ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	199/1223	423/7206	3.68228088731e-50
ko04724	Glutamatergic synapse	89/1223	152/7206	1.41648246128e-31
ko05033	Nicotine addiction	46/1223	56/7206	1.11575678653e-26
ko05032	Morphine addiction	66/1223	110/7206	1.68419174737e-24
ko04713	Circadian entrainment	75/1223	136/7206	1.80422887254e-24
ko04727	GABAergic synapse	64/1223	110/7206	9.27887409352e-23
ko04721	Synaptic vesicle cycle	52/1223	80/7206	7.6150223977e-22
ko04725	Cholinergic synapse	77/1223	160/7206	2.90425912944e-20
ko04728	Dopaminergic synapse	83/1223	185/7206	2.52645350408e-19
ko04024	cAMP signaling pathway	104/1223	279/7206	1.47571568337e-16
ko04742	Taste transduction	39/1223	61/7206	2.54282001469e-16
ko04020	Calcium signaling pathway	99/1223	265/7206	4.80503902274e-16
ko04723	Retrograde endocannabinoid signaling	74/1223	175/7206	1.28143688704e-15
ko04911	Insulin secretion	56/1223	117/7206	6.36098181437e-15
ko04744	Phototransduction	27/1223	36/7206	2.44366845225e-14
ko04726	Serotonergic synapse	61/1223	137/7206	2.56394406986e-14
ko04921	Oxytocin signaling pathway	79/1223	209/7206	3.26960821086e-13
ko04740	Olfactory transduction	40/1223	80/7206	8.64321474355e-12
ko03040	Spliceosome	1/1223	145/7206	7.13032642724e-11
ko04261	Adrenergic signaling in cardiomyocytes	73/1223	205/7206	7.25775641181e-11
ko04970	Salivary secretion	43/1223	95/7206	9.30104478425e-11
ko05031	Amphetamine addiction	41/1223	91/7206	3.04613455996e-10
ko04720	Long-term potentiation	42/1223	99/7206	1.81301802133e-09
ko05168	Herpes simplex infection	6/1223	182/7206	1.00177019132e-08
ko04022	cGMP-PKG signaling pathway	68/1223	216/7206	9.86654976738e-08
ko05203	Viral carcinogenesis	18/1223	277/7206	2.07052196157e-07
ko04925	Aldosterone synthesis and secretion	39/1223	105/7206	5.60439455394e-07
ko05164	Influenza A	7/1223	167/7206	5.77662991601e-07
ko04360	Axon guidance	69/1223	233/7206	1.20853996342e-06
ko04120	Ubiquitin mediated proteolysis	5/1223	138/7206	1.68561872648e-06
ko04971	Gastric acid secretion	36/1223	98/7206	2.06997789593e-06
ko04621	NOD-like receptor signaling pathway	7/1223	157/7206	2.51278941322e-06
ko03013	RNA transport	8/1223	166/7206	2.86219685779e-06
ko04966	Collecting duct acid secretion	15/1223	26/7206	3.0695796982e-06
ko04540	Gap junction	43/1223	128/7206	3.89464484815e-06
ko05030	Cocaine addiction	29/1223	73/7206	4.1965060572e-06
ko05322	Systemic lupus erythematosus	7/1223	151/7206	5.14876553811e-06
ko04060	Cytokine-cytokine receptor interaction	12/1223	191/7206	1.39444541222e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1223	74/7206	1.4361491107e-05
ko04514	Cell adhesion molecules (CAMs)	42/1223	130/7206	1.53805160977e-05
ko04110	Cell cycle	7/1223	145/7206	1.54898095708e-05
ko04924	Renin secretion	31/1223	86/7206	1.67073749086e-05
ko05169	Epstein-Barr virus infection	14/1223	206/7206	1.90140729358e-05
ko04730	Long-term depression	29/1223	78/7206	2.18885681659e-05
ko04141	Protein processing in endoplasmic reticulum	12/1223	184/7206	3.70202266815e-05
ko04972	Pancreatic secretion	36/1223	111/7206	5.73902518353e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1223	79/7206	6.05381900638e-05
ko04010	MAPK signaling pathway	82/1223	321/7206	6.94948444454e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1223	79/7206	0.000110791827858
ko04976	Bile secretion	28/1223	80/7206	0.00011801563193
ko04260	Cardiac muscle contraction	32/1223	98/7206	0.000118718865587
ko05140	Leishmaniasis	2/1223	75/7206	0.000162697475551
ko04064	NF-kappa B signaling pathway	4/1223	96/7206	0.000183153250107
ko04745	Phototransduction - fly	16/1223	38/7206	0.00022685967997
ko05205	Proteoglycans in cancer	25/1223	271/7206	0.000268744857758
ko04014	Ras signaling pathway	70/1223	279/7206	0.000440757445038
ko05162	Measles	7/1223	120/7206	0.000496707770914
ko05414	Dilated cardiomyopathy	34/1223	112/7206	0.00050077448799
ko05110	Vibrio cholerae infection	22/1223	63/7206	0.000531009381122
