ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 43/383 191/7206 1.539278379e-16 ko04621 NOD-like receptor signaling pathway 35/383 157/7206 1.65083855426e-13 ko04650 Natural killer cell mediated cytotoxicity 26/383 97/7206 2.73860466281e-12 ko05340 Primary immunodeficiency 15/383 30/7206 4.35358556139e-12 ko05164 Influenza A 32/383 167/7206 1.3451666145e-10 ko05162 Measles 26/383 120/7206 4.79507163426e-10 ko05140 Leishmaniasis 20/383 75/7206 1.06956183158e-09 ko04380 Osteoclast differentiation 27/383 134/7206 1.23482418883e-09 ko05145 Toxoplasmosis 26/383 126/7206 1.47377512106e-09 ko04612 Antigen processing and presentation 20/383 77/7206 1.77671734536e-09 ko04659 Th17 cell differentiation 23/383 106/7206 4.8198584351e-09 ko05320 Autoimmune thyroid disease 12/383 29/7206 9.77230709327e-09 ko05330 Allograft rejection 11/383 24/7206 1.10777436275e-08 ko04217 Necroptosis 30/383 178/7206 1.24790067066e-08 ko05150 Staphylococcus aureus infection 13/383 36/7206 1.66912095935e-08 ko05321 Inflammatory bowel disease (IBD) 16/383 56/7206 1.74858957592e-08 ko05168 Herpes simplex infection 30/383 182/7206 2.12010312748e-08 ko05152 Tuberculosis 30/383 187/7206 4.01385332362e-08 ko04630 Jak-STAT signaling pathway 24/383 132/7206 8.5381946664e-08 ko05332 Graft-versus-host disease 9/383 18/7206 9.78298994801e-08 ko04672 Intestinal immune network for IgA production 12/383 37/7206 2.36501995692e-07 ko04660 T cell receptor signaling pathway 22/383 124/7206 4.65279250629e-07 ko04658 Th1 and Th2 cell differentiation 19/383 96/7206 4.99972303151e-07 ko04064 NF-kappa B signaling pathway 19/383 96/7206 4.99972303151e-07 ko04620 Toll-like receptor signaling pathway 19/383 100/7206 9.67785954056e-07 ko04062 Chemokine signaling pathway 28/383 201/7206 2.24187778833e-06 ko05167 Kaposi's sarcoma-associated herpesvirus infection 26/383 191/7206 7.99540297329e-06 ko04640 Hematopoietic cell lineage 13/383 64/7206 2.43031864739e-05 ko04940 Type I diabetes mellitus 9/383 32/7206 2.89867331854e-05 ko04622 RIG-I-like receptor signaling pathway 12/383 62/7206 8.22683181492e-05 ko05144 Malaria 10/383 45/7206 9.56165096478e-05 ko04145 Phagosome 21/383 162/7206 0.000123188836237 ko05310 Asthma 6/383 17/7206 0.000162572693838 ko05133 Pertussis 14/383 87/7206 0.000175010825853 ko04662 B cell receptor signaling pathway 14/383 88/7206 0.00019826695623 ko05323 Rheumatoid arthritis 14/383 89/7206 0.000224139570078 ko00120 Primary bile acid biosynthesis 6/383 20/7206 0.00044431592765 ko03050 Proteasome 10/383 54/7206 0.000467359609226 ko05142 Chagas disease (American trypanosomiasis) 17/383 130/7206 0.000486184312081 ko04611 Platelet activation 20/383 163/7206 0.000497078806692 ko04610 Complement and coagulation cascades 12/383 79/7206 0.00086110694765 ko05161 Hepatitis B 20/383 173/7206 0.000881863910747 ko04310 Wnt signaling pathway 1/383 181/7206 0.0010884044925 ko04623 Cytosolic DNA-sensing pathway 8/383 41/7206 0.00120346511137 ko05034 Alcoholism 3/383 238/7206 0.00178488949514 ko04664 Fc epsilon RI signaling pathway 11/383 77/7206 0.00232851215924 ko04530 Tight junction 3/383 228/7206 0.00251469007221 ko04360 Axon guidance 3/383 233/7206 0.00256241102144 ko04666 Fc gamma R-mediated phagocytosis 15/383 122/7206 0.00314345237915 ko04390 Hippo signaling pathway 2/383 188/7206 0.00438163464226 ko04514 Cell adhesion molecules (CAMs) 15/383 130/7206 0.00438831175216 ko00980 Metabolism of xenobiotics by cytochrome P450 7/383 40/7206 0.00461080805044 ko00590 Arachidonic acid metabolism 8/383 52/7206 0.00569378614131 ko05206 MicroRNAs in cancer 2/383 177/7206 0.00611885608184 ko04916 Melanogenesis 1/383 142/7206 0.00704265750476 ko03040 Spliceosome 1/383 145/7206 0.00733664159069 ko05416 Viral myocarditis 8/383 55/7206 0.008022715411 ko05224 Breast cancer 2/383 174/7206 0.00898589935852 ko05160 Hepatitis C 16/383 153/7206 0.00918376254821 ko04152 AMPK signaling pathway 2/383 161/7206 0.01230248926 ko00982 Drug metabolism - cytochrome P450 6/383 37/7206 0.0124173453157 ko05204 Chemical carcinogenesis 7/383 48/7206 0.0126603023326 ko03010 Ribosome 1/383 129/7206 0.0151669802319 ko04670 Leukocyte transendothelial migration 15/383 151/7206 0.0163561582412 ko04142 Lysosome 15/383 151/7206 0.0163561582412 ko04210 Apoptosis 17/383 180/7206 0.0179148068298 ko04911 Insulin secretion 1/383 117/7206 0.0211527901019 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/383 5/7206 0.0253151420077 ko05143 African trypanosomiasis 5/383 32/7206 0.02542765588 ko04012 ErbB signaling pathway 1/383 109/7206 0.0305104034014 ko05032 Morphine addiction 1/383 110/7206 0.0305699342783 ko05132 Salmonella infection 10/383 98/7206 0.0392448179789 ko05146 Amoebiasis 10/383 99/7206 0.0411511075621 ko00511 Other glycan degradation 4/383 26/7206 0.04648948629