ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	152/910	423/7206	2.07312681981e-37
ko04724	Glutamatergic synapse	71/910	152/7206	1.57363250003e-25
ko05033	Nicotine addiction	40/910	56/7206	2.9271150769e-24
ko04713	Circadian entrainment	59/910	136/7206	2.12401116812e-19
ko05032	Morphine addiction	50/910	110/7206	1.17134387124e-17
ko04727	GABAergic synapse	49/910	110/7206	7.00503401612e-17
ko04723	Retrograde endocannabinoid signaling	64/910	175/7206	2.04313879351e-16
ko04921	Oxytocin signaling pathway	71/910	209/7206	4.12927382067e-16
ko04020	Calcium signaling pathway	83/910	265/7206	4.35335218382e-16
ko04721	Synaptic vesicle cycle	39/910	80/7206	2.57908073763e-15
ko04728	Dopaminergic synapse	64/910	185/7206	4.65089365487e-15
ko04911	Insulin secretion	48/910	117/7206	7.6718684136e-15
ko04725	Cholinergic synapse	57/910	160/7206	3.61841102813e-14
ko04726	Serotonergic synapse	48/910	137/7206	8.04441278866e-12
ko04024	cAMP signaling pathway	76/910	279/7206	1.94002722179e-11
ko05031	Amphetamine addiction	35/910	91/7206	3.07482017842e-10
ko04261	Adrenergic signaling in cardiomyocytes	59/910	205/7206	3.50329667834e-10
ko04970	Salivary secretion	35/910	95/7206	1.21118130927e-09
ko04022	cGMP-PKG signaling pathway	58/910	216/7206	9.12858330414e-09
ko04720	Long-term potentiation	34/910	99/7206	1.68336858961e-08
ko04742	Taste transduction	25/910	61/7206	2.41508319896e-08
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	29/910	79/7206	3.54618701392e-08
ko04730	Long-term depression	27/910	78/7206	4.20319246594e-07
ko05322	Systemic lupus erythematosus	2/910	151/7206	6.51400814245e-07
ko03010	Ribosome	1/910	129/7206	7.19340763662e-07
ko03040	Spliceosome	2/910	145/7206	1.47863768195e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	25/910	74/7206	1.88341919604e-06
ko04971	Gastric acid secretion	30/910	98/7206	1.93796372862e-06
ko05203	Viral carcinogenesis	12/910	277/7206	3.02935438205e-06
ko04120	Ubiquitin mediated proteolysis	2/910	138/7206	3.17988326599e-06
ko05168	Herpes simplex infection	5/910	182/7206	4.04918678805e-06
ko04260	Cardiac muscle contraction	28/910	98/7206	1.98434542908e-05
ko05164	Influenza A	5/910	167/7206	2.59834852602e-05
ko04925	Aldosterone synthesis and secretion	29/910	105/7206	3.65737706055e-05
ko04010	MAPK signaling pathway	66/910	321/7206	4.56724618708e-05
ko05030	Cocaine addiction	22/910	73/7206	5.85361284504e-05
ko05410	Hypertrophic cardiomyopathy (HCM)	27/910	100/7206	9.56171674077e-05
ko04964	Proximal tubule bicarbonate reclamation	12/910	29/7206	0.00010123152387
ko04924	Renin secretion	24/910	86/7206	0.000115784201805
ko04745	Phototransduction - fly	14/910	38/7206	0.000121909836848
ko05414	Dilated cardiomyopathy	29/910	112/7206	0.000131752529203
ko05162	Measles	3/910	120/7206	0.000143174148086
ko04514	Cell adhesion molecules (CAMs)	32/910	130/7206	0.00014787117931
ko04966	Collecting duct acid secretion	11/910	26/7206	0.000155713346253
ko04630	Jak-STAT signaling pathway	4/910	132/7206	0.000177175448683
ko04621	NOD-like receptor signaling pathway	6/910	157/7206	0.000226300604441
ko04972	Pancreatic secretion	28/910	111/7206	0.000243941326409
ko00010	Glycolysis / Gluconeogenesis	21/910	74/7206	0.000264295156854
ko03013	RNA transport	7/910	166/7206	0.000335405670235
ko04060	Cytokine-cytokine receptor interaction	9/910	191/7206	0.000352571911421
ko03008	Ribosome biogenesis in eukaryotes	1/910	79/7206	0.000488310487434
ko04360	Axon guidance	48/910	233/7206	0.000579698737212
ko04626	Plant-pathogen interaction	8/910	18/7206	0.000853080400397
ko04110	Cell cycle	6/910	145/7206	0.000875495576397
ko04214	Apoptosis - fly	1/910	72/7206	0.0010798343325
ko00710	Carbon fixation in photosynthetic organisms	10/910	27/7206	0.00109042906984
ko04960	Aldosterone-regulated sodium reabsorption	13/910	41/7206	0.00111729755822
