ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko05033	Nicotine addiction	21/515	56/7206	7.36953524931e-11
ko04974	Protein digestion and absorption	25/515	96/7206	7.87397678717e-09
ko04724	Glutamatergic synapse	31/515	152/7206	6.87209438868e-08
ko04721	Synaptic vesicle cycle	21/515	80/7206	1.08695085953e-07
ko04728	Dopaminergic synapse	34/515	185/7206	2.28635704647e-07
ko04151	PI3K-Akt signaling pathway	56/515	390/7206	2.82711501318e-07
ko04512	ECM-receptor interaction	20/515	79/7206	4.15733964885e-07
ko04080	Neuroactive ligand-receptor interaction	59/515	423/7206	4.39751013139e-07
ko04727	GABAergic synapse	24/515	110/7206	5.85384628376e-07
ko04725	Cholinergic synapse	30/515	160/7206	7.66253438234e-07
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	19/515	79/7206	1.88634289644e-06
ko04911	Insulin secretion	24/515	117/7206	1.90655201907e-06
ko04713	Circadian entrainment	26/515	136/7206	2.89245389404e-06
ko04360	Axon guidance	37/515	233/7206	3.29585271104e-06
ko04010	MAPK signaling pathway	45/515	321/7206	1.0672879071e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	17/515	74/7206	1.26966715731e-05
ko04260	Cardiac muscle contraction	20/515	98/7206	1.48720969731e-05
ko04261	Adrenergic signaling in cardiomyocytes	32/515	205/7206	2.27647571337e-05
ko04514	Cell adhesion molecules (CAMs)	23/515	130/7206	3.99170049813e-05
ko05164	Influenza A	1/515	167/7206	9.73072549431e-05
ko04964	Proximal tubule bicarbonate reclamation	9/515	29/7206	0.000124422543481
ko05031	Amphetamine addiction	17/515	91/7206	0.000203567815171
ko05410	Hypertrophic cardiomyopathy (HCM)	18/515	100/7206	0.000217518167271
ko05168	Herpes simplex infection	2/515	182/7206	0.000219392146848
ko04723	Retrograde endocannabinoid signaling	26/515	175/7206	0.000292851311927
ko04976	Bile secretion	15/515	80/7206	0.00045713012441
ko04120	Ubiquitin mediated proteolysis	1/515	138/7206	0.000668294948272
ko04060	Cytokine-cytokine receptor interaction	3/515	191/7206	0.000860719119374
ko05032	Morphine addiction	18/515	110/7206	0.00099347492122
ko04024	cAMP signaling pathway	35/515	279/7206	0.00119352718314
ko04978	Mineral absorption	9/515	40/7206	0.00167535810499
ko05030	Cocaine addiction	13/515	73/7206	0.00176844669138
ko05322	Systemic lupus erythematosus	2/515	151/7206	0.00201247043079
ko04726	Serotonergic synapse	20/515	137/7206	0.00205224490863
ko05162	Measles	1/515	120/7206	0.00210722026471
ko04921	Oxytocin signaling pathway	27/515	209/7206	0.00241422686445
ko05414	Dilated cardiomyopathy	17/515	112/7206	0.00257949356119
ko04961	Endocrine and other factor-regulated calcium reabsorption	11/515	59/7206	0.00269077317449
ko05203	Viral carcinogenesis	8/515	277/7206	0.00277199215963
ko05016	Huntington's disease	5/515	215/7206	0.00280744051808
ko03013	RNA transport	3/515	166/7206	0.00336713125177
ko00240	Pyrimidine metabolism	1/515	110/7206	0.00450950527489
ko04510	Focal adhesion	29/515	240/7206	0.00470811198331
ko04015	Rap1 signaling pathway	32/515	278/7206	0.00616090253416
ko04914	Progesterone-mediated oocyte maturation	1/515	104/7206	0.00657084967981
ko04621	NOD-like receptor signaling pathway	3/515	157/7206	0.00682750215019
ko04217	Necroptosis	4/515	178/7206	0.00720365163757
ko04960	Aldosterone-regulated sodium reabsorption	8/515	41/7206	0.00753281729825
ko04973	Carbohydrate digestion and absorption	8/515	42/7206	0.00873956745726
ko04141	Protein processing in endoplasmic reticulum	5/515	184/7206	0.0132404623448
ko04140	Autophagy - animal	4/515	164/7206	0.0133459106619
ko04540	Gap junction	17/515	128/7206	0.0135270963776
ko05416	Viral myocarditis	9/515	55/7206	0.0150210433018
ko05224	Breast cancer	21/515	174/7206	0.0162450139828
ko02024	Quorum sensing	4/515	15/7206	0.0186763613622
ko05218	Melanoma	12/515	85/7206	0.0188193648773
ko04657	IL-17 signaling pathway	1/515	87/7206	0.0202030815457
ko04142	Lysosome	4/515	151/7206	0.0247924299465
ko04971	Gastric acid secretion	13/515	98/7206	0.0273489178038
ko00350	Tyrosine metabolism	6/515	33/7206	0.0274010295219
ko04720	Long-term potentiation	13/515	99/7206	0.0286911472216
ko04138	Autophagy - yeast	1/515	81/7206	0.0292595938305
ko04022	cGMP-PKG signaling pathway	24/515	216/7206	0.0305507559373
ko04924	Renin secretion	12/515	86/7206	0.0311809616355
ko04916	Melanogenesis	17/515	142/7206	0.0314301443108
ko04211	Longevity regulating pathway	3/515	123/7206	0.0341563878114
ko00190	Oxidative phosphorylation	3/515	127/7206	0.0347555088245
ko04020	Calcium signaling pathway	28/515	265/7206	0.0376329735177
ko04932	Non-alcoholic fatty liver disease (NAFLD)	6/515	182/7206	0.0402425040256
ko05140	Leishmaniasis	1/515	75/7206	0.0423043485568
ko04611	Platelet activation	5/515	163/7206	0.0436483864387
ko04610	Complement and coagulation cascades	1/515	79/7206	0.043765275802
ko04970	Salivary secretion	12/515	95/7206	0.0442915780924