ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	185/1232	423/7206	2.46535602689e-40
ko05033	Nicotine addiction	48/1232	56/7206	2.41769678335e-29
ko04724	Glutamatergic synapse	86/1232	152/7206	8.78050581326e-29
ko04727	GABAergic synapse	68/1232	110/7206	4.11452852684e-26
ko05032	Morphine addiction	68/1232	110/7206	4.11452852684e-26
ko04713	Circadian entrainment	72/1232	136/7206	6.36263695707e-22
ko04728	Dopaminergic synapse	83/1232	185/7206	4.07412578342e-19
ko04723	Retrograde endocannabinoid signaling	78/1232	175/7206	8.02948215691e-18
ko04024	cAMP signaling pathway	106/1232	279/7206	1.83140575838e-17
ko04725	Cholinergic synapse	73/1232	160/7206	1.92816241084e-17
ko04721	Synaptic vesicle cycle	45/1232	80/7206	1.81719426686e-15
ko04744	Phototransduction	28/1232	36/7206	1.89447667059e-15
ko04742	Taste transduction	37/1232	61/7206	2.23541830201e-14
ko04020	Calcium signaling pathway	94/1232	265/7206	1.95502808114e-13
ko04911	Insulin secretion	52/1232	117/7206	3.16516093223e-12
ko04921	Oxytocin signaling pathway	77/1232	209/7206	3.9715857605e-12
ko04726	Serotonergic synapse	57/1232	137/7206	1.32781456167e-11
ko05031	Amphetamine addiction	41/1232	91/7206	3.8445894143e-10
ko03040	Spliceosome	2/1232	145/7206	9.60050898037e-10
ko03010	Ribosome	1/1232	129/7206	1.60162120726e-09
ko04261	Adrenergic signaling in cardiomyocytes	69/1232	205/7206	4.69334110964e-09
ko04970	Salivary secretion	38/1232	95/7206	1.05154485957e-07
ko04720	Long-term potentiation	39/1232	99/7206	1.05758125389e-07
ko04925	Aldosterone synthesis and secretion	40/1232	105/7206	2.52465482165e-07
ko05322	Systemic lupus erythematosus	5/1232	151/7206	2.57888277965e-07
ko04022	cGMP-PKG signaling pathway	67/1232	216/7206	3.08813733716e-07
ko03013	RNA transport	7/1232	166/7206	5.71303392002e-07
ko05030	Cocaine addiction	30/1232	73/7206	1.02339952996e-06
ko04740	Olfactory transduction	32/1232	80/7206	1.20382664488e-06
ko05203	Viral carcinogenesis	20/1232	277/7206	1.82170117339e-06
ko05168	Herpes simplex infection	10/1232	182/7206	3.34387829587e-06
ko04971	Gastric acid secretion	35/1232	98/7206	8.45889216897e-06
ko04141	Protein processing in endoplasmic reticulum	11/1232	184/7206	9.7650087642e-06
ko05164	Influenza A	10/1232	167/7206	2.56871201968e-05
ko04745	Phototransduction - fly	17/1232	38/7206	6.33848710254e-05
ko04972	Pancreatic secretion	36/1232	111/7206	6.36803050199e-05
ko04924	Renin secretion	30/1232	86/7206	6.41293943168e-05
ko04070	Phosphatidylinositol signaling system	36/1232	112/7206	0.000109131627181
ko04072	Phospholipase D signaling pathway	55/1232	197/7206	0.000111414342663
ko03008	Ribosome biogenesis in eukaryotes	2/1232	79/7206	0.000113023622108
ko04966	Collecting duct acid secretion	13/1232	26/7206	0.000115123988977
ko04976	Bile secretion	28/1232	80/7206	0.000123204475762
ko04110	Cell cycle	9/1232	145/7206	0.000132161095343
ko05014	Amyotrophic lateral sclerosis (ALS)	26/1232	74/7206	0.000146479639236
ko04060	Cytokine-cytokine receptor interaction	15/1232	191/7206	0.000279255173629
ko05161	Hepatitis B	13/1232	173/7206	0.000311617282778
ko05162	Measles	7/1232	120/7206	0.000341397918206
ko04120	Ubiquitin mediated proteolysis	9/1232	138/7206	0.000351512903316
ko04964	Proximal tubule bicarbonate reclamation	13/1232	29/7206	0.000452906985148
ko05169	Epstein-Barr virus infection	18/1232	206/7206	0.000679792671756
ko04621	NOD-like receptor signaling pathway	12/1232	157/7206	0.000807525359808
ko00520	Amino sugar and nucleotide sugar metabolism	1/1232	55/7206	0.000857271860513
ko05205	Proteoglycans in cancer	27/1232	271/7206	0.000959197311275
ko05140	Leishmaniasis	3/1232	75/7206	0.000989465850943
ko04730	Long-term depression	25/1232	78/7206	0.00120793931565
