ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko05033	Nicotine addiction	45/771	56/7206	3.06194891939e-34
ko04080	Neuroactive ligand-receptor interaction	133/771	423/7206	1.31400787369e-33
ko04724	Glutamatergic synapse	74/771	152/7206	7.18841384496e-33
ko05032	Morphine addiction	55/771	110/7206	2.29903343136e-25
ko04727	GABAergic synapse	54/771	110/7206	2.01867138497e-24
ko04728	Dopaminergic synapse	67/771	185/7206	8.43798819678e-21
ko04713	Circadian entrainment	56/771	136/7206	1.2502581249e-20
ko04723	Retrograde endocannabinoid signaling	64/771	175/7206	3.62335307464e-20
ko04725	Cholinergic synapse	57/771	160/7206	1.87007925655e-17
ko04721	Synaptic vesicle cycle	38/771	80/7206	6.71814599706e-17
ko04024	cAMP signaling pathway	76/771	279/7206	2.527171537e-15
ko04911	Insulin secretion	44/771	117/7206	1.0145879143e-14
ko05030	Cocaine addiction	31/771	73/7206	2.18630126571e-12
ko05031	Amphetamine addiction	32/771	91/7206	3.6052504622e-10
ko04261	Adrenergic signaling in cardiomyocytes	53/771	205/7206	4.90458545949e-10
ko04742	Taste transduction	25/771	61/7206	7.61583266021e-10
ko04720	Long-term potentiation	33/771	99/7206	9.47441127516e-10
ko04020	Calcium signaling pathway	61/771	265/7206	3.38900153238e-09
ko04726	Serotonergic synapse	39/771	137/7206	5.07195183277e-09
ko04921	Oxytocin signaling pathway	51/771	209/7206	9.0024197561e-09
ko05203	Viral carcinogenesis	5/771	277/7206	1.30586075536e-08
ko04010	MAPK signaling pathway	66/771	321/7206	9.34522587121e-08
ko04744	Phototransduction	16/771	36/7206	2.35173811434e-07
ko04970	Salivary secretion	27/771	95/7206	1.23373967337e-06
ko04060	Cytokine-cytokine receptor interaction	3/771	191/7206	1.24318311348e-06
ko04072	Phospholipase D signaling pathway	44/771	197/7206	1.65503835853e-06
ko03040	Spliceosome	1/771	145/7206	2.0228631424e-06
ko04514	Cell adhesion molecules (CAMs)	32/771	130/7206	4.54422508235e-06
ko04360	Axon guidance	48/771	233/7206	6.84746703419e-06
ko04925	Aldosterone synthesis and secretion	27/771	105/7206	1.62244048877e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	21/771	74/7206	1.92087338317e-05
ko04972	Pancreatic secretion	27/771	111/7206	3.26394324875e-05
ko04730	Long-term depression	21/771	78/7206	4.57701863864e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	21/771	79/7206	5.61920258468e-05
ko04971	Gastric acid secretion	24/771	98/7206	8.60915156021e-05
ko03013	RNA transport	4/771	166/7206	0.00010288804415
ko05414	Dilated cardiomyopathy	26/771	112/7206	0.000137412101939
ko04350	TGF-beta signaling pathway	1/771	103/7206	0.000167468943514
ko04915	Estrogen signaling pathway	28/771	131/7206	0.000284388862789
ko05168	Herpes simplex infection	6/771	182/7206	0.000360100609566
ko04540	Gap junction	27/771	128/7206	0.000445367936233
ko04022	cGMP-PKG signaling pathway	40/771	216/7206	0.000463484642116
ko05169	Epstein-Barr virus infection	8/771	206/7206	0.000530465072356
ko04260	Cardiac muscle contraction	22/771	98/7206	0.000716593355268
ko04621	NOD-like receptor signaling pathway	5/771	157/7206	0.000927173308425
ko04120	Ubiquitin mediated proteolysis	4/771	138/7206	0.00117175330039
ko03018	RNA degradation	1/771	84/7206	0.00120783343032
ko05322	Systemic lupus erythematosus	5/771	151/7206	0.00125848348505
