ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	187/1130	423/7206	1.73221381706e-47
ko04724	Glutamatergic synapse	85/1130	152/7206	8.78501881517e-31
ko05033	Nicotine addiction	46/1130	56/7206	3.17539317303e-28
ko04713	Circadian entrainment	73/1130	136/7206	4.63850661969e-25
ko05032	Morphine addiction	64/1130	110/7206	1.02553096238e-24
ko04727	GABAergic synapse	62/1130	110/7206	5.91332195522e-23
ko04721	Synaptic vesicle cycle	50/1130	80/7206	1.67871220699e-21
ko04728	Dopaminergic synapse	82/1130	185/7206	6.14770295249e-21
ko04725	Cholinergic synapse	74/1130	160/7206	2.53116052088e-20
ko04723	Retrograde endocannabinoid signaling	75/1130	175/7206	3.34893533873e-18
ko04911	Insulin secretion	58/1130	117/7206	5.94327393029e-18
ko04020	Calcium signaling pathway	96/1130	265/7206	6.98650348598e-17
ko04024	cAMP signaling pathway	99/1130	279/7206	1.12728307994e-16
ko04726	Serotonergic synapse	60/1130	137/7206	2.56647740132e-15
ko04921	Oxytocin signaling pathway	77/1130	209/7206	3.65720426081e-14
ko04742	Taste transduction	34/1130	61/7206	5.9390092962e-13
ko05031	Amphetamine addiction	41/1130	91/7206	2.37286164786e-11
ko04720	Long-term potentiation	43/1130	99/7206	3.41904275925e-11
ko04970	Salivary secretion	41/1130	95/7206	1.25595808145e-10
ko04261	Adrenergic signaling in cardiomyocytes	67/1130	205/7206	9.80419886265e-10
ko04744	Phototransduction	21/1130	36/7206	5.5446952834e-09
ko03040	Spliceosome	2/1130	145/7206	1.03029213897e-08
ko03010	Ribosome	1/1130	129/7206	1.08941150031e-08
ko04925	Aldosterone synthesis and secretion	40/1130	105/7206	1.69458654884e-08
ko04971	Gastric acid secretion	38/1130	98/7206	2.20234833712e-08
ko04740	Olfactory transduction	33/1130	80/7206	3.1748600129e-08
ko05203	Viral carcinogenesis	14/1130	277/7206	4.3224836543e-08
ko05322	Systemic lupus erythematosus	4/1130	151/7206	3.27805132141e-07
ko04060	Cytokine-cytokine receptor interaction	8/1130	191/7206	8.17088114127e-07
ko04022	cGMP-PKG signaling pathway	62/1130	216/7206	8.55449775694e-07
ko04972	Pancreatic secretion	38/1130	111/7206	1.06526691634e-06
ko05168	Herpes simplex infection	8/1130	182/7206	2.3264825337e-06
ko03013	RNA transport	7/1130	166/7206	4.14947873518e-06
ko04730	Long-term depression	29/1130	78/7206	4.35910297522e-06
ko04514	Cell adhesion molecules (CAMs)	41/1130	130/7206	4.50878040372e-06
ko04360	Axon guidance	63/1130	233/7206	5.90725050397e-06
ko04010	MAPK signaling pathway	81/1130	321/7206	6.32371445551e-06
ko04966	Collecting duct acid secretion	14/1130	26/7206	7.56064722108e-06
ko05030	Cocaine addiction	27/1130	73/7206	1.05794707266e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1130	74/7206	1.23759498623e-05
ko05110	Vibrio cholerae infection	24/1130	63/7206	1.24573155004e-05
ko04621	NOD-like receptor signaling pathway	7/1130	157/7206	1.78345784978e-05
ko04745	Phototransduction - fly	17/1130	38/7206	2.00356341914e-05
ko04070	Phosphatidylinositol signaling system	35/1130	112/7206	3.26787005947e-05
ko05164	Influenza A	9/1130	167/7206	5.52777933187e-05
ko04540	Gap junction	38/1130	128/7206	6.28583599417e-05
ko04976	Bile secretion	27/1130	80/7206	6.44848005846e-05
ko04110	Cell cycle	7/1130	145/7206	6.96666111375e-05
ko04750	Inflammatory mediator regulation of TRP channels	36/1130	122/7206	0.000123473372293
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1130	79/7206	0.000124779226844
ko04141	Protein processing in endoplasmic reticulum	12/1130	184/7206	0.000196517718738
ko04924	Renin secretion	27/1130	86/7206	0.00024614023423
ko03008	Ribosome biogenesis in eukaryotes	2/1130	79/7206	0.000266530053769
ko04072	Phospholipase D signaling pathway	50/1130	197/7206	0.00032477210737
ko04014	Ras signaling pathway	66/1130	279/7206	0.000390262718845
ko04612	Antigen processing and presentation	2/1130	77/7206	0.000397975138415
ko04260	Cardiac muscle contraction	29/1130	98/7206	0.000405456744501
ko05169	Epstein-Barr virus infection	15/1130	206/7206	0.00041559304271
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1130	59/7206	0.000453863295266
ko04120	Ubiquitin mediated proteolysis	8/1130	138/7206	0.000536251513902
