ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04724	Glutamatergic synapse	52/446	152/7206	5.19727653193e-26
ko05033	Nicotine addiction	32/446	56/7206	8.05130068479e-25
ko04080	Neuroactive ligand-receptor interaction	82/446	423/7206	7.00482396902e-22
ko05032	Morphine addiction	38/446	110/7206	2.11494526821e-19
ko04727	GABAergic synapse	37/446	110/7206	1.8100606117e-18
ko04723	Retrograde endocannabinoid signaling	45/446	175/7206	4.41618849604e-17
ko04728	Dopaminergic synapse	45/446	185/7206	4.39174766617e-16
ko04713	Circadian entrainment	37/446	136/7206	4.4673121014e-15
ko04024	cAMP signaling pathway	51/446	279/7206	9.84928741753e-13
ko04020	Calcium signaling pathway	49/446	265/7206	1.83225860032e-12
ko05031	Amphetamine addiction	27/446	91/7206	2.6582207782e-12
ko04720	Long-term potentiation	26/446	99/7206	1.42116805239e-10
ko05030	Cocaine addiction	22/446	73/7206	2.10327727109e-10
ko04911	Insulin secretion	28/446	117/7206	2.93505505596e-10
ko04725	Cholinergic synapse	33/446	160/7206	4.98264382101e-10
ko04742	Taste transduction	18/446	61/7206	1.3887949041e-08
ko04261	Adrenergic signaling in cardiomyocytes	35/446	205/7206	2.78805797292e-08
ko04921	Oxytocin signaling pathway	34/446	209/7206	1.50240030154e-07
ko04721	Synaptic vesicle cycle	19/446	80/7206	2.56668655575e-07
ko04010	MAPK signaling pathway	44/446	321/7206	5.76600669962e-07
ko04072	Phospholipase D signaling pathway	31/446	197/7206	1.14109130234e-06
ko05414	Dilated cardiomyopathy	21/446	112/7206	3.89174141634e-06
ko04925	Aldosterone synthesis and secretion	20/446	105/7206	5.149893684e-06
ko05203	Viral carcinogenesis	2/446	277/7206	5.26060400259e-06
ko04726	Serotonergic synapse	23/446	137/7206	9.49482186384e-06
ko04970	Salivary secretion	18/446	95/7206	1.64718698269e-05
ko04972	Pancreatic secretion	19/446	111/7206	4.29519863465e-05
ko04915	Estrogen signaling pathway	21/446	131/7206	4.72893100697e-05
ko04971	Gastric acid secretion	17/446	98/7206	9.097598073e-05
ko04740	Olfactory transduction	15/446	80/7206	9.43110335378e-05
ko04060	Cytokine-cytokine receptor interaction	1/446	191/7206	0.000100995789424
ko05014	Amyotrophic lateral sclerosis (ALS)	14/446	74/7206	0.000145404027288
ko04730	Long-term depression	14/446	78/7206	0.000259932831741
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	14/446	79/7206	0.000298442204916
ko04022	cGMP-PKG signaling pathway	27/446	216/7206	0.000443372470118
ko04145	Phagosome	1/446	162/7206	0.000720307076045
ko04923	Regulation of lipolysis in adipocytes	13/446	77/7206	0.000788213840156
ko04621	NOD-like receptor signaling pathway	1/446	157/7206	0.00108847220949
ko04744	Phototransduction	8/446	36/7206	0.0013128562662
ko04110	Cell cycle	1/446	145/7206	0.00149546545101
ko05231	Choline metabolism in cancer	18/446	134/7206	0.00161971022062
ko04912	GnRH signaling pathway	17/446	122/7206	0.00167512135839
ko03013	RNA transport	2/446	166/7206	0.00294342075888
ko00515	Mannose type O-glycan biosynthesis	6/446	25/7206	0.00350649037246
ko00190	Oxidative phosphorylation	1/446	127/7206	0.00466482920893
ko05410	Hypertrophic cardiomyopathy (HCM)	14/446	100/7206	0.00482683959633
ko05168	Herpes simplex infection	3/446	182/7206	0.00709624457377
ko04540	Gap junction	16/446	128/7206	0.00786919441686
ko04012	ErbB signaling pathway	14/446	109/7206	0.00793411233788
ko04260	Cardiac muscle contraction	13/446	98/7206	0.00889448357063
ko04070	Phosphatidylinositol signaling system	14/446	112/7206	0.00964733217431
ko04211	Longevity regulating pathway	15/446	123/7206	0.0119892975454
ko04932	Non-alcoholic fatty liver disease (NAFLD)	4/446	182/7206	0.0186136051212
ko04141	Protein processing in endoplasmic reticulum	4/446	184/7206	0.0188040845742
ko04213	Longevity regulating pathway - multiple species	11/446	86/7206	0.0204073723713
ko04350	TGF-beta signaling pathway	1/446	103/7206	0.0210776514065
ko04015	Rap1 signaling pathway	27/446	278/7206	0.0211752864879
ko04750	Inflammatory mediator regulation of TRP channels	14/446	122/7206	0.0216408228407
ko04666	Fc gamma R-mediated phagocytosis	14/446	122/7206	0.0216408228407
ko01522	Endocrine resistance	14/446	124/7206	0.0237447192986
ko04142	Lysosome	3/446	151/7206	0.0253461418926
ko04360	Axon guidance	23/446	233/7206	0.0257159528408
ko00601	Glycosphingolipid biosynthesis - lacto and neolacto series	5/446	28/7206	0.0267535806627
ko04745	Phototransduction - fly	6/446	38/7206	0.027747935184
ko00512	Mucin type O-glycan biosynthesis	5/446	29/7206	0.0307389094388
ko04976	Bile secretion	10/446	80/7206	0.0308618689613
ko00510	N-Glycan biosynthesis	7/446	50/7206	0.0329459614879
ko04914	Progesterone-mediated oocyte maturation	12/446	104/7206	0.0362933048079
ko04924	Renin secretion	10/446	86/7206	0.0427917750346
ko04918	Thyroid hormone synthesis	10/446	86/7206	0.0427917750346
ko00513	Various types of N-glycan biosynthesis	6/446	42/7206	0.042913122818
ko04146	Peroxisome	1/446	89/7206	0.0435356650031
ko05120	Epithelial cell signaling in Helicobacter pylori infection	1/446	92/7206	0.0452358802909
ko04930	Type II diabetes mellitus	7/446	54/7206	0.0473836738888