ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 50/571 191/7206 9.9548662789e-15 ko04380 Osteoclast differentiation 36/571 134/7206 2.79306046748e-11 ko00120 Primary bile acid biosynthesis 12/571 20/7206 3.82594192948e-09 ko04610 Complement and coagulation cascades 24/571 79/7206 4.17311314925e-09 ko04621 NOD-like receptor signaling pathway 35/571 157/7206 1.21473188802e-08 ko05164 Influenza A 35/571 167/7206 6.43296451914e-08 ko05340 Primary immunodeficiency 13/571 30/7206 1.4416598761e-07 ko04064 NF-kappa B signaling pathway 24/571 96/7206 2.64311483707e-07 ko04630 Jak-STAT signaling pathway 28/571 132/7206 1.05527390924e-06 ko05162 Measles 26/571 120/7206 1.68085913922e-06 ko05150 Staphylococcus aureus infection 13/571 36/7206 1.78121006479e-06 ko05140 Leishmaniasis 19/571 75/7206 3.79109983363e-06 ko05145 Toxoplasmosis 26/571 126/7206 4.40694956227e-06 ko05168 Herpes simplex infection 33/571 182/7206 5.03149364141e-06 ko04620 Toll-like receptor signaling pathway 22/571 100/7206 8.15374237209e-06 ko04217 Necroptosis 32/571 178/7206 8.37767360282e-06 ko04650 Natural killer cell mediated cytotoxicity 21/571 97/7206 1.69803345232e-05 ko00360 Phenylalanine metabolism 8/571 17/7206 1.89206678586e-05 ko05321 Inflammatory bowel disease (IBD) 15/571 56/7206 1.93627938485e-05 ko00350 Tyrosine metabolism 11/571 33/7206 2.70773174076e-05 ko03013 RNA transport 1/571 166/7206 2.8673247459e-05 ko04146 Peroxisome 19/571 89/7206 5.22717959315e-05 ko04668 TNF signaling pathway 23/571 120/7206 5.41284581721e-05 ko04659 Th17 cell differentiation 21/571 106/7206 6.87552637802e-05 ko04672 Intestinal immune network for IgA production 11/571 37/7206 8.92741502603e-05 ko04723 Retrograde endocannabinoid signaling 2/571 175/7206 9.94802759538e-05 ko05133 Pertussis 18/571 87/7206 0.000125757093607 ko03040 Spliceosome 1/571 145/7206 0.000136081185446 ko04612 Antigen processing and presentation 16/571 77/7206 0.000280496633691 ko04660 T cell receptor signaling pathway 22/571 124/7206 0.000286553820887 ko05167 Kaposi's sarcoma-associated herpesvirus infection 30/571 191/7206 0.000314201855255 ko04310 Wnt signaling pathway 3/571 181/7206 0.00040063208934 ko03010 Ribosome 1/571 129/7206 0.000435687493868 ko04662 B cell receptor signaling pathway 17/571 88/7206 0.000454278419014 ko04658 Th1 and Th2 cell differentiation 18/571 96/7206 0.000456332308856 ko05161 Hepatitis B 27/571 173/7206 0.000538870473917 ko00950 Isoquinoline alkaloid biosynthesis 5/571 10/7206 0.000552796644821 ko05224 Breast cancer 3/571 174/7206 0.000569237456612 ko05034 Alcoholism 6/571 238/7206 0.000569568329608 ko05144 Malaria 11/571 45/7206 0.000591610384401 ko00590 Arachidonic acid metabolism 12/571 52/7206 0.000592719413375 ko04062 Chemokine signaling pathway 30/571 201/7206 0.000757129428985 ko05152 Tuberculosis 28/571 187/7206 0.000876084045573 ko04110 Cell cycle 2/571 145/7206 0.000925926746237 ko04623 Cytosolic DNA-sensing pathway 10/571 41/7206 0.00106337827147 ko04210 Apoptosis 27/571 180/7206 