ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 176/1069 423/7206 1.07609055418e-43 ko04721 Synaptic vesicle cycle 55/1069 80/7206 6.71219484141e-28 ko04724 Glutamatergic synapse 78/1069 152/7206 1.17339981675e-26 ko05033 Nicotine addiction 44/1069 56/7206 1.46219495635e-26 ko05032 Morphine addiction 59/1069 110/7206 1.11546338333e-21 ko04727 GABAergic synapse 58/1069 110/7206 7.66606405878e-21 ko04728 Dopaminergic synapse 77/1069 185/7206 3.1979356083e-19 ko04713 Circadian entrainment 62/1069 136/7206 4.78413851143e-18 ko04725 Cholinergic synapse 68/1069 160/7206 1.12739325558e-17 ko04723 Retrograde endocannabinoid signaling 67/1069 175/7206 1.09449894321e-14 ko04024 cAMP signaling pathway 90/1069 279/7206 5.84053256948e-14 ko04742 Taste transduction 34/1069 61/7206 1.13409470664e-13 ko04911 Insulin secretion 48/1069 117/7206 3.7722275941e-12 ko04726 Serotonergic synapse 53/1069 137/7206 4.43172863684e-12 ko04744 Phototransduction 22/1069 36/7206 2.26706304607e-10 ko05031 Amphetamine addiction 38/1069 91/7206 3.69172313949e-10 ko04020 Calcium signaling pathway 77/1069 265/7206 1.67392258783e-09 ko03040 Spliceosome 1/1069 145/7206 3.69102317231e-09 ko04921 Oxytocin signaling pathway 63/1069 209/7206 9.17155913587e-09 ko05030 Cocaine addiction 31/1069 73/7206 9.62758794748e-09 ko04360 Axon guidance 68/1069 233/7206 1.03993319398e-08 ko04261 Adrenergic signaling in cardiomyocytes 62/1069 205/7206 1.11507573647e-08 ko04966 Collecting duct acid secretion 16/1069 26/7206 6.0438358918e-08 ko05168 Herpes simplex infection 5/1069 182/7206 7.1423136175e-08 ko04720 Long-term potentiation 36/1069 99/7206 8.25458099839e-08 ko04060 Cytokine-cytokine receptor interaction 6/1069 191/7206 1.39114789236e-07 ko03013 RNA transport 5/1069 166/7206 7.05282439926e-07 ko05014 Amyotrophic lateral sclerosis (ALS) 28/1069 74/7206 8.95478934826e-07 ko05203 Viral carcinogenesis 15/1069 277/7206 1.00448019848e-06 ko04740 Olfactory transduction 29/1069 80/7206 1.61389805862e-06 ko04970 Salivary secretion 32/1069 95/7206 3.22798535015e-06 ko05164 Influenza A 6/1069 167/7206 4.0852928559e-06 ko04260 Cardiac muscle contraction 32/1069 98/7206 8.77858423645e-06 ko05110 Vibrio cholerae infection 23/1069 63/7206 1.67657627907e-05 ko04971 Gastric acid secretion 31/1069 98/7206 2.06559038453e-05 ko04120 Ubiquitin mediated proteolysis 5/1069 138/7206 2.89901495719e-05 ko04010 MAPK signaling pathway 75/1069 321/7206 3.64180834521e-05 ko04925 Aldosterone synthesis and secretion 32/1069 105/7206 3.91506225963e-05 ko04961 Endocrine and other factor-regulated calcium reabsorption 21/1069 59/7206 5.99509840631e-05 ko03008 Ribosome biogenesis in eukaryotes 1/1069 79/7206 8.27436683007e-05 ko04141 Protein processing in endoplasmic reticulum 10/1069 184/7206 8.43069031647e-05 ko05322 Systemic lupus erythematosus 7/1069 151/7206 0.000106692734653 ko04514 Cell adhesion molecules (CAMs) 36/1069 130/7206 0.000143046074339 ko04621 NOD-like receptor signaling pathway 8/1069 157/7206 0.000154116977224 ko04540 Gap junction 35/1069 128/7206 0.000218416529469 ko05162 Measles 5/1069 120/7206 0.000248482686184 ko00604 Glycosphingolipid biosynthesis - ganglio series 8/1069 14/7206 0.000297814683251 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 24/1069 79/7206 0.000356706449393 ko04924 Renin secretion 25/1069 86/7206 0.000620309998737 ko04146 Peroxisome 3/1069 89/7206 0.000788862163317 ko04022 cGMP-PKG signaling pathway 