ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 43/624 191/7206 2.88521364417e-09 ko04621 NOD-like receptor signaling pathway 36/624 157/7206 3.51324674483e-08 ko05340 Primary immunodeficiency 14/624 30/7206 4.54299517542e-08 ko00120 Primary bile acid biosynthesis 11/624 20/7206 1.531862197e-07 ko04610 Complement and coagulation cascades 22/624 79/7206 5.06315612186e-07 ko04064 NF-kappa B signaling pathway 24/624 96/7206 1.34146682149e-06 ko04380 Osteoclast differentiation 29/624 134/7206 2.70191876248e-06 ko04146 Peroxisome 22/624 89/7206 4.52071927178e-06 ko05150 Staphylococcus aureus infection 13/624 36/7206 4.8277065398e-06 ko04650 Natural killer cell mediated cytotoxicity 23/624 97/7206 5.8787093427e-06 ko05164 Influenza A 32/624 167/7206 1.66067245392e-05 ko05145 Toxoplasmosis 26/624 126/7206 3.16811893805e-05 ko04620 Toll-like receptor signaling pathway 22/624 100/7206 3.30305786207e-05 ko05034 Alcoholism 5/624 238/7206 3.32290286003e-05 ko03040 Spliceosome 1/624 145/7206 3.97849249556e-05 ko05162 Measles 25/624 120/7206 4.36025897946e-05 ko05321 Inflammatory bowel disease (IBD) 15/624 56/7206 5.50561056403e-05 ko04630 Jak-STAT signaling pathway 26/624 132/7206 5.63212916241e-05 ko00350 Tyrosine metabolism 11/624 33/7206 6.18596496919e-05 ko04390 Hippo signaling pathway 3/624 188/7206 6.26918702732e-05 ko03013 RNA transport 2/624 166/7206 6.55230955049e-05 ko00590 Arachidonic acid metabolism 14/624 52/7206 9.14668051876e-05 ko00592 alpha-Linolenic acid metabolism 8/624 19/7206 9.6461797399e-05 ko04310 Wnt signaling pathway 3/624 181/7206 0.000132780664382 ko05140 Leishmaniasis 17/624 75/7206 0.000174129841595 ko03010 Ribosome 1/624 129/7206 0.000194467896504 ko04710 Circadian rhythm 12/624 43/7206 0.000199497958794 ko04640 Hematopoietic cell lineage 15/624 64/7206 0.00028129401565 ko00360 Phenylalanine metabolism 7/624 17/7206 0.000317162336087 ko05133 Pertussis 18/624 87/7206 0.000380965301243 ko04110 Cell cycle 2/624 145/7206 0.000448429937056 ko03320 PPAR signaling pathway 15/624 69/7206 0.000665488501443 ko05168 Herpes simplex infection 30/624 182/7206 0.000684759241275 ko00950 Isoquinoline alkaloid biosynthesis 5/624 10/7206 0.000835192382558 ko04068 FoxO signaling pathway 27/624 167/7206 0.0012418160182 ko05144 Malaria 11/624 45/7206 0.00124241152594 ko04662 B cell receptor signaling pathway 17/624 88/7206 0.00157052710537 ko00140 Steroid hormone biosynthesis 10/624 41/7206 0.00208951442316 ko04622 RIG-I-like receptor signaling pathway 13/624 62/7206 0.00211721296455 ko04916 Melanogenesis 3/624 142/7206 0.00225187234281 ko04659 Th17 cell differentiation 19/624 106/7206 0.0023821030224 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 3/624 4/7206 0.00241874627528 ko05167 Kaposi's sarcoma-associated herpesvirus infection 29/624 191/7206 0.00247720978089 ko05320 Autoimmune thyroid disease 8/624 29/7206 0.00251559552573 ko00983 Drug metabolism - other enzymes 10/624 42/7206 0.00253451994896 ko00051 Fructose and mannose metabolism 10/624 42/7206 0.00253451994896 ko04660 T cell receptor signaling pathway 21/624 124/7206 0.00305799606488 ko04612 Antigen processing and presentation 15/624 77/7206 0.0030644366016 ko05330 Allograft rejection 7/624 24/7206 0.00330174169334 ko04672 Intestinal immune network for IgA production 9/624 37/7206 0.0035263044613 ko04217 Necroptosis 27/624 178/7206 0.00408759889307 ko00071 Fatty acid degradation 10/624 45/7206 0.00433931418494 ko03015 mRNA surveillance pathway 1/624 93/7206 0.00438769406129 ko04137 Mitophagy - animal 15/624 82/7206 0.00465103120291 ko04658 Th1 and Th2 cell differentiation 17/624 96/7206 0.00490273804907 ko04728 Dopaminergic synapse 6/624 185/7206 0.00503780173441 ko02010 ABC transporters 9/624 39/7206 0.00514003004891 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 3/624 5/7206 0.00565763152203 ko04360 Axon guidance 9/624 233/7206 0.0060515136732 ko04623 Cytosolic DNA-sensing pathway 9/624 41/7206 0.00727400969545 ko00254 Aflatoxin biosynthesis 2/624 2/7206 0.00748763030585 ko05152 Tuberculosis 27/624 187/7206 0.00781852747654 ko04530 Tight junction 9/624 228/7206 0.0079881104059 ko04975 Fat digestion and absorption 8/624 35/7206 0.00868913852368 ko05224 Breast cancer 6/624 174/7206 0.00918518143953 ko00591 Linoleic acid metabolism 6/624 22/7206 0.0092051765345 ko04723 Retrograde endocannabinoid signaling 6/624 175/7206 0.00920960908009 ko00380 Tryptophan metabolism 10/624 50/7206 0.00944177753151 ko00362 Benzoate degradation 3/624 6/7206 0.0105902485019 ko05142 Chagas disease (American trypanosomiasis) 20/624 130/7206 0.01074098185 ko00130 Ubiquinone and other terpenoid-quinone biosynthesis 4/624 11/7206 0.0112145894157 ko05323 Rheumatoid arthritis 15/624 89/7206 0.0117534211923 ko00982 Drug metabolism - cytochrome P450 8/624 37/7206 0.0122290900608 ko04721 Synaptic vesicle cycle 1/624 80/7206 0.0140520846403 ko00620 Pyruvate metabolism 9/624 46/7206 0.0155334080374 ko05332 Graft-versus-host disease 5/624 18/7206 0.0158527363651 ko04550 Signaling pathways regulating pluripotency of stem cells 6/624 165/7206 0.0166055272526 ko00330 Arginine and proline metabolism 11/624 61/7206 0.0183285893269 ko05161 Hepatitis B 24/624 173/7206 0.0192166923319 ko00980 Metabolism of xenobiotics by cytochrome P450 8/624 40/7206 0.0193751340342 ko04668 TNF signaling pathway 18/624 120/7206 0.0203209730509 ko04062 Chemokine signaling pathway 27/624 201/7206 0.0211196005663 ko00561 Glycerolipid metabolism 11/624 63/7206 0.0214192894583 ko05160 Hepatitis C 21/624 153/7206 0.0292637143782 ko00100 Steroid biosynthesis 5/624 21/7206 0.0303524526839 ko04120 Ubiquitin mediated proteolysis 5/624 138/7206 0.0313159380948 ko05204 Chemical carcinogenesis 9/624 48/7206 0.0330149520829 ko04350 TGF-beta signaling pathway 3/624 103/7206 0.0330304682999 ko04611 Platelet activation 22/624 163/7206 0.0336214598523 ko00643 Styrene degradation 2/624 4/7206 0.0399210799518 ko04740 Olfactory transduction 2/624 80/7206 0.0448874447695