ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	208/1334	423/7206	7.52876636782e-50
ko04724	Glutamatergic synapse	94/1334	152/7206	7.44021369556e-33
ko05032	Morphine addiction	74/1334	110/7206	1.47939048416e-29
ko05033	Nicotine addiction	49/1334	56/7206	3.68101870756e-29
ko04727	GABAergic synapse	71/1334	110/7206	1.05308996868e-26
ko04713	Circadian entrainment	79/1334	136/7206	3.57088025518e-25
ko04721	Synaptic vesicle cycle	52/1334	80/7206	4.58558728954e-20
ko04728	Dopaminergic synapse	88/1334	185/7206	6.3930903757e-20
ko04725	Cholinergic synapse	79/1334	160/7206	3.17320205431e-19
ko04024	cAMP signaling pathway	111/1334	279/7206	2.65424061713e-17
ko04723	Retrograde endocannabinoid signaling	80/1334	175/7206	6.34473271812e-17
ko04020	Calcium signaling pathway	106/1334	265/7206	8.17234587203e-17
ko04726	Serotonergic synapse	65/1334	137/7206	6.08757977017e-15
ko04911	Insulin secretion	58/1334	117/7206	1.57555391153e-14
ko04744	Phototransduction	28/1334	36/7206	1.57698605631e-14
ko04742	Taste transduction	37/1334	61/7206	2.96794932501e-13
ko04921	Oxytocin signaling pathway	83/1334	209/7206	3.51405072452e-13
ko05031	Amphetamine addiction	45/1334	91/7206	1.62500354169e-11
ko04261	Adrenergic signaling in cardiomyocytes	78/1334	205/7206	2.72613659001e-11
ko03040	Spliceosome	2/1334	145/7206	8.31969386554e-11
ko03010	Ribosome	1/1334	129/7206	1.22520830361e-10
ko04970	Salivary secretion	44/1334	95/7206	4.17656937655e-10
ko04720	Long-term potentiation	44/1334	99/7206	3.47628547371e-09
ko04022	cGMP-PKG signaling pathway	74/1334	216/7206	2.0724054624e-08
ko05203	Viral carcinogenesis	19/1334	277/7206	2.28722162872e-08
ko03013	RNA transport	7/1334	166/7206	4.75327059163e-08
ko05322	Systemic lupus erythematosus	6/1334	151/7206	1.18419116986e-07
ko05030	Cocaine addiction	33/1334	73/7206	1.33999886662e-07
ko04070	Phosphatidylinositol signaling system	44/1334	112/7206	2.18276937951e-07
ko04360	Axon guidance	75/1334	233/7206	3.13804203803e-07
ko05168	Herpes simplex infection	10/1334	182/7206	3.3692640088e-07
ko04060	Cytokine-cytokine receptor interaction	11/1334	191/7206	3.69619429164e-07
ko04740	Olfactory transduction	34/1334	80/7206	6.01143172195e-07
ko04925	Aldosterone synthesis and secretion	41/1334	105/7206	7.10595716099e-07
ko04971	Gastric acid secretion	38/1334	98/7206	2.31434820156e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1334	74/7206	1.2210768756e-05
ko04923	Regulation of lipolysis in adipocytes	30/1334	77/7206	2.23605637735e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1334	79/7206	2.79283006914e-05
ko04110	Cell cycle	9/1334	145/7206	3.08810573241e-05
ko04924	Renin secretion	32/1334	86/7206	3.61274177236e-05
ko05164	Influenza A	12/1334	167/7206	4.46529535018e-05
ko04745	Phototransduction - fly	18/1334	38/7206	4.5093568163e-05
ko04966	Collecting duct acid secretion	14/1334	26/7206	5.38278001735e-05
ko04514	Cell adhesion molecules (CAMs)	43/1334	130/7206	5.50312809426e-05
ko04976	Bile secretion	30/1334	80/7206	6.00593067365e-05
ko04972	Pancreatic secretion	38/1334	111/7206	6.43424620328e-05
ko04072	Phospholipase D signaling pathway	59/1334	197/7206	8.06045012822e-05
ko04730	Long-term depression	29/1334	78/7206	9.38953617107e-05
ko04141	Protein processing in endoplasmic reticulum	15/1334	184/7206	0.000102848798264
ko05169	Epstein-Barr virus infection	18/1334	206/7206	0.000115091862367
ko05414	Dilated cardiomyopathy	37/1334	112/7206	0.000195999861591
ko04010	MAPK signaling pathway	86/1334	321/7206	0.000219577309722
ko05110	Vibrio cholerae infection	24/1334	63/7206	0.000235719604455
ko04064	NF-kappa B signaling pathway	5/1334	96/7206	0.000276111895165
ko00520	Amino sugar and nucleotide sugar metabolism	1/1334	55/7206	0.000326580724428
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1334	79/7206	0.000354546900199
ko04621	NOD-like receptor signaling pathway	13/1334	157/7206	0.000379712020758
ko05140	Leishmaniasis	3/1334	75/7206	0.000438819606411
ko04710	Circadian rhythm	18/1334	43/7206	0.000465601490462
ko04540	Gap junction	40/1334	128/7206	0.000488369197218
