ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	200/1229	423/7206	1.69685846179e-50
ko04724	Glutamatergic synapse	89/1229	152/7206	2.09090144399e-31
ko05033	Nicotine addiction	47/1229	56/7206	5.83076811896e-28
ko05032	Morphine addiction	68/1229	110/7206	3.54237728367e-26
ko04713	Circadian entrainment	75/1229	136/7206	2.48023279877e-24
ko04727	GABAergic synapse	64/1229	110/7206	1.22306187021e-22
ko04725	Cholinergic synapse	78/1229	160/7206	8.15381319843e-21
ko04728	Dopaminergic synapse	83/1229	185/7206	3.47617116759e-19
ko04024	cAMP signaling pathway	109/1229	279/7206	3.64984262329e-19
ko04020	Calcium signaling pathway	105/1229	265/7206	6.71535731434e-19
ko04723	Retrograde endocannabinoid signaling	76/1229	175/7206	1.13269488984e-16
ko04721	Synaptic vesicle cycle	46/1229	80/7206	2.4840051735e-16
ko04911	Insulin secretion	58/1229	117/7206	3.38655866851e-16
ko04921	Oxytocin signaling pathway	84/1229	209/7206	1.00307123847e-15
ko04726	Serotonergic synapse	60/1229	137/7206	1.30466330558e-13
ko04970	Salivary secretion	45/1229	95/7206	5.72920359184e-12
ko05031	Amphetamine addiction	43/1229	91/7206	1.88788103849e-11
ko04261	Adrenergic signaling in cardiomyocytes	74/1229	205/7206	2.49695274733e-11
ko04742	Taste transduction	33/1229	61/7206	4.28998847728e-11
ko04744	Phototransduction	24/1229	36/7206	4.63797438257e-11
ko04022	cGMP-PKG signaling pathway	74/1229	216/7206	5.16862227898e-10
ko04720	Long-term potentiation	43/1229	99/7206	5.53968403311e-10
ko03040	Spliceosome	2/1229	145/7206	9.64848525924e-10
ko03010	Ribosome	1/1229	129/7206	1.5694448984e-09
ko04971	Gastric acid secretion	41/1229	98/7206	5.41284418562e-09
ko04925	Aldosterone synthesis and secretion	43/1229	105/7206	7.56565870521e-09
ko05322	Systemic lupus erythematosus	4/1229	151/7206	3.62200316804e-08
ko05168	Herpes simplex infection	8/1229	182/7206	2.21515539967e-07
ko04070	Phosphatidylinositol signaling system	41/1229	112/7206	6.56542319336e-07
ko05030	Cocaine addiction	30/1229	73/7206	9.70121918916e-07
ko04360	Axon guidance	69/1229	233/7206	1.32605189595e-06
ko05203	Viral carcinogenesis	20/1229	277/7206	1.7999396293e-06
ko03013	RNA transport	8/1229	166/7206	2.90822300945e-06
ko04972	Pancreatic secretion	39/1229	111/7206	4.73200527156e-06
ko04730	Long-term depression	30/1229	78/7206	5.40559316924e-06
ko04745	Phototransduction - fly	18/1229	38/7206	1.41649689163e-05
ko04740	Olfactory transduction	30/1229	80/7206	1.41925808074e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1229	74/7206	1.56236545664e-05
ko04540	Gap junction	41/1229	128/7206	2.57181353055e-05
ko04072	Phospholipase D signaling pathway	57/1229	197/7206	2.91713842104e-05
ko04976	Bile secretion	29/1229	80/7206	3.21114486697e-05
ko04141	Protein processing in endoplasmic reticulum	12/1229	184/7206	3.75274978052e-05
ko04750	Inflammatory mediator regulation of TRP channels	39/1229	122/7206	4.6108425238e-05
ko04110	Cell cycle	8/1229	145/7206	4.67590267056e-05
ko04010	MAPK signaling pathway	83/1229	321/7206	5.10489030637e-05
ko04924	Renin secretion	30/1229	86/7206	6.25191176616e-05
ko04621	NOD-like receptor signaling pathway	10/1229	157/7206	9.64492937147e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1229	79/7206	0.000112110584863
ko04966	Collecting duct acid secretion	13/1229	26/7206	0.000112173499495
ko04060	Cytokine-cytokine receptor interaction	14/1229	191/7206	0.000122420551802
ko04612	Antigen processing and presentation	2/1229	77/7206	0.000172134426976
ko05414	Dilated cardiomyopathy	35/1229	112/7206	0.000193162943792
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1229	79/7206	0.000214438516639
ko04514	Cell adhesion molecules (CAMs)	39/1229	130/7206	0.000222590587707
ko05164	Influenza A	12/1229	167/7206	0.000240820646861
ko04120	Ubiquitin mediated proteolysis	9/1229	138/7206	0.000352290989321
ko04710	Circadian rhythm	17/1229	43/7206	0.000382362598601
