ko pathway ratio_in_study ratio_in_pop p_value ko03040 Spliceosome 66/472 145/7206 1.44778786702e-40 ko03030 DNA replication 28/472 38/7206 8.51313050635e-26 ko04110 Cell cycle 45/472 145/7206 1.21236558696e-19 ko04111 Cell cycle - yeast 34/472 90/7206 4.13564136494e-18 ko03013 RNA transport 43/472 166/7206 1.38947212009e-15 ko03008 Ribosome biogenesis in eukaryotes 29/472 79/7206 3.15117221895e-15 ko03430 Mismatch repair 15/472 22/7206 1.57613017525e-13 ko03410 Base excision repair 18/472 38/7206 3.54431564944e-12 ko00240 Pyrimidine metabolism 30/472 110/7206 7.70537836304e-12 ko03015 mRNA surveillance pathway 27/472 93/7206 1.78575862703e-11 ko03420 Nucleotide excision repair 19/472 46/7206 1.7963411519e-11 ko04113 Meiosis - yeast 23/472 70/7206 3.50204797882e-11 ko03460 Fanconi anemia pathway 14/472 51/7206 3.009901134e-06 ko00230 Purine metabolism 31/472 194/7206 4.34981299006e-06 ko03440 Homologous recombination 12/472 41/7206 7.44904518892e-06 ko05166 HTLV-I infection 37/472 292/7206 8.76367294964e-05 ko05168 Herpes simplex infection 26/472 182/7206 0.000177155588427 ko03018 RNA degradation 15/472 84/7206 0.000311071415462 ko04072 Phospholipase D signaling pathway 2/472 197/7206 0.000340154330314 ko03020 RNA polymerase 8/472 29/7206 0.000401882129365 ko04022 cGMP-PKG signaling pathway 3/472 216/7206 0.000635886385993 ko04724 Glutamatergic synapse 1/472 152/7206 0.000696344213069 ko04723 Retrograde endocannabinoid signaling 2/472 175/7206 0.000982030632782 ko04024 cAMP signaling pathway 6/472 279/7206 0.00115688241068 ko04726 Serotonergic synapse 1/472 137/7206 0.00147457449442 ko04144 Endocytosis 9/472 342/7206 0.00154185979129 ko04915 Estrogen signaling pathway 1/472 131/7206 0.00215737963116 ko05231 Choline metabolism in cancer 1/472 134/7206 0.00219654094534 ko04921 Oxytocin signaling pathway 4/472 209/7206 0.00269378547898 ko04621 NOD-like receptor signaling pathway 2/472 157/7206 0.00290991299055 ko04725 Cholinergic synapse 2/472 160/7206 0.00301380594179 ko04514 Cell adhesion molecules (CAMs) 1/472 130/7206 0.00333940532271 ko04932 Non-alcoholic fatty liver disease (NAFLD) 3/472 182/7206 0.00345685852496 ko05217 Basal cell carcinoma 11/472 68/7206 0.0043160029098 ko04066 HIF-1 signaling pathway 1/472 123/7206 0.00477497401918 ko04371 Apelin signaling pathway 3/472 177/7206 0.00492394969782 ko04062 Chemokine signaling pathway 4/472 201/7206 0.00533583330094 ko04911 Insulin secretion 1/472 117/7206 0.00696766925829 ko03022 Basal transcription factors 8/472 44/7206 0.00698128022859 ko04910 Insulin signaling pathway 3/472 172/7206 0.00702900307681 ko04060 Cytokine-cytokine receptor interaction 4/472 191/7206 0.00715702027766 ko04727 GABAergic synapse 1/472 110/7206 0.00997947515483 ko05032 Morphine addiction 1/472 110/7206 0.00997947515483 ko04972 Pancreatic secretion 1/472 111/7206 0.0101521252188 ko04070 Phosphatidylinositol signaling system 1/472 112/7206 0.0103735043595 ko04713 Circadian entrainment 2/472 136/7206 0.0125565036395 ko04270 Vascular smooth muscle contraction 3/472 154/7206 0.0130770452779 ko04261 Adrenergic signaling in cardiomyocytes 5/472 205/7206 0.0137829135936 ko05169 Epstein-Barr virus infection 23/472 206/7206 0.0139547860294 ko04925 Aldosterone synthesis and secretion 1/472 105/7206 0.0147683583668 ko01200 Carbon metabolism 2/472 128/7206 0.017267747238 ko04218 Cellular senescence 20/472 177/7206 0.0193593974754 ko04115 p53 signaling pathway 10/472 74/7206 0.028142556038 ko00562 Inositol phosphate metabolism 1/472 89/7206 0.029715395642 ko04810 Regulation of actin cytoskeleton 9/472 264/7206 0.0311633426196 ko04071 Sphingolipid signaling pathway 4/472 162/7206 0.0347324618153 ko04010 MAPK signaling pathway 12/472 321/7206 0.0370559367424 ko04924 Renin secretion 1/472 86/7206 0.0441924247201 ko04918 Thyroid hormone synthesis 1/472 86/7206 0.0441924247201 ko05133 Pertussis 1/472 87/7206 0.0449605504469 ko04510 Focal adhesion 8/472 240/7206 0.0449700398734 ko04151 PI3K-Akt signaling pathway 16/472 390/7206 0.0450581678994 ko04142 Lysosome 4/472 151/7206 0.0459606181719 ko05160 Hepatitis C 4/472 153/7206 0.0461032096621 ko04659 Th17 cell differentiation 2/472 106/7206 0.0469642706197 ko05222 Small cell lung cancer 11/472 89/7206 0.0470128087961 ko04922 Glucagon signaling pathway 3/472 128/7206 0.0474226226713 ko04540 Gap junction 3/472 128/7206 0.0474226226713 ko05142 Chagas disease (American trypanosomiasis) 3/472 130/7206 0.0475589372207 ko04012 ErbB signaling pathway 2/472 109/7206 0.0478710646508 ko04630 Jak-STAT signaling pathway 3/472 132/7206 0.0481781926367 ko04380 Osteoclast differentiation 3/472 134/7206 0.0492774080606