ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	172/960	423/7206	6.76565197658e-48
ko04724	Glutamatergic synapse	81/960	152/7206	1.50828320724e-32
ko05033	Nicotine addiction	46/960	56/7206	1.9452621014e-31
ko04713	Circadian entrainment	68/960	136/7206	2.70346193258e-25
ko04727	GABAergic synapse	60/960	110/7206	4.81253535508e-25
ko05032	Morphine addiction	60/960	110/7206	4.81253535508e-25
ko04721	Synaptic vesicle cycle	50/960	80/7206	8.90996281573e-25
ko04725	Cholinergic synapse	72/960	160/7206	3.34801018975e-23
ko04728	Dopaminergic synapse	78/960	185/7206	7.59329721629e-23
ko04723	Retrograde endocannabinoid signaling	72/960	175/7206	2.05245613448e-20
ko04024	cAMP signaling pathway	90/960	279/7206	6.17998594331e-17
ko04911	Insulin secretion	52/960	117/7206	9.089487041e-17
ko04726	Serotonergic synapse	54/960	137/7206	1.2292882548e-14
ko04742	Taste transduction	33/960	61/7206	3.58225268779e-14
ko04921	Oxytocin signaling pathway	68/960	209/7206	3.63363914482e-13
ko04020	Calcium signaling pathway	78/960	265/7206	2.10874119386e-12
ko05031	Amphetamine addiction	38/960	91/7206	1.41587529257e-11
ko04720	Long-term potentiation	40/960	99/7206	1.43149446777e-11
ko04261	Adrenergic signaling in cardiomyocytes	63/960	205/7206	4.1500945511e-11
ko04744	Phototransduction	21/960	36/7206	2.58194054431e-10
ko04970	Salivary secretion	36/960	95/7206	1.26343873418e-09
ko04360	Axon guidance	64/960	233/7206	5.75285553154e-09
ko04740	Olfactory transduction	31/960	80/7206	9.61339170076e-09
ko04925	Aldosterone synthesis and secretion	36/960	105/7206	2.80789184795e-08
ko03040	Spliceosome	1/960	145/7206	3.67909881077e-08
ko05030	Cocaine addiction	28/960	73/7206	6.49861971754e-08
ko04971	Gastric acid secretion	33/960	98/7206	1.73462671102e-07
ko04120	Ubiquitin mediated proteolysis	2/960	138/7206	8.57199869868e-07
ko04966	Collecting duct acid secretion	14/960	26/7206	1.02941149875e-06
ko05168	Herpes simplex infection	5/960	182/7206	1.2407739304e-06
ko05203	Viral carcinogenesis	13/960	277/7206	2.10139787943e-06
ko04060	Cytokine-cytokine receptor interaction	6/960	191/7206	2.25357123086e-06
ko04010	MAPK signaling pathway	72/960	321/7206	4.62756387843e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	25/960	74/7206	5.04439627262e-06
ko04514	Cell adhesion molecules (CAMs)	37/960	130/7206	5.08807071811e-06
ko05164	Influenza A	5/960	167/7206	7.97851731304e-06
ko05110	Vibrio cholerae infection	22/960	63/7206	1.01234299566e-05
ko04730	Long-term depression	25/960	78/7206	1.44530814867e-05
ko04540	Gap junction	35/960	128/7206	1.88025508926e-05
ko04621	NOD-like receptor signaling pathway	5/960	157/7206	2.33386335302e-05
ko03013	RNA transport	6/960	166/7206	3.91794148316e-05
ko04972	Pancreatic secretion	31/960	111/7206	5.09388345635e-05
ko04745	Phototransduction - fly	15/960	38/7206	5.1401023601e-05
ko04260	Cardiac muscle contraction	28/960	98/7206	6.11427770592e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	24/960	79/7206	6.87899215459e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/960	59/7206	0.000141686593291
ko04022	cGMP-PKG signaling pathway	49/960	216/7206	0.000142060314579
ko05322	Systemic lupus erythematosus	6/960	151/7206	0.000225303816219
ko04924	Renin secretion	24/960	86/7206	0.000308567453599
ko04612	Antigen processing and presentation	1/960	77/7206	0.000310146465567
ko04072	Phospholipase D signaling pathway	44/960	197/7206	0.000405339505477
ko04014	Ras signaling pathway	58/960	279/7206	0.00041886167024
ko04141	Protein processing in endoplasmic reticulum	10/960	184/7206	0.000607572618663
ko04750	Inflammatory mediator regulation of TRP channels	30/960	122/7206	0.00065631755432
ko05169	Epstein-Barr virus infection	12/960	206/7206	0.000776918754272
ko04915	Estrogen signaling pathway	31/960	131/7206	0.0010536997134
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/960	14/7206	0.00106538820752
ko04110	Cell cycle	7/960	145/7206	0.0011765312153
