ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	178/1060	423/7206	1.31314673715e-45
ko04724	Glutamatergic synapse	87/1060	152/7206	9.894497538e-35
ko05033	Nicotine addiction	48/1060	56/7206	1.89950587325e-32
ko05032	Morphine addiction	67/1060	110/7206	3.44443533329e-29
ko04727	GABAergic synapse	64/1060	110/7206	2.54266821233e-26
ko04713	Circadian entrainment	72/1060	136/7206	5.33406971373e-26
ko04728	Dopaminergic synapse	86/1060	185/7206	1.18129236848e-25
ko04721	Synaptic vesicle cycle	51/1060	80/7206	8.60975306509e-24
ko04725	Cholinergic synapse	75/1060	160/7206	9.27192140637e-23
ko04723	Retrograde endocannabinoid signaling	77/1060	175/7206	3.2061676159e-21
ko04024	cAMP signaling pathway	99/1060	279/7206	9.6093347178e-19
ko04744	Phototransduction	27/1060	36/7206	6.19163619193e-16
ko04911	Insulin secretion	53/1060	117/7206	1.29850205919e-15
ko04726	Serotonergic synapse	57/1060	137/7206	1.12089705812e-14
ko04720	Long-term potentiation	46/1060	99/7206	3.17244524224e-14
ko04921	Oxytocin signaling pathway	74/1060	209/7206	3.55183911242e-14
ko04742	Taste transduction	34/1060	61/7206	8.79836627858e-14
ko05031	Amphetamine addiction	43/1060	91/7206	1.06056731665e-13
ko04020	Calcium signaling pathway	86/1060	265/7206	1.32525461526e-13
ko04261	Adrenergic signaling in cardiomyocytes	69/1060	205/7206	6.91985112074e-12
ko03040	Spliceosome	1/1060	145/7206	3.52182378355e-09
ko04970	Salivary secretion	37/1060	95/7206	5.02956689606e-09
ko04925	Aldosterone synthesis and secretion	39/1060	105/7206	9.42631646399e-09
ko05030	Cocaine addiction	30/1060	73/7206	3.39827490213e-08
ko04740	Olfactory transduction	31/1060	80/7206	1.01938332837e-07
ko04971	Gastric acid secretion	35/1060	98/7206	1.6878596403e-07
ko04060	Cytokine-cytokine receptor interaction	6/1060	191/7206	2.14683030835e-07
ko05168	Herpes simplex infection	6/1060	182/7206	6.4319587734e-07
ko04360	Axon guidance	63/1060	233/7206	6.83223298357e-07
ko04730	Long-term depression	29/1060	78/7206	7.3421781652e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1060	74/7206	7.51194246613e-07
ko04010	MAPK signaling pathway	79/1060	321/7206	1.60504366169e-06
ko04070	Phosphatidylinositol signaling system	36/1060	112/7206	2.43912969946e-06
ko04966	Collecting duct acid secretion	14/1060	26/7206	3.48308809631e-06
ko05203	Viral carcinogenesis	16/1060	277/7206	3.54013422569e-06
ko05322	Systemic lupus erythematosus	5/1060	151/7206	6.82391153356e-06
ko04022	cGMP-PKG signaling pathway	56/1060	216/7206	1.35776388314e-05
ko04072	Phospholipase D signaling pathway	52/1060	197/7206	1.41731493545e-05
ko04972	Pancreatic secretion	34/1060	111/7206	1.69740499151e-05
ko04621	NOD-like receptor signaling pathway	6/1060	157/7206	1.75201654103e-05
ko04141	Protein processing in endoplasmic reticulum	9/1060	184/7206	3.10574813828e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1060	79/7206	3.75540407372e-05
ko04745	Phototransduction - fly	16/1060	38/7206	3.89447425554e-05
ko04120	Ubiquitin mediated proteolysis	5/1060	138/7206	4.4420955475e-05
ko04514	Cell adhesion molecules (CAMs)	37/1060	130/7206	4.55478006074e-05
ko05110	Vibrio cholerae infection	22/1060	63/7206	4.93086955306e-05
ko04260	Cardiac muscle contraction	30/1060	98/7206	6.7120362801e-05
ko03013	RNA transport	8/1060	166/7206	8.25955431993e-05
ko04915	Estrogen signaling pathway	36/1060	131/7206	0.000143464784229
ko04924	Renin secretion	26/1060	86/7206	0.000186652930092
ko04540	Gap junction	35/1060	128/7206	0.000201995284028
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1060	59/7206	0.000252330763874
ko04014	Ras signaling pathway	63/1060	279/7206	0.000372037786022
ko04626	Plant-pathogen interaction	9/1060	18/7206	0.000431980280366
ko05164	Influenza A	10/1060	167/7206	0.000557562835361
ko04610	Complement and coagulation cascades	2/1060	79/7206	0.00062635748011
ko05414	Dilated cardiomyopathy	30/1060	112/7206	0.000697952331279
ko04750	Inflammatory mediator regulation of TRP channels	32/1060	122/7206	0.000718569266496
ko04110	Cell cycle	8/1060	145/7206	0.000795711603541
ko04612	Antigen processing and presentation	2/1060	77/7206	0.000941933215795
