ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	213/1348	423/7206	1.63101980134e-52
ko04724	Glutamatergic synapse	98/1348	152/7206	4.49902037624e-36
ko05032	Morphine addiction	75/1348	110/7206	3.1441145562e-30
ko04713	Circadian entrainment	84/1348	136/7206	4.78302819872e-29
ko05033	Nicotine addiction	49/1348	56/7206	6.09722895593e-29
ko04727	GABAergic synapse	70/1348	110/7206	1.67188058163e-25
ko04728	Dopaminergic synapse	91/1348	185/7206	1.63022491086e-21
ko04725	Cholinergic synapse	82/1348	160/7206	6.11261025779e-21
ko04020	Calcium signaling pathway	113/1348	265/7206	6.11228110309e-20
ko04723	Retrograde endocannabinoid signaling	84/1348	175/7206	4.46977801312e-19
ko04024	cAMP signaling pathway	114/1348	279/7206	1.79679088455e-18
ko04721	Synaptic vesicle cycle	49/1348	80/7206	3.40587409415e-17
ko04726	Serotonergic synapse	67/1348	137/7206	5.7467914235e-16
ko04911	Insulin secretion	57/1348	117/7206	1.11768647709e-13
ko04921	Oxytocin signaling pathway	84/1348	209/7206	2.10406531431e-13
ko05031	Amphetamine addiction	48/1348	91/7206	2.24278215609e-13
ko04744	Phototransduction	27/1348	36/7206	2.89769263852e-13
ko04742	Taste transduction	36/1348	61/7206	2.76558133626e-12
ko04720	Long-term potentiation	48/1348	99/7206	1.25557026314e-11
ko04970	Salivary secretion	46/1348	95/7206	3.57654397809e-11
ko03040	Spliceosome	2/1348	145/7206	8.40251921978e-11
ko03010	Ribosome	1/1348	129/7206	1.2390326113e-10
ko04261	Adrenergic signaling in cardiomyocytes	76/1348	205/7206	4.32964811e-10
ko04022	cGMP-PKG signaling pathway	78/1348	216/7206	8.16784285116e-10
ko04925	Aldosterone synthesis and secretion	47/1348	105/7206	9.43561008434e-10
ko05322	Systemic lupus erythematosus	4/1348	151/7206	2.30500790066e-09
ko04070	Phosphatidylinositol signaling system	46/1348	112/7206	2.91513534633e-08
ko05030	Cocaine addiction	34/1348	73/7206	4.52438440646e-08
ko03013	RNA transport	8/1348	166/7206	1.74214760571e-07
ko04971	Gastric acid secretion	40/1348	98/7206	2.99842404115e-07
ko04072	Phospholipase D signaling pathway	65/1348	197/7206	1.09365250414e-06
ko04730	Long-term depression	32/1348	78/7206	5.34151254591e-06
ko05203	Viral carcinogenesis	25/1348	277/7206	6.6052838182e-06
ko04110	Cell cycle	8/1348	145/7206	7.09140469144e-06
ko04740	Olfactory transduction	32/1348	80/7206	8.08408010345e-06
ko05168	Herpes simplex infection	13/1348	182/7206	1.16930155215e-05
ko04972	Pancreatic secretion	40/1348	111/7206	1.27522064306e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1348	74/7206	1.34482293488e-05
ko04360	Axon guidance	70/1348	233/7206	2.38809264141e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1348	79/7206	2.85373758524e-05
ko04141	Protein processing in endoplasmic reticulum	14/1348	184/7206	3.08924360722e-05
ko04750	Inflammatory mediator regulation of TRP channels	42/1348	122/7206	3.11923371642e-05
ko04270	Vascular smooth muscle contraction	50/1348	154/7206	3.66859522997e-05
ko04014	Ras signaling pathway	80/1348	279/7206	4.0894086491e-05
ko04745	Phototransduction - fly	18/1348	38/7206	5.21342486375e-05
ko04924	Renin secretion	32/1348	86/7206	6.4307859734e-05
ko04060	Cytokine-cytokine receptor interaction	16/1348	191/7206	7.04045021886e-05
ko04923	Regulation of lipolysis in adipocytes	29/1348	77/7206	8.88125103212e-05
ko04010	MAPK signaling pathway	88/1348	321/7206	9.56115040827e-05
ko04710	Circadian rhythm	19/1348	43/7206	0.00010594844363
ko04540	Gap junction	42/1348	128/7206	0.000128365495279
ko04966	Collecting duct acid secretion	13/1348	26/7206	0.00029643008452
ko00520	Amino sugar and nucleotide sugar metabolism	1/1348	55/7206	0.000334974130691
ko04514	Cell adhesion molecules (CAMs)	41/1348	130/7206	0.000378182161691
ko04915	Estrogen signaling pathway	41/1348	131/7206	0.000418715450093
ko04976	Bile secretion	28/1348	80/7206	0.000460504667147
ko04930	Type II diabetes mellitus	21/1348	54/7206	0.00059025967459
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1348	59/7206	0.000667380634842
ko05231	Choline metabolism in cancer	41/1348	134/7206	0.000734079018293
ko04960	Aldosterone-regulated sodium reabsorption	17/1348	41/7206	0.000804839420877
ko04621	NOD-like receptor signaling pathway	14/1348	157/7206	0.000852932527733
ko04371	Apelin signaling pathway	51/1348	177/7206	0.000858064027143
ko05169	Epstein-Barr virus infection	21/1348	206/7206	0.00102560671948
