ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 59/544 191/7206 3.69981521939e-22 ko04380 Osteoclast differentiation 43/544 134/7206 4.37419510725e-17 ko05321 Inflammatory bowel disease (IBD) 23/544 56/7206 2.95468281821e-12 ko04064 NF-kappa B signaling pathway 30/544 96/7206 6.08220851258e-12 ko05164 Influenza A 40/544 167/7206 2.33953587982e-11 ko05340 Primary immunodeficiency 16/544 30/7206 4.8368040622e-11 ko04621 NOD-like receptor signaling pathway 38/544 157/7206 5.39701336987e-11 ko05140 Leishmaniasis 25/544 75/7206 7.56655491173e-11 ko04659 Th17 cell differentiation 30/544 106/7206 9.87395523039e-11 ko05162 Measles 32/544 120/7206 1.28254817633e-10 ko05145 Toxoplasmosis 32/544 126/7206 5.03501107462e-10 ko04658 Th1 and Th2 cell differentiation 27/544 96/7206 1.01639789554e-09 ko05150 Staphylococcus aureus infection 16/544 36/7206 1.58325626395e-09 ko04650 Natural killer cell mediated cytotoxicity 26/544 97/7206 6.4238605239e-09 ko04217 Necroptosis 37/544 178/7206 9.21260438144e-09 ko05152 Tuberculosis 38/544 187/7206 1.114771992e-08 ko04672 Intestinal immune network for IgA production 15/544 37/7206 2.40074817601e-08 ko04630 Jak-STAT signaling pathway 30/544 132/7206 2.89960280214e-08 ko05330 Allograft rejection 12/544 24/7206 3.54816481189e-08 ko04610 Complement and coagulation cascades 22/544 79/7206 4.4898304358e-08 ko05168 Herpes simplex infection 36/544 182/7206 5.70423826707e-08 ko04620 Toll-like receptor signaling pathway 25/544 100/7206 5.76387081735e-08 ko04660 T cell receptor signaling pathway 28/544 124/7206 9.79929013343e-08 ko04640 Hematopoietic cell lineage 19/544 64/7206 1.22960932463e-07 ko05320 Autoimmune thyroid disease 12/544 29/7206 4.78987161846e-07 ko05167 Kaposi's sarcoma-associated herpesvirus infection 35/544 191/7206 8.63237281603e-07 ko05323 Rheumatoid arthritis 21/544 89/7206 1.86449885668e-06 ko05332 Graft-versus-host disease 9/544 18/7206 1.95555881872e-06 ko04668 TNF signaling pathway 25/544 120/7206 2.35256449147e-06 ko04612 Antigen processing and presentation 19/544 77/7206 2.82395805373e-06 ko05144 Malaria 14/544 45/7206 3.08550892748e-06 ko05161 Hepatitis B 31/544 173/7206 5.49568657609e-06 ko00120 Primary bile acid biosynthesis 9/544 20/7206 5.88695718192e-06 ko05310 Asthma 8/544 17/7206 1.32265621996e-05 ko05133 Pertussis 19/544 87/7206 1.9020999465e-05 ko03013 RNA transport 1/544 166/7206 6.87040504802e-05 ko04662 B cell receptor signaling pathway 18/544 88/7206 7.87899768573e-05 ko04062 Chemokine signaling pathway 31/544 201/7206 0.000111763160981 ko05142 Chagas disease (American trypanosomiasis) 23/544 130/7206 0.000126875152991 ko04622 RIG-I-like receptor signaling pathway 14/544 62/7206 0.000162189868253 ko04723 Retrograde endocannabinoid signaling 2/544 175/7206 0.000218038675567 ko05160 Hepatitis C 25/544 153/7206 0.000250045934109 ko03040 Spliceosome 1/544 145/7206 0.000326182744657 ko05034 Alcoholism 5/544 238/7206 0.000393370610442 ko04940 Type I diabetes mellitus 9/544 32/7206 0.000432360895107 ko05418 Fluid shear stress and