ko04146	Peroxisome	4/1223	89/7206	0.000550827615943
ko04750	Inflammatory mediator regulation of TRP channels	36/1223	122/7206	0.00055726659706
ko04612	Antigen processing and presentation	3/1223	77/7206	0.000681927965294
ko04610	Complement and coagulation cascades	3/1223	79/7206	0.000709917987185
ko04371	Apelin signaling pathway	47/1223	177/7206	0.00110034963569
ko00590	Arachidonic acid metabolism	1/1223	52/7206	0.00125104090376
ko05166	HTLV-I infection	30/1223	292/7206	0.0013882238596
ko04964	Proximal tubule bicarbonate reclamation	12/1223	29/7206	0.00165038186804
ko04330	Notch signaling pathway	2/1223	62/7206	0.00177642021115
ko04923	Regulation of lipolysis in adipocytes	24/1223	77/7206	0.00195157520235
ko05161	Hepatitis B	15/1223	173/7206	0.00202302576886
ko04070	Phosphatidylinositol signaling system	32/1223	112/7206	0.00207949722793
ko04915	Estrogen signaling pathway	36/1223	131/7206	0.0021389150178
ko04710	Circadian rhythm	15/1223	43/7206	0.00375204545743
ko03022	Basal transcription factors	1/1223	44/7206	0.00427790691761
ko00071	Fatty acid degradation	1/1223	45/7206	0.00433898587208
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1223	59/7206	0.00441304504212
ko00240	Pyrimidine metabolism	8/1223	110/7206	0.0045203939788
ko03420	Nucleotide excision repair	1/1223	46/7206	0.00458269338004
ko04072	Phospholipase D signaling pathway	49/1223	197/7206	0.00500233804853
ko05145	Toxoplasmosis	10/1223	126/7206	0.00546703480834
ko00280	Valine, leucine and isoleucine degradation	2/1223	54/7206	0.00555096325543
ko04626	Plant-pathogen interaction	8/1223	18/7206	0.00592101193629
ko04622	RIG-I-like receptor signaling pathway	3/1223	62/7206	0.00627781678689
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1223	100/7206	0.00666645215304
ko04630	Jak-STAT signaling pathway	11/1223	132/7206	0.00667049562605
ko05131	Shigellosis	5/1223	82/7206	0.00696380598498
ko05133	Pertussis	6/1223	87/7206	0.00914754123617
ko04217	Necroptosis	18/1223	178/7206	0.0113582879647
ko04922	Glucagon signaling pathway	33/1223	128/7206	0.01195781666
ko04270	Vascular smooth muscle contraction	38/1223	154/7206	0.012521261405
ko00630	Glyoxylate and dicarboxylate metabolism	1/1223	38/7206	0.0149009733533
ko04932	Non-alcoholic fatty liver disease (NAFLD)	19/1223	182/7206	0.0160849266017
ko04916	Melanogenesis	35/1223	142/7206	0.0174756182888
ko04930	Type II diabetes mellitus	16/1223	54/7206	0.0177254723594
ko04214	Apoptosis - fly	5/1223	72/7206	0.0179278090416
ko00310	Lysine degradation	5/1223	73/7206	0.0179303682127
ko04115	p53 signaling pathway	5/1223	74/7206	0.0182577582797
ko00480	Glutathione metabolism	3/1223	55/7206	0.0182724284103
ko05321	Inflammatory bowel disease (IBD)	3/1223	56/7206	0.0185745980341
ko04658	Th1 and Th2 cell differentiation	8/1223	96/7206	0.0197878616628
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1223	14/7206	0.0206638902461
ko04657	IL-17 signaling pathway	7/1223	87/7206	0.0215203809751
ko00640	Propanoate metabolism	1/1223	34/7206	0.0217572362229
ko00860	Porphyrin and chlorophyll metabolism	1/1223	34/7206	0.0217572362229
ko04350	TGF-beta signaling pathway	9/1223	103/7206	0.0239188218078
ko05206	MicroRNAs in cancer	19/1223	177/7206	0.0252692444769
ko00330	Arginine and proline metabolism	4/1223	61/7206	0.025603466329
ko04912	GnRH signaling pathway	30/1223	122/7206	0.0283284414526
ko01524	Platinum drug resistance	6/1223	76/7206	0.0312519646442
ko04620	Toll-like receptor signaling pathway	9/1223	100/7206	0.0313361104964
ko05418	Fluid shear stress and atherosclerosis	19/1223	173/7206	0.0313985318062
ko05016	Huntington's disease	25/1223	215/7206	0.0336894845534
ko05217	Basal cell carcinoma	5/1223	68/7206	0.0337092967098
ko00380	Tryptophan metabolism	3/1223	50/7206	0.0365876677439
ko04015	Rap1 signaling pathway	60/1223	278/7206	0.0414237257025
ko05320	Autoimmune thyroid disease	1/1223	29/7206	0.0484265188718
ko05340	Primary immunodeficiency	1/1223	30/7206	0.0486447521099