ko04010	MAPK signaling pathway	77/1232	321/7206	0.00137973687342
ko04915	Estrogen signaling pathway	37/1232	131/7206	0.0013955558471
ko04710	Circadian rhythm	16/1232	43/7206	0.0015682158714
ko04923	Regulation of lipolysis in adipocytes	24/1232	77/7206	0.00207824726252
ko04514	Cell adhesion molecules (CAMs)	36/1232	130/7206	0.00211575035944
ko04371	Apelin signaling pathway	46/1232	177/7206	0.0023355680193
ko03420	Nucleotide excision repair	1/1232	46/7206	0.00282125024532
ko05016	Huntington's disease	21/1232	215/7206	0.00308679159923
ko04930	Type II diabetes mellitus	18/1232	54/7206	0.0031961538027
ko04750	Inflammatory mediator regulation of TRP channels	34/1232	122/7206	0.00326717885502
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	24/1232	79/7206	0.00372220573731
ko05110	Vibrio cholerae infection	20/1232	63/7206	0.00381453012685
ko04922	Glucagon signaling pathway	35/1232	128/7206	0.00410559870436
ko03022	Basal transcription factors	1/1232	44/7206	0.00425087512509
ko05414	Dilated cardiomyopathy	31/1232	112/7206	0.00496101562892
ko00280	Valine, leucine and isoleucine degradation	2/1232	54/7206	0.00557624288243
ko04622	RIG-I-like receptor signaling pathway	3/1232	62/7206	0.00622856818191
ko04014	Ras signaling pathway	65/1232	279/7206	0.00723811267662
ko04064	NF-kappa B signaling pathway	7/1232	96/7206	0.00882734595191
ko05130	Pathogenic Escherichia coli infection	5/1232	77/7206	0.00931473991987
ko04612	Antigen processing and presentation	5/1232	77/7206	0.00931473991987
ko04260	Cardiac muscle contraction	27/1232	98/7206	0.00955221051148
ko00562	Inositol phosphate metabolism	25/1232	89/7206	0.00992282954482
ko05166	HTLV-I infection	34/1232	292/7206	0.010905744153
ko05206	MicroRNAs in cancer	18/1232	177/7206	0.01130303861
ko05145	Toxoplasmosis	11/1232	126/7206	0.0115503153277
ko05219	Bladder cancer	2/1232	48/7206	0.0117297853393
ko03018	RNA degradation	6/1232	84/7206	0.0124884640519
ko04115	p53 signaling pathway	5/1232	74/7206	0.0129399357284
ko04630	Jak-STAT signaling pathway	12/1232	132/7206	0.0136301499461
ko03410	Base excision repair	1/1232	38/7206	0.015031090762
ko04210	Apoptosis	19/1232	180/7206	0.0160050642224
ko04270	Vascular smooth muscle contraction	38/1232	154/7206	0.0167100136662
ko05131	Shigellosis	6/1232	82/7206	0.0171964023722
ko05200	Pathways in cancer	65/1232	492/7206	0.0182427612533
ko05416	Viral myocarditis	3/1232	55/7206	0.0182579834561
ko04217	Necroptosis	19/1232	178/7206	0.0200980608628
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1232	14/7206	0.0213863511436
ko04657	IL-17 signaling pathway	7/1232	87/7206	0.0214017231719
ko05133	Pertussis	7/1232	87/7206	0.0214017231719
ko00860	Porphyrin and chlorophyll metabolism	1/1232	34/7206	0.0216236827705
ko05150	Staphylococcus aureus infection	1/1232	36/7206	0.0230792972708
ko04626	Plant-pathogen interaction	7/1232	18/7206	0.0233896686862
ko04350	TGF-beta signaling pathway	9/1232	103/7206	0.0240458034343
ko05144	Malaria	2/1232	45/7206	0.0261217188257
ko04360	Axon guidance	53/1232	233/7206	0.0265243811097
ko05217	Basal cell carcinoma	5/1232	68/7206	0.0338352475715
ko00680	Methane metabolism	11/1232	34/7206	0.0354826724317
ko04510	Focal adhesion	29/1232	240/7206	0.0361441927091
ko05215	Prostate cancer	11/1232	111/7206	0.041891825949
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1232	100/7206	0.043729838107
ko04932	Non-alcoholic fatty liver disease (NAFLD)	21/1232	182/7206	0.04568622647
ko05231	Choline metabolism in cancer	32/1232	134/7206	0.0478752851398
ko05320	Autoimmune thyroid disease	1/1232	29/7206	0.0481795656947
ko05321	Inflammatory bowel disease (IBD)	4/1232	56/7206	0.0488972526119
ko00480	Glutathione metabolism	4/1232	55/7206	0.0489157439276