ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko03040	Spliceosome	76/480	145/7206	5.0229402817e-52
ko04110	Cell cycle	58/480	145/7206	1.76252479347e-31
ko04111	Cell cycle - yeast	43/480	90/7206	2.21358977429e-27
ko03030	DNA replication	27/480	38/7206	5.17324530846e-24
ko04113	Meiosis - yeast	32/480	70/7206	6.79045790131e-20
ko03410	Base excision repair	20/480	38/7206	2.2005349606e-14
ko03013	RNA transport	40/480	166/7206	3.38974735622e-13
ko03430	Mismatch repair	14/480	22/7206	5.49870468823e-12
ko03460	Fanconi anemia pathway	19/480	51/7206	2.05663524845e-10
ko03440	Homologous recombination	17/480	41/7206	2.57747562019e-10
ko03015	mRNA surveillance pathway	25/480	93/7206	8.92699198375e-10
ko00240	Pyrimidine metabolism	27/480	110/7206	1.71591300909e-09
ko03420	Nucleotide excision repair	16/480	46/7206	1.80075801321e-08
ko04144	Endocytosis	3/480	342/7206	1.72630068843e-07
ko03008	Ribosome biogenesis in eukaryotes	19/480	79/7206	6.4810388344e-07
ko05322	Systemic lupus erythematosus	25/480	151/7206	1.81149119096e-05
ko05010	Alzheimer's disease	1/480	202/7206	2.06793817697e-05
ko05166	HTLV-I infection	39/480	292/7206	3.24727694602e-05
ko05203	Viral carcinogenesis	37/480	277/7206	3.77562055185e-05
ko04114	Oocyte meiosis	23/480	139/7206	3.94817730583e-05
ko04060	Cytokine-cytokine receptor interaction	1/480	191/7206	4.57804079949e-05
ko04024	cAMP signaling pathway	4/480	279/7206	6.50145053225e-05
ko04932	Non-alcoholic fatty liver disease (NAFLD)	1/480	182/7206	0.000106683676838
ko04723	Retrograde endocannabinoid signaling	1/480	175/7206	0.000152753114719
ko04072	Phospholipase D signaling pathway	2/480	197/7206	0.000225186888708
ko04022	cGMP-PKG signaling pathway	3/480	216/7206	0.000427097498483
ko05168	Herpes simplex infection	25/480	182/7206	0.000444792721285
ko04914	Progesterone-mediated oocyte maturation	17/480	104/7206	0.00046022847278
ko05152	Tuberculosis	2/480	187/7206	0.000483116089507
ko04724	Glutamatergic synapse	1/480	152/7206	0.000730201585183
ko04062	Chemokine signaling pathway	3/480	201/7206	0.00085392490932
ko04218	Cellular senescence	24/480	177/7206	0.00105013614667
ko03018	RNA degradation	14/480	84/7206	0.00117980734999
ko05034	Alcoholism	29/480	238/7206	0.00134053398292
ko04071	Sphingolipid signaling pathway	2/480	162/7206	0.0020508456541
ko05142	Chagas disease (American trypanosomiasis)	1/480	130/7206	0.00215106434887
ko04380	Osteoclast differentiation	1/480	134/7206	0.00228731495537
ko04330	Notch signaling pathway	11/480	62/7206	0.00233014792868
ko04141	Protein processing in endoplasmic reticulum	3/480	184/7206	0.0024264951964
ko04120	Ubiquitin mediated proteolysis	19/480	138/7206	0.00263260296923
ko04261	Adrenergic signaling in cardiomyocytes	4/480	205/7206	0.00268787967641
ko04921	Oxytocin signaling pathway	4/480	209/7206	0.0027291358885
ko04530	Tight junction	5/480	228/7206	0.00283542102492
ko04270	Vascular smooth muscle contraction	2/480	154/7206	0.00289360673792
ko04360	Axon guidance	5/480	233/7206	0.00291078975132
ko05145	Toxoplasmosis	1/480	126/7206	0.00320621646797
ko01200	Carbon metabolism	1/480	128/7206	0.00333898322882
ko04670	Leukocyte transendothelial migration	2/480	151/7206	0.00427103750324
