ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 164/1035 423/7206 7.88932066647e-38 ko04724 Glutamatergic synapse 78/1035 152/7206 1.28208856768e-27 ko05033 Nicotine addiction 41/1035 56/7206 2.57393767184e-23 ko05032 Morphine addiction 55/1035 110/7206 4.32768275813e-19 ko04728 Dopaminergic synapse 72/1035 185/7206 6.34047355549e-17 ko04713 Circadian entrainment 59/1035 136/7206 1.17228131268e-16 ko04727 GABAergic synapse 51/1035 110/7206 5.01262026109e-16 ko04723 Retrograde endocannabinoid signaling 67/1035 175/7206 2.10554624818e-15 ko04725 Cholinergic synapse 63/1035 160/7206 3.11619397618e-15 ko04911 Insulin secretion 49/1035 117/7206 2.52205445485e-13 ko04020 Calcium signaling pathway 83/1035 265/7206 6.76184673259e-13 ko04024 cAMP signaling pathway 86/1035 279/7206 7.14414088979e-13 ko04726 Serotonergic synapse 52/1035 137/7206 4.69904053757e-12 ko04721 Synaptic vesicle cycle 35/1035 80/7206 1.59446444221e-10 ko04360 Axon guidance 69/1035 233/7206 9.68322896966e-10 ko03040 Spliceosome 1/1035 145/7206 5.64599009727e-09 ko04742 Taste transduction 27/1035 61/7206 1.48571853762e-08 ko04921 Oxytocin signaling pathway 61/1035 209/7206 1.83963461163e-08 ko04261 Adrenergic signaling in cardiomyocytes 60/1035 205/7206 2.31637914668e-08 ko05031 Amphetamine addiction 33/1035 91/7206 1.41710486654e-07 ko05322 Systemic lupus erythematosus 3/1035 151/7206 2.51952135612e-07 ko03013 RNA transport 4/1035 166/7206 2.54618224982e-07 ko05030 Cocaine addiction 28/1035 73/7206 3.27540816988e-07 ko04072 Phospholipase D signaling pathway 55/1035 197/7206 4.88575842316e-07 ko04514 Cell adhesion molecules (CAMs) 40/1035 130/7206 1.48252336246e-06 ko04070 Phosphatidylinositol signaling system 36/1035 112/7206 1.68628982414e-06 ko04970 Salivary secretion 32/1035 95/7206 1.83249748667e-06 ko04022 cGMP-PKG signaling pathway 56/1035 216/7206 6.79573544306e-06 ko04720 Long-term potentiation 31/1035 99/7206 1.52789093337e-05 ko04730 Long-term depression 26/1035 78/7206 2.26010553171e-05 ko04972 Pancreatic secretion 33/1035 111/7206 2.68085635447e-05 ko04010 MAPK signaling pathway 73/1035 321/7206 4.06823319518e-05 ko05203 Viral carcinogenesis 18/1035 277/7206 5.04372768621e-05 ko04014 Ras signaling pathway 65/1035 279/7206 5.29756713135e-05 ko04710 Circadian rhythm 16/1035 43/7206 0.00016932846996 ko05014 Amyotrophic lateral sclerosis (ALS) 23/1035 74/7206 0.00018615047315 ko04925 Aldosterone synthesis and secretion 29/1035 105/7206 0.000356713787351 ko04930 Type II diabetes mellitus 18/1035 54/7206 0.000560463432918 ko04971 Gastric acid secretion 27/1035 98/7206 0.000663189187802 ko05231 Choline metabolism in cancer 34/1035 134/7206 0.000674033723238 ko04120 Ubiquitin mediated proteolysis 7/1035 138/7206 0.000808620469704 ko04612 Antigen processing and presentation 2/1035 77/7206 0.000938387823541 ko04146 Peroxisome 3/1035 89/7206 0.0011740707498 ko04260 Cardiac muscle contraction 26/1035 98/7206 0.00128182242136 