atherosclerosis 26/544 173/7206 0.000641792998832 ko04933 AGE-RAGE signaling pathway in diabetic complications 22/544 135/7206 0.000719357532642 ko03010 Ribosome 1/544 129/7206 0.00103024898442 ko04611 Platelet activation 24/544 163/7206 0.00137540977564 ko04210 Apoptosis 25/544 180/7206 0.00248173054948 ko04310 Wnt signaling pathway 4/544 181/7206 0.00260943215555 ko04713 Circadian entrainment 2/544 136/7206 0.00280006040709 ko04623 Cytosolic DNA-sensing pathway 9/544 41/7206 0.00293220101138 ko05032 Morphine addiction 1/544 110/7206 0.00304771724918 ko05166 HTLV-I infection 36/544 292/7206 0.00306252692016 ko04145 Phagosome 23/544 162/7206 0.00361996843471 ko05169 Epstein-Barr virus infection 27/544 206/7206 0.00449652527168 ko00590 Arachidonic acid metabolism 10/544 52/7206 0.00485643832095 ko04666 Fc gamma R-mediated phagocytosis 18/544 122/7206 0.00510590775408 ko01200 Carbon metabolism 2/544 128/7206 0.0059240688659 ko04728 Dopaminergic synapse 5/544 185/7206 0.00709312327614 ko04390 Hippo signaling pathway 5/544 188/7206 0.00719952045289 ko05143 African trypanosomiasis 7/544 32/7206 0.00859056714369 ko04114 Oocyte meiosis 3/544 139/7206 0.00912921727725 ko04916 Melanogenesis 3/544 142/7206 0.00927035299919 ko03015 mRNA surveillance pathway 1/544 93/7206 0.00944405858965 ko04137 Mitophagy - animal 13/544 82/7206 0.00951885984335 ko00140 Steroid hormone biosynthesis 8/544 41/7206 0.0103637937444 ko00592 alpha-Linolenic acid metabolism 5/544 19/7206 0.0115079363124 ko04710 Circadian rhythm 8/544 43/7206 0.0137777037504 ko04664 Fc epsilon RI signaling pathway 12/544 77/7206 0.0143853810801 ko04727 GABAergic synapse 2/544 110/7206 0.0165916965219 ko04724 Glutamatergic synapse 4/544 152/7206 0.018455713432 ko05132 Salmonella infection 14/544 98/7206 0.0187426813099 ko00982 Drug metabolism - cytochrome P450 7/544 37/7206 0.0189607990741 ko05146 Amoebiasis 14/544 99/7206 0.0197630415255 ko05010 Alzheimer's disease 7/544 202/7206 0.0213119509979 ko04657 IL-17 signaling pathway 13/544 87/7206 0.0214627661358 ko04110 Cell cycle 4/544 145/7206 0.0247928622658 ko04514 Cell adhesion molecules (CAMs) 17/544 130/7206 0.0270785668451 ko05131 Shigellosis 12/544 82/7206 0.0313685803382 ko05212 Pancreatic cancer 12/544 83/7206 0.0323538829538 ko04720 Long-term potentiation 2/544 99/7206 0.0330324338088 ko04726 Serotonergic synapse 4/544 137/7206 0.0333571002298 ko04911 Insulin secretion 3/544 117/7206 0.0338316901217 ko05416 Viral myocarditis 9/544 55/7206 0.033914837811 ko00950 Isoquinoline alkaloid biosynthesis 3/544 10/7206 0.0344009522801 ko05016 Huntington's disease 8/544 215/7206 0.0345277522056 ko00350 Tyrosine metabolism 6/544 33/7206 0.0346648841175 ko00051 Fructose and mannose metabolism 7/544 42/7206 0.0359431076329 ko03320 PPAR signaling pathway 10/544 69/7206 0.0375060095023 ko04530 Tight junction 9/544 228/7206 0.0401447608347 ko05224 Breast cancer 6/544 174/7206 0.0403426340705 ko00310 Lysine degradation 1/544 73/7206 0.0422783254157 ko00010 Glycolysis / Gluconeogenesis 1/544 74/7206 0.0428010330048