ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 36/439 152/7206 6.57062227755e-13 ko04713 Circadian entrainment 33/439 136/7206 3.05177533473e-12 ko05033 Nicotine addiction 21/439 56/7206 3.48792434943e-12 ko04721 Synaptic vesicle cycle 23/439 80/7206 1.6998059315e-10 ko04723 Retrograde endocannabinoid signaling 34/439 175/7206 9.42442392886e-10 ko04728 Dopaminergic synapse 34/439 185/7206 4.29750777484e-09 ko04727 GABAergic synapse 25/439 110/7206 6.12247960437e-09 ko05032 Morphine addiction 25/439 110/7206 6.12247960437e-09 ko04725 Cholinergic synapse 30/439 160/7206 2.24724558803e-08 ko04911 Insulin secretion 22/439 117/7206 1.6730851601e-06 ko04024 cAMP signaling pathway 38/439 279/7206 2.2680100181e-06 ko05031 Amphetamine addiction 18/439 91/7206 7.07981936695e-06 ko04921 Oxytocin signaling pathway 30/439 209/7206 1.00602114833e-05 ko04080 Neuroactive ligand-receptor interaction 46/439 423/7206 9.08598760093e-05 ko00010 Glycolysis / Gluconeogenesis 14/439 74/7206 0.000122915509748 ko04060 Cytokine-cytokine receptor interaction 1/439 191/7206 0.000156141501094 ko04020 Calcium signaling pathway 32/439 265/7206 0.000187896098055 ko04726 Serotonergic synapse 20/439 137/7206 0.000215960630368 ko04744 Phototransduction 9/439 36/7206 0.000228669879372 ko04720 Long-term potentiation 16/439 99/7206 0.000283983107371 ko04745 Phototransduction - fly 9/439 38/7206 0.000355090963909 ko01230 Biosynthesis of amino acids 14/439 85/7206 0.000553346885508 ko04360 Axon guidance 28/439 233/7206 0.000656792122231 ko04966 Collecting duct acid secretion 7/439 26/7206 0.000708182494425 ko00680 Methane metabolism 8/439 34/7206 0.000791547030969 ko04740 Olfactory transduction 13/439 80/7206 0.000986190508199 ko04514 Cell adhesion molecules (CAMs) 18/439 130/7206 0.00110481012361 ko05014 Amyotrophic lateral sclerosis (ALS) 12/439 74/7206 0.00155837209489 ko04261 Adrenergic signaling in cardiomyocytes 24/439 205/7206 0.00169334532737 ko01200 Carbon metabolism 17/439 128/7206 0.00215174241724 ko04922 Glucagon signaling pathway 17/439 128/7206 0.00215174241724 ko04730 Long-term depression 12/439 78/7206 0.00247343695666 ko04010 MAPK signaling pathway 33/439 321/7206 0.00265175700021 ko05203 Viral carcinogenesis 6/439 277/7206 0.00293887553567 ko04120 Ubiquitin mediated proteolysis 1/439 138/7206 0.00328542417279 ko05030 Cocaine addiction 11/439 73/7206 0.0043555778956 ko00710 Carbon fixation in photosynthetic organisms 6/439 27/7206 0.00488273595026 ko05010 Alzheimer's disease 22/439 202/7206 0.00682020418856 ko05168 Herpes simplex infection 3/439 182/7206 0.00687663950064 ko04970 Salivary secretion 13/439 95/7206 0.00720662282033 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 11/439 79/7206 0.00797268074503 ko00030 Pentose phosphate pathway 6/439 32/7206 0.0115553693208 ko03040 Spliceosome 2/439 145/7206 0.0124654588801 ko04371 Apelin signaling pathway 19/439 177/7206 0.0155425473568 ko05410 Hypertrophic cardiomyopathy (HCM) 12/439 100/7206 0.0196930862254 ko00620 Pyruvate metabolism 7/439 46/7206 0.0201566745589 ko00290 Valine, leucine and isoleucine biosynthesis 2/439 4/7206 0.0204644467648 ko04925 Aldosterone synthesis and secretion 12/439 105/7206 0.0356061377986 ko00190 Oxidative phosphorylation 14/439 127/7206 0.0360320939133 ko04146 Peroxisome 1/439 89/7206 0.0433063438859 ko03013 RNA transport 4/439 166/7206 0.0467954025628 ko05164 Influenza A 4/439 167/7206 0.047130547064 ko00604 Glycosphingolipid biosynthesis - ganglio series 3/439 14/7206 0.049460541739