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 22/1035 79/7206 0.00174595483984 ko00562 Inositol phosphate metabolism 24/1035 89/7206 0.00193079232393 ko05164 Influenza A 11/1035 167/7206 0.0024007750959 ko04110 Cell cycle 9/1035 145/7206 0.00267609296897 ko04141 Protein processing in endoplasmic reticulum 13/1035 184/7206 0.00273849515963 ko04540 Gap junction 31/1035 128/7206 0.00307877550181 ko04071 Sphingolipid signaling pathway 37/1035 162/7206 0.0030895640916 ko04744 Phototransduction 12/1035 36/7206 0.0032394225216 ko05168 Herpes simplex infection 13/1035 182/7206 0.00361864827502 ko04915 Estrogen signaling pathway 31/1035 131/7206 0.00367387865274 ko04015 Rap1 signaling pathway 57/1035 278/7206 0.00504594851801 ko04960 Aldosterone-regulated sodium reabsorption 13/1035 41/7206 0.00534271145607 ko04621 NOD-like receptor signaling pathway 11/1035 157/7206 0.00556572558165 ko04750 Inflammatory mediator regulation of TRP channels 29/1035 122/7206 0.00569978244528 ko04711 Circadian rhythm - fly 6/1035 13/7206 0.00601220085632 ko04961 Endocrine and other factor-regulated calcium reabsorption 16/1035 59/7206 0.00857571775887 ko00330 Arginine and proline metabolism 2/1035 61/7206 0.00913665205889 ko00604 Glycosphingolipid biosynthesis - ganglio series 6/1035 14/7206 0.00925975662868 ko03420 Nucleotide excision repair 1/1035 46/7206 0.0107829678844 ko04924 Renin secretion 21/1035 86/7206 0.0123447753005 ko04973 Carbohydrate digestion and absorption 12/1035 42/7206 0.0140675688041 ko04610 Complement and coagulation cascades 4/1035 79/7206 0.0145876376659 ko01200 Carbon metabolism 9/1035 128/7206 0.0150795611064 ko04060 Cytokine-cytokine receptor interaction 16/1035 191/7206 0.0157352330298 ko03022 Basal transcription factors 1/1035 44/7206 0.0160837518273 ko05144 Malaria 1/1035 45/7206 0.0165455000851 ko00071 Fatty acid degradation 1/1035 45/7206 0.0165455000851 ko04745 Phototransduction - fly 11/1035 38/7206 0.0177381186852 ko04064 NF-kappa B signaling pathway 6/1035 96/7206 0.0186700769394 ko05416 Viral myocarditis 2/1035 55/7206 0.0189967534531 ko05414 Dilated cardiomyopathy 25/1035 112/7206 0.0204562321298 ko05205 Proteoglycans in cancer 26/1035 271/7206 0.021464158868 ko04976 Bile secretion 19/1035 80/7206 0.0234637315683 ko03018 RNA degradation 5/1035 84/7206 0.0270381731346 ko00310 Lysine degradation 4/1035 73/7206 0.0279524279842 ko04964 Proximal tubule bicarbonate reclamation 9/1035 29/7206 0.0280002817642 ko04918 Thyroid hormone synthesis 20/1035 86/7206 0.0285763873786 ko05016 Huntington's disease 20/1035 215/7206 0.029774869963 ko03410 Base excision repair 1/1035 38/7206 0.0351552339758 ko00380 Tryptophan metabolism 2/1035 50/7206 0.0399219182637 ko04145 Phagosome 14/1035 162/7206 0.0404248974559 ko05133 Pertussis 6/1035 87/7206 0.0450710616853 ko04142 Lysosome 13/1035 151/7206 0.0452923100809 ko04931 Insulin resistance 28/1035 137/7206 0.0483294689415 ko05130 Pathogenic Escherichia coli infection 5/1035 77/7206 0.0489829521775