ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	203/1371	423/7206	1.81999309638e-44
ko05032	Morphine addiction	74/1371	110/7206	9.47579572137e-29
ko04724	Glutamatergic synapse	89/1371	152/7206	1.11103593641e-27
ko05033	Nicotine addiction	46/1371	56/7206	1.83802513106e-24
ko04727	GABAergic synapse	69/1371	110/7206	3.69067689617e-24
ko04713	Circadian entrainment	78/1371	136/7206	1.41943370269e-23
ko04723	Retrograde endocannabinoid signaling	83/1371	175/7206	5.57695028375e-18
ko04728	Dopaminergic synapse	85/1371	185/7206	3.21949407002e-17
ko04725	Cholinergic synapse	77/1371	160/7206	3.22563337622e-17
ko04020	Calcium signaling pathway	105/1371	265/7206	1.8293042545e-15
ko04911	Insulin secretion	59/1371	117/7206	1.24543283815e-14
ko04024	cAMP signaling pathway	107/1371	279/7206	1.69358488957e-14
ko04721	Synaptic vesicle cycle	44/1371	80/7206	6.01451695028e-13
ko04742	Taste transduction	37/1371	61/7206	7.15233781844e-13
ko04921	Oxytocin signaling pathway	82/1371	209/7206	5.25644353778e-12
ko04726	Serotonergic synapse	60/1371	137/7206	2.44554228352e-11
ko03040	Spliceosome	2/1371	145/7206	5.12901007749e-11
ko03010	Ribosome	1/1371	129/7206	7.32948012254e-11
ko05322	Systemic lupus erythematosus	4/1371	151/7206	1.4427390774e-09
ko03013	RNA transport	6/1371	166/7206	4.80450261984e-09
ko04970	Salivary secretion	43/1371	95/7206	5.57997125253e-09
ko04744	Phototransduction	22/1371	36/7206	2.91239570803e-08
ko04261	Adrenergic signaling in cardiomyocytes	72/1371	205/7206	3.51676161049e-08
ko05031	Amphetamine addiction	40/1371	91/7206	4.15585918985e-08
ko05203	Viral carcinogenesis	22/1371	277/7206	1.98526903934e-07
ko04022	cGMP-PKG signaling pathway	73/1371	216/7206	2.15268632362e-07
ko04925	Aldosterone synthesis and secretion	42/1371	105/7206	4.94962089704e-07
ko04971	Gastric acid secretion	40/1371	98/7206	6.91488043647e-07
ko05030	Cocaine addiction	31/1371	73/7206	3.32822516186e-06
ko04976	Bile secretion	33/1371	80/7206	4.14218049917e-06
ko04360	Axon guidance	73/1371	233/7206	5.45104407607e-06
ko05164	Influenza A	11/1371	167/7206	5.59247231383e-06
ko04072	Phospholipase D signaling pathway	63/1371	197/7206	1.19420045406e-05
ko04110	Cell cycle	9/1371	145/7206	1.43873306654e-05
ko04720	Long-term potentiation	37/1371	99/7206	1.5105472938e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1371	79/7206	1.74413755524e-05
ko04514	Cell adhesion molecules (CAMs)	45/1371	130/7206	2.23537717315e-05
ko04972	Pancreatic secretion	40/1371	111/7206	2.33792408997e-05
ko04740	Olfactory transduction	31/1371	80/7206	3.74171106924e-05
ko05168	Herpes simplex infection	15/1371	182/7206	7.36578609578e-05
ko04621	NOD-like receptor signaling pathway	12/1371	157/7206	7.9799440686e-05
ko05205	Proteoglycans in cancer	28/1371	271/7206	0.000100813387609
ko04010	MAPK signaling pathway	89/1371	321/7206	0.000106298485374
ko04923	Regulation of lipolysis in adipocytes	29/1371	77/7206	0.000110348295653
ko04060	Cytokine-cytokine receptor interaction	17/1371	191/7206	0.000116974080676
ko04612	Antigen processing and presentation	3/1371	77/7206	0.00018869698148
ko04961	Endocrine and other factor-regulated calcium reabsorption	23/1371	59/7206	0.000330292086029
ko04730	Long-term depression	28/1371	78/7206	0.000400455860934
ko04120	Ubiquitin mediated proteolysis	11/1371	138/7206	0.000402148816298
ko04924	Renin secretion	30/1371	86/7206	0.000453058603557
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1371	74/7206	0.000460177133362
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1371	79/7206	0.000475784307253
ko04710	Circadian rhythm	18/1371	43/7206	0.000564915293043
ko05133	Pertussis	5/1371	87/7206	0.000793087614197
ko04141	Protein processing in endoplasmic reticulum	18/1371	184/7206	0.000795755279962
ko04540	Gap junction	40/1371	128/7206	0.000868168657375
ko04711	Circadian rhythm - fly	8/1371	13/7206	0.000869158191617
ko05414	Dilated cardiomyopathy	36/1371	112/7206	0.000908781348461
ko03420	Nucleotide excision repair	1/1371	46/7206	0.0010884428298