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/771	14/7206	0.00207435482682
ko04110	Cell cycle	5/771	145/7206	0.00248126699282
ko03008	Ribosome biogenesis in eukaryotes	1/771	79/7206	0.00270976635549
ko04932	Non-alcoholic fatty liver disease (NAFLD)	8/771	182/7206	0.00330185298094
ko05164	Influenza A	7/771	167/7206	0.00337922644402
ko04141	Protein processing in endoplasmic reticulum	8/771	184/7206	0.00338945566427
ko00515	Mannose type O-glycan biosynthesis	8/771	25/7206	0.00340491594778
ko05205	Proteoglycans in cancer	15/771	271/7206	0.00350971261534
ko04740	Olfactory transduction	17/771	80/7206	0.00527127542463
ko04630	Jak-STAT signaling pathway	5/771	132/7206	0.0064021016685
ko04015	Rap1 signaling pathway	44/771	278/7206	0.00726813778996
ko04923	Regulation of lipolysis in adipocytes	16/771	77/7206	0.00821121563529
ko05231	Choline metabolism in cancer	24/771	134/7206	0.0104295870028
ko04140	Autophagy - animal	8/771	164/7206	0.010488632482
ko04064	NF-kappa B signaling pathway	3/771	96/7206	0.0116113749032
ko00240	Pyrimidine metabolism	4/771	110/7206	0.0120098576536
ko04924	Renin secretion	17/771	86/7206	0.01234702195
ko04930	Type II diabetes mellitus	12/771	54/7206	0.0124378045116
ko04640	Hematopoietic cell lineage	1/771	64/7206	0.0127639377282
ko05410	Hypertrophic cardiomyopathy (HCM)	19/771	100/7206	0.0130790934686
ko04218	Cellular senescence	9/771	177/7206	0.0130805878245
ko04612	Antigen processing and presentation	2/771	77/7206	0.0149327072338
ko04966	Collecting duct acid secretion	7/771	26/7206	0.0166566840647
ko05034	Alcoholism	37/771	238/7206	0.018500860953
ko00330	Arginine and proline metabolism	1/771	61/7206	0.0191981240378
ko04070	Phosphatidylinositol signaling system	20/771	112/7206	0.0197739694526
ko04214	Apoptosis - fly	2/771	72/7206	0.0212646190947
ko00310	Lysine degradation	2/771	73/7206	0.0212744080091
ko05140	Leishmaniasis	2/771	75/7206	0.0219319366399
ko04918	Thyroid hormone synthesis	16/771	86/7206	0.0224481025388
ko05133	Pertussis	3/771	87/7206	0.0225020727419
ko04217	Necroptosis	10/771	178/7206	0.0262100581039
ko00280	Valine, leucine and isoleucine degradation	1/771	54/7206	0.0265708395968
ko05321	Inflammatory bowel disease (IBD)	1/771	56/7206	0.0271107734174
ko04976	Bile secretion	15/771	80/7206	0.0273873729879
ko01200	Carbon metabolism	6/771	128/7206	0.0288449542448
ko00512	Mucin type O-glycan biosynthesis	7/771	29/7206	0.029831905446
ko03320	PPAR signaling pathway	2/771	69/7206	0.0302194037768
ko04961	Endocrine and other factor-regulated calcium reabsorption	12/771	59/7206	0.0304072573118
ko04670	Leukocyte transendothelial migration	8/771	151/7206	0.0319630980937
ko05418	Fluid shear stress and atherosclerosis	10/771	173/7206	0.0335597465987
ko05161	Hepatitis B	10/771	173/7206	0.0335597465987
ko05162	Measles	6/771	120/7206	0.0372034455645
ko04014	Ras signaling pathway	41/771	279/7206	0.0372580371563
ko00380	Tryptophan metabolism	1/771	50/7206	0.038826145226
ko05110	Vibrio cholerae infection	12/771	63/7206	0.0395757261522
ko04138	Autophagy - yeast	3/771	81/7206	0.0441734481677
ko05131	Shigellosis	3/771	82/7206	0.0450675168308
ko04137	Mitophagy - animal	3/771	82/7206	0.0450675168308