ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	129/702	423/7206	1.86670412397e-35
ko04724	Glutamatergic synapse	70/702	152/7206	7.89326778196e-32
ko05033	Nicotine addiction	42/702	56/7206	1.66592973364e-31
ko04727	GABAergic synapse	47/702	110/7206	5.79395834592e-20
ko05032	Morphine addiction	47/702	110/7206	5.79395834592e-20
ko04728	Dopaminergic synapse	62/702	185/7206	1.87209768482e-19
ko05030	Cocaine addiction	36/702	73/7206	4.46623877019e-18
ko04713	Circadian entrainment	50/702	136/7206	8.24659587757e-18
ko04723	Retrograde endocannabinoid signaling	56/702	175/7206	1.2486784431e-16
ko04024	cAMP signaling pathway	73/702	279/7206	6.00263154611e-16
ko04911	Insulin secretion	43/702	117/7206	1.80749314819e-15
ko05031	Amphetamine addiction	37/702	91/7206	4.03516340296e-15
ko04020	Calcium signaling pathway	66/702	265/7206	2.14525639658e-13
ko04720	Long-term potentiation	35/702	99/7206	3.00448012885e-12
ko04010	MAPK signaling pathway	72/702	321/7206	5.87192108581e-12
ko04725	Cholinergic synapse	45/702	160/7206	2.15295365356e-11
ko04261	Adrenergic signaling in cardiomyocytes	51/702	205/7206	1.39766674042e-10
ko04921	Oxytocin signaling pathway	51/702	209/7206	2.9564786449e-10
ko04721	Synaptic vesicle cycle	28/702	80/7206	6.10262201155e-10
ko04742	Taste transduction	23/702	61/7206	4.02681475982e-09
ko04726	Serotonergic synapse	36/702	137/7206	1.66985271735e-08
ko04970	Salivary secretion	28/702	95/7206	4.68778547798e-08
ko04730	Long-term depression	24/702	78/7206	1.75632669463e-07
ko04925	Aldosterone synthesis and secretion	28/702	105/7206	4.77281249944e-07
ko04072	Phospholipase D signaling pathway	41/702	197/7206	2.08240973945e-06
ko05203	Viral carcinogenesis	7/702	277/7206	3.75959748525e-06
ko04514	Cell adhesion molecules (CAMs)	30/702	130/7206	6.48736114655e-06
ko03040	Spliceosome	1/702	145/7206	1.18344489856e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	21/702	79/7206	1.36270974176e-05
ko04971	Gastric acid secretion	24/702	98/7206	1.54064687737e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	20/702	74/7206	1.66842493746e-05
ko04915	Estrogen signaling pathway	29/702	131/7206	1.83347013295e-05
ko04972	Pancreatic secretion	26/702	111/7206	2.66210122238e-05
ko05414	Dilated cardiomyopathy	26/702	112/7206	2.85781307327e-05
ko04540	Gap junction	28/702	128/7206	3.17199379723e-05
ko04022	cGMP-PKG signaling pathway	40/702	216/7206	5.71587089012e-05
ko04110	Cell cycle	2/702	145/7206	9.15119532116e-05
ko04740	Olfactory transduction	19/702	80/7206	0.000181445089454
ko04360	Axon guidance	40/702	233/7206	0.000296637252719
ko05168	Herpes simplex infection	5/702	182/7206	0.000347039115093
ko04260	Cardiac muscle contraction	21/702	98/7206	0.00043135847423
ko04350	TGF-beta signaling pathway	1/702	103/7206	0.000595904947081
ko05322	Systemic lupus erythematosus	4/702	151/7206	0.00122238186153
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/702	14/7206	0.00126623921192
ko03013	RNA transport	5/702	166/7206	0.00132039704879
ko04141	Protein processing in endoplasmic reticulum	6/702	184/7206	0.00142286273044
ko04630	Jak-STAT signaling pathway	3/702	132/7206	0.00154614288634