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1334	59/7206	0.000593686939545
ko04750	Inflammatory mediator regulation of TRP channels	38/1334	122/7206	0.000604721937129
ko04014	Ras signaling pathway	74/1334	279/7206	0.00070290577667
ko04964	Proximal tubule bicarbonate reclamation	13/1334	29/7206	0.000999933905664
ko04612	Antigen processing and presentation	4/1334	77/7206	0.00102894336126
ko04260	Cardiac muscle contraction	31/1334	98/7206	0.00151951404369
ko05321	Inflammatory bowel disease (IBD)	2/1334	56/7206	0.00157613794469
ko04371	Apelin signaling pathway	50/1334	177/7206	0.00158358227097
ko05144	Malaria	1/1334	45/7206	0.0017128089691
ko03420	Nucleotide excision repair	1/1334	46/7206	0.00175224735344
ko04120	Ubiquitin mediated proteolysis	12/1334	138/7206	0.00179200241816
ko05205	Proteoglycans in cancer	31/1334	271/7206	0.00179401626073
ko05161	Hepatitis B	17/1334	173/7206	0.00201528410378
ko04626	Plant-pathogen interaction	9/1334	18/7206	0.00241328630429
ko03022	Basal transcription factors	1/1334	44/7206	0.00269640984029
ko04622	RIG-I-like receptor signaling pathway	3/1334	62/7206	0.0027741458325
ko05162	Measles	10/1334	120/7206	0.0027832524165
ko04915	Estrogen signaling pathway	38/1334	131/7206	0.00298648973505
ko04610	Complement and coagulation cascades	5/1334	79/7206	0.00319497072958
ko04657	IL-17 signaling pathway	6/1334	87/7206	0.00321385642424
ko05133	Pertussis	6/1334	87/7206	0.00321385642424
ko04658	Th1 and Th2 cell differentiation	7/1334	96/7206	0.00322928857584
ko04930	Type II diabetes mellitus	19/1334	54/7206	0.00400746824776
ko03018	RNA degradation	6/1334	84/7206	0.00445472289509
ko03410	Base excision repair	1/1334	38/7206	0.00599350760383
ko05131	Shigellosis	6/1334	82/7206	0.00618163885739
ko05145	Toxoplasmosis	12/1334	126/7206	0.00740805201749
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1334	14/7206	0.00746303084495
ko04922	Glucagon signaling pathway	36/1334	128/7206	0.00780637597181
ko00480	Glutathione metabolism	3/1334	55/7206	0.0083879398309
ko00240	Pyrimidine metabolism	10/1334	110/7206	0.00890420452782
ko05410	Hypertrophic cardiomyopathy (HCM)	29/1334	100/7206	0.00923819703676
ko05016	Huntington's disease	26/1334	215/7206	0.0124121258914
ko00562	Inositol phosphate metabolism	26/1334	89/7206	0.0128658476593
ko04918	Thyroid hormone synthesis	25/1334	86/7206	0.016688897338
ko04630	Jak-STAT signaling pathway	14/1334	132/7206	0.0171087508786
ko05132	Salmonella infection	9/1334	98/7206	0.0174957328551
ko04912	GnRH signaling pathway	33/1334	122/7206	0.0183489125786
ko04217	Necroptosis	21/1334	178/7206	0.0187060756718
ko04270	Vascular smooth muscle contraction	40/1334	154/7206	0.0205903133483
ko05166	HTLV-I infection	39/1334	292/7206	0.0207838101541
ko04711	Circadian rhythm - fly	6/1334	13/7206	0.0208458318321
ko00290	Valine, leucine and isoleucine biosynthesis	3/1334	4/7206	0.0218202197997
ko04214	Apoptosis - fly	6/1334	72/7206	0.021940263169
ko04510	Focal adhesion	31/1334	240/7206	0.022319230006
ko04115	p53 signaling pathway	6/1334	74/7206	0.0226269511893
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1334	40/7206	0.0236386787715
ko05219	Bladder cancer	3/1334	48/7206	0.0245845925548
ko05320	Autoimmune thyroid disease	1/1334	29/7206	0.0309258376635
ko05231	Choline metabolism in cancer	35/1334	134/7206	0.0320546453168
ko00630	Glyoxylate and dicarboxylate metabolism	2/1334	38/7206	0.0344952770523
ko04213	Longevity regulating pathway - multiple species	24/1334	86/7206	0.0347714304142
ko03320	PPAR signaling pathway	6/1334	69/7206	0.0411137855908
ko04960	Aldosterone-regulated sodium reabsorption	13/1334	41/7206	0.0411719622708
ko04932	Non-alcoholic fatty liver disease (NAFLD)	23/1334	182/7206	0.0418371625075
ko00650	Butanoate metabolism	9/1334	26/7206	0.0429174358876
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1334	15/7206	0.043613216567
ko04933	AGE-RAGE signaling pathway in diabetic complications	16/1334	135/7206	0.0439820973767
ko04973	Carbohydrate digestion and absorption	13/1334	42/7206	0.0456183601819
ko00590	Arachidonic acid metabolism	4/1334	52/7206	0.047194946515