ko pathway ratio_in_study ratio_in_pop p_value ko04260 Cardiac muscle contraction 19/281 98/7206 4.96622809961e-09 ko05410 Hypertrophic cardiomyopathy (HCM) 18/281 100/7206 4.31631654102e-08 ko04261 Adrenergic signaling in cardiomyocytes 24/281 205/7206 1.19861030627e-06 ko05414 Dilated cardiomyopathy 17/281 112/7206 1.3018538848e-06 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 14/281 79/7206 1.72838178016e-06 ko04974 Protein digestion and absorption 15/281 96/7206 3.82697322276e-06 ko04020 Calcium signaling pathway 26/281 265/7206 1.18042389285e-05 ko04921 Oxytocin signaling pathway 22/281 209/7206 1.91136776024e-05 ko01200 Carbon metabolism 16/281 128/7206 3.37884500255e-05 ko05010 Alzheimer's disease 21/281 202/7206 3.58051011179e-05 ko05033 Nicotine addiction 10/281 56/7206 5.02548352124e-05 ko04976 Bile secretion 12/281 80/7206 5.48502017735e-05 ko04964 Proximal tubule bicarbonate reclamation 7/281 29/7206 9.48239747627e-05 ko04022 cGMP-PKG signaling pathway 20/281 216/7206 0.00043462967213 ko00010 Glycolysis / Gluconeogenesis 10/281 74/7206 0.000545730126625 ko04911 Insulin secretion 13/281 117/7206 0.000594659874667 ko04978 Mineral absorption 7/281 40/7206 0.000784155181703 ko04512 ECM-receptor interaction 10/281 79/7206 0.000921922691454 ko04970 Salivary secretion 11/281 95/7206 0.00110320446222 ko04723 Retrograde endocannabinoid signaling 16/281 175/7206 0.00126709900323 ko04971 Gastric acid secretion 11/281 98/7206 0.00142763550327 ko04080 Neuroactive ligand-receptor interaction 30/281 423/7206 0.00161856831234 ko04510 Focal adhesion 20/281 240/7206 0.00172557415023 ko00710 Carbon fixation in photosynthetic organisms 5/281 27/7206 0.00346649511038 ko04740 Olfactory transduction 9/281 80/7206 0.00375018928491 ko00190 Oxidative phosphorylation 12/281 127/7206 0.00383916657641 ko04062 Chemokine signaling pathway 1/281 201/7206 0.00493612197393 ko01230 Biosynthesis of amino acids 9/281 85/7206 0.0056232823021 ko04713 Circadian entrainment 12/281 136/7206 0.00664291854216 ko04060 Cytokine-cytokine receptor interaction 1/281 191/7206 0.00717522815912 ko00030 Pentose phosphate pathway 5/281 32/7206 0.00737787337942 ko04925 Aldosterone synthesis and secretion 10/281 105/7206 0.00760259274334 ko05014 Amyotrophic lateral sclerosis (ALS) 8/281 74/7206 0.00782474832826 ko05012 Parkinson's disease 13/281 155/7206 0.00930321379941 ko00680 Methane metabolism 5/281 34/7206 0.00956964559171 ko04727 GABAergic synapse 10/281 110/7206 0.0104308935028 ko05016 Huntington's disease 16/281 215/7206 0.0113514706776 ko04721 Synaptic vesicle cycle 8/281 80/7206 0.0123241439291 ko00220 Arginine biosynthesis 4/281 24/7206 0.0129816446901 ko00250 Alanine, aspartate and glutamate metabolism 5/281 38/7206 0.0152173131138 ko05161 Hepatitis B 1/281 173/7206 0.0152211412592 ko04922 Glucagon signaling pathway 11/281 128/7206 0.016961864058 ko04010 MAPK signaling pathway 21/281 321/7206 0.0176208223721 ko04924 Renin secretion 8/281 86/7206 0.0184861780327 ko05416 Viral myocarditis 6/281 55/7206 0.0194556553593 ko04550 Signaling pathways regulating pluripotency of stem cells 1/281 165/7206 0.0223706801009 ko03013 RNA transport 1/281 166/7206 0.0225984670139 ko04973 Carbohydrate digestion and absorption 5/281 42/7206 0.0227467974518 ko05164 Influenza A 1/281 167/7206 0.0228598452874 ko04961 Endocrine and other factor-regulated calcium reabsorption 6/281 59/7206 0.0265994107574 ko04144 Endocytosis 6/281 342/7206 0.0313768682679 ko04730 Long-term depression 7/281 78/7206 0.0317923207727 ko00620 Pyruvate metabolism 5/281 46/7206 0.0323478401611 ko04725 Cholinergic synapse 12/281 160/7206 0.0344046332542 ko04072 Phospholipase D signaling pathway 2/281 197/7206 0.0366851042388 ko00350 Tyrosine metabolism 4/281 33/7206 0.0380785973708 ko01210 2-Oxocarboxylic acid metabolism 3/281 20/7206 0.0409293419572 ko04120 Ubiquitin mediated proteolysis 1/281 138/7206 0.0449316853391 ko00020 Citrate cycle (TCA cycle) 4/281 35/7206 0.0458878231123 ko00500 Starch and sucrose metabolism 4/281 35/7206 0.0458878231123 ko03040 Spliceosome 1/281 145/7206 0.0465206344196 ko04210 Apoptosis 2/281 180/7206 0.0491165661851