ko04930	Type II diabetes mellitus	13/702	54/7206	0.00162355574246
ko00240	Pyrimidine metabolism	2/702	110/7206	0.00176951621549
ko04146	Peroxisome	1/702	89/7206	0.00187156102709
ko00515	Mannose type O-glycan biosynthesis	8/702	25/7206	0.00187204673447
ko03018	RNA degradation	1/702	84/7206	0.00275958416203
ko04923	Regulation of lipolysis in adipocytes	16/702	77/7206	0.00297124072359
ko05410	Hypertrophic cardiomyopathy (HCM)	19/702	100/7206	0.0036146045097
ko05034	Alcoholism	37/702	238/7206	0.00366746797968
ko04912	GnRH signaling pathway	22/702	122/7206	0.00479030892846
ko00512	Mucin type O-glycan biosynthesis	8/702	29/7206	0.00523552640932
ko05169	Epstein-Barr virus infection	9/702	206/7206	0.0058023424708
ko03008	Ribosome biogenesis in eukaryotes	1/702	79/7206	0.00622886466145
ko04015	Rap1 signaling pathway	41/702	278/7206	0.00695101581234
ko05231	Choline metabolism in cancer	23/702	134/7206	0.00726052073249
ko00190	Oxidative phosphorylation	4/702	127/7206	0.00925411491996
ko04924	Renin secretion	16/702	86/7206	0.00955634353395
ko04918	Thyroid hormone synthesis	16/702	86/7206	0.00955634353395
ko04932	Non-alcoholic fatty liver disease (NAFLD)	8/702	182/7206	0.0108314017476
ko04962	Vasopressin-regulated water reabsorption	12/702	58/7206	0.0114682722056
ko04142	Lysosome	6/702	151/7206	0.0119856103846
ko03320	PPAR signaling pathway	1/702	69/7206	0.0128873959071
ko04012	ErbB signaling pathway	19/702	109/7206	0.0130936938455
ko05205	Proteoglycans in cancer	15/702	271/7206	0.0158502900055
ko00513	Various types of N-glycan biosynthesis	9/702	42/7206	0.0177559927552
ko04270	Vascular smooth muscle contraction	24/702	154/7206	0.0188158341538
ko05418	Fluid shear stress and atherosclerosis	8/702	173/7206	0.0188397529954
ko04750	Inflammatory mediator regulation of TRP channels	20/702	122/7206	0.0195317807951
ko04744	Phototransduction	8/702	36/7206	0.0201160018759
ko04621	NOD-like receptor signaling pathway	7/702	157/7206	0.0202142410403
ko04071	Sphingolipid signaling pathway	25/702	162/7206	0.0214935060077
ko04064	NF-kappa B signaling pathway	3/702	96/7206	0.0231842563236
ko05164	Influenza A	8/702	167/7206	0.0246429533406
ko04320	Dorso-ventral axis formation	7/702	31/7206	0.0266471430465
ko04217	Necroptosis	9/702	178/7206	0.0293174877135
ko04914	Progesterone-mediated oocyte maturation	17/702	104/7206	0.0293240180328
ko04014	Ras signaling pathway	38/702	279/7206	0.0303350383142
ko04070	Phosphatidylinositol signaling system	18/702	112/7206	0.0346142786738
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	6/702	26/7206	0.0354006941239
ko04144	Endocytosis	45/702	342/7206	0.0391252648577
ko00480	Glutathione metabolism	1/702	55/7206	0.0397767563288
ko05321	Inflammatory bowel disease (IBD)	1/702	56/7206	0.039873754842
ko00430	Taurine and hypotaurine metabolism	4/702	14/7206	0.040457083229
ko05162	Measles	5/702	120/7206	0.041573399111
ko04961	Endocrine and other factor-regulated calcium reabsorption	11/702	59/7206	0.0424400664249
ko05222	Small cell lung cancer	3/702	89/7206	0.0452156016083
ko04916	Melanogenesis	21/702	142/7206	0.0454278742409