaling pathway	23/894	122/7206	0.0368200233591
ko05144	Malaria	1/894	45/7206	0.0378114582544
ko00071	Fatty acid degradation	1/894	45/7206	0.0378114582544
ko03420	Nucleotide excision repair	1/894	46/7206	0.0390622870813
ko05321	Inflammatory bowel disease (IBD)	2/894	56/7206	0.0409423425673