ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	174/1064	423/7206	1.18002615437e-42
ko04724	Glutamatergic synapse	83/1064	152/7206	5.17031132091e-31
ko05033	Nicotine addiction	47/1064	56/7206	7.344506742e-31
ko05032	Morphine addiction	66/1064	110/7206	4.06468260677e-28
ko04727	GABAergic synapse	63/1064	110/7206	2.6382523134e-25
ko04713	Circadian entrainment	70/1064	136/7206	3.05404039644e-24
ko04728	Dopaminergic synapse	82/1064	185/7206	1.09873195165e-22
ko04725	Cholinergic synapse	72/1064	160/7206	1.68234743881e-20
ko04723	Retrograde endocannabinoid signaling	74/1064	175/7206	4.15205282136e-19
ko04024	cAMP signaling pathway	98/1064	279/7206	5.07324448562e-18
ko04721	Synaptic vesicle cycle	45/1064	80/7206	5.59782360827e-18
ko04744	Phototransduction	27/1064	36/7206	6.82472309372e-16
ko04742	Taste transduction	33/1064	61/7206	7.16777471613e-13
ko04911	Insulin secretion	49/1064	117/7206	7.37799094566e-13
ko04921	Oxytocin signaling pathway	71/1064	209/7206	1.48266407962e-12
ko04020	Calcium signaling pathway	83/1064	265/7206	2.93964551447e-12
ko04261	Adrenergic signaling in cardiomyocytes	69/1064	205/7206	7.3801274112e-12
ko04726	Serotonergic synapse	51/1064	137/7206	5.06932553855e-11
ko05031	Amphetamine addiction	39/1064	91/7206	7.25808025941e-11
ko04720	Long-term potentiation	40/1064	99/7206	3.64073275822e-10
ko03040	Spliceosome	2/1064	145/7206	4.08921952215e-08
ko05203	Viral carcinogenesis	13/1064	277/7206	8.92902845822e-08
ko05030	Cocaine addiction	29/1064	73/7206	1.5167710969e-07
ko04925	Aldosterone synthesis and secretion	37/1064	105/7206	1.69028837553e-07
ko04970	Salivary secretion	34/1064	95/7206	2.61911722584e-07
ko04740	Olfactory transduction	29/1064	80/7206	1.46287237219e-06
ko04621	NOD-like receptor signaling pathway	5/1064	157/7206	3.33507769146e-06
ko04360	Axon guidance	61/1064	233/7206	3.39847560666e-06
ko04060	Cytokine-cytokine receptor interaction	8/1064	191/7206	3.73337888141e-06
ko03013	RNA transport	6/1064	166/7206	3.91910575745e-06
ko05322	Systemic lupus erythematosus	5/1064	151/7206	6.90201057543e-06
ko04971	Gastric acid secretion	32/1064	98/7206	8.35222241909e-06
ko05168	Herpes simplex infection	8/1064	182/7206	1.04971852811e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	26/1064	74/7206	1.66909369328e-05
ko04010	MAPK signaling pathway	76/1064	321/7206	1.68377727907e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1064	79/7206	3.97537118808e-05
ko04745	Phototransduction - fly	16/1064	38/7206	4.08407758543e-05
ko04022	cGMP-PKG signaling pathway	54/1064	216/7206	5.6209813395e-05
ko05164	Influenza A	8/1064	167/7206	5.72072450563e-05
ko03008	Ribosome biogenesis in eukaryotes	1/1064	79/7206	8.22171316456e-05
ko04070	Phosphatidylinositol signaling system	32/1064	112/7206	0.000135169065501
ko04260	Cardiac muscle contraction	29/1064	98/7206	0.000142961911457
ko04072	Phospholipase D signaling pathway	49/1064	197/7206	0.000144891157832
ko04730	Long-term depression	24/1064	78/7206	0.000288543123977
ko04141	Protein processing in endoplasmic reticulum	11/1064	184/7206	0.000297803937458
ko04972	Pancreatic secretion	31/1064	111/7206	0.000351214333342
ko05414	Dilated cardiomyopathy	31/1064	112/7206	0.00038019512342
ko04064	NF-kappa B signaling pathway	3/1064	96/7206	0.000387260543208
ko05205	Proteoglycans in cancer	21/1064	271/7206	0.000457668818917
ko04120	Ubiquitin mediated proteolysis	7/1064	138/7206	0.000582531606332
ko04966	Collecting duct acid secretion	11/1064	26/7206	0.000630324026151
ko04514	Cell adhesion molecules (CAMs)	34/1064	130/7206	0.000638384992265