ko05161	Hepatitis B	17/1371	173/7206	0.00113769709689
ko04964	Proximal tubule bicarbonate reclamation	13/1371	29/7206	0.00130579435484
ko04371	Apelin signaling pathway	51/1371	177/7206	0.00131101025195
ko05169	Epstein-Barr virus infection	22/1371	206/7206	0.00151840772827
ko00520	Amino sugar and nucleotide sugar metabolism	2/1371	55/7206	0.00153879405056
ko03022	Basal transcription factors	1/1371	44/7206	0.00165944426811
ko05144	Malaria	1/1371	45/7206	0.0017174816584
ko04014	Ras signaling pathway	74/1371	279/7206	0.00178815297464
ko04622	RIG-I-like receptor signaling pathway	3/1371	62/7206	0.00185793026709
ko04620	Toll-like receptor signaling pathway	8/1371	100/7206	0.00296335123839
ko04745	Phototransduction - fly	15/1371	38/7206	0.00301248937838
ko03018	RNA degradation	6/1371	84/7206	0.0031130721732
ko04142	Lysosome	15/1371	151/7206	0.00314146641664
ko04070	Phosphatidylinositol signaling system	34/1371	112/7206	0.00339846445591
ko04218	Cellular senescence	19/1371	177/7206	0.00346905515858
ko05131	Shigellosis	6/1371	82/7206	0.00433917882654
ko04115	p53 signaling pathway	5/1371	74/7206	0.00435005079482
ko05162	Measles	11/1371	120/7206	0.00453789025795
ko04750	Inflammatory mediator regulation of TRP channels	36/1371	122/7206	0.0049085659526
ko05219	Bladder cancer	2/1371	48/7206	0.00498720646205
ko04210	Apoptosis	20/1371	180/7206	0.00509789033165
ko04966	Collecting duct acid secretion	11/1371	26/7206	0.0052682778404
ko05321	Inflammatory bowel disease (IBD)	3/1371	56/7206	0.00567843237593
ko04657	IL-17 signaling pathway	7/1371	87/7206	0.00582647783787
ko05110	Vibrio cholerae infection	21/1371	63/7206	0.00588170890975
ko03410	Base excision repair	1/1371	38/7206	0.00590130589397
ko04260	Cardiac muscle contraction	30/1371	98/7206	0.00598077339433
ko04214	Apoptosis - fly	5/1371	72/7206	0.00612219709632
ko04270	Vascular smooth muscle contraction	43/1371	154/7206	0.00668609496594
ko05231	Choline metabolism in cancer	38/1371	134/7206	0.00749762708181
ko05150	Staphylococcus aureus infection	1/1371	36/7206	0.00901262310142
ko05140	Leishmaniasis	6/1371	75/7206	0.0114888530901
ko04217	Necroptosis	21/1371	178/7206	0.0116828716239
ko04922	Glucagon signaling pathway	36/1371	128/7206	0.011929719464
ko05016	Huntington's disease	27/1371	215/7206	0.0132880258279
ko05215	Prostate cancer	11/1371	111/7206	0.0140802789571
ko05410	Hypertrophic cardiomyopathy (HCM)	29/1371	100/7206	0.0143291865137
ko04660	T cell receptor signaling pathway	13/1371	124/7206	0.0147407493432
ko05166	HTLV-I infection	40/1371	292/7206	0.0180661920909
ko05418	Fluid shear stress and atherosclerosis	21/1371	173/7206	0.0183623483011
ko04113	Meiosis - yeast	6/1371	70/7206	0.0215515837471
ko05145	Toxoplasmosis	14/1371	126/7206	0.0215666302465
ko03015	mRNA surveillance pathway	9/1371	93/7206	0.0227362198253
ko00965	Betalain biosynthesis	3/1371	4/7206	0.0235821664752
ko00290	Valine, leucine and isoleucine biosynthesis	3/1371	4/7206	0.0235821664752
ko04930	Type II diabetes mellitus	17/1371	54/7206	0.0238942005729
ko00480	Glutathione metabolism	4/1371	55/7206	0.0239373866928
ko05416	Viral myocarditis	4/1371	55/7206	0.0239373866928
ko04630	Jak-STAT signaling pathway	15/1371	132/7206	0.0245489094186
ko04973	Carbohydrate digestion and absorption	14/1371	42/7206	0.0277238980188
ko05012	Parkinson's disease	19/1371	155/7206	0.0295352141402
ko04915	Estrogen signaling pathway	35/1371	131/7206	0.0319842602347
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1371	14/7206	0.0349600693597
ko04658	Th1 and Th2 cell differentiation	10/1371	96/7206	0.0350405986258
ko04064	NF-kappa B signaling pathway	10/1371	96/7206	0.0350405986258
ko00630	Glyoxylate and dicarboxylate metabolism	2/1371	38/7206	0.0351415348152
ko02010	ABC transporters	13/1371	39/7206	0.0374809734426
ko04918	Thyroid hormone synthesis	24/1371	86/7206	0.0385929575569
ko04978	Mineral absorption	13/1371	40/7206	0.0409864272572
ko04932	Non-alcoholic fatty liver disease (NAFLD)	24/1371	182/7206	0.0441970685626