ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	197/1201	423/7206	4.23372188951e-50
ko04724	Glutamatergic synapse	88/1201	152/7206	2.48145378186e-31
ko05032	Morphine addiction	69/1201	110/7206	9.86273592885e-28
ko05033	Nicotine addiction	46/1201	56/7206	4.93807959609e-27
ko04713	Circadian entrainment	77/1201	136/7206	1.2247939031e-26
ko04727	GABAergic synapse	65/1201	110/7206	4.45928293465e-24
ko04728	Dopaminergic synapse	85/1201	185/7206	3.9235610457e-21
ko04725	Cholinergic synapse	77/1201	160/7206	9.26437491472e-21
ko04721	Synaptic vesicle cycle	50/1201	80/7206	2.67485290395e-20
ko04723	Retrograde endocannabinoid signaling	79/1201	175/7206	3.92014633291e-19
ko04911	Insulin secretion	58/1201	117/7206	1.12858974425e-16
ko04742	Taste transduction	39/1201	61/7206	1.33939163864e-16
ko04020	Calcium signaling pathway	98/1201	265/7206	5.29320990582e-16
ko04726	Serotonergic synapse	61/1201	137/7206	1.08287882714e-14
ko04921	Oxytocin signaling pathway	80/1201	209/7206	3.95907580767e-14
ko04024	cAMP signaling pathway	97/1201	279/7206	6.32319946779e-14
ko04261	Adrenergic signaling in cardiomyocytes	73/1201	205/7206	2.60683805716e-11
ko04744	Phototransduction	24/1201	36/7206	2.79853820635e-11
ko03040	Spliceosome	1/1201	145/7206	1.1769412979e-10
ko04360	Axon guidance	78/1201	233/7206	1.63198410306e-10
ko05031	Amphetamine addiction	41/1201	91/7206	1.70688705494e-10
ko04970	Salivary secretion	42/1201	95/7206	2.13452894757e-10
ko04720	Long-term potentiation	43/1201	99/7206	2.60403539708e-10
ko04925	Aldosterone synthesis and secretion	42/1201	105/7206	1.27892042783e-08
ko04971	Gastric acid secretion	39/1201	98/7206	4.99529259178e-08
ko04060	Cytokine-cytokine receptor interaction	8/1201	191/7206	1.12073744653e-07
ko04740	Olfactory transduction	33/1201	80/7206	1.43677036021e-07
ko05164	Influenza A	6/1201	167/7206	1.56478810586e-07
ko03013	RNA transport	6/1201	166/7206	2.33382954913e-07
ko05322	Systemic lupus erythematosus	5/1201	151/7206	3.80514262805e-07
ko05203	Viral carcinogenesis	18/1201	277/7206	4.09531719878e-07
ko04022	cGMP-PKG signaling pathway	64/1201	216/7206	1.6082863791e-06
ko05168	Herpes simplex infection	9/1201	182/7206	1.61938149696e-06
ko05030	Cocaine addiction	29/1201	73/7206	2.06659454213e-06
ko04010	MAPK signaling pathway	86/1201	321/7206	2.53674971415e-06
ko04514	Cell adhesion molecules (CAMs)	42/1201	130/7206	1.25057640993e-05
ko04972	Pancreatic secretion	37/1201	111/7206	1.47007419386e-05
ko04540	Gap junction	41/1201	128/7206	1.88836223544e-05
ko04976	Bile secretion	29/1201	80/7206	2.44861607763e-05
ko04745	Phototransduction - fly	17/1201	38/7206	4.52918240183e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1201	74/7206	4.96199995074e-05
ko04621	NOD-like receptor signaling pathway	9/1201	157/7206	5.0556438711e-05
ko04141	Protein processing in endoplasmic reticulum	12/1201	184/7206	5.20857342537e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	23/1201	59/7206	5.37536603693e-05
ko04750	Inflammatory mediator regulation of TRP channels	38/1201	122/7206	6.65718915789e-05
ko04966	Collecting duct acid secretion	13/1201	26/7206	8.76882300724e-05
ko04730	Long-term depression	27/1201	78/7206	9.46273284381e-05
ko04924	Renin secretion	29/1201	86/7206	0.000103856350305
ko04610	Complement and coagulation cascades	2/1201	79/7206	0.000111566717116
ko03008	Ribosome biogenesis in eukaryotes	2/1201	79/7206	0.000111566717116
ko05110	Vibrio cholerae infection	23/1201	63/7206	0.000120674471098
ko04014	Ras signaling pathway	71/1201	279/7206	0.00014807401769
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1201	79/7206	0.000181200381025
ko04120	Ubiquitin mediated proteolysis	8/1201	138/7206	0.000187067200154
ko04371	Apelin signaling pathway	48/1201	177/7206	0.000453188338934
ko05162	Measles	7/1201	120/7206	0.000494221406727
ko04260	Cardiac muscle contraction	30/1201	98/7206	0.000539824316917
ko04146	Peroxisome	4/1201	89/7206	0.000819544673743
ko04612	Antigen processing and presentation	3/1201	77/7206	0.00101972370202
ko04932	Non-alcoholic fatty liver disease (NAFLD)	15/1201	182/7206	0.00118762641535
ko05169	Epstein-Barr virus infection	18/1201	206/7206	0.00119336167204
ko05414	Dilated cardiomyopathy	32/1201	112/7206	0.00130857463619
ko04070	Phosphatidylinositol signaling system	32/1201	112/7206	0.00130857463619
ko05140	Leishmaniasis	3/1201	75/7206	0.00150440283387
ko04072	Phospholipase D signaling pathway	50/1201	197/7206	0.00178340408436
ko04916	Melanogenesis	38/1201	142/7206	0.00200413320743
ko05205	Proteoglycans in cancer	27/1201	271/7206	0.00201163905514
ko04110	Cell cycle	11/1201	145/7206	0.00216077073906
ko00330	Arginine and proline metabolism	2/1201	61/7206	0.00271358998257
ko04657	IL-17 signaling pathway	5/1201	87/7206	0.00350339596195
ko04064	NF-kappa B signaling pathway	6/1201	96/7206	0.00353127885223
ko00071	Fatty acid degradation	1/1201	45/7206	0.00434272987093
ko03420	Nucleotide excision repair	1/1201	46/7206	0.00443889708039
ko03018	RNA degradation	5/1201	84/7206	0.00490263547615
ko04964	Proximal tubule bicarbonate reclamation	11/1201	29/7206	0.00493010599677
ko01200	Carbon metabolism	10/1201	128/7206	0.0055081798028
ko00280	Valine, leucine and isoleucine degradation	2/1201	54/7206	0.00560480570725
ko04915	Estrogen signaling pathway	34/1201	131/7206	0.00620139284222
ko00240	Pyrimidine metabolism	8/1201	110/7206	0.00627735305148
ko04640	Hematopoietic cell lineage	3/1201	64/7206	0.00637445716767
ko04620	Toll-like receptor signaling pathway	7/1201	100/7206	0.00650683829116
ko03022	Basal transcription factors	1/1201	44/7206	0.00683109043593
ko05131	Shigellosis	5/1201	82/7206	0.00683750734484
ko05161	Hepatitis B	16/1201	173/7206	0.00694922177888
ko04217	Necroptosis	17/1201	178/7206	0.00794169881523
ko00590	Arachidonic acid metabolism	2/1201	52/7206	0.00819011832257
ko04630	Jak-STAT signaling pathway	11/1201	132/7206	0.00896323589773
ko04622	RIG-I-like receptor signaling pathway	3/1201	62/7206	0.00922589803685
ko04214	Apoptosis - fly	4/1201	72/7206	0.00988146310697
ko04270	Vascular smooth muscle contraction	38/1201	154/7206	0.0114066592297
ko00380	Tryptophan metabolism	2/1201	50/7206	0.0120350355485
ko05133	Pertussis	6/1201	87/7206	0.012910337286
ko01524	Platinum drug resistance	5/1201	76/7206	0.0131479164957
ko04912	GnRH signaling pathway	31/1201	122/7206	0.0135996978752
ko05215	Prostate cancer	9/1201	111/7206	0.0139960346659
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1201	100/7206	0.0149601172663
ko04930	Type II diabetes mellitus	16/1201	54/7206	0.0159876792993
ko04115	p53 signaling pathway	5/1201	74/7206	0.0180927523653
ko05321	Inflammatory bowel disease (IBD)	3/1201	56/7206	0.0184761719778
ko04918	Thyroid hormone synthesis	23/1201	86/7206	0.0186516162696
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1201	14/7206	0.0189719838378
ko04626	Plant-pathogen interaction	7/1201	18/7206	0.0204977854948
ko00500	Starch and sucrose metabolism	1/1201	35/7206	0.0219493529051
ko05418	Fluid shear stress and atherosclerosis	18/1201	173/7206	0.0230174856293
ko04710	Circadian rhythm	13/1201	43/7206	0.0231854754447
ko05144	Malaria	2/1201	45/7206	0.0253990232031
ko05016	Huntington's disease	24/1201	215/7206	0.0257747517438
ko00561	Glycerolipid metabolism	4/1201	63/7206	0.0260081248553
ko00620	Pyruvate metabolism	2/1201	46/7206	0.0262963563978
ko04658	Th1 and Th2 cell differentiation	8/1201	96/7206	0.026605723885
ko00480	Glutathione metabolism	3/1201	55/7206	0.0270611679782
ko05145	Toxoplasmosis	12/1201	126/7206	0.0294206514064
ko04015	Rap1 signaling pathway	60/1201	278/7206	0.0324076178443
ko03320	PPAR signaling pathway	5/1201	69/7206	0.0339459000028
ko00860	Porphyrin and chlorophyll metabolism	1/1201	34/7206	0.0340659893393
ko04923	Regulation of lipolysis in adipocytes	20/1201	77/7206	0.0437191663656
ko04668	TNF signaling pathway	12/1201	120/7206	0.0479920038348
ko05340	Primary immunodeficiency	1/1201	30/7206	0.0487369220887