ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	189/1114	423/7206	6.82933712077e-50
ko05033	Nicotine addiction	49/1114	56/7206	5.78315447981e-33
ko04724	Glutamatergic synapse	83/1114	152/7206	1.55648790037e-29
ko05032	Morphine addiction	62/1114	110/7206	2.69695543835e-23
ko04713	Circadian entrainment	69/1114	136/7206	3.0104854701e-22
ko04727	GABAergic synapse	60/1114	110/7206	1.38642169445e-21
ko04728	Dopaminergic synapse	75/1114	185/7206	6.43689390752e-17
ko04723	Retrograde endocannabinoid signaling	72/1114	175/7206	1.06884156102e-16
ko04742	Taste transduction	37/1114	61/7206	8.00294459996e-16
ko04725	Cholinergic synapse	66/1114	160/7206	1.81519267094e-15
ko04744	Phototransduction	26/1114	36/7206	3.39937193338e-14
ko04024	cAMP signaling pathway	92/1114	279/7206	1.37349364113e-13
ko04721	Synaptic vesicle cycle	40/1114	80/7206	3.89966179207e-13
ko04726	Serotonergic synapse	56/1114	137/7206	4.149780128e-13
ko04020	Calcium signaling pathway	85/1114	265/7206	4.67148633429e-12
ko04740	Olfactory transduction	38/1114	80/7206	1.14326457096e-11
ko04911	Insulin secretion	48/1114	117/7206	1.73901591749e-11
ko04921	Oxytocin signaling pathway	69/1114	209/7206	1.4999122624e-10
ko05203	Viral carcinogenesis	11/1114	277/7206	9.00202893312e-10
ko04970	Salivary secretion	38/1114	95/7206	5.34165536164e-09
ko04261	Adrenergic signaling in cardiomyocytes	64/1114	205/7206	1.03195988935e-08
ko03040	Spliceosome	2/1114	145/7206	1.66948096513e-08
ko05031	Amphetamine addiction	36/1114	91/7206	1.91066190131e-08
ko04120	Ubiquitin mediated proteolysis	2/1114	138/7206	3.6708034966e-08
ko04720	Long-term potentiation	36/1114	99/7206	2.92099220135e-07
ko04976	Bile secretion	31/1114	80/7206	3.2151785732e-07
ko05030	Cocaine addiction	29/1114	73/7206	4.14958980436e-07
ko04972	Pancreatic secretion	38/1114	111/7206	8.09161355306e-07
ko05164	Influenza A	6/1114	167/7206	1.20347592204e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1114	74/7206	2.08970941028e-06
ko05168	Herpes simplex infection	8/1114	182/7206	3.40939130393e-06
ko04060	Cytokine-cytokine receptor interaction	9/1114	191/7206	3.73072050959e-06
ko05162	Measles	3/1114	120/7206	5.17533365664e-06
ko03013	RNA transport	7/1114	166/7206	6.08683029024e-06
ko04260	Cardiac muscle contraction	33/1114	98/7206	6.58758388538e-06
ko04971	Gastric acid secretion	33/1114	98/7206	6.58758388538e-06
ko05169	Epstein-Barr virus infection	11/1114	206/7206	8.29568827261e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1114	79/7206	1.0754811864e-05
ko04925	Aldosterone synthesis and secretion	34/1114	105/7206	1.42582171382e-05
ko04621	NOD-like receptor signaling pathway	7/1114	157/7206	1.76336817967e-05
ko05166	HTLV-I infection	21/1114	292/7206	2.14241926753e-05
ko04514	Cell adhesion molecules (CAMs)	39/1114	130/7206	2.23457874339e-05
ko04964	Proximal tubule bicarbonate reclamation	14/1114	29/7206	3.23541359386e-05
ko04974	Protein digestion and absorption	31/1114	96/7206	4.21890587313e-05
ko04110	Cell cycle	7/1114	145/7206	0.000101472063568
ko05161	Hepatitis B	10/1114	173/7206	0.000109985669554
ko04141	Protein processing in endoplasmic reticulum	11/1114	184/7206	0.000110909676807
ko04022	cGMP-PKG signaling pathway	55/1114	216/7206	0.000113627690973
ko04978	Mineral absorption	16/1114	40/7206	0.000151023077597
ko04730	Long-term depression	25/1114	78/7206	0.000208631778927
ko04010	MAPK signaling pathway	74/1114	321/7206	0.000258848036475
ko04745	Phototransduction - fly	15/1114	38/7206	0.000287930090456
ko04932	Non-alcoholic fatty liver disease (NAFLD)	12/1114	182/7206	0.000367444843943
ko05205	Proteoglycans in cancer	22/1114	271/7206	0.00040668803939
ko03008	Ribosome biogenesis in eukaryotes	2/1114	79/7206	0.000418497546293
ko04540	Gap junction	35/1114	128/7206	0.000475807859882
ko05322	Systemic lupus erythematosus	9/1114	151/7206	0.000553998799683
ko04064	NF-kappa B signaling pathway	4/1114	96/7206	0.000890351448965
ko04924	Renin secretion	25/1114	86/7206	0.00131886874453
ko04668	TNF signaling pathway	7/1114	120/7206	0.00199333131941
ko00520	Amino sugar and nucleotide sugar metabolism	1/1114	55/7206	0.00211192794818
ko05414	Dilated cardiomyopathy	30/1114	112/7206	0.00212899718188
