ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	180/1005	423/7206	1.28706708659e-50
ko04724	Glutamatergic synapse	74/1005	152/7206	3.23495460551e-25
ko05033	Nicotine addiction	42/1005	56/7206	4.4687692175e-25
ko05032	Morphine addiction	56/1005	110/7206	1.60825958247e-20
ko04728	Dopaminergic synapse	73/1005	185/7206	2.85749939539e-18
ko04713	Circadian entrainment	60/1005	136/7206	5.57549146934e-18
ko04020	Calcium signaling pathway	89/1005	265/7206	1.0210124557e-16
ko04727	GABAergic synapse	51/1005	110/7206	1.42419002903e-16
ko04721	Synaptic vesicle cycle	41/1005	80/7206	1.7680066936e-15
ko04723	Retrograde endocannabinoid signaling	65/1005	175/7206	7.25510813387e-15
ko04725	Cholinergic synapse	59/1005	160/7206	1.92735091203e-13
ko04726	Serotonergic synapse	53/1005	137/7206	3.62202776606e-13
ko04024	cAMP signaling pathway	84/1005	279/7206	1.38258045595e-12
ko04911	Insulin secretion	46/1005	117/7206	6.92984416291e-12
ko04921	Oxytocin signaling pathway	65/1005	209/7206	8.73411994779e-11
ko04742	Taste transduction	28/1005	61/7206	1.47550087824e-09
ko05031	Amphetamine addiction	35/1005	91/7206	4.65881984013e-09
ko04970	Salivary secretion	34/1005	95/7206	6.38533151846e-08
ko03040	Spliceosome	2/1005	145/7206	1.5877746681e-07
ko04261	Adrenergic signaling in cardiomyocytes	56/1005	205/7206	3.2461681388e-07
ko04120	Ubiquitin mediated proteolysis	2/1005	138/7206	3.53108483761e-07
ko05322	Systemic lupus erythematosus	3/1005	151/7206	5.91100689585e-07
ko05030	Cocaine addiction	27/1005	73/7206	6.83185050661e-07
ko04925	Aldosterone synthesis and secretion	34/1005	105/7206	1.10210057532e-06
ko04022	cGMP-PKG signaling pathway	56/1005	216/7206	2.01533734464e-06
ko05164	Influenza A	5/1005	167/7206	2.40821239642e-06
ko04720	Long-term potentiation	32/1005	99/7206	2.43426285657e-06
ko03013	RNA transport	5/1005	166/7206	3.64070109059e-06
ko05203	Viral carcinogenesis	15/1005	277/7206	5.2139250295e-06
ko04971	Gastric acid secretion	31/1005	98/7206	5.44218222942e-06
ko05168	Herpes simplex infection	7/1005	182/7206	1.03733560636e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	25/1005	74/7206	1.15095246389e-05
ko04972	Pancreatic secretion	33/1005	111/7206	1.22410908737e-05
ko04360	Axon guidance	56/1005	233/7206	2.87659692292e-05
ko04514	Cell adhesion molecules (CAMs)	36/1005	130/7206	3.11389932189e-05
ko05110	Vibrio cholerae infection	21/1005	63/7206	7.15382986436e-05
ko04966	Collecting duct acid secretion	12/1005	26/7206	7.41088241812e-05
ko04270	Vascular smooth muscle contraction	40/1005	154/7206	7.88656208275e-05
ko04730	Long-term depression	24/1005	78/7206	0.000103362944938
ko04014	Ras signaling pathway	62/1005	279/7206	0.0001335714944
ko04110	Cell cycle	6/1005	145/7206	0.000146209340659
ko05162	Measles	4/1005	120/7206	0.000160581415919
ko04010	MAPK signaling pathway	69/1005	321/7206	0.000187510511653
ko03008	Ribosome biogenesis in eukaryotes	1/1005	79/7206	0.000211175543918
ko04060	Cytokine-cytokine receptor interaction	11/1005	191/7206	0.000421968180104
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	23/1005	79/7206	0.000422590487896
ko05169	Epstein-Barr virus infection	13/1005	206/7206	0.000691087144643
ko04072	Phospholipase D signaling pathway	45/1005	197/7206	0.000753008369396
ko04141	Protein processing in endoplasmic reticulum	11/1005	184/7206	0.000763229358235