ko04110	Cell cycle	8/1064	145/7206	0.000803237379506
ko05140	Leishmaniasis	2/1064	75/7206	0.00091457991169
ko05169	Epstein-Barr virus infection	15/1064	206/7206	0.00132768199924
ko04915	Estrogen signaling pathway	33/1064	131/7206	0.00166018245439
ko04923	Regulation of lipolysis in adipocytes	22/1064	77/7206	0.00172885617238
ko04924	Renin secretion	24/1064	86/7206	0.00181073269739
ko04014	Ras signaling pathway	60/1064	279/7206	0.00188831527626
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1064	14/7206	0.00198627565781
ko05161	Hepatitis B	12/1064	173/7206	0.00220908564372
ko00480	Glutathione metabolism	1/1064	55/7206	0.00332019873847
ko04612	Antigen processing and presentation	3/1064	77/7206	0.00339419847802
ko05162	Measles	7/1064	120/7206	0.00389936570626
ko00240	Pyrimidine metabolism	6/1064	110/7206	0.00398713461891
ko04750	Inflammatory mediator regulation of TRP channels	30/1064	122/7206	0.00419084025582
ko04640	Hematopoietic cell lineage	2/1064	64/7206	0.00419924743906
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/1064	59/7206	0.00488329898573
ko04540	Gap junction	31/1064	128/7206	0.00519387941344
ko05166	HTLV-I infection	28/1064	292/7206	0.0089891066642
ko04146	Peroxisome	5/1064	89/7206	0.0102565065031
ko05144	Malaria	1/1064	45/7206	0.0106018831662
ko00071	Fatty acid degradation	1/1064	45/7206	0.0106018831662
ko03420	Nucleotide excision repair	1/1064	46/7206	0.0107491760852
ko04626	Plant-pathogen interaction	7/1064	18/7206	0.0107575496673
ko05110	Vibrio cholerae infection	17/1064	63/7206	0.0111388423955
ko05145	Toxoplasmosis	9/1064	126/7206	0.0112155364666
ko04930	Type II diabetes mellitus	15/1064	54/7206	0.0113898974918
ko04510	Focal adhesion	22/1064	240/7206	0.0121405334761
ko05321	Inflammatory bowel disease (IBD)	2/1064	56/7206	0.0129031750008
ko04371	Apelin signaling pathway	38/1064	177/7206	0.0135656699728
ko04658	Th1 and Th2 cell differentiation	6/1064	96/7206	0.0136021770996
ko04657	IL-17 signaling pathway	5/1064	87/7206	0.0141708718771
ko05410	Hypertrophic cardiomyopathy (HCM)	24/1064	100/7206	0.01475217887
ko03022	Basal transcription factors	1/1064	44/7206	0.0164619272106
ko04350	TGF-beta signaling pathway	7/1064	103/7206	0.0173101549469
ko03018	RNA degradation	5/1064	84/7206	0.0194017627975
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1064	40/7206	0.0235227492132
ko00562	Inositol phosphate metabolism	21/1064	89/7206	0.0235876868207
ko04722	Neurotrophin signaling pathway	34/1064	160/7206	0.0238653251673
ko04217	Necroptosis	16/1064	178/7206	0.0247166913097
ko04062	Chemokine signaling pathway	41/1064	201/7206	0.0263403602466
ko00330	Arginine and proline metabolism	3/1064	61/7206	0.02801363351
ko04214	Apoptosis - fly	4/1064	72/7206	0.0281145173079
ko04622	RIG-I-like receptor signaling pathway	3/1064	62/7206	0.0286880826268
ko04964	Proximal tubule bicarbonate reclamation	9/1064	29/7206	0.0297204297302
ko05034	Alcoholism	47/1064	238/7206	0.0322925850459
ko05133	Pertussis	6/1064	87/7206	0.0333935278519
ko00982	Drug metabolism - cytochrome P450	1/1064	37/7206	0.0347555470092
ko04630	Jak-STAT signaling pathway	11/1064	132/7206	0.0347929286463
ko03410	Base excision repair	1/1064	38/7206	0.0355599167091
ko04976	Bile secretion	19/1064	80/7206	0.0373119108404
ko05219	Bladder cancer	2/1064	48/7206	0.0388225935093
ko04210	Apoptosis	17/1064	180/7206	0.0427441612861
ko00513	Various types of N-glycan biosynthesis	11/1064	42/7206	0.0473065228455
ko04973	Carbohydrate digestion and absorption	11/1064	42/7206	0.0473065228455
ko04115	p53 signaling pathway	5/1064	74/7206	0.0484301170254