ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 110/687 423/7206 2.14542936497e-24 ko05033 Nicotine addiction 30/687 56/7206 7.9383694321e-17 ko04724 Glutamatergic synapse 47/687 152/7206 7.32672043182e-14 ko04727 GABAergic synapse 37/687 110/7206 2.08622633856e-12 ko04728 Dopaminergic synapse 50/687 185/7206 3.60517402194e-12 ko05032 Morphine addiction 34/687 110/7206 2.30024797884e-10 ko04911 Insulin secretion 35/687 117/7206 3.40753712527e-10 ko04713 Circadian entrainment 38/687 136/7206 5.36331830292e-10 ko04721 Synaptic vesicle cycle 27/687 80/7206 1.93616107069e-09 ko04974 Protein digestion and absorption 29/687 96/7206 8.90369465968e-09 ko04723 Retrograde endocannabinoid signaling 42/687 175/7206 1.03106823059e-08 ko04514 Cell adhesion molecules (CAMs) 34/687 130/7206 2.77918900107e-08 ko05030 Cocaine addiction 23/687 73/7206 1.31869882417e-07 ko04261 Adrenergic signaling in cardiomyocytes 44/687 205/7206 1.78474830364e-07 ko04260 Cardiac muscle contraction 27/687 98/7206 2.41644394059e-07 ko04725 Cholinergic synapse 37/687 160/7206 3.09754633295e-07 ko04512 ECM-receptor interaction 23/687 79/7206 6.48597896131e-07 ko04024 cAMP signaling pathway 52/687 279/7206 1.86920597346e-06 ko04010 MAPK signaling pathway 57/687 321/7206 3.47183573317e-06 ko05203 Viral carcinogenesis 7/687 277/7206 5.25524844203e-06 ko04742 Taste transduction 17/687 61/7206 3.52104447346e-05 ko04950 Maturity onset diabetes of the young 11/687 29/7206 3.79220722243e-05 ko05014 Amyotrophic lateral sclerosis (ALS) 19/687 74/7206 4.3615507844e-05 ko04360 Axon guidance 42/687 233/7206 5.44833747674e-05 ko05164 Influenza A 3/687 167/7206 8.54183415178e-05 ko05031 Amphetamine addiction 21/687 91/7206 9.60788215428e-05 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 19/687 79/7206 0.000113958633017 ko05162 Measles 1/687 120/7206 0.000122061303829 ko04140 Autophagy - animal 3/687 164/7206 0.000124541176317 ko05168 Herpes simplex infection 4/687 182/7206 0.00015925958661 ko04120 Ubiquitin mediated proteolysis 2/687 138/7206 0.000191797632331 ko04964 Proximal tubule bicarbonate reclamation 10/687 29/7206 0.000216600846506 ko04978 Mineral absorption 12/687 40/7206 0.000232549499351 ko04060 Cytokine-cytokine receptor interaction 5/687 191/7206 0.000249808230786 ko04970 Salivary secretion 21/687 95/7206 0.000253065826997 ko04726 Serotonergic synapse 27/687 137/7206 0.000304504450432 ko04976 Bile secretion 18/687 80/7206 0.000416060785336 ko03013 RNA transport 4/687 166/7206 0.000436907243208 ko04218 Cellular senescence 5/687 177/7206 0.000687685220815 ko05166 HTLV-I infection 12/687 292/7206 0.000702790653199 ko00230 Purine metabolism 6/687 194/7206 0.000731981656318 ko04020 Calcium signaling pathway 42/687 265/7206 0.000864947250319 ko00564 Glycerophospholipid metabolism 1/687 99/7206 0.000868380033335 ko04621 NOD-like receptor signaling pathway 4/687 157/7206 0.000870842754206 ko04151 PI3K-Akt signaling pathway 57/687 390/7206 0.000962838973503 ko04730 Long-term depression 17/687 78/7206 0.00126456544574 ko05410 Hypertrophic cardiomyopathy (HCM) 20/687 100/7206 0.00150540844037 ko05322 Systemic lupus erythematosus 4/687 151/7206 0.00176184229775 ko04932 Non-alcoholic fatty liver disease (NAFLD) 6/687 182/7206 0.00192661170297 ko04110 Cell cycle 4/687 145/7206 0.00241475426694 ko04217 Necroptosis 6/687 178/7206 0.00265160883695 ko05414 Dilated cardiomyopathy 21/687 112/7206 0.00285325081081 ko04211 Longevity regulating pathway 3/687 123/7206 0.00305706634259 ko05152 Tuberculosis 7/687 187/7206 0.00354056191571 ko05161 Hepatitis B 6/687 173/7206 0.00359968772099 ko04921 Oxytocin signaling pathway 33/687 209/7206 0.00376073346796 ko04137 Mitophagy - animal 1/687 82/7206 0.00409054293661 ko04150 mTOR signaling pathway 7/687 184/7206 0.00479794648993 ko04142 Lysosome 5/687 151/7206 0.00484813812687 ko04540 Gap junction 22/687 128/7206 0.00569946757368 ko03008 Ribosome biogenesis in eukaryotes 1/687 79/7206 0.00604946842048 ko04630 Jak-STAT signaling pathway 4/687 132/7206 0.00652659647976 ko04611 Platelet activation 6/687 163/7206 0.00661022140179 ko00430 Taurine and hypotaurine metabolism 5/687 14/7206 0.00748098383614 ko05169 Epstein-Barr virus infection 9/687 206/7206 0.00772629553001 ko04612 Antigen processing and presentation 1/687 77/7206 0.00935987260154 ko04113 Meiosis - yeast 1/687 70/7206 0.0129185165352 ko04972 Pancreatic secretion 19/687 111/7206 0.0130164676258 ko04214 Apoptosis - fly 1/687 72/7206 0.0133682213345 ko04141 Protein processing in endoplasmic reticulum 8/687 184/7206 0.0147794911198 ko04740 Olfactory transduction 14/687 80/7206 0.0209548630908 ko04014 Ras signaling pathway 38/687 279/7206 0.0218939565664 ko04138 Autophagy - yeast 2/687 81/7206 0.0220027051334 ko03018 RNA degradation 2/687 84/7206 0.0226357858035 ko04961 Endocrine and other factor-regulated calcium reabsorption 11/687 59/7206 0.0245921674164 ko00330 Arginine and proline metabolism 1/687 61/7206 0.0274741379279 ko04640 Hematopoietic cell lineage 1/687 64/7206 0.0288523317301 ko04068 FoxO signaling pathway 8/687 167/7206 0.0323472433004 ko04510 Focal adhesion 33/687 240/7206 0.0327001971039 ko00350 Tyrosine metabolism 7/687 33/7206 0.0329967626943 ko04930 Type II diabetes mellitus 10/687 54/7206 0.0338186134437 ko04971 Gastric acid secretion 16/687 98/7206 0.0349503222083 ko04720 Long-term potentiation 16/687 99/7206 0.0360779963483 ko04015 Rap1 signaling pathway 37/687 278/7206 0.0364888944215 ko00604 Glycosphingolipid biosynthesis - ganglio series 4/687 14/7206 0.0377529280203 ko04914 Progesterone-mediated oocyte maturation 4/687 104/7206 0.043235231439 ko05016 Huntington's disease 12/687 215/7206 0.0446188148922 ko05140 Leishmaniasis 2/687 75/7206 0.044953953955 ko01524 Platinum drug resistance 2/687 76/7206 0.0458738697278 ko02024 Quorum sensing 4/687 15/7206 0.0477155169924 ko05418 Fluid shear stress and atherosclerosis 9/687 173/7206 0.0489350461079