ko04064	NF-kappa B signaling pathway	3/960	96/7206	0.00125127402937
ko05162	Measles	5/960	120/7206	0.00157094182983
ko05414	Dilated cardiomyopathy	27/960	112/7206	0.00176728870121
ko03008	Ribosome biogenesis in eukaryotes	2/960	79/7206	0.00220853060748
ko04640	Hematopoietic cell lineage	1/960	64/7206	0.00240904330199
ko05205	Proteoglycans in cancer	20/960	271/7206	0.00250188228762
ko04146	Peroxisome	3/960	89/7206	0.00255099479754
ko04964	Proximal tubule bicarbonate reclamation	10/960	29/7206	0.00306452961864
ko05140	Leishmaniasis	2/960	75/7206	0.00313015027761
ko00330	Arginine and proline metabolism	1/960	61/7206	0.00359314248702
ko00240	Pyrimidine metabolism	5/960	110/7206	0.00419678534364
ko05161	Hepatitis B	11/960	173/7206	0.00441649023757
ko04070	Phosphatidylinositol signaling system	26/960	112/7206	0.00448030833877
ko04214	Apoptosis - fly	2/960	72/7206	0.00455635689311
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/960	92/7206	0.00497459355986
ko04932	Non-alcoholic fatty liver disease (NAFLD)	12/960	182/7206	0.00541234411341
ko04626	Plant-pathogen interaction	7/960	18/7206	0.00609541761699
ko04912	GnRH signaling pathway	27/960	122/7206	0.00670165961413
ko00280	Valine, leucine and isoleucine degradation	1/960	54/7206	0.00768069593239
ko04350	TGF-beta signaling pathway	5/960	103/7206	0.00793890398981
ko00480	Glutathione metabolism	1/960	55/7206	0.00796316244341
ko05034	Alcoholism	46/960	238/7206	0.00848573605971
ko04371	Apelin signaling pathway	36/960	177/7206	0.0094664098282
ko01524	Platinum drug resistance	3/960	76/7206	0.0104369705021
ko04976	Bile secretion	19/960	80/7206	0.0116591959148
ko04930	Type II diabetes mellitus	14/960	54/7206	0.0134669612111
ko05166	HTLV-I infection	25/960	292/7206	0.0135523974548
ko04668	TNF signaling pathway	7/960	120/7206	0.0138461480057
ko00561	Glycerolipid metabolism	2/960	63/7206	0.0138699414348
ko00310	Lysine degradation	3/960	73/7206	0.0147335363087
ko03018	RNA degradation	4/960	84/7206	0.0150656989618
ko00260	Glycine, serine and threonine metabolism	1/960	48/7206	0.0169049112322
ko04916	Melanogenesis	29/960	142/7206	0.0170914021337
ko04973	Carbohydrate digestion and absorption	11/960	42/7206	0.0212138537874
ko03022	Basal transcription factors	1/960	44/7206	0.0245658217907
ko00071	Fatty acid degradation	1/960	45/7206	0.0250169124006
ko04210	Apoptosis	14/960	180/7206	0.025787376541
ko00620	Pyruvate metabolism	1/960	46/7206	0.0259694408646
ko03420	Nucleotide excision repair	1/960	46/7206	0.0259694408646
ko04062	Chemokine signaling pathway	38/960	201/7206	0.0262971624182
ko04630	Jak-STAT signaling pathway	9/960	132/7206	0.0269697241973
ko05321	Inflammatory bowel disease (IBD)	2/960	56/7206	0.0281470337646
ko03320	PPAR signaling pathway	3/960	69/7206	0.0302307968317
ko04217	Necroptosis	14/960	178/7206	0.0329446661513
ko04722	Neurotrophin signaling pathway	31/960	160/7206	0.0331393246726
ko01200	Carbon metabolism	9/960	128/7206	0.034869853282
ko05410	Hypertrophic cardiomyopathy (HCM)	21/960	100/7206	0.036196429128
ko00980	Metabolism of xenobiotics by cytochrome P450	1/960	40/7206	0.0362164616823
ko00983	Drug metabolism - other enzymes	1/960	42/7206	0.0369498540355
ko00565	Ether lipid metabolism	1/960	42/7206	0.0369498540355
ko04657	IL-17 signaling pathway	5/960	87/7206	0.0375756267269
ko04015	Rap1 signaling pathway	49/960	278/7206	0.0379259058556
ko05323	Rheumatoid arthritis	19/960	89/7206	0.0391736529368
ko04115	p53 signaling pathway	4/960	74/7206	0.0393924026118
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	5/960	15/7206	0.0395181888163
ko00600	Sphingolipid metabolism	3/960	63/7206	0.0405235938061
ko05418	Fluid shear stress and atherosclerosis	14/960	173/7206	0.0409841172017
ko04114	Oocyte meiosis	27/960	139/7206	0.042536879155
ko05145	Toxoplasmosis	9/960	126/7206	0.0458095528633
ko00512	Mucin type O-glycan biosynthesis	8/960	29/7206	0.0472652163419
ko04658	Th1 and Th2 cell differentiation	6/960	96/7206	0.0473683879187