ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 29/288 152/7206 1.04609224285e-12 ko04020 Calcium signaling pathway 31/288 265/7206 5.46049390185e-08 ko04070 Phosphatidylinositol signaling system 19/288 112/7206 7.27581679851e-08 ko04713 Circadian entrainment 21/288 136/7206 8.01968524511e-08 ko04728 Dopaminergic synapse 24/288 185/7206 2.79508023392e-07 ko04727 GABAergic synapse 18/288 110/7206 2.852516495e-07 ko05032 Morphine addiction 18/288 110/7206 2.852516495e-07 ko04720 Long-term potentiation 17/288 99/7206 3.01071830693e-07 ko04911 Insulin secretion 18/288 117/7206 7.37253207343e-07 ko04723 Retrograde endocannabinoid signaling 22/288 175/7206 1.53574579678e-06 ko05031 Amphetamine addiction 15/288 91/7206 2.6005987876e-06 ko04725 Cholinergic synapse 20/288 160/7206 5.08638425604e-06 ko05033 Nicotine addiction 11/288 56/7206 1.02592470959e-05 ko04925 Aldosterone synthesis and secretion 15/288 105/7206 1.59237850556e-05 ko04970 Salivary secretion 14/288 95/7206 2.13616352377e-05 ko04024 cAMP signaling pathway 27/288 279/7206 2.51938184255e-05 ko05030 Cocaine addiction 12/288 73/7206 2.72941999424e-05 ko04080 Neuroactive ligand-receptor interaction 35/288 423/7206 3.1345949499e-05 ko04072 Phospholipase D signaling pathway 21/288 197/7206 3.54269654999e-05 ko00562 Inositol phosphate metabolism 13/288 89/7206 4.63656459806e-05 ko04022 cGMP-PKG signaling pathway 22/288 216/7206 4.66305819929e-05 ko04915 Estrogen signaling pathway 16/288 131/7206 6.06472938641e-05 ko04261 Adrenergic signaling in cardiomyocytes 21/288 205/7206 6.39276960159e-05 ko04742 Taste transduction 10/288 61/7206 0.000131360835525 ko04062 Chemokine signaling pathway 20/288 201/7206 0.00014309373023 ko04914 Progesterone-mediated oocyte maturation 13/288 104/7206 0.000235687823988 ko04912 GnRH signaling pathway 14/288 122/7206 0.000338673798775 ko04211 Longevity regulating pathway 14/288 123/7206 0.000368708155145 ko04972 Pancreatic secretion 13/288 111/7206 0.000450471640155 ko04971 Gastric acid secretion 12/288 98/7206 0.000494114555277 ko04213 Longevity regulating pathway - multiple species 11/288 86/7206 0.000580215870226 ko04371 Apelin signaling pathway 17/288 177/7206 0.000678300585677 ko05231 Choline metabolism in cancer 14/288 134/7206 0.000880387164592 ko04923 Regulation of lipolysis in adipocytes 10/288 77/7206 0.000909041437484 ko04726 Serotonergic synapse 14/288 137/7206 0.00109542346577 ko04144 Endocytosis 26/288 342/7206 0.00155178831151 ko04918 Thyroid hormone synthesis 10/288 86/7206 0.00213913772507 ko04750 Inflammatory mediator regulation of TRP channels 12/288 122/7206 0.00336809916487 ko04740 Olfactory transduction 9/288 80/7206 0.00440985048579 ko00564 Glycerophospholipid metabolism 10/288 99/7206 0.00597305239421 ko04973 Carbohydrate digestion and absorption 6/288 42/7206 0.00603330581519 ko04924 Renin secretion 9/288 86/7206 0.00710406037595 ko04320 Dorso-ventral axis formation 5/288 31/7206 0.00712032533524 ko04270 Vascular smooth muscle contraction 13/288 154/7206 0.0102370434879 ko04921 Oxytocin signaling pathway 16/288 209/7206 0.0110705174282 ko04015 Rap1 signaling pathway 20/288 278/7206 0.0111595278251 ko05213 Endometrial cancer 7/288 62/7206 0.0113397086032 ko04012 ErbB signaling pathway 10/288 109/7206 0.0115394196748 ko00561 Glycerolipid metabolism 7/288 63/7206 0.0123346935142 ko05214 Glioma 8/288 79/7206 0.0131636490248 ko04745 Phototransduction - fly 5/288 38/7206 0.0167706390623 ko05034 Alcoholism 17/288 238/7206 0.0176005386721 ko04540 Gap junction 11/288 128/7206 0.0183125235156 ko04114 Oocyte meiosis 11/288 139/7206 0.0262813931859 ko00512 Mucin type O-glycan biosynthesis 4/288 29/7206 0.0269977270573 ko04916 Melanogenesis 11/288 142/7206 0.0293408987774 ko04666 Fc gamma R-mediated phagocytosis 10/288 122/7206 0.0303851923026 ko04110 Cell cycle 1/288 145/7206 0.0312271270932 ko05202 Transcriptional misregulation in cancer 2/288 188/7206 0.0354549668626 ko04922 Glucagon signaling pathway 10/288 128/7206 0.0369689986331 ko04360 Axon guidance 16/288 233/7206 0.0383578895303 ko04611 Platelet activation 12/288 163/7206 0.0392953268708 ko04976 Bile secretion 7/288 80/7206 0.040105084826 ko04010 MAPK signaling pathway 20/288 321/7206 0.041388342324 ko05230 Central carbon metabolism in cancer 7/288 81/7206 0.0424647245268 ko04016 MAPK signaling pathway - plant 3/288 20/7206 0.0435362826387 ko05414 Dilated cardiomyopathy 9/288 112/7206 0.0447525029553 ko05223 Non-small cell lung cancer 6/288 66/7206 0.0474067155627 ko00380 Tryptophan metabolism 5/288 50/7206 0.0482149734949