ko pathway ratio_in_study ratio_in_pop p_value ko03040 Spliceosome 102/786 145/7206 2.80497201266e-66 ko04110 Cell cycle 69/786 145/7206 2.23338800654e-29 ko04111 Cell cycle - yeast 49/786 90/7206 1.66641745063e-24 ko03030 DNA replication 30/786 38/7206 1.69979322957e-22 ko03013 RNA transport 62/786 166/7206 1.12476912997e-19 ko03460 Fanconi anemia pathway 29/786 51/7206 1.14118930905e-15 ko04113 Meiosis - yeast 34/786 70/7206 2.28671324571e-15 ko03410 Base excision repair 24/786 38/7206 1.26064687787e-14 ko03440 Homologous recombination 23/786 41/7206 1.61718546729e-12 ko03015 mRNA surveillance pathway 36/786 93/7206 1.85093433669e-12 ko03420 Nucleotide excision repair 24/786 46/7206 4.36002252557e-12 ko03430 Mismatch repair 16/786 22/7206 1.38136872966e-11 ko03008 Ribosome biogenesis in eukaryotes 31/786 79/7206 4.34660788006e-11 ko04144 Endocytosis 6/786 342/7206 5.47153016698e-11 ko03018 RNA degradation 30/786 84/7206 1.33747782291e-09 ko05010 Alzheimer's disease 1/786 202/7206 2.87583433783e-09 ko03022 Basal transcription factors 20/786 44/7206 6.19578491075e-09 ko00240 Pyrimidine metabolism 34/786 110/7206 8.09581359791e-09 ko04072 Phospholipase D signaling pathway 2/786 197/7206 7.48033284089e-08 ko05322 Systemic lupus erythematosus 38/786 151/7206 4.95560753821e-07 ko04723 Retrograde endocannabinoid signaling 2/786 175/7206 8.17600776604e-07 ko04921 Oxytocin signaling pathway 4/786 209/7206 8.20933877386e-07 ko05217 Basal cell carcinoma 22/786 68/7206 1.51701232933e-06 ko04022 cGMP-PKG signaling pathway 5/786 216/7206 2.28264718503e-06 ko04932 Non-alcoholic fatty liver disease (NAFLD) 3/786 182/7206 2.72664711729e-06 ko04621 NOD-like receptor signaling pathway 2/786 157/7206 3.65367827808e-06 ko04060 Cytokine-cytokine receptor interaction 4/786 191/7206 5.30690027569e-06 ko05012 Parkinson's disease 2/786 155/7206 5.498529431e-06 ko04724 Glutamatergic synapse 2/786 152/7206 8.29855294812e-06 ko04024 cAMP signaling pathway 10/786 279/7206 8.59322776898e-06 ko03010 Ribosome 1/786 129/7206 1.03239191512e-05 ko05168 Herpes simplex infection 40/786 182/7206 1.05816485583e-05 ko04514 Cell adhesion molecules (CAMs) 1/786 130/7206 1.08141944266e-05 ko05203 Viral carcinogenesis 53/786 277/7206 3.15246964569e-05 ko04270 Vascular smooth muscle contraction 3/786 154/7206 3.69076830699e-05 ko04933 AGE-RAGE signaling pathway in diabetic complications 2/786 135/7206 3.76681179597e-05 ko04726 Serotonergic synapse 2/786 137/7206 3.88658462538e-05 ko04070 Phosphatidylinositol signaling system 1/786 112/7206 4.9856131763e-05 ko05414 Dilated cardiomyopathy 1/786 112/7206 4.9856131763e-05 ko04330 Notch signaling pathway 18/786 62/7206 6.94658598472e-05 ko05166 HTLV-I infection 54/786 292/7206 7.47070628763e-05 ko04725 Cholinergic synapse 4/786 160/7206 9.7949846668e-05 ko04659 Th17 cell differentiation 1/786 106/7206 0.000111473843318 ko04014 Ras signaling pathway 12/786 279/7206 0.000112610131062 ko04660 T cell receptor signaling pathway 2/786 124/7206 0.000119139054333 ko04261 Adrenergic signaling in cardiomyocytes 7/786 205/7206 0.000142685167282 ko04912 GnRH signaling pathway 2/786 122/7206 