ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	204/1216	423/7206	3.6832116505e-54
ko05033	Nicotine addiction	49/1216	56/7206	4.13027280037e-31
ko04724	Glutamatergic synapse	88/1216	152/7206	6.5798315032e-31
ko05032	Morphine addiction	68/1216	110/7206	1.84206656926e-26
ko04727	GABAergic synapse	67/1216	110/7206	1.51595939363e-25
ko04713	Circadian entrainment	75/1216	136/7206	1.24156639515e-24
ko04721	Synaptic vesicle cycle	53/1216	80/7206	5.94065646405e-23
ko04728	Dopaminergic synapse	85/1216	185/7206	9.14101555942e-21
ko04725	Cholinergic synapse	75/1216	160/7206	4.51288592462e-19
ko04723	Retrograde endocannabinoid signaling	78/1216	175/7206	3.61976864611e-18
ko04024	cAMP signaling pathway	106/1216	279/7206	5.99358054731e-18
ko04911	Insulin secretion	58/1216	117/7206	2.04173903643e-16
ko04742	Taste transduction	38/1216	61/7206	1.79976478231e-15
ko04020	Calcium signaling pathway	96/1216	265/7206	8.97344054765e-15
ko04726	Serotonergic synapse	61/1216	137/7206	1.95362973521e-14
ko04740	Olfactory transduction	42/1216	80/7206	2.47554943936e-13
ko04921	Oxytocin signaling pathway	78/1216	209/7206	6.36788163784e-13
ko04720	Long-term potentiation	45/1216	99/7206	2.3159239517e-11
ko05031	Amphetamine addiction	42/1216	91/7206	5.89751420869e-11
ko04261	Adrenergic signaling in cardiomyocytes	73/1216	205/7206	6.46872823958e-11
ko04360	Axon guidance	79/1216	233/7206	1.1244870665e-10
ko03040	Spliceosome	1/1216	145/7206	1.23203561012e-10
ko04744	Phototransduction	23/1216	36/7206	3.44522385843e-10
ko04970	Salivary secretion	41/1216	95/7206	1.27136441322e-09
ko05203	Viral carcinogenesis	15/1216	277/7206	9.67364993695e-09
ko05168	Herpes simplex infection	6/1216	182/7206	1.58688661225e-08
ko03013	RNA transport	5/1216	166/7206	2.38971112378e-08
ko04925	Aldosterone synthesis and secretion	41/1216	105/7206	4.55430587363e-08
ko05030	Cocaine addiction	32/1216	73/7206	5.34575217189e-08
ko04971	Gastric acid secretion	39/1216	98/7206	6.11565822267e-08
ko04120	Ubiquitin mediated proteolysis	4/1216	138/7206	4.08904489979e-07
ko04022	cGMP-PKG signaling pathway	65/1216	216/7206	1.12551563118e-06
ko04060	Cytokine-cytokine receptor interaction	10/1216	191/7206	1.77401358591e-06
ko04260	Cardiac muscle contraction	36/1216	98/7206	1.85487295573e-06
ko04976	Bile secretion	31/1216	80/7206	2.63416686251e-06
ko05164	Influenza A	8/1216	167/7206	2.89918352999e-06
ko04961	Endocrine and other factor-regulated calcium reabsorption	25/1216	59/7206	3.28230254018e-06
ko04141	Protein processing in endoplasmic reticulum	10/1216	184/7206	3.43516735467e-06
ko04010	MAPK signaling pathway	86/1216	321/7206	5.70312273938e-06
ko04540	Gap junction	42/1216	128/7206	7.65183704508e-06
ko04621	NOD-like receptor signaling pathway	8/1216	157/7206	1.19650679684e-05
ko04610	Complement and coagulation cascades	1/1216	79/7206	1.26054799315e-05
ko03008	Ribosome biogenesis in eukaryotes	1/1216	79/7206	1.26054799315e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1216	74/7206	1.30364526232e-05
ko04924	Renin secretion	31/1216	86/7206	1.52382473845e-05
ko04972	Pancreatic secretion	37/1216	111/7206	1.80203119155e-05
ko04966	Collecting duct acid secretion	14/1216	26/7206	1.8166839724e-05
ko05110	Vibrio cholerae infection	25/1216	63/7206	2.16030400381e-05
ko05322	Systemic lupus erythematosus	8/1216	151/7206	2.37560612478e-05
ko04514	Cell adhesion molecules (CAMs)	41/1216	130/7206	4.24856361327e-05
ko04730	Long-term depression	28/1216	78/7206	4.57780888241e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1216	79/7206	5.57009941005e-05
ko05169	Epstein-Barr virus infection	15/1216	206/7206	6.40078609553e-05
ko04964	Proximal tubule bicarbonate reclamation	14/1216	29/7206	8.82295573602e-05
ko05162	Measles	6/1216	120/7206	0.000115666045365
ko04110	Cell cycle	9/1216	145/7206	0.000186840194138
ko04745	Phototransduction - fly	16/1216	38/7206	0.000211752089158
ko05140	Leishmaniasis	2/1216	75/7206	0.000254178372312
ko04064	NF-kappa B signaling pathway	4/1216	96/7206	0.000275782839769
ko05205	Proteoglycans in cancer	25/1216	271/7206	0.000350458058599
ko00240	Pyrimidine metabolism	6/1216	110/7206	0.000466145317792
ko04146	Peroxisome	4/1216	89/7206	0.000556344999367
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1216	14/7206	0.000738973129931
ko05414	Dilated cardiomyopathy	33/1216	112/7206	0.000822200172269