0.00111354800308 ko04916 Melanogenesis 2/571 142/7206 0.00136906236122 ko04390 Hippo signaling pathway 4/571 188/7206 0.00138197704177 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 3/571 4/7206 0.00186339680035 ko05160 Hepatitis C 23/571 153/7206 0.00231211828666 ko03320 PPAR signaling pathway 13/571 69/7206 0.00261992638139 ko00592 alpha-Linolenic acid metabolism 6/571 19/7206 0.0026732185659 ko04622 RIG-I-like receptor signaling pathway 12/571 62/7206 0.00299353413629 ko00140 Steroid hormone biosynthesis 9/571 41/7206 0.0040635216235 ko04540 Gap junction 2/571 128/7206 0.00417671140622 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 3/571 5/7206 0.00438410396734 ko05323 Rheumatoid arthritis 15/571 89/7206 0.00456516593812 ko00380 Tryptophan metabolism 10/571 50/7206 0.00510694041486 ko04728 Dopaminergic synapse 5/571 185/7206 0.00524494592806 ko05320 Autoimmune thyroid disease 7/571 29/7206 0.00632683059484 ko04114 Oocyte meiosis 3/571 139/7206 0.00645841207742 ko04360 Axon guidance 8/571 233/7206 0.00646892506162 ko00071 Fatty acid degradation 9/571 45/7206 0.00774242484874 ko05142 Chagas disease (American trypanosomiasis) 19/571 130/7206 0.0080346344609 ko00362 Benzoate degradation 3/571 6/7206 0.00825390229137 ko04713 Circadian entrainment 3/571 136/7206 0.00925306301958 ko05330 Allograft rejection 6/571 24/7206 0.00944040749994 ko04724 Glutamatergic synapse 4/571 152/7206 0.00947332148779 ko04727 GABAergic synapse 2/571 110/7206 0.0115674675669 ko04611 Platelet activation 22/571 163/7206 0.0120261704626 ko04137 Mitophagy - animal 13/571 82/7206 0.0128486417265 ko04740 Olfactory transduction 1/571 80/7206 0.0199797792498 ko00100 Steroid biosynthesis 5/571 21/7206 0.0215221829762 ko04720 Long-term potentiation 2/571 99/7206 0.0231094999553 ko00982 Drug metabolism - cytochrome P450 7/571 37/7206 0.0240959293098 ko04933 AGE-RAGE signaling pathway in diabetic complications 18/571 135/7206 0.0241801004751 ko02010 ABC transporters 7/571 39/7206 0.0314146983134 ko04080 Neuroactive ligand-receptor interaction 22/571 423/7206 0.0324476081018 ko05010 Alzheimer's disease 8/571 202/7206 0.0335729040847 ko00643 Styrene degradation 2/571 4/7206 0.0337687272334 ko05020 Prion diseases 7/571 40/7206 0.0355780716577 ko05131 Shigellosis 12/571 82/7206 0.0361328162819 ko00220 Arginine biosynthesis 5/571 24/7206 0.0369667700864 ko00920 Sulfur metabolism 3/571 10/7206 0.0389911307077 ko05310 Asthma 4/571 17/7206 0.040486898451 ko00983 Drug metabolism - other enzymes 7/571 42/7206 0.0449607161739 ko00051 Fructose and mannose metabolism 7/571 42/7206 0.0449607161739 ko05418 Fluid shear stress and atherosclerosis 21/571 173/7206 0.0451768254223 ko04670 Leukocyte transendothelial migration 19/571 151/7206 0.0455371186236 ko05134 Legionellosis 11/571 74/7206 0.0463021865402 ko05032 Morphine addiction 3/571 110/7206 0.047426286748 ko05332 Graft-versus-host disease 4/571 18/7206 0.0489013324841 ko01524 Platinum drug resistance 11/571 76/7206 0.0498905112807