ko04750	Inflammatory mediator regulation of TRP channels	32/1114	122/7206	0.00214905002773
ko04657	IL-17 signaling pathway	4/1114	87/7206	0.00253187915402
ko04218	Cellular senescence	14/1114	177/7206	0.00313759552184
ko04961	Endocrine and other factor-regulated calcium reabsorption	18/1114	59/7206	0.00316915256679
ko04630	Jak-STAT signaling pathway	9/1114	132/7206	0.00341224365421
ko03018	RNA degradation	4/1114	84/7206	0.00357894368367
ko05220	Chronic myeloid leukemia	4/1114	85/7206	0.00363329020398
ko04330	Notch signaling pathway	2/1114	62/7206	0.00409289753098
ko04142	Lysosome	11/1114	151/7206	0.00411939475646
ko05219	Bladder cancer	1/1114	48/7206	0.00462099949506
ko04214	Apoptosis - fly	3/1114	72/7206	0.00473307225493
ko00310	Lysine degradation	3/1114	73/7206	0.00487839154399
ko05215	Prostate cancer	7/1114	111/7206	0.00506663077042
ko04140	Autophagy - animal	13/1114	164/7206	0.00594575781831
ko04217	Necroptosis	15/1114	178/7206	0.00626575129621
ko03420	Nucleotide excision repair	1/1114	46/7206	0.00690907407942
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1114	100/7206	0.00739643511122
ko04660	T cell receptor signaling pathway	9/1114	124/7206	0.00819933106286
ko05321	Inflammatory bowel disease (IBD)	2/1114	56/7206	0.00863176076648
ko04150	mTOR signaling pathway	16/1114	184/7206	0.0094081245968
ko05016	Huntington's disease	20/1114	215/7206	0.00951800447929
ko05211	Renal cell carcinoma	6/1114	96/7206	0.00981057106424
ko04658	Th1 and Th2 cell differentiation	6/1114	96/7206	0.00981057106424
ko05140	Leishmaniasis	4/1114	75/7206	0.00998577825234
ko05418	Fluid shear stress and atherosclerosis	15/1114	173/7206	0.0103739694758
ko03022	Basal transcription factors	1/1114	44/7206	0.0104608841742
ko05144	Malaria	1/1114	45/7206	0.0109429397724
ko04210	Apoptosis	16/1114	180/7206	0.0118965908869
ko04350	TGF-beta signaling pathway	7/1114	103/7206	0.0126915139446
ko00290	Valine, leucine and isoleucine biosynthesis	3/1114	4/7206	0.0130392364076
ko00561	Glycerolipid metabolism	3/1114	63/7206	0.0136137316285
ko05131	Shigellosis	5/1114	82/7206	0.013760822867
ko04137	Mitophagy - animal	5/1114	82/7206	0.013760822867
ko04115	p53 signaling pathway	4/1114	74/7206	0.0141525317856
ko04933	AGE-RAGE signaling pathway in diabetic complications	11/1114	135/7206	0.0157643627401
ko04923	Regulation of lipolysis in adipocytes	20/1114	77/7206	0.0162570967325
ko04620	Toll-like receptor signaling pathway	7/1114	100/7206	0.0170191428075
ko04146	Peroxisome	6/1114	89/7206	0.0179855704005
ko04113	Meiosis - yeast	4/1114	70/7206	0.019396238765
ko00330	Arginine and proline metabolism	3/1114	61/7206	0.0194216560624
ko04622	RIG-I-like receptor signaling pathway	3/1114	62/7206	0.0199333191335
ko04930	Type II diabetes mellitus	15/1114	54/7206	0.0210430527268
ko04550	Signaling pathways regulating pluripotency of stem cells	15/1114	165/7206	0.0216167341703
ko04341	Hedgehog signaling pathway - fly	1/1114	38/7206	0.0229160278494
ko04612	Antigen processing and presentation	5/1114	77/7206	0.0258192558827
ko05217	Basal cell carcinoma	4/1114	68/7206	0.0270755859355
ko00830	Retinol metabolism	12/1114	42/7206	0.0292274936356
ko03015	mRNA surveillance pathway	7/1114	93/7206	0.0301274904333
ko00680	Methane metabolism	10/1114	34/7206	0.0319654162199
ko05212	Pancreatic cancer	6/1114	83/7206	0.0327470532033
ko00240	Pyrimidine metabolism	9/1114	110/7206	0.0327982485799
ko00500	Starch and sucrose metabolism	1/1114	35/7206	0.0339679897999
ko05145	Toxoplasmosis	11/1114	126/7206	0.0341240828412
ko01524	Platinum drug resistance	5/1114	76/7206	0.0361506181468
ko04640	Hematopoietic cell lineage	4/1114	64/7206	0.0371058732986
ko00071	Fatty acid degradation	2/1114	45/7206	0.0376432597077
ko04915	Estrogen signaling pathway	29/1114	131/7206	0.0379101735764
ko00280	Valine, leucine and isoleucine degradation	3/1114	54/7206	0.0382849037528
ko05200	Pathways in cancer	60/1114	492/7206	0.0385951846087
ko04512	ECM-receptor interaction	19/1114	79/7206	0.0411191505832
ko04138	Autophagy - yeast	6/1114	81/7206	0.0438205346584
ko04072	Phospholipase D signaling pathway	41/1114	197/7206	0.0448935407322
ko00564	Glycerophospholipid metabolism	8/1114	99/7206	0.0484154326339
ko04966	Collecting duct acid secretion	8/1114	26/7206	0.0499659352308