ko05161	Hepatitis B	10/1005	173/7206	0.000792156311042
ko05166	HTLV-I infection	23/1005	292/7206	0.00137965784168
ko04070	Phosphatidylinositol signaling system	28/1005	112/7206	0.00145136182645
ko04924	Renin secretion	23/1005	86/7206	0.00147927234672
ko04540	Gap junction	31/1005	128/7206	0.00175079825841
ko04740	Olfactory transduction	21/1005	80/7206	0.00307304404629
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1005	100/7206	0.00315496092105
ko00310	Lysine degradation	2/1005	73/7206	0.00317729989724
ko04750	Inflammatory mediator regulation of TRP channels	29/1005	122/7206	0.00334869335342
ko04621	NOD-like receptor signaling pathway	10/1005	157/7206	0.00346425709011
ko05414	Dilated cardiomyopathy	27/1005	112/7206	0.00351871073452
ko04745	Phototransduction - fly	12/1005	38/7206	0.00417688797318
ko04260	Cardiac muscle contraction	24/1005	98/7206	0.00475341257391
ko00280	Valine, leucine and isoleucine degradation	1/1005	54/7206	0.00497213136562
ko05205	Proteoglycans in cancer	23/1005	271/7206	0.00710954501065
ko04630	Jak-STAT signaling pathway	8/1005	132/7206	0.00716366327032
ko04614	Renin-angiotensin system	7/1005	18/7206	0.00786729039937
ko04218	Cellular senescence	13/1005	177/7206	0.00811138648537
ko04976	Bile secretion	20/1005	80/7206	0.00833279362555
ko05212	Pancreatic cancer	4/1005	83/7206	0.0106119611013
ko05140	Leishmaniasis	3/1005	75/7206	0.0106362676283
ko05219	Bladder cancer	1/1005	48/7206	0.0109754516631
ko04371	Apelin signaling pathway	37/1005	177/7206	0.0109822504208
ko04710	Circadian rhythm	12/1005	43/7206	0.0137537807839
ko03420	Nucleotide excision repair	1/1005	46/7206	0.0165994711172
ko04930	Type II diabetes mellitus	14/1005	54/7206	0.0167691527851
ko05215	Prostate cancer	7/1005	111/7206	0.0179725109646
ko04620	Toll-like receptor signaling pathway	6/1005	100/7206	0.0190711288685
ko04146	Peroxisome	5/1005	89/7206	0.0199582666834
ko05130	Pathogenic Escherichia coli infection	4/1005	77/7206	0.0204284839694
ko04612	Antigen processing and presentation	4/1005	77/7206	0.0204284839694
ko04915	Estrogen signaling pathway	28/1005	131/7206	0.0209354505706
ko04961	Endocrine and other factor-regulated calcium reabsorption	15/1005	59/7206	0.0210318780549
ko04550	Signaling pathways regulating pluripotency of stem cells	13/1005	165/7206	0.0223567430558
ko04932	Non-alcoholic fatty liver disease (NAFLD)	15/1005	182/7206	0.0225436793845
ko04660	T cell receptor signaling pathway	9/1005	124/7206	0.0262304656089
ko04015	Rap1 signaling pathway	52/1005	278/7206	0.026788222895
ko04922	Glucagon signaling pathway	27/1005	128/7206	0.0274703360862
ko04217	Necroptosis	15/1005	178/7206	0.0284553629283
ko00520	Amino sugar and nucleotide sugar metabolism	2/1005	55/7206	0.0287425554642
ko04626	Plant-pathogen interaction	6/1005	18/7206	0.0302968889268
ko00604	Glycosphingolipid biosynthesis - ganglio series	5/1005	14/7206	0.0352583527474
ko04916	Melanogenesis	29/1005	142/7206	0.0363661630499
ko00330	Arginine and proline metabolism	3/1005	61/7206	0.0399263371549
ko04140	Autophagy - animal	14/1005	164/7206	0.0403480729499
ko04622	RIG-I-like receptor signaling pathway	3/1005	62/7206	0.0405023429595
ko05222	Small cell lung cancer	6/1005	89/7206	0.0455615320102
ko05120	Epithelial cell signaling in Helicobacter pylori infection	20/1005	92/7206	0.0469335477444
ko04210	Apoptosis	16/1005	180/7206	0.0493306212229