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1060	14/7206	0.00194188659486
ko04064	NF-kappa B signaling pathway	4/1060	96/7206	0.00194762790042
ko00480	Glutathione metabolism	1/1060	55/7206	0.00329877104755
ko03008	Ribosome biogenesis in eukaryotes	3/1060	79/7206	0.00347033753106
ko05169	Epstein-Barr virus infection	16/1060	206/7206	0.00357246298655
ko04146	Peroxisome	4/1060	89/7206	0.00374919806719
ko05162	Measles	7/1060	120/7206	0.00387422651547
ko04912	GnRH signaling pathway	30/1060	122/7206	0.00411565393917
ko05140	Leishmaniasis	3/1060	75/7206	0.00486954557978
ko00590	Arachidonic acid metabolism	1/1060	52/7206	0.00488618989883
ko04930	Type II diabetes mellitus	16/1060	54/7206	0.00553812898523
ko05214	Glioma	21/1060	79/7206	0.00579661211919
ko04960	Aldosterone-regulated sodium reabsorption	13/1060	41/7206	0.00593584450352
ko04062	Chemokine signaling pathway	44/1060	201/7206	0.00607115704884
ko04976	Bile secretion	21/1060	80/7206	0.00630287459303
ko04964	Proximal tubule bicarbonate reclamation	10/1060	29/7206	0.00634891991647
ko04973	Carbohydrate digestion and absorption	13/1060	42/7206	0.00688090582529
ko04214	Apoptosis - fly	3/1060	72/7206	0.00694476837608
ko00310	Lysine degradation	3/1060	73/7206	0.00703346808107
ko05231	Choline metabolism in cancer	31/1060	134/7206	0.00914013729804
ko04371	Apelin signaling pathway	39/1060	177/7206	0.00944371917043
ko04012	ErbB signaling pathway	26/1060	109/7206	0.0094469813639
ko00240	Pyrimidine metabolism	7/1060	110/7206	0.00958311269766
ko03320	PPAR signaling pathway	3/1060	69/7206	0.00987682322002
ko00071	Fatty acid degradation	1/1060	45/7206	0.0106299037339
ko03420	Nucleotide excision repair	1/1060	46/7206	0.0107269408816
ko05321	Inflammatory bowel disease (IBD)	2/1060	56/7206	0.0129074749283
ko00562	Inositol phosphate metabolism	22/1060	89/7206	0.0147350737594
ko03022	Basal transcription factors	1/1060	44/7206	0.0163741433695
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1060	92/7206	0.017102937844
ko05166	HTLV-I infection	29/1060	292/7206	0.0179322417883
ko03018	RNA degradation	5/1060	84/7206	0.0193907266135
ko05034	Alcoholism	48/1060	238/7206	0.01966551733
ko04640	Hematopoietic cell lineage	3/1060	64/7206	0.0199040695453
ko04115	p53 signaling pathway	4/1060	74/7206	0.0199530379305
ko04923	Regulation of lipolysis in adipocytes	19/1060	77/7206	0.0218204792814
ko05161	Hepatitis B	15/1060	173/7206	0.0220696475326
ko05410	Hypertrophic cardiomyopathy (HCM)	23/1060	100/7206	0.022825856904
ko05205	Proteoglycans in cancer	27/1060	271/7206	0.0229117758502
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1060	40/7206	0.0235167548001
ko04350	TGF-beta signaling pathway	7/1060	103/7206	0.0237077747341
ko00140	Steroid hormone biosynthesis	1/1060	41/7206	0.0241004452659
ko00330	Arginine and proline metabolism	3/1060	61/7206	0.0279709373025
ko04330	Notch signaling pathway	3/1060	62/7206	0.0285399125402
ko04622	RIG-I-like receptor signaling pathway	3/1060	62/7206	0.0285399125402
ko00512	Mucin type O-glycan biosynthesis	9/1060	29/7206	0.0294482719306
ko05145	Toxoplasmosis	10/1060	126/7206	0.030235670125
ko04918	Thyroid hormone synthesis	20/1060	86/7206	0.0311977264043
ko04217	Necroptosis	16/1060	178/7206	0.0313642033279
ko04071	Sphingolipid signaling pathway	34/1060	162/7206	0.0321219895003
ko00982	Drug metabolism - cytochrome P450	1/1060	37/7206	0.0347675226158
ko03410	Base excision repair	1/1060	38/7206	0.0354513265092
ko00260	Glycine, serine and threonine metabolism	2/1060	48/7206	0.0387515481826
ko04916	Melanogenesis	30/1060	142/7206	0.0407794516637
ko04658	Th1 and Th2 cell differentiation	7/1060	96/7206	0.0410460169171
ko04919	Thyroid hormone signaling pathway	30/1060	143/7206	0.0416492601015
ko04210	Apoptosis	17/1060	180/7206	0.0427468149695
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1060	182/7206	0.0431767785657
ko04922	Glucagon signaling pathway	27/1060	128/7206	0.0440295852788
ko04657	IL-17 signaling pathway	6/1060	87/7206	0.0457963552155
ko05133	Pertussis	6/1060	87/7206	0.0457963552155
ko05202	Transcriptional misregulation in cancer	18/1060	188/7206	0.0468326630378
ko01524	Platinum drug resistance	5/1060	76/7206	0.0489698541928