ko05414	Dilated cardiomyopathy	31/1130	112/7206	0.000968739300124
ko04610	Complement and coagulation cascades	3/1130	79/7206	0.00156816047501
ko05161	Hepatitis B	13/1130	173/7206	0.0019738161462
ko04710	Circadian rhythm	15/1130	43/7206	0.00216990221584
ko04915	Estrogen signaling pathway	34/1130	131/7206	0.00221352661051
ko04064	NF-kappa B signaling pathway	5/1130	96/7206	0.00265972987155
ko04964	Proximal tubule bicarbonate reclamation	11/1130	29/7206	0.00302763661229
ko05140	Leishmaniasis	3/1130	75/7206	0.00341720834773
ko04630	Jak-STAT signaling pathway	9/1130	132/7206	0.00342433834569
ko04626	Plant-pathogen interaction	8/1130	18/7206	0.00357833365692
ko04371	Apelin signaling pathway	42/1130	177/7206	0.00451215567291
ko05166	HTLV-I infection	29/1130	292/7206	0.0050562268415
ko04922	Glucagon signaling pathway	32/1130	128/7206	0.00645862913671
ko03420	Nucleotide excision repair	1/1130	46/7206	0.00693007419984
ko04657	IL-17 signaling pathway	5/1130	87/7206	0.00714166961615
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1130	100/7206	0.00780350430739
ko05205	Proteoglycans in cancer	27/1130	271/7206	0.00804395336933
ko05321	Inflammatory bowel disease (IBD)	2/1130	56/7206	0.00865829716395
ko04960	Aldosterone-regulated sodium reabsorption	13/1130	41/7206	0.00870114822762
ko04350	TGF-beta signaling pathway	7/1130	103/7206	0.00921222580188
ko03022	Basal transcription factors	1/1130	44/7206	0.0106251153873
ko05162	Measles	9/1130	120/7206	0.0108452415192
ko04912	GnRH signaling pathway	30/1130	122/7206	0.0112888959594
ko04217	Necroptosis	16/1130	178/7206	0.0118449036166
ko04330	Notch signaling pathway	3/1130	62/7206	0.0134965434115
ko04622	RIG-I-like receptor signaling pathway	3/1130	62/7206	0.0134965434115
ko04640	Hematopoietic cell lineage	3/1130	64/7206	0.0140565107585
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1130	14/7206	0.0141927242243
ko04973	Carbohydrate digestion and absorption	13/1130	42/7206	0.0164275404893
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1130	182/7206	0.0170514857457
ko04923	Regulation of lipolysis in adipocytes	20/1130	77/7206	0.0174787474655
ko04146	Peroxisome	6/1130	89/7206	0.0179801138911
ko04270	Vascular smooth muscle contraction	35/1130	154/7206	0.0185011018496
ko03320	PPAR signaling pathway	4/1130	69/7206	0.0192463779004
ko00330	Arginine and proline metabolism	3/1130	61/7206	0.0196937925099
ko04930	Type II diabetes mellitus	15/1130	54/7206	0.0222429379004
ko04658	Th1 and Th2 cell differentiation	7/1130	96/7206	0.0226924640732
ko03410	Base excision repair	1/1130	38/7206	0.0229690560493
ko05133	Pertussis	6/1130	87/7206	0.0246779270177
ko05219	Bladder cancer	2/1130	48/7206	0.0263490677428
ko04015	Rap1 signaling pathway	57/1130	278/7206	0.0284719891403
ko05131	Shigellosis	6/1130	82/7206	0.032507654846
ko03018	RNA degradation	6/1130	84/7206	0.0330519918519
ko00240	Pyrimidine metabolism	9/1130	110/7206	0.0332326429292
ko04114	Oocyte meiosis	31/1130	139/7206	0.0340624462304
ko00310	Lysine degradation	5/1130	73/7206	0.0348953069528
ko04918	Thyroid hormone synthesis	21/1130	86/7206	0.035176654638
ko04115	p53 signaling pathway	5/1130	74/7206	0.0352125050431
ko04210	Apoptosis	18/1130	180/7206	0.0371498733995
ko00071	Fatty acid degradation	2/1130	45/7206	0.0376669990618
ko00280	Valine, leucine and isoleucine degradation	3/1130	54/7206	0.0379715696021
ko00480	Glutathione metabolism	3/1130	55/7206	0.03845989725
ko05222	Small cell lung cancer	7/1130	89/7206	0.0397249064602
ko04711	Circadian rhythm - fly	5/1130	13/7206	0.0404274240598
ko05231	Choline metabolism in cancer	30/1130	134/7206	0.0404747610251
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1130	92/7206	0.0416670713466
ko02010	ABC transporters	11/1130	39/7206	0.0436724648852
ko05016	Huntington's disease	23/1130	215/7206	0.0449642980139
ko04916	Melanogenesis	31/1130	142/7206	0.0472651676263
ko04214	Apoptosis - fly	5/1130	72/7206	0.0484400438513
ko05215	Prostate cancer	10/1130	111/7206	0.0489549635402
ko01200	Carbon metabolism	12/1130	128/7206	0.049232863169