50/1069 216/7206 0.000903381654643 ko04064 NF-kappa B signaling pathway 4/1069 96/7206 0.00129685476914 ko04915 Estrogen signaling pathway 33/1069 131/7206 0.00171507827311 ko05120 Epithelial cell signaling in Helicobacter pylori infection 25/1069 92/7206 0.00176155345674 ko04730 Long-term depression 22/1069 78/7206 0.00201220879601 ko04626 Plant-pathogen interaction 8/1069 18/7206 0.00249602956345 ko05169 Epstein-Barr virus infection 16/1069 206/7206 0.00269574022456 ko00240 Pyrimidine metabolism 6/1069 110/7206 0.00280995789798 ko04014 Ras signaling pathway 59/1069 279/7206 0.00345142481897 ko01200 Carbon metabolism 8/1069 128/7206 0.00368385399948 ko05205 Proteoglycans in cancer 24/1069 271/7206 0.00388943712106 ko04640 Hematopoietic cell lineage 2/1069 64/7206 0.00418869192039 ko04972 Pancreatic secretion 28/1069 111/7206 0.00421123108453 ko05140 Leishmaniasis 3/1069 75/7206 0.00487711814621 ko03018 RNA degradation 4/1069 84/7206 0.00520622315581 ko00330 Arginine and proline metabolism 2/1069 61/7206 0.00609654348498 ko04976 Bile secretion 21/1069 80/7206 0.00667626173753 ko04950 Maturity onset diabetes of the young 10/1069 29/7206 0.00674656897068 ko04964 Proximal tubule bicarbonate reclamation 10/1069 29/7206 0.00674656897068 ko04214 Apoptosis - fly 3/1069 72/7206 0.00694391603516 ko00310 Lysine degradation 3/1069 73/7206 0.0071169394725 ko04932 Non-alcoholic fatty liver disease (NAFLD) 15/1069 182/7206 0.0107743495006 ko00620 Pyruvate metabolism 1/1069 46/7206 0.0107891190258 ko00480 Glutathione metabolism 2/1069 55/7206 0.0128416450207 ko05321 Inflammatory bowel disease (IBD) 2/1069 56/7206 0.0129147811034 ko04962 Vasopressin-regulated water reabsorption 16/1069 58/7206 0.0139187362428 ko05414 Dilated cardiomyopathy 26/1069 112/7206 0.0156588148776 ko00983 Drug metabolism - other enzymes 1/1069 42/7206 0.0157282093079 ko00533 Glycosaminoglycan biosynthesis - keratan sulfate 6/1069 15/7206 0.0158510198468 ko03022 Basal transcription factors 1/1069 44/7206 0.0165877709963 ko04145 Phagosome 35/1069 162/7206 0.0184780760789 ko00590 Arachidonic acid metabolism 2/1069 52/7206 0.0185695747043 ko00280 Valine, leucine and isoleucine degradation 2/1069 54/7206 0.0190429834306 ko04140 Autophagy - animal 14/1069 164/7206 0.0193593678717 ko00600 Sphingolipid metabolism 3/1069 63/7206 0.0197222396688 ko04115 p53 signaling pathway 4/1069 74/7206 0.0200384601249 ko04916 Melanogenesis 31/1069 142/7206 0.0229540851153 ko00980 Metabolism of xenobiotics by cytochrome P450 1/1069 40/7206 0.0235488888559 ko05323 Rheumatoid arthritis 21/1069 89/7206 0.024186687721 ko04110 Cell cycle 12/1069 145/7206 0.0242796453191 ko00140 Steroid hormone biosynthesis 1/1069 41/7206 0.0243430335642 ko04750 Inflammatory mediator regulation of TRP channels 27/1069 122/7206 0.0283013095627 ko05146 Amoebiasis 7/1069 99/7206 0.0312898250117 ko05034 Alcoholism 47/1069 238/7206 0.033023148769 ko00982 Drug metabolism - cytochrome P450 1/1069 37/7206 0.034763122494 ko04391 Hippo signaling pathway - fly 21/1069 90/7206 0.0349119677989 ko00630 Glyoxylate and dicarboxylate metabolism 1/1069 38/7206 0.0357193464685 ko00270 Cysteine and methionine metabolism 2/1069 47/7206 0.0383426147657 ko05204 Chemical carcinogenesis 2/1069 48/7206 0.038943287949 ko05161 Hepatitis B 16/1069 173/7206 0.0389484568934 ko05166 HTLV-I infection 31/1069 292/7206 0.043159244908 ko01524 Platinum drug resistance 5/1069 76/7206 0.0493862503182