ko00480	Glutathione metabolism	1/1216	55/7206	0.000838948047003
ko04750	Inflammatory mediator regulation of TRP channels	35/1216	122/7206	0.000920589716754
ko05161	Hepatitis B	14/1216	173/7206	0.000957922689969
ko04612	Antigen processing and presentation	3/1216	77/7206	0.00104243069869
ko04014	Ras signaling pathway	68/1216	279/7206	0.00106653086763
ko03018	RNA degradation	4/1216	84/7206	0.00114695946657
ko04640	Hematopoietic cell lineage	2/1216	64/7206	0.00118161258932
ko00590	Arachidonic acid metabolism	1/1216	52/7206	0.00125241998548
ko04072	Phospholipase D signaling pathway	51/1216	197/7206	0.00134206624134
ko04070	Phosphatidylinositol signaling system	32/1216	112/7206	0.00200437717726
ko04915	Estrogen signaling pathway	36/1216	131/7206	0.00203327851404
ko04371	Apelin signaling pathway	46/1216	177/7206	0.0021272488173
ko04214	Apoptosis - fly	3/1216	72/7206	0.00219130445727
ko00260	Glycine, serine and threonine metabolism	1/1216	48/7206	0.00293023130054
ko04217	Necroptosis	16/1216	178/7206	0.00315929224403
ko04657	IL-17 signaling pathway	5/1216	87/7206	0.00352118892458
ko05321	Inflammatory bowel disease (IBD)	2/1216	56/7206	0.00377685923338
ko03022	Basal transcription factors	1/1216	44/7206	0.00431102329269
ko00071	Fatty acid degradation	1/1216	45/7206	0.00432810474661
ko04668	TNF signaling pathway	9/1216	120/7206	0.00433693374721
ko03420	Nucleotide excision repair	1/1216	46/7206	0.00452382656709
ko01524	Platinum drug resistance	4/1216	76/7206	0.00488547055664
ko05145	Toxoplasmosis	10/1216	126/7206	0.00541308588405
ko00983	Drug metabolism - other enzymes	1/1216	42/7206	0.00646557168367
ko04620	Toll-like receptor signaling pathway	7/1216	100/7206	0.00657659908947
ko01200	Carbon metabolism	11/1216	128/7206	0.00869955590423
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1216	182/7206	0.00897326429838
ko04916	Melanogenesis	36/1216	142/7206	0.00899472566392
ko00330	Arginine and proline metabolism	3/1216	61/7206	0.00909164961775
ko05133	Pertussis	6/1216	87/7206	0.00916223118418
ko04622	RIG-I-like receptor signaling pathway	3/1216	62/7206	0.00939459994149
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1216	40/7206	0.00976218438912
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1216	100/7206	0.0100500413292
ko05418	Fluid shear stress and atherosclerosis	17/1216	173/7206	0.0100607672135
ko00140	Steroid hormone biosynthesis	1/1216	41/7206	0.0101464450064
ko05215	Prostate cancer	9/1216	111/7206	0.0103073879995
ko00982	Drug metabolism - cytochrome P450	1/1216	37/7206	0.0145613989391
ko03410	Base excision repair	1/1216	38/7206	0.0148283312754
ko05131	Shigellosis	6/1216	82/7206	0.0171037157473
ko00270	Cysteine and methionine metabolism	2/1216	47/7206	0.0174099810195
ko04115	p53 signaling pathway	5/1216	74/7206	0.0181437357698
ko04918	Thyroid hormone synthesis	23/1216	86/7206	0.0196264054838
ko04923	Regulation of lipolysis in adipocytes	21/1216	77/7206	0.0206796904799
ko04270	Vascular smooth muscle contraction	37/1216	154/7206	0.0218301460298
ko00640	Propanoate metabolism	1/1216	34/7206	0.0218936591528
ko04218	Cellular senescence	19/1216	177/7206	0.0252794262763
ko05144	Malaria	2/1216	45/7206	0.0256404917798
ko00600	Sphingolipid metabolism	4/1216	63/7206	0.0262725118911
ko00280	Valine, leucine and isoleucine degradation	3/1216	54/7206	0.0265776702979
ko04912	GnRH signaling pathway	30/1216	122/7206	0.0275875108021
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	9/1216	26/7206	0.0300625630786
ko04978	Mineral absorption	12/1216	40/7206	0.0337157003713
ko04630	Jak-STAT signaling pathway	13/1216	132/7206	0.0337792350101
ko03320	PPAR signaling pathway	5/1216	69/7206	0.0341344255294
ko04210	Apoptosis	20/1216	180/7206	0.0344085133711
ko04962	Vasopressin-regulated water reabsorption	16/1216	58/7206	0.0346435360242
ko00380	Tryptophan metabolism	3/1216	50/7206	0.0366584524492
ko05212	Pancreatic cancer	7/1216	83/7206	0.0384451341023
ko04974	Protein digestion and absorption	24/1216	96/7206	0.0390051216342
ko04015	Rap1 signaling pathway	60/1216	278/7206	0.0407147416712
ko05132	Salmonella infection	9/1216	98/7206	0.0410671320792
ko05034	Alcoholism	52/1216	238/7206	0.0426284043621
ko04930	Type II diabetes mellitus	15/1216	54/7206	0.0428092357505
ko04140	Autophagy - animal	18/1216	164/7206	0.0444537528966
ko05222	Small cell lung cancer	8/1216	89/7206	0.0457844665709