ko04120	Ubiquitin mediated proteolysis	12/1348	138/7206	0.00131451335377
ko05164	Influenza A	16/1348	167/7206	0.00171137443564
ko03420	Nucleotide excision repair	1/1348	46/7206	0.00178246625602
ko05110	Vibrio cholerae infection	22/1348	63/7206	0.00188844339324
ko04922	Glucagon signaling pathway	38/1348	128/7206	0.00268666354428
ko03022	Basal transcription factors	1/1348	44/7206	0.00275461391434
ko04622	RIG-I-like receptor signaling pathway	3/1348	62/7206	0.0027699324343
ko04612	Antigen processing and presentation	5/1348	77/7206	0.00315166463868
ko04912	GnRH signaling pathway	36/1348	122/7206	0.00326125006069
ko04711	Circadian rhythm - fly	7/1348	13/7206	0.00471298576726
ko05414	Dilated cardiomyopathy	33/1348	112/7206	0.00483714849452
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	25/1348	79/7206	0.00534593005265
ko03410	Base excision repair	1/1348	38/7206	0.00592228780209
ko05162	Measles	11/1348	120/7206	0.00618773040008
ko05133	Pertussis	7/1348	87/7206	0.00810399355117
ko00280	Valine, leucine and isoleucine degradation	3/1348	54/7206	0.0083354605801
ko04973	Carbohydrate digestion and absorption	15/1348	42/7206	0.00859903538656
ko04672	Intestinal immune network for IgA production	1/1348	37/7206	0.00933963953813
ko04626	Plant-pathogen interaction	8/1348	18/7206	0.0108147193904
ko05144	Malaria	2/1348	45/7206	0.0111904317146
ko04630	Jak-STAT signaling pathway	14/1348	132/7206	0.0131722390814
ko05161	Hepatitis B	20/1348	173/7206	0.0133688029723
ko00562	Inositol phosphate metabolism	26/1348	89/7206	0.0137026869653
ko04964	Proximal tubule bicarbonate reclamation	11/1348	29/7206	0.0143926009134
ko04217	Necroptosis	21/1348	178/7206	0.0148381313568
ko05131	Shigellosis	7/1348	82/7206	0.0149679394017
ko04142	Lysosome	17/1348	151/7206	0.015220728176
ko04115	p53 signaling pathway	6/1348	74/7206	0.0159667951036
ko04064	NF-kappa B signaling pathway	9/1348	96/7206	0.0170481875949
ko05166	HTLV-I infection	39/1348	292/7206	0.0172877054124
ko04213	Longevity regulating pathway - multiple species	25/1348	86/7206	0.0175556120519
ko04918	Thyroid hormone synthesis	25/1348	86/7206	0.0175556120519
ko00240	Pyrimidine metabolism	11/1348	110/7206	0.0184843169998
ko04657	IL-17 signaling pathway	8/1348	87/7206	0.0186119718312
ko05016	Huntington's disease	27/1348	215/7206	0.0205469441332
ko00965	Betalain biosynthesis	3/1348	4/7206	0.0224768737797
ko00480	Glutathione metabolism	4/1348	55/7206	0.02421123422
ko05416	Viral myocarditis	4/1348	55/7206	0.02421123422
ko05321	Inflammatory bowel disease (IBD)	4/1348	56/7206	0.0242240629901
ko04666	Fc gamma R-mediated phagocytosis	33/1348	122/7206	0.025237330357
ko05130	Pathogenic Escherichia coli infection	7/1348	77/7206	0.0272022354048
ko04062	Chemokine signaling pathway	50/1348	201/7206	0.0273860802849
ko05145	Toxoplasmosis	14/1348	126/7206	0.0279348122539
ko05214	Glioma	23/1348	79/7206	0.0281217934523
ko04916	Melanogenesis	37/1348	142/7206	0.0291787454488
ko04113	Meiosis - yeast	6/1348	70/7206	0.029830051504
ko04330	Notch signaling pathway	5/1348	62/7206	0.0320868437866
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1348	14/7206	0.0323842626927
ko03018	RNA degradation	8/1348	84/7206	0.0334696379977
ko04932	Non-alcoholic fatty liver disease (NAFLD)	23/1348	182/7206	0.0338619413395
ko00630	Glyoxylate and dicarboxylate metabolism	2/1348	38/7206	0.0346016435079
ko00071	Fatty acid degradation	3/1348	45/7206	0.034686026819
ko04658	Th1 and Th2 cell differentiation	10/1348	96/7206	0.0347723216095
ko04260	Cardiac muscle contraction	27/1348	98/7206	0.035675016546
ko02010	ABC transporters	13/1348	39/7206	0.0361801484031
ko05202	Transcriptional misregulation in cancer	24/1348	188/7206	0.0365978655522
ko00564	Glycerophospholipid metabolism	27/1348	99/7206	0.0367880633876
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1348	100/7206	0.0383458194817
ko05217	Basal cell carcinoma	6/1348	68/7206	0.0405950739151
ko05200	Pathways in cancer	75/1348	492/7206	0.0416960627636
ko03015	mRNA surveillance pathway	10/1348	93/7206	0.0452373669284
ko05205	Proteoglycans in cancer	38/1348	271/7206	0.0468249818773
ko04214	Apoptosis - fly	7/1348	72/7206	0.0485043161051
ko00310	Lysine degradation	7/1348	73/7206	0.0487147681412
ko04015	Rap1 signaling pathway	65/1348	278/7206	0.0494778575192
ko00230	Purine metabolism	47/1348	194/7206	0.0499207931425