ko05202	Transcriptional misregulation in cancer	23/480	188/7206	0.00429306399506
ko04911	Insulin secretion	1/480	117/7206	0.00458163496898
ko04668	TNF signaling pathway	1/480	120/7206	0.00467862653392
ko04912	GnRH signaling pathway	1/480	122/7206	0.0048680317817
ko05217	Basal cell carcinoma	11/480	68/7206	0.00490018026691
ko04015	Rap1 signaling pathway	8/480	278/7206	0.00666493289203
ko04972	Pancreatic secretion	1/480	111/7206	0.00667709568835
ko00230	Purine metabolism	23/480	194/7206	0.007673149613
ko04933	AGE-RAGE signaling pathway in diabetic complications	2/480	135/7206	0.00838295367164
ko04713	Circadian entrainment	2/480	136/7206	0.00840799685685
ko04726	Serotonergic synapse	2/480	137/7206	0.0084674251473
ko04722	Neurotrophin signaling pathway	3/480	160/7206	0.0094371628407
ko04725	Cholinergic synapse	3/480	160/7206	0.0094371628407
ko04925	Aldosterone synthesis and secretion	1/480	105/7206	0.00971529455868
ko04659	Th17 cell differentiation	1/480	106/7206	0.00973485316213
ko04611	Platelet activation	3/480	163/7206	0.00978881593003
ko04550	Signaling pathways regulating pluripotency of stem cells	20/480	165/7206	0.0101887753333
ko04727	GABAergic synapse	1/480	110/7206	0.0103048050433
ko05032	Morphine addiction	1/480	110/7206	0.0103048050433
ko04810	Regulation of actin cytoskeleton	8/480	264/7206	0.0116676555307
ko04540	Gap junction	2/480	128/7206	0.0119038435164
ko04915	Estrogen signaling pathway	2/480	131/7206	0.0120313153992
ko05231	Choline metabolism in cancer	2/480	134/7206	0.0125844700577
ko05160	Hepatitis C	3/480	153/7206	0.013081314707
ko05100	Bacterial invasion of epithelial cells	1/480	99/7206	0.0141118356822
ko00564	Glycerophospholipid metabolism	1/480	99/7206	0.0141118356822
ko05146	Amoebiasis	1/480	99/7206	0.0141118356822
ko04010	MAPK signaling pathway	11/480	321/7206	0.0155760637648
ko04510	Focal adhesion	7/480	240/7206	0.01677003125
ko04750	Inflammatory mediator regulation of TRP channels	2/480	122/7206	0.016840678245
ko04066	HIF-1 signaling pathway	2/480	123/7206	0.0168471686489
ko04660	T cell receptor signaling pathway	2/480	124/7206	0.0169171416036
ko04014	Ras signaling pathway	9/480	279/7206	0.0190094252637
ko05206	MicroRNAs in cancer	20/480	177/7206	0.0204330676725
ko04151	PI3K-Akt signaling pathway	15/480	390/7206	0.0210322141893
ko04650	Natural killer cell mediated cytotoxicity	1/480	97/7206	0.0212427523183
ko04310	Wnt signaling pathway	20/480	181/7206	0.0226784577635
ko04728	Dopaminergic synapse	5/480	185/7206	0.0243301172967
ko03022	Basal transcription factors	7/480	44/7206	0.0249074502702
ko04662	B cell receptor signaling pathway	1/480	88/7206	0.0296951528521
ko04115	p53 signaling pathway	10/480	74/7206	0.029966491591
ko04371	Apelin signaling pathway	5/480	177/7206	0.0325706355861
ko04630	Jak-STAT signaling pathway	3/480	132/7206	0.0345036779219
ko05131	Shigellosis	1/480	82/7206	0.0428999553215
ko04910	Insulin signaling pathway	5/480	172/7206	0.0434389304791
ko05418	Fluid shear stress and atherosclerosis	5/480	173/7206	0.0435568841223
ko01230	Biosynthesis of amino acids	1/480	85/7206	0.0444058994316
ko04924	Renin secretion	1/480	86/7206	0.0452650245508
ko04918	Thyroid hormone synthesis	1/480	86/7206	0.0452650245508
ko05222	Small cell lung cancer	11/480	89/7206	0.0489078345983