ko05161	Hepatitis B	9/910	173/7206	0.00161052400052
ko04540	Gap junction	29/910	128/7206	0.00171672979028
ko05110	Vibrio cholerae infection	17/910	63/7206	0.0017829287289
ko00680	Methane metabolism	11/910	34/7206	0.0022182270836
ko04922	Glucagon signaling pathway	28/910	128/7206	0.00290264288603
ko04610	Complement and coagulation cascades	2/910	79/7206	0.00323536018351
ko04070	Phosphatidylinositol signaling system	25/910	112/7206	0.00374174448128
ko04371	Apelin signaling pathway	36/910	177/7206	0.00384029131177
ko05169	Epstein-Barr virus infection	13/910	206/7206	0.00388072630159
ko04141	Protein processing in endoplasmic reticulum	11/910	184/7206	0.00461244537604
ko00030	Pentose phosphate pathway	10/910	32/7206	0.00462414964601
ko05140	Leishmaniasis	2/910	75/7206	0.00464962365726
ko01230	Biosynthesis of amino acids	20/910	85/7206	0.00470467106444
ko01524	Platinum drug resistance	2/910	76/7206	0.00471362266015
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/910	14/7206	0.00486909078541
ko04657	IL-17 signaling pathway	3/910	87/7206	0.00535113376082
ko04750	Inflammatory mediator regulation of TRP channels	26/910	122/7206	0.00578626080493
ko04740	Olfactory transduction	19/910	80/7206	0.00580904690297
ko04930	Type II diabetes mellitus	14/910	54/7206	0.00656430535624
ko05166	HTLV-I infection	22/910	292/7206	0.0067152954904
ko05010	Alzheimer's disease	39/910	202/7206	0.00682332657459
ko05220	Chronic myeloid leukemia	3/910	85/7206	0.0076937681098
ko05321	Inflammatory bowel disease (IBD)	1/910	56/7206	0.0078018525444
ko04710	Circadian rhythm	12/910	43/7206	0.00854140921886
ko04961	Endocrine and other factor-regulated calcium reabsorption	15/910	59/7206	0.00864595381286
ko00590	Arachidonic acid metabolism	1/910	52/7206	0.0115556538426
ko05205	Proteoglycans in cancer	21/910	271/7206	0.0116694231045
ko00280	Valine, leucine and isoleucine degradation	1/910	54/7206	0.0117824340064
ko04612	Antigen processing and presentation	3/910	77/7206	0.0150999098465
ko04146	Peroxisome	4/910	89/7206	0.0154335820791
ko05222	Small cell lung cancer	4/910	89/7206	0.0154335820791
ko04550	Signaling pathways regulating pluripotency of stem cells	11/910	165/7206	0.0172928364285
ko04330	Notch signaling pathway	2/910	62/7206	0.0200239535552
ko03420	Nucleotide excision repair	1/910	46/7206	0.025064849618
ko04668	TNF signaling pathway	7/910	120/7206	0.0252789881839
ko05219	Bladder cancer	1/910	48/7206	0.025997924273
ko05120	Epithelial cell signaling in Helicobacter pylori infection	19/910	92/7206	0.0261614089202
ko04270	Vascular smooth muscle contraction	29/910	154/7206	0.0263700149536
ko04978	Mineral absorption	10/910	40/7206	0.0283351033856
ko04210	Apoptosis	13/910	180/7206	0.0299081973296
ko01040	Biosynthesis of unsaturated fatty acids	7/910	25/7206	0.0309516036019
ko04014	Ras signaling pathway	47/910	279/7206	0.0343750537885
ko05200	Pathways in cancer	47/910	492/7206	0.0346635616698
ko00051	Fructose and mannose metabolism	10/910	42/7206	0.036294230263
ko04973	Carbohydrate digestion and absorption	10/910	42/7206	0.036294230263
ko00562	Inositol phosphate metabolism	18/910	89/7206	0.0363694102472
ko04114	Oocyte meiosis	26/910	139/7206	0.0380209733345
ko05144	Malaria	1/910	45/7206	0.038535379814
ko00520	Amino sugar and nucleotide sugar metabolism	2/910	55/7206	0.0407005933171
ko04152	AMPK signaling pathway	29/910	161/7206	0.0414864959399
ko04140	Autophagy - animal	12/910	164/7206	0.0421706471394
ko00240	Pyrimidine metabolism	7/910	110/7206	0.0430364653441
ko05215	Prostate cancer	7/910	111/7206	0.0430666690049
ko01200	Carbon metabolism	24/910	128/7206	0.0431264572067
ko04620	Toll-like receptor signaling pathway	6/910	100/7206	0.0473478200468
ko00250	Alanine, aspartate and glutamate metabolism	9/910	38/7206	0.0490158048481