0.000179012864578 ko05152 Tuberculosis 6/786 187/7206 0.000184763396241 ko04062 Chemokine signaling pathway 7/786 201/7206 0.00019765729632 ko04510 Focal adhesion 10/786 240/7206 0.000206826588226 ko04971 Gastric acid secretion 1/786 98/7206 0.000245419733833 ko05146 Amoebiasis 1/786 99/7206 0.000248640799855 ko04120 Ubiquitin mediated proteolysis 30/786 138/7206 0.000250470576233 ko04911 Insulin secretion 2/786 117/7206 0.000255630277977 ko05410 Hypertrophic cardiomyopathy (HCM) 1/786 100/7206 0.000256365730918 ko04712 Circadian rhythm - plant 5/786 7/7206 0.000265316420301 ko04810 Regulation of actin cytoskeleton 12/786 264/7206 0.000267798786429 ko04670 Leukocyte transendothelial migration 4/786 151/7206 0.000290337981423 ko05202 Transcriptional misregulation in cancer 37/786 188/7206 0.000315569680882 ko04611 Platelet activation 5/786 163/7206 0.000323783744811 ko04340 Hedgehog signaling pathway 16/786 58/7206 0.00033336080326 ko04915 Estrogen signaling pathway 3/786 131/7206 0.000336237485137 ko04371 Apelin signaling pathway 6/786 177/7206 0.000352823896745 ko04650 Natural killer cell mediated cytotoxicity 1/786 97/7206 0.000392510887343 ko01200 Carbon metabolism 3/786 128/7206 0.000485306072255 ko04114 Oocyte meiosis 29/786 139/7206 0.000491281508536 ko05142 Chagas disease (American trypanosomiasis) 3/786 130/7206 0.000508124804236 ko04727 GABAergic synapse 2/786 110/7206 0.000547006228084 ko05120 Epithelial cell signaling in Helicobacter pylori infection 1/786 92/7206 0.000553665176742 ko04972 Pancreatic secretion 2/786 111/7206 0.000559388679868 ko03020 RNA polymerase 10/786 29/7206 0.000649092526166 ko04141 Protein processing in endoplasmic reticulum 7/786 184/7206 0.000706961989958 ko05145 Toxoplasmosis 3/786 126/7206 0.000722849035252 ko05133 Pertussis 1/786 87/7206 0.000804135196164 ko04662 B cell receptor signaling pathway 1/786 88/7206 0.000814966500178 ko04920 Adipocytokine signaling pathway 1/786 89/7206 0.000839793141779 ko00562 Inositol phosphate metabolism 1/786 89/7206 0.000839793141779 ko05160 Hepatitis C 5/786 153/7206 0.000900055541215 ko05034 Alcoholism 43/786 238/7206 0.000931581715874 ko04668 TNF signaling pathway 3/786 120/7206 0.000992884189359 ko04750 Inflammatory mediator regulation of TRP channels 3/786 122/7206 0.0010272633251 ko04380 Osteoclast differentiation 4/786 134/7206 0.00114296600607 ko05231 Choline metabolism in cancer 4/786 134/7206 0.00114296600607 ko04713 Circadian entrainment 4/786 136/7206 0.00117364731604 ko04071 Sphingolipid signaling pathway 6/786 162/7206 0.00130390397246 ko00564 Glycerophospholipid metabolism 2/786 99/7206 0.00168334075951 ko04620 Toll-like receptor signaling pathway 2/786 100/7206 0.00172474967294 ko04151 PI3K-Akt signaling pathway 25/786 390/7206 0.00253499805298 ko04370 VEGF signaling pathway 1/786 77/7206 0.00264727705001 ko04923 Regulation of lipolysis in adipocytes 1/786 77/7206 0.00264727705001 ko05032 Morphine addiction 3/786 110/7206 0.00292521041411 ko04066 HIF-1 signaling pathway 4/786 123/7206 0.00317693261548 ko04142 Lysosome 6/786 151/7206 0.00339308289648 ko05134 Legionellosis 1/786 74/7206 0.00398337928962 ko04925 Aldosterone synthesis and secretion 3/786 105/7206 0.0040806741096 ko04010 MAPK signaling pathway 20/786 321/7206 0.00439295854263 ko04722 Neurotrophin signaling pathway 7/786 160/7206 0.00453446728707 ko04630 Jak-STAT signaling pathway 5/786 132/7206 0.00459106509719 ko04917 Prolactin signaling pathway 2/786 87/7206 0.00502706667833 ko04657 IL-17 signaling pathway 2/786 87/7206 0.00502706667833 ko04310 Wnt signaling pathway 32/786 181/7206 0.00519050166456 ko04146 Peroxisome 2/786 89/7206 0.00523386457433 ko04728 Dopaminergic synapse 9/786 185/7206 0.00560725369355 ko03320 PPAR signaling pathway 1/786 69/7206 0.00570578976666 ko04390 Hippo signaling pathway 33/786 188/7206 0.00592785624351 ko04910 Insulin signaling pathway 8/786 172/7206 0.00597448897788 ko04015 Rap1 signaling pathway 17/786 278/7206 0.00774624366727 ko05132 Salmonella infection 3/786 98/7206 0.00819634975711 ko04152 AMPK signaling pathway 8/786 161/7206 0.0104124282016 ko04740 Olfactory transduction 2/786 80/7206 0.0104373385119 ko04138 Autophagy - yeast 2/786 81/7206 0.0106470767164 ko04550 Signaling pathways regulating pluripotency of stem cells 29/786 165/7206 0.0107564254097 ko04931 Insulin resistance 6/786 137/7206 0.0118242360476 ko04012 ErbB signaling pathway 4/786 109/7206 0.012117151802 ko00330 Arginine and proline metabolism 1/786 61/7206 0.0122933482678 ko05169 Epstein-Barr virus infection 34/786 206/7206 0.0122958594163 ko04622 RIG-I-like receptor signaling pathway 1/786 62/7206 0.0124353028447 ko05110 Vibrio cholerae infection 1/786 63/7206 0.0127520306294 ko00561 Glycerolipid metabolism 1/786 63/7206 0.0127520306294 ko04218 Cellular senescence 30/786 177/7206 0.0139167651983 ko04664 Fc epsilon RI signaling pathway 2/786 77/7206 0.0151497351972 ko04730 Long-term depression 2/786 78/7206 0.0155717592039 ko04139 Mitophagy - yeast 9/786 37/7206 0.0156196376829 ko01212 Fatty acid metabolism 1/786 60/7206 0.0191874268001 ko01230 Biosynthesis of amino acids 3/786 85/7206 0.0223512820774 ko04213 Longevity regulating pathway - multiple species 3/786 86/7206 0.0224474842013 ko04924 Renin secretion 3/786 86/7206 0.0224474842013 ko04720 Long-term potentiation 4/786 99/7206 0.0224517022226 ko00230 Purine metabolism 31/786 194/7206 0.0262418292221 ko04145 Phagosome 9/786 162/7206 0.0290476975107 ko04530 Tight junction 15/786 228/7206 0.0306811341157 ko05230 Central carbon metabolism in cancer 3/786 81/7206 0.0311014481901 ko04115 p53 signaling pathway 14/786 74/7206 0.0368488055132 ko00510 N-Glycan biosynthesis 1/786 50/7206 0.0386866063392 ko01521 EGFR tyrosine kinase inhibitor resistance 5/786 106/7206 0.0398939383479 ko00590 Arachidonic acid metabolism 1/786 52/7206 0.040231118638 ko05031 Amphetamine addiction 4/786 91/7206 0.0418557327753 ko04913 Ovarian steroidogenesis 2/786 63/7206 0.0425567050633 ko00600 Sphingolipid metabolism 2/786 63/7206 0.0425567050633 ko04140 Autophagy - animal 10/786 164/7206 0.0427209221101 ko04512 ECM-receptor interaction 3/786 79/7206 0.0436438053942 ko04922 Glucagon signaling pathway 7/786 128/7206 0.0448109832946 ko04540 Gap junction 7/786 128/7206 0.0448109832946