ko04964	Proximal tubule bicarbonate reclamation	13/1229	29/7206	0.000441885528357
ko04915	Estrogen signaling pathway	38/1229	131/7206	0.000590948151103
ko05169	Epstein-Barr virus infection	18/1229	206/7206	0.000682476258693
ko04922	Glucagon signaling pathway	37/1229	128/7206	0.000785665357125
ko04014	Ras signaling pathway	69/1229	279/7206	0.000840858375133
ko04260	Cardiac muscle contraction	30/1229	98/7206	0.000970795223984
ko05140	Leishmaniasis	3/1229	75/7206	0.000989010089625
ko04923	Regulation of lipolysis in adipocytes	25/1229	77/7206	0.00108539609301
ko04371	Apelin signaling pathway	47/1229	177/7206	0.00115822267634
ko04973	Carbohydrate digestion and absorption	16/1229	42/7206	0.00129189724008
ko04270	Vascular smooth muscle contraction	42/1229	154/7206	0.00152230878498
ko05110	Vibrio cholerae infection	21/1229	63/7206	0.00192376651445
ko04064	NF-kappa B signaling pathway	6/1229	96/7206	0.00249262246242
ko04960	Aldosterone-regulated sodium reabsorption	15/1229	41/7206	0.00256342465688
ko03420	Nucleotide excision repair	1/1229	46/7206	0.00283190495895
ko05410	Hypertrophic cardiomyopathy (HCM)	29/1229	100/7206	0.00287529437795
ko04930	Type II diabetes mellitus	18/1229	54/7206	0.00313332251329
ko05162	Measles	9/1229	120/7206	0.00314368155236
ko03022	Basal transcription factors	1/1229	44/7206	0.00425794190789
ko04626	Plant-pathogen interaction	8/1229	18/7206	0.00610600458283
ko04217	Necroptosis	17/1229	178/7206	0.00614949388989
ko04622	RIG-I-like receptor signaling pathway	3/1229	62/7206	0.00624118476744
ko00590	Arachidonic acid metabolism	2/1229	52/7206	0.00828677574014
ko04961	Endocrine and other factor-regulated calcium reabsorption	18/1229	59/7206	0.00893239891991
ko04657	IL-17 signaling pathway	6/1229	87/7206	0.00916701376475
ko05133	Pertussis	6/1229	87/7206	0.00916701376475
ko04610	Complement and coagulation cascades	5/1229	79/7206	0.00961632837204
ko05161	Hepatitis B	17/1229	173/7206	0.0101175083265
ko00240	Pyrimidine metabolism	9/1229	110/7206	0.0102372275132
ko04912	GnRH signaling pathway	32/1229	122/7206	0.0102398807786
ko05145	Toxoplasmosis	11/1229	126/7206	0.0114987886142
ko04918	Thyroid hormone synthesis	24/1229	86/7206	0.0131502070122
ko03410	Base excision repair	1/1229	38/7206	0.0149831200092
ko00562	Inositol phosphate metabolism	24/1229	89/7206	0.0158757837429
ko04142	Lysosome	15/1229	151/7206	0.0160431203291
ko05166	HTLV-I infection	35/1229	292/7206	0.01712004154
ko05131	Shigellosis	6/1229	82/7206	0.0171548580046
ko04115	p53 signaling pathway	5/1229	74/7206	0.0184012980482
ko05321	Inflammatory bowel disease (IBD)	3/1229	56/7206	0.0186763673798
ko04658	Th1 and Th2 cell differentiation	8/1229	96/7206	0.0197330428933
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1229	14/7206	0.0211435480111
ko00860	Porphyrin and chlorophyll metabolism	1/1229	34/7206	0.021662979143
ko04146	Peroxisome	7/1229	89/7206	0.0220286224082
ko04015	Rap1 signaling pathway	62/1229	278/7206	0.0224437433599
ko04113	Meiosis - yeast	5/1229	70/7206	0.0245387263113
ko04630	Jak-STAT signaling pathway	13/1229	132/7206	0.025916790347
ko05144	Malaria	2/1229	45/7206	0.0260138773122
ko05231	Choline metabolism in cancer	33/1229	134/7206	0.0267340699498
ko00280	Valine, leucine and isoleucine degradation	3/1229	54/7206	0.026992880487
ko05205	Proteoglycans in cancer	33/1229	271/7206	0.0319106554514
ko04916	Melanogenesis	34/1229	142/7206	0.0320544795185
ko05214	Glioma	21/1229	79/7206	0.0336717578893
ko05016	Huntington's disease	25/1229	215/7206	0.0337514483628
ko05200	Pathways in cancer	67/1229	492/7206	0.0348043244979
ko05230	Central carbon metabolism in cancer	21/1229	81/7206	0.0376661992949
ko04114	Oocyte meiosis	33/1229	139/7206	0.0400079451334
ko04640	Hematopoietic cell lineage	5/1229	64/7206	0.0456181523057
ko04932	Non-alcoholic fatty liver disease (NAFLD)	